Relative adrenal insufficiency in critical illness: A review of the evidence

Current Opinion in Endocrinology and Diabetes

Volumn 11, Issue 3, 2004, Pages 147-152

  Knapp, Philip E ^a   Arum, Seth M ^a   Melby, James C ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acute disease; Adrenal gland hypofunction; Adrenal insufficiency; Corticosteroids; Cortisol; Critical illness; Glucocorticoids; Hypothalamic pituitary adrenal axis; Septic shock

Indexed keywords

CORTICOSTEROID DERIVATIVE; CYTOKINE; GLUCOCORTICOID;

ADRENAL INSUFFICIENCY; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CRITICAL ILLNESS; DISEASE ASSOCIATION; EVIDENCE BASED MEDICINE; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INFLAMMATION; MEDICAL LITERATURE; PATHOPHYSIOLOGY; REVIEW; SEPTIC SHOCK;

EID: 33645252269     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.med.0000136121.99139.00     Document Type: Review

References (67)

1. Vermes I, Belshuizen A, Hampsink RM: Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. J Clin Endocrinol Metab 1995, 80:1238-1242.
2. Esteban NV, Loughlin T, Yergey AL, et al.: Daily cortisol production rate in man determined by stable isotope dilution/mass spectropetry. J Clin Endocrinol Metab 1991, 72:39-45.
3. Salem M, Tainish RE, Bromberg J, et al.: Perioperative Glucocorticoid Coverage 1994, 219:416-425.
4. Burchard K: A Review of the adrenal cortex and severe inflammation: quest of the "eucorticoid" state. J Trauma 2001, 51:800-814.
5. Melby JC, Spifik WW: Comparative studies of adrenal cortical function and cortisol metabolism in healthy adults and in patients with shock due to infection. J Clin Invest 1958, 37:1791-1798.
6. Lamberts SWJ, Bruning HA, De Jong FH: Corticosteroid therapy in severe illness. N Engl J Med 1997, 337:1285-1292.
7. Wade CE, Lindberg JS, Cockrell JL, et al.: Upon-admission adrenal steroidogenesis is adapted to the degree of illness in intensive care unit patients. J Clin Endocrinol Metab 1987, 67:223-227.
8. Barton RN, Stoner HB, Watson SM: Relationships among plasma cortisol, adrenocorticotropin and severity of injury in recently injured patients. J Trauma 1987, 27:384-392.
9. Chernow B, Alexander HR, Smallridge RC, et al.: Hormonal responses to graded surgical stress. Arch Intern Med 1987, 147:1273-1278.
10. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995, 332:1351-1362.
11. Bernardini R, Kamilaris TC, Calogero AE, et al.: Interactions between tumor necrosis factor-α, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology 1990, 126:2876-2881.
12. Sapolsky R, Rivier C, Yamamoto G, et al.: Interleukin-1 stiumlates the secretion of hypothalamic corticotropin-releasing factor. Science 1987, 238:522-524.
13. Mastorakos G, Weber JS, Magiakou MA, et al.: J Clin Endocrinol Metab 1995, 79:934-939.
14. Marik PE, Zaloga GP: Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 2002, 122:1784-1796.
15. Sakaue M, Hoffman BB: Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest 1991, 88:385-389.
16. Collins S, Caron MG, Lefkowitz RJ: β2-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 1988, 263:9067-9070.
17. Saito T, Takanashi M, Gallagher E, et al.: Corticosteroid effect on early beta-adrenergic down-regulation during circulatory shock: hemodynamic study and beta-adrenergic receptor assay. Intensive Care Med 1995, 21:204-210.
18. Manglik S, Flores E, Lubarsky L, et al.: Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial. Crit Care Med 2003, 31:1668-1675. A good observational study establishing the rate of adrenal insufficiency in septic patients.
19. Marik PE, Zaloga GP: Adrenal insufficiency during septic shock. Crit Care Med 2003, 31:141-145. An observational study attempting to confirm the hypothesis that a single baseline cortisol level is an adequate test for adrenal insuffiency.
20. Barquist E, Kirton O: Adrenal insufficiency in the surgical intensive care unit patient. J Trauma 1997, 42:27-31.
21. Rivers EP, Gaspari M, Saad GA, et al.: Adrenal insufficiency in high risk surgical ICU patients. Chest 2001, 119:889-896.
22. Malik KJ, Wakelin K, Dean S, et al.: Cushing's syndrome and hypothalamic-pituitary adrenal axis suppression by medroxyprogesterone acetate. Ann Clin Biochem 1996, 33:187-189.
23. Subramanian S, Goker H, Kanji A, et al.: Clinical adrenal insufficiency in patients receiving megestrol therapy. Arch Intern Med 1997, 157:1008-1011.
24. Wagner RL, White PF, Kan PB, et al.: Inhibition of adrenal steroidogenesis by the anesthetic agent etomidate. N Engl J Med 1984, 310:1415-1421.
25. De Jong FH, Mallios C, Jansen C, et al.: Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation. J Clin Endocrinol Metab 1984, 59:1143-1147.
26. Couch RM, Muller J, Pery YS, et al.: Kinetic analysis of inhibition of human adrenal steroidogenesis by ketoconazole. J Clin Endocrinol Metab 1987, 65:551-554.
27. Ayub M, Levell MJ: Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J Steroid Biochem 1989, 32:515-524.
28. Siu SC, Kitzman DW, Sheedy PF, et al.: Adrnal insufficiency from bilateral adrenal hemmorhage. Mayo Clin Proc 1990; 65:664-70.
29. Norbiato G, Galli M, Velella R, et al.: The syndrome of acquired glucocorticoid resisance in HIV infection. Baillieres Clin Endocrinol Metab 1994, 8:777-787.
30. Sibbald WJ, Short A, Cohen MP, et al. Variations in adrenocortical responsiveness during severe bacterial infections. Ann Surg 77; 186:29-33.
