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Volumn 5, Issue 1, 2006, Pages 78-87

The hay wells syndrome-derived TAp63αQ540L mutant has impaired transcriptional and cell growth regulatory activity

Author keywords

Genetic alteration; Hay Wells syndrome; Microarray; TAp63 ; Transcription regulation

Indexed keywords

MUTANT PROTEIN; PROTEIN P63;

EID: 33645290551     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.1.2268     Document Type: Article
Times cited : (16)

References (55)
  • 1
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398:708-13.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 3
    • 0942301281 scopus 로고    scopus 로고
    • p63 is the molecular switch for initiation of an epithelial stratification program
    • see comment
    • Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 2004; 18:126-31, [see comment].
    • (2004) Genes Dev , vol.18 , pp. 126-131
    • Koster, M.I.1    Kim, S.2    Mills, A.A.3    DeMayo, F.J.4    Roop, D.R.5
  • 4
    • 1642538322 scopus 로고    scopus 로고
    • The role of p63 in development and differentiation of the epidermis
    • Koster MI, Roop DR. The role of p63 in development and differentiation of the epidermis. Journal of Dermatological Science 2004; 34:3-9.
    • (2004) Journal of Dermatological Science , vol.34 , pp. 3-9
    • Koster, M.I.1    Roop, D.R.2
  • 5
    • 4644248840 scopus 로고    scopus 로고
    • Transgenic mouse models provide new insights into the role of p63 in epidermal development
    • Koster MI, Roop DR. Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle 2004; 3:411-3.
    • (2004) Cell Cycle , vol.3 , pp. 411-413
    • Koster, M.I.1    Roop, D.R.2
  • 7
    • 25444475263 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome: A p53 family affair
    • Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: A p53 family affair. Cell Cycle 2005; 4:865-7.
    • (2005) Cell Cycle , vol.4 , pp. 865-867
    • Iwakuma, T.1    Lozano, G.2    Flores, E.R.3
  • 8
    • 26444583296 scopus 로고    scopus 로고
    • DeltaNp63alpha levels correlate with clinical tumor response to cisplatin
    • Zangen R, Ratovitski E, Sidransky D. DeltaNp63alpha levels correlate with clinical tumor response to cisplatin. Cell Cycle 2005; 4:1313-5.
    • (2005) Cell Cycle , vol.4 , pp. 1313-1315
    • Zangen, R.1    Ratovitski, E.2    Sidransky, D.3
  • 9
    • 33645280273 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome: A p53 family affair
    • Blandino G, Dobbelstein M. Li-Fraumeni syndrome: A p53 family affair. Cell Cycle 2004; 3:865-7.
    • (2004) Cell Cycle , vol.3 , pp. 865-867
    • Blandino, G.1    Dobbelstein, M.2
  • 10
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V, Andrews NC, Caput D, McKeon F. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2:305-16.
    • (1998) Mol Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 12
    • 0033575719 scopus 로고    scopus 로고
    • Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
    • Chi SW, Ayed A, Arrowsmith CH. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO Journal 1999; 18:4438-45.
    • (1999) EMBO Journal , vol.18 , pp. 4438-4445
    • Chi, S.W.1    Ayed, A.2    Arrowsmith, C.H.3
  • 14
    • 25144501596 scopus 로고    scopus 로고
    • Destabilization of ΔNp63α by Nedd4-mediated ubiquitination Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo
    • Bakkers J, Camacho-Carvajal M, Novak M, Kramer C, Danger B, Hammerschmidt M. Destabilization of ΔNp63α by Nedd4-mediated ubiquitination Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 2005; 4:790-800.
    • (2005) Cell Cycle , vol.4 , pp. 790-800
