Acute head-only exposure of dogs to phosgene. Part III. Comparison of indicators of lung injury in dogs and rats

Inhalation Toxicology

Volumn 18, Issue 9, 2006, Pages 609-621

  Pauluhn, Jürgen ^a,b  

^a BAYER PHARMA AG   (Germany)

^b Institute of Toxicology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; PHOSGENE; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; BREATHING PATTERN; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DOG; EXPOSURE; EXUDATE; FEMALE; HISTOPATHOLOGY; INFLAMMATION; LUNG INJURY; LUNG LAVAGE; LUNG MINUTE VOLUME; LUNG WEIGHT; MALE; MORTALITY; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; CHEMICAL WARFARE AGENTS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHALATION EXPOSURE; LUNG; MACROPHAGES, ALVEOLAR; MALE; NEUTROPHILS; ORGAN SIZE; PHOSGENE; PHOSPHOLIPIDS; PROTEINS; PULMONARY ALVEOLI; RATS; RESPIRATION; SPECIES SPECIFICITY;

CANIS FAMILIARIS; RODENTIA;

EID: 33645319375     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370600742797     Document Type: Article

References (27)

1. Bide, R. W., Armour, S. J., and Yee, E. 2000. Allometric respiration/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans. J. Appl. Toxicol. 20:273-290.
2. Cucinell, S. A., and Edgewood, A. 1974. Review of the toxicity of long-term phosgene exposure. Arch. Envrion. Health 28:272-275.
3. DeGeorge, J. J., Ahn, C. H., Andrews, P. A., Brower, M. E., Choi, Y. S., Chun, M. Y., Du, T., Lee-Ham, D. Y., McGuinn, W. D., Pei, L., Sancilio, L. F., Schmidt, W., Sheevers, H. V., Sun, C. J., Tripathi, S., Vogel, W. M., Whitehurst, V., Williams, S., and Taylor, A. S. 1997. Considerations for toxicology studies of respiratory drug products. Regul. Toxicol. Pharmacol. 25:189-193.
4. Diller, W. F., and Zante, R. 1982. Dosis-Wirkungs-Beziehungen bei Phosgeneinwirkung auf Mensch und Tier. Zbl. Arbeitsmed. 32:360-368.
5. European Commission. 1986. Directive 86/609/EEC. Guideline of the Council dated November 24, 1986 on the reconciliation of legal and administrative regulations of the member countries for the protection of animals used for studies and other scientific purposes. J. Eur. Commun. Legal Spec. L358 29:1-28.
6. 2 effects on the respiratory system in dogs; Changes in mechanical behavior at different levels of the respiratory system during acute exposure to the gas. Arch. Environ. Health 11:624-634.
7. Hatch, G. E. 1992. Comparative biochemistry of airway lining fluid. In Treatise on pulmonary toxicology - Comparative biology of the normal lung, vol. I, ed. R. A. Parent, pp. 617-632. Boca Raton, FL: CRC Press.
8. Hatch, G. E., Kodavanti, U., Crissman, K., Slade, R., and Costa, D. 2001. An "injury-time integral" model for extrapolating from acute to chronic effects of phosgene. Toxicol. Ind. Health 17:285-293.
9. Heyder, J., and Takenaka, S. 1996. Long-term canine exposure studies with ambient air pollutants. Eur. Respir. J. 9:571-584.
10. Kodavanti, U. P., Costa, D. L., Giri, S. N., Starcher, B., and Hatch, G. E. 1997. Pulmonary structural and extracellular matrix alterations in Fischer 344 rats following subchronic exposure. Fundam. Appl. Toxicol. 37:54-63.
11. Kreyling, W. G., Dirscherl, P., Ferron, G. A., Heilmann, P., Josten, M., Miaskowski, U., Neuner, M., Ruprecht, L., Schumann, G., Tabenaka, S., Ziesenis, A., and Heyder, J. 1999. Health effects of sulfur-related environmental air pollution. III. Nonspecific respiratory defense capacities. Inhal. Toxicol. 11:391-422.
12. Lee, L.-Y. and Widdicombe, J. G. 2001. Modulation of airway sensitivity to inhaled irritants: Role of inflammatory mediators. Environ. Health Perspect. 109(suppl. 4):585-589.
13. Mautone, A. J., Katz, Z., and Scarpelli, E. M. 1985. Acute responses to phosgene inhalation and selected corrective measures (including surfactant). Toxicol. Ind. Health 1: 37-55.
14. Melville, G. N., Kumar, M., Ismail, S., and Mills, J. L. 1982. Response to the central and peripheral airways to cigarette smoking in humans and rats. Respiration 43:29-34.
15. National Research Council. 2002. AEGL (acute exposure guideline levels) for slected airborne chemicals, vol. 2. Phosgene. Washington, D.C: National Academies Press.
16. Nerbrink, O., Fagerström, P.-O., Wendel, T., Eirefelt, S., Källén, A., Marchner, H., and Dahlbäck, M. 1997. A novel dry powder aerosol delivery system for real-time measurement of the inhaled dose to large animals (dogs). Aerosol Sci. Technol. 27:147-161.
17. Okonek, S., Schuster, S., Löser, E., and Pauluhn, J. 1987. Hämodynamik und biochemische Veränderungen im toxischen Lungenödem durch Phosgen. MuPHefte, pp. 36-44.
18. Organization for Economic Cooperation and Development. 1983. [Publication of the German version of the OECD Principles of Good Laboratory Practice (GLP).] Bundesanzeiger 35 (42a), March 2.
19. Park, S. S., Kikkawa, Y., Goldring, I. P., Daly, M. M., Zelefsky, M., Shim, C., Spierer, M., and Morita, T. 1977. An animal model of cigarette smoking in beagle dogs: Correlative evaluation of effects on pulmonary function, defense, and morphology. Am. Rev. Respir. Dis. 115:971-979.
20. Pauluhn, J. 2002. Aniline-induced methemoglobinemia in dogs: Pitfalls of route-to-route extrapolations. Inhal. Toxicol. 14:959-973.
21. Pauluhn, J. 2005. Concentration-dependence of aniline-induced methemoglobinemia in dogs: A derivation of an acute reference concentration. Toxicology 214:140-150.
22. 50s and nonlethal threshold concentrations and analysis of breathing patterns. Inhal. Toxicol. 18:423-435.
23. Pauluhn, J. 2006b. Acute nose-only exposure of rats to phosgene. Part II. Concentration x time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months. Inhal. Toxicol. 18:595-607.
24. Persson, C. G. A., Erjefält, J. S., Andersson, M., Greiff, L., and Svensson C. 1996. Extravasation, lamina propria flooding and luminal entry of bulk plasma exudates in mucosal defence, inflammation and repair. Pulmon. Pharmacol. 9:129-139.
25. Pittet, J. F., Mackersie, R. C., Martin, T. R., and Matthay, M. A. 1997. Biological markers of acute lung injury: Prognostic and pathogenetic significance. Am. J. Respir. Crit. Care Med. 155:1187-1205.
26. Takenaka, S., Heini, A., Ritter, B., and Heyder, J. 1996. Morphometric evaluation of bronchial glands of beagle dogs. Toxicol. Lett. 88:279-285.
27. Takenaka, S., Heini, A., Ritter, B., and Heyder, J. 1998. The respiratory bronchiole of beagle dogs: structural characteristics. Toxicol. Lett. 96-97: 301-308.