Interleukin-12 increases proliferation and interferon-γ production but not cytolytic activity of human antigen-specific effector memory cytotoxic T lymphocytes: Power of the effect depends on the functional avidity of the T cell and the antigen concentration

Human Immunology

Volumn 66, Issue 11, 2005, Pages 1137-1145

  Bontkes, Hetty J ^a   Ruizendaal, Janneke J ^a   Kramer, Duco ^a   Meijer, Chris J L M ^a   Schreurs, Marco W J ^a   Hooijberg, Erik ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Avidity; Cytotoxic T lymphocyte; Interferon ; Interleukin 12; Vaccination

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MITOGENIC AGENT;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION;

ANTIGEN PRESENTATION; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; INTERLEUKIN-12; PROTEIN BINDING; T-LYMPHOCYTES, CYTOTOXIC; VIRAL MATRIX PROTEINS;

EID: 33645241423     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2006.02.002     Document Type: Article

References (37)

1. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev 3 2003 133
2. C.S. Schmidt, M.F. Mescher Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12 J Immunol 168 2002 5521
3. J. Valenzuela, C. Schmidt, M. Mescher The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells J Immunol 169 2002 6842
4. C.S. Schmidt, M.F. Mescher Adjuvant effect of IL-12 conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo J Immunol 163 1999 2561
5. V. Athie-Morales, H.H. Smits, D.A. Cantrell, C.M. Hilkens Sustained IL-12 signaling is required for Th1 development J Immunol 172 2004 61
6. L.A. Hussmann, M.J. Bevan Cooperation between helper T cells and cytotoxic T lymphocyte precursors Ann NY Acad Sci 532 1988 158
7. S.P. Schoenberger, R.E.M. Toes, E.I.H. van der Voort, R. Offringa, C.J.M. Melief T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature 393 1998 480
8. S.R.M. Bennett, F.R. Carbone, F. Karamalis, R.A. Flavell, J.F.A.P. Miller, W.R. Heath Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature 393 1998 478
9. J.P. Ridge, F. DiRosa, P. Matzinger A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell Nature 393 1998 474
10. A. Snijders, P. Kalinski, C.M. Hilkens, M.L. Kapsenberg High-level IL-12 production by human dendritic cells requires two signals Int Immunol 10 1998 1593
11. M.K. Gately, B.B. Desai, A.G. Wolitzky, P.M. Quinn, C.M. Dwyer, F.J. Podlaski, P.C. Familletti, F. Sinigaglia, R. Chizonnite, U. Gubler Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor) J Immunol 147 1991 874
12. P.T. Mehrotra, D. Wu, J.A. Crim, H.S. Mostowski, J.P. Siegel Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes J Immunol 151 1993 2444
13. H.J. Bontkes, T.D. De Gruijl, G.J. Schuurhuis, R.J. Scheper, C.J. Meijer, E. Hooijberg Expansion of dendritic cell precursors from human CD34(+) progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome J Leukoc Biol 72 2002 321
14. N. Romani, D. Reider, M. Heuer, S. Ebner, E. Kampgen, B. Eibl, D. Niederwieser, G. Schuler Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability J Immunol Methods 196 1996 137
15. M.W. Schreurs, K.B. Scholten, E.W. Kueter, J.J. Ruizendaal, C.J. Meijer, E. Hooijberg In vitro generation and life span extension of human papillomavirus type 16-specific, healthy donor-derived CTL clones J Immunol 171 2003 2912
16. H. Yssel, J.E. De Vries, M. Koken, W. Van Blitterswijk, H. Spits Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones J Immunol Methods 72 1984 219
17. M.H. Heemskerk, E. Hooijberg, J.J. Ruizendaal, M.M. van der Weide, E. Kueter, A.Q. Bakker, T.N. Schumacher, H. Spits Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells Cell Immunol 195 1999 10
18. J.H. Kessler, B. Mommaas, T. Mutis, I. Huijbers, D. Vissers, W.E. Benckhuijsen, G.M. Schreuder, R. Offringa, E. Goulmy, C.J. Melief, S.H. van der Burg, J.W. Drijfhout Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides Hum Immunol 64 2003 245
19. N.C.V. Verra, A. Jorritsma, K. Weijer, J.J. Ruizendaal, A. Voordouw, P. Weder, E. Hooijberg, T.N.M. Schumacher, J.B.A.G. Haanen, H. Spits, R.M. Luiten Human Telomerase Reverse Transcriptase-Transduced Human Cytotoxic T Cells Suppress the Growth of Human Melanoma in Immunodeficient Mice Cancer Res 64 2004 2153
20. E. Hooijberg, J.J. Ruizendaal, P.J. Snijders, E.W. Kueter, J.M. Walboomers, H. Spits Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase J Immunol 165 2000 4239
21. M.R. Betts, J.M. Brenchley, D.A. Price, S.C. De Rosa, D.C. Douek, M. Roederer, R.A. Koup Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation J Immunol Methods 281 2003 65
22. V. Rubio, T.B. Stuge, N. Singh, M.R. Betts, J.S. Weber, M. Roederer, P.P. Lee Ex vivo identification, isolation and analysis of tumor-cytolytic T cells Nat Med 9 2003 1377
23. J.M. Curtsinger, C.S. Schmidt, A. Mondino, D.C. Lins, R.M. Kedl, M.K. Jenkins, M.F. Mescher Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells J Immunol 162 1999 3256
24. M.S. Seaman, F.W. Peyerl, S.S. Jackson, M.A. Lifton, D.A. Gorgone, J.E. Schmitz, N.L. Letvin Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo J Virol 78 2004 206
25. S. Xu, G.K. Koski, M. Faries, I. Bedrosian