31. Rothwell PM, Udwadia ZF, Lawler PG: Cortisol response to corticotropin and survival in septic shock. Lancet 1991, 337:582-583.
32. Moran JL, Chapman MJ, O'Fathartaigh MS, et al.: Hypocortisolaemia and adrenocortical responsiveness at onset of septic shock. Intensive Care Med 1994, 20:489-495.
33. Soni A, Pepper G, Wyrwiniski PM, et al.: Adrenal Insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 1995, 98:266-271.
34. Briegel J, Schelling G, Haller M, et al.: A comparison of the adrenocortical response during septic shock and after complete recovery. Intensive Care Med 1996, 22:894-899.
35. Gaillard R, Turnill D, Sappino P: Tumor necorsis factor α inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 1990, 127:101-106.
36. Vankelecom H, Carmeliet P, Heremans H: Interferon-γ inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures. Endocrinology 1990, 126:2919-2926.
37. Gearing DP, Gough NM, King JA: Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor(LIF). EMBO J 1987, 6:3995-4002.
38. Ferrara N, Winer J, Henzel W: Piltuitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor. Proc Natl Acad Sci USA 1992, 89:698-702.
39. Akita S, Webster J, Ren SG: Human and murine pituitary expression of leukemia inhibitory factor: novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J Clin Invest 1995, 95:1288-1298.
40. Auernhammer CJ, Melmed S: The central role of SOCS-3 in integrating the neuro-immunoendocrine interface. J Clin Invest 2001, 108:1735-1740.
41. Grunfeld C, Zhao C, Fuller J: Endotoxin and cytokines induce expression of Leptin, the ob gene product, in hamsters. J Clin Invest 1996, 97:2152-2157.
42. Murakami T, Iida M, Shima K: Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem and Biophys Res Com 1995, 214:1260-1267.
43. Ahima RS, Prabakaran D, Mantzoros C: Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382:250-252.
44. Pralong FP, Roduit R, Waeber G: Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 1998, 139:4264-4268.
45. Bouachour G, Tirot P, Gouello JP, et al.: Adrenocortical function during septic shock. Intensive Care Med 1995, 21:57-62.
46. Schroeder S, Wichers M, Klingmuller D, et al.: The hypothalamic- pituitary-adrenal axis of patients with severe sepsis: Altered response to corticotropin-releasing hormone. Crit Care Med 2001, 29:310-316.
47. Sprung CL, Caralis PV, Marcial EH, et al.: The effects of high-dose corticosteroids in patients with septic shock: a prospective, controlled study. N Engl J Med 1984, 311:1137-1143.
48. Bone RC, Fisher CJ, Clemmer TP, et al.: A Controlled trial of high-dose methyl prednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987, 317:653-658.
49. The Veterans Administration Systemic Sepsis Cooperative Study Group: Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987, 317:659-665.
50. Luce JM, Montgomery AB, Marks JD, et al.: Ineffectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am Rev Respir Dis 1988, 138:62-68.
51. Cronin L, Kook DJ, Carlet J, et al.: Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 1995, 23:1430-1439.
52. Lefering R, Neugebauer EAM: Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 1995, 23:1294-1303.
53. Cooper MS, Stewart PM: Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003, 348:727-734. A high profile review article advocating an appealing but untested algorithm.
54. Annane D, Sebille V, Troche G, et al.: A 3-level prognostic classification in septic shock based on cortisol levels and Cortisol response to corticotropin. JAMA 2000, 283:1038-1045.
55. Annane D, Sebille V, Charpentier C, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288:862-871.
56. Bollaert PE, Reux F, Charpentier C, et al.: Baseline cortisol levels, cortisol response to corticotropin, and prognosis in late septic shock. Shock 2003, 19:13-15. A randomized trial similar to [55] but smaller. See text.
57. Millo J: Corticosteroids for patients with septic shock. JAMA 2003, 289:41-44.
58. Bloomfield R, Macmillan M, Noble DW: N Engl J Med 2003, 348:2157-2159.
59. Absalom A, Pledger D, Kong A: Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 1999, 54:861-867.
60. Watt I, Ledingham I: Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia 1984, 39:973-981.
61. Bollaert PE, Charpentier C, Levy B, et al.: Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998, 26:645-650.
62. Breigel J, Forst H, Haller M, et al.: Stress doses of hydrocortisone reduce hyperdynamic septic shock: a prospective, randomized, double-blind, single center study. Crit Care Med 1999, 27:723-732.
63. Keh D, Boehnke T, Weber-Cartens S: Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003, 167:512-520. A randomized trial of hydrocortisone in septic patients designed to evaluate its effect on cytokines and the immune system.
64. Annane D, Bellissant E, Sebille V, et al.: Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998, 46:589-597.
65. Le Roux CW, Chapman GA, Kong WS, et al.: Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery. J Clin Endcorinol Metab 2003, 88:2045-2048. Good observational study characterizing changes in CBG with surgery.
66. Beishuizen A, Thijs LG, Vermes I: Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. Intensive Care Med 2001, 27:1584-1591.
67. Hamrahian AH, Oseni TS, Arafah BM: Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004, 350:1629-1638. Important observational study demonstrating normal free cortisol levels despite depressed total cortisol levels.