    • Bakkers, J.1    Camacho-Carvajal, M.2    Novak, M.3    Kramer, C.4    Danger, B.5    Hammerschmidt, M.6
  • 15
    • 0037169519 scopus 로고    scopus 로고
    • The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
    • Calabro V, Mansueto G, Parisi T, Vivo M, Calogero RA, La Mantia G. The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. J Biol Chem 2002; 277:2674-81.
    • (2002) J Biol Chem , vol.277 , pp. 2674-2681
    • Calabro, V.1    Mansueto, G.2    Parisi, T.3    Vivo, M.4    Calogero, R.A.5    La Mantia, G.6
  • 16
    • 4544240597 scopus 로고    scopus 로고
    • Inhibition of p63 transcriptional activity by p14ARF: Functional and physical link between human ARF tumor suppressor and a member of the p53 family
    • Calabro V, Mansueto G, Santoro R, Gentilella A, Pollice A, Ghioni P, Guerrini L, La Mantia G. Inhibition of p63 transcriptional activity by p14ARF: Functional and physical link between human ARF tumor suppressor and a member of the p53 family. Mol Cell Biol 2004; 24:8529-40.
    • (2004) Mol Cell Biol , vol.24 , pp. 8529-8540
    • Calabro, V.1    Mansueto, G.2    Santoro, R.3    Gentilella, A.4    Pollice, A.5    Ghioni, P.6    Guerrini, L.7    La Mantia, G.8
  • 18
    • 20244362375 scopus 로고    scopus 로고
    • Altered sumoylation of p63α contributes to the Split-hand/foot malformation phenotype
    • Huang YP, Wu G, Guo Z, Osada M, Fomenkov A, Ratovitski EA. Altered sumoylation of p63α contributes to the Split-hand/foot malformation phenotype. Cell Cycle 2004; 3:1587-96.
    • (2004) Cell Cycle , vol.3 , pp. 1587-1596
    • Huang, Y.P.1    Wu, G.2    Guo, Z.3    Osada, M.4    Fomenkov, A.5    Ratovitski, E.A.6
  • 19
    • 25144495237 scopus 로고    scopus 로고
    • Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of ΔNP63α
    • Westfall MD, Joyner AS, Barbieri CE, Livingstone M, Pietenpol JA. Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of ΔNP63α. Cell Cycle 2005; 4:710-6.
    • (2005) Cell Cycle , vol.4 , pp. 710-716
    • Westfall, M.D.1    Joyner, A.S.2    Barbieri, C.E.3    Livingstone, M.4    Pietenpol, J.A.5
  • 24
    • 0017118874 scopus 로고
    • The syndrome of ankyloblepharon, ectodermal defects and cleft lip and palate: An autosomal dominant condition
    • Hay RJ, Wells RS. The syndrome of ankyloblepharon, ectodermal defects and cleft lip and palate: An autosomal dominant condition. Brit J Dermatol 1976; 94:277-89.
    • (1976) Brit J Dermatol , vol.94 , pp. 277-289
    • Hay, R.J.1    Wells, R.S.2
  • 25
    • 0036892018 scopus 로고    scopus 로고
    • Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains
    • Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L. Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains. Mol Cell Biol 2002; 22:8659-68.
    • (2002) Mol Cell Biol , vol.22 , pp. 8659-8668
    • Ghioni, P.1    Bolognese, F.2    Duijf, P.H.3    Van Bokhoven, H.4    Mantovani, R.5    Guerrini, L.6
  • 26
    • 0036297530 scopus 로고    scopus 로고
    • Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors
    • Parisi T, Pollice A, Di Cristofano A, Calabro V, La Mantia G. Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors. Biochem Biophys Res Commun 2002; 291:1138-45.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 1138-1145
    • Parisi, T.1    Pollice, A.2    Di Cristofano, A.3    Calabro, V.4    La Mantia, G.5
  • 27
    • 0037377761 scopus 로고    scopus 로고
    • The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
    • Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 2003; 23:2264-76.
    • (2003) Mol Cell Biol , vol.23 , pp. 2264-2276
    • Westfall, M.D.1    Mays, D.J.2    Sniezek, J.C.3    Pietenpol, J.A.4
  • 29
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003; 19:185-93.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 31
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • erratum appears in Proc Natl Acad Sci USA 2001 Aug 28;98:10515
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the United States of America 2001; 98:5116-21, [erratum appears in Proc Natl Acad Sci USA 2001 Aug 28;98:10515.
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 34
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Duluth
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (Duluth) 2001; 25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 35
    • 0034743628 scopus 로고    scopus 로고
    • p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
    • Dohn M, Zhang S, Chen X. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 2001; 20:3193-205.
    • (2001) Oncogene , vol.20 , pp. 3193-3205
    • Dohn, M.1    Zhang, S.2    Chen, X.3
  • 36
    • 22544441310 scopus 로고    scopus 로고
    • Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: Importance for the regulation of genes involved in cell-cycle arrest and apoptosis
    • Koutsodontis G, Vasilaki E, Chou WC, Papakosta P, Kardassis D. Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: Importance for the regulation of genes involved in cell-cycle arrest and apoptosis. Biochem J 2005; 15:443-55.
    • (2005) Biochem J , vol.15 , pp. 443-455
    • Koutsodontis, G.1    Vasilaki, E.2    Chou, W.C.3    Papakosta, P.4    Kardassis, D.5
  • 37
    • 0037505736 scopus 로고    scopus 로고
    • p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells
    • Phelps M, Darley M, Primrose JN, Blaydes JP. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res 2003; 63:2616-23.
    • (2003) Cancer Res , vol.63 , pp. 2616-2623
    • Phelps, M.1    Darley, M.2    Primrose, J.N.3    Blaydes, J.P.4
  • 38
    • 21744440252 scopus 로고    scopus 로고
    • DNA-binding and transactivation activities are essential for TAp63 protein degradation
    • Ying H, Chang DL, Zheng H, McKeon F, Xiao Z. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol 2005; 25:6154-64.
    • (2005) Mol Cell Biol , vol.25 , pp. 6154-6164
    • Ying, H.1    Chang, D.L.2    Zheng, H.3    McKeon, F.4    Xiao, Z.5
  • 39
    • 27744597937 scopus 로고    scopus 로고
    • Regulation of the cyclin-dependent kinase inhibitor p57kip2 expression by p63
    • Beretta C, Chiarelli A, Testoni B, Mantovani R, Guerrini L. Regulation of the cyclin-dependent kinase inhibitor p57kip2 expression by p63. Cell Cycle 2005; 4:1623-9.
    • (2005) Cell Cycle , vol.4 , pp. 1623-1629
    • Beretta, C.1    Chiarelli, A.2    Testoni, B.3    Mantovani, R.4    Guerrini, L.5
  • 42
    • 0035367767 scopus 로고    scopus 로고
    • Calmin, a protein with calponin homology and transmembrane domains expressed in maturing spermatogenic cells
    • Ishisaki Z, Takaishi M, Furuta I, Huh N. Calmin, a protein with calponin homology and transmembrane domains expressed in maturing spermatogenic cells. Genomics 2001; 74:172-9.
    • (2001) Genomics , vol.74 , pp. 172-179
    • Ishisaki, Z.1    Takaishi, M.2    Furuta, I.3    Huh, N.4
  • 43
    • 0029077807 scopus 로고
    • Carboxypeptidase M is identical to the MAX. 1 antigen and its expression is associated with monocyte to macrophage differentiation
    • Rehli M, Krause SW, Kreutz M, Andreesen R. Carboxypeptidase M is identical to the MAX. 1 antigen and its expression is associated with monocyte to macrophage differentiation. J Biol Chem 1995; 270:15644-9.
    • (1995) J Biol Chem , vol.270 , pp. 15644-15649
    • Rehli, M.1    Krause, S.W.2    Kreutz, M.3    Andreesen, R.4
  • 44
    • 0037303039 scopus 로고    scopus 로고
    • Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells
    • Uchida K, Chaudhary LR, Sugimura Y, Adkisson HD, Hruska KA. Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells. J Cell Biochem 2003; 88:394-9.
    • (2003) J Cell Biochem , vol.88 , pp. 394-399
    • Uchida, K.1    Chaudhary, L.R.2    Sugimura, Y.3    Adkisson, H.D.4    Hruska, K.A.5
  • 46
    • 0033755690 scopus 로고    scopus 로고
    • FGF5 stimulates expansion of connective tissue fibroblasts and inhibits skeletal muscle development in the limb
    • Clase KL, Mitchell PJ, Ward PJ, Dorman CM, Johnson SE, Hannon K. FGF5 stimulates expansion of connective tissue fibroblasts and inhibits skeletal muscle development in the limb. Dev Dynam 2000; 219:368-80.
    • (2000) Dev Dynam , vol.219 , pp. 368-380
    • Clase, K.L.1    Mitchell, P.J.2    Ward, P.J.3    Dorman, C.M.4    Johnson, S.E.5    Hannon, K.6
  • 48
    • 0025305523 scopus 로고
    • Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis
    • Hebert JM, Basilico C, Goldfarb M, Haub O, Martin GR. Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev Biol 1990; 138:454-63.
    • (1990) Dev Biol , vol.138 , pp. 454-463
    • Hebert, J.M.1    Basilico, C.2    Goldfarb, M.3    Haub, O.4    Martin, G.R.5
  • 49
  • 50
    • 0034602650 scopus 로고    scopus 로고
    • PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway
    • USA
    • Tan M, Wang Y, Guan K, Sun Y. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Nat Acad Sci USA 2000; 97:109-14.
    • (2000) Proc Nat Acad Sci , vol.97 , pp. 109-114
    • Tan, M.1    Wang, Y.2    Guan, K.3    Sun, Y.4
  • 51
    • 0037135581 scopus 로고    scopus 로고
    • A novel p53 transcriptional repressor element (p53TRE) and the asymmetrical contribution of two p53 binding sites modulate the response of the placental transforming growth factor-beta promoter to p53
    • Wong J, Li PX, Klamut HJ. A novel p53 transcriptional repressor element (p53TRE) and the asymmetrical contribution of two p53 binding sites modulate the response of the placental transforming growth factor-beta promoter to p53. J Biol Chem 2002; 277:26699-707.
    • (2002) J Biol Chem , vol.277 , pp. 26699-26707
    • Wong, J.1    Li, P.X.2    Klamut, H.J.3
  • 52
    • 3242891755 scopus 로고    scopus 로고
    • Bves is expressed in the epithelial components of the retina, lens, and cornea
    • Ripley AN, Chang MS, Bader DM. Bves is expressed in the epithelial components of the retina, lens, and cornea. Invest Ophthalmol Visual Sci 2004; 45:2475-83.
    • (2004) Invest Ophthalmol Visual Sci , vol.45 , pp. 2475-2483
    • Ripley, A.N.1    Chang, M.S.2    Bader, D.M.3
  • 53
    • 1542318289 scopus 로고    scopus 로고
    • Bves expression during avian embryogenesis
    • Osler ME, Bader DM. Bves expression during avian embryogenesis. Dev Dynamics 2004; 229:658-67.
    • (2004) Dev Dynamics , vol.229 , pp. 658-667
    • Osler, M.E.1    Bader, D.M.2
  • 55
    • 4243138117 scopus 로고    scopus 로고
    • A dynamic model of keratinocyte stem cell renewal and differentiation: Role of the p21WAF1/Cip1 and Notch1 signaling pathways
    • Okuyama R, LeFort K, Dotto GP. A dynamic model of keratinocyte stem cell renewal and differentiation: Role of the p21WAF1/Cip1 and Notch1 signaling pathways. J Invest Dermatol Symp Proc 2004; 9:248-52.
    • (2004) J Invest Dermatol Symp Proc , vol.9 , pp. 248-252
    • Okuyama, R.1    LeFort, K.2    Dotto, G.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.