Familial multiple sclerosis: Volumetric assessment in clinically symptomatic and asymptomatic individuals

Multiple Sclerosis

Volumn 5, Issue 2, 1999, Pages 74-77

  Fulton, Jennifer C ^a   Grossman, Robert I ^a   Mannon, Lois J ^a   Udupa, Jayaram ^a   Kolson, Dennis L ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Genetics; Magnetic Resonance imaging; T2 lesion volume

Indexed keywords

ARTICLE; BRAIN INJURY; DEMYELINATION; FAMILIAL DISEASE; FEMALE; GENETIC PREDISPOSITION; HUMAN; MALE; MONOZYGOTIC TWINS; MULTIPLE SCLEROSIS; SIBLING;

EID: 0032891960     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245859900500202     Document Type: Article

References (41)

1. Ebers GC et al. (1986) A population-based study of multiple sclerosis in twins. The N Engl J Med 315: 1638-1642.
2. Ebers G. (1994) Genetics and Multiple Sclerosis: An Overview. Ann Neurol 36: S12-S14.
3. Ebers GC et al. (1996) A full genome search in multiple sclerosis. Nature Genetics 13: 472-476.
4. Epplen C et al. (1997) Genetic Predisposition to Multiple Sclerosis as Revealed by Immunoprinting. Ann Neurol 41: 341-352.
5. Ebers GC, Sadovnick AD, Risch NJ et al. (1995) A Genetic Basis for Familial Aggregation in Multiple Sclerosis. Nature 377: 150-151.
6. Robertson NP, Clayton D, Fraser M, Deans J, Compston DAS. (1995) Clinical concordance in sibling pairs with multiple sclerosis. Neurology 47: 347-352.
7. Sadovnick AD, Armstrong H, Rice R, Bulman D, Hashimoti H, Pary DW, Hashimoto SA, Warren S et al. (1993) A Population-Based Study of Multiple Sclerosis in Twins: Update. N Engl J Med 33: 1638-1642.
8. Sadovnick AD. (1994) Genetics of Multiple Sclerosis in British Columbia and throughout Canada. Ann Neurol 36: S18-S21.
9. Goodkin DE, Rudnick RA, Ross JS. (1994) The Use of Brain Magnetic Resonance Imaging in Multiple Sclerosis. Arch Neurol 51: 505-516.
10. Koopmans RA LD, Oger JJ et al. (1989) The lesion of multiple sclerosis: imaging of acute and chronic stages. Neurology 39.
11. Issac C, Li DK, Genton M et al. (1988) Multiple Sclerosis: a serial study using MRI in relapsing patients. Neurology 38: 1511-1515.
12. Finelli P. (1991) Conjugal multiple sclerosis: A clinical and laboratory study. Neurology 41: 1329-1321.
13. Constantinescu C, Grossman RI, Finelli PF, Kamoun M, Zmijeski C, Cohen JA. (1995) Clinical and subclinical neurologial involvement in children of conjugal multiple sclerosis patients. Multiple Sclerosis 1: 170-172.
14. Udupa JK, Samarasekera S. (1996) Fuzzy connectedness and object definition: Theory, algorithms and applications in image segmentation. Graphical Models and Image Processing 58: 246-261.
15. Udupa JK, Odhener D, Samaraskera S et al. (1994) 3DVIEWNIX: an open, transportable, multidimensional, multimodality, multiparametric imaging software system. SPIE Proceedings Vol. 2164.
16. Udupa JK, Wei L, Samarasekera S, Miki Y, VanBudhem MA, Grossman RI. (1997) Multiple Sclerosis lesion quantification using fuzzy connectedness principles. IEEE Trans Med Imaging 16: 598-609.
17. Miki Y, Grossman RI, Udupa JK et al. (1997) Isolated Ufiber Involvement in Multiple Sclerosis: Preliminary Observations. Neurology. In Press.
18. Kurtzke J. (1983) Rating neurological impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 33: 1444-1452.
19. van Walderveen MAA, Barkof F, Hommes OR et al. (1995) Correlating MRI and clinical disease activity in multiple sclerosis: Relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spin-echo images. Neurology 45: 1684-1690.
