Proton magnetic resonance spectroscopy of normal appearing white matter in asymptomatic relatives of multiple sclerosis patients

European Journal of Neurology

Volumn 13, Issue 3, 2006, Pages 296-298

  Siger Zajdel, M ^a   Selmaj, K ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Multiple sclerosis; Relatives of MS patients; Spectroscopy

Indexed keywords

CHOLINE DERIVATIVE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; MALE; METABOLITE; MULTIPLE SCLEROSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RELATIVE; WHITE MATTER;

ADULT; ASPARTIC ACID; CHOLINE; CREATINE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MULTIPLE SCLEROSIS; PROTONS;

EID: 33645288274     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2006.01177.x     Document Type: Article

References (13)

1. Fulton JC Grossman RI Mannon LJ Mannon LJ Udupa J Kolson DL. Familial multiple sclerosis: volumetric assessment in clinically symptomatic and asymptomatic individuals. Multiple Sclerosis 1999 5 74 77.
2. Engell T. A clinical patho-anatomical study of clinically silent multiple sclerosis. Acta Neurologica Scandinavica 1989 79 428 430.
3. Siger-Zajdel M Filippi M Selmaj K. MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS. Neurology 2002 58 317 320.
4. Urenjak J Williams SR Gadian DG Noble M. H-NMR spectroscopy unambiguously identifies different neural cell types. Journal of Neuroscience 1993 13 981 989.
5. Cercignani M Bozzali M Iannucci G Comi G Filippi M. Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 2001 70 311 317.
6. Tortorella C Viti B Bozzali M et al. A magnetization transfer histogram study of normal-appearing brain tissue in MS. Neurology 2000 54 186 193.
7. Hiehle JF Lenkinski E Grossman RI et al. Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. Magnetic Resonance in Medicine 1994 32 285 293.
8. Pike GB de Stefano N Narayanan S Francis GS Antel JP Arnold DL. Combined magnetization transfer and proton spectroscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis. AJNR. American Journal of Neuroradiology 1999 20 829 837.
9. Filippi M Rocca MA Martino G Horsfield MA Comi G. Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Annals of Neurology 1998 43 809 814.
10. Arnold DL Matthews PM Francis GS O'Connor J Antel JP. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Annals of Neurology 1992 31 235 241.
11. Brenner RE Munro PM Wiliams SC Bell JD Baker GJ Hawkins CP. The proton NMR spectrum in acute EAE: the significance of the changes in the Cho:Cr ratio. Magnetic Resonance in Medicine 1993 29 737 745.
12. Davie CA Barker GJ Thompson AJ Tofta PS McDonald WI Miller DH. H-magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 1997 63 736 742.
13. Kapeller P Brex PA Chard D et al. Quantitative 1HMRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis. Multiple Sclerosis 2002 8 207 210.