hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

British Journal of Cancer

Volumn 94, Issue 6, 2006, Pages 870-878

  Chang, J T ^a   Lu, Y C ^b   Chen, Y J ^b   Tseng, C P ^b   Chen, Y L ^b   Fang, C W ^b   Cheng, A J ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

hTERT; Phosphorylation; PKC isoenzymes; Telomerase

Indexed keywords

5 CHLORO N HEPTYL 1 NAPHTHALENESULFONAMIDE; BISINDOLYLMALEIMIDE; CISPLATIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HOLOENZYME; NOVOBIOCIN; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARCINOGENESIS; CHEMOSENSITIVITY; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBUNIT; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE;

CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEAD AND NECK NEOPLASMS; HUMANS; PHOSPHORYLATION; PROTEIN KINASE C; RNA INTERFERENCE; TELOMERASE; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 33645304018     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603008     Document Type: Article

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