20. Miki Y, Grossman RI, Udupa JK, Samarasekera S, van Buchem MA, Cooney BS, Pollack SN, Kolson DL et al. (1997) Computer-assisted quantitation of enhancing lesions in Multiple Sclerosis: Correlation with Clinical Classification. Am J of Neuroradiol 18: 705-710.
21. Comi G et al. (1989) Correlation between multi-modal evoked potentials and magnetic resonance imaging in multiple sclerosis. J Neurol 236: 4-8.
22. Koopmans RA et al. (1989) Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 25: 74-81.
23. Lynch SJ, Rose JW, Smoker W, Petajan JH. (1990) MRI in familial multiple sclerosis. Neurology 40: 900-903.
24. Tienari P, Salonen O, Wikström J, Valanne L, Palo J. (1992) Familial Multiple Sclerosis: MRI findings in clinically affected and unaffected siblings. J Neurol Neurosurgery and Psychiatry 55: 883-886.
25. Campi AFM, Comi G et al. (1995) Acute transverse myelopathy: spinal and cranial MR study with clinical follow-up. Am J Neuroradiol 16: 115-123.
26. Tas MW BF, van Walderveen MA et al. (1995) The effect of gadolium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis. Am J Neuroradiol 16: 259-264.
27. Soderstrom M. LM, Hillert J et al. (1994) Optic Neuritis: findings on MRI, CSF examination and HLA class II typing in 60 patients and results of a short-term follow-up. Am J Neuroradiol 241: 391-397.
28. Morrissey SP MD, Kendall BE et al. (1993) The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis: A 5-year follow-up study. Brain 116: 135-146.
29. Francis DA CD, Batchelor JR, McDonald WI. (1987) A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow up. Journal of Neurology, Neurosurgery and Psychiatry. 50: 758-765.
30. Miller DH OI, Rudge P et al. (1989) The early risk of multiple sclerosis following isolated acute syndromes of the brainstem and spinal cord. Annals of Neurology 26: 635-639.
31. Horikoshi T, Yagi S, Fukamachi A. (1993) Incidental high-intensity foci in white matter on TE-weighted magnetic resonance imaging: Frequency and clinical significance in symptom-free adults. Neuroradiol 35: 151-155.
32. Hendrie HC, Farlow MR, Austrom MG, Edwards MK, Williams MA (1989) Foci of increased T2 signal intensity on brain MR scans of healthy elderly subjects. Am J of Neuroradiol 10: 703-707.
33. Chalmers R, Robertson N, Kellar-Wood H, Compston DAS, Harding AE. (1995) Sequence of the human homologue of a mitochondrially encoded murine transplantation antigen in patients with multiple sclerosis. J Neurol 242: 332-334.
34. Davenport C. (1922) Multiple sclerosis from the standpoint of geographic distribution and race. Arch Neurol 8: 51-58.
35. Sadovnick AD, Macleod PMJ. (1981) The familial nature of Multiple Sclerosis: Emperic recurrence risks for first, second, and third degree relatives of patients. Neurology 31: 1039-1041.
36. Sadovnick A, Ebers GC, Dyment DA, Risch NJ et al. (1996) Evidence for genetic basis of multiple sclerosis. Lancet 347: 1728-1730.
37. Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Compston DAS. (1994) The British Isles survey of multiple sclerosis in twins. Neurology 44: 11-15.
38. Robertson N, O'Riordan JI, Chataway J, Kingsley DP, Miller DH, Clayton D, Compston DAS. (1997) Offspring recurrence rate and clinical characteristics of conjugal multiple sclerosis. Lancet 349: 1587-1590.
39. Dyment DA, Sadnovich AD, Ebers GC. (1997) Genetics of multiple sclerosis. Human Molecular Genetics 6: 1693-1698.
40. Goodkin D, Rudnick RA, Eds. (1996) Multiple Sclerosis: Advances in Clinical Trial Design, Treatment and Future Perspectives.
41. Hillert J et al. (1994) The HLA-Dw2 haplotype segregates closely with multiple sclerosis in multiplex families. J Neuroimmunol 50: 95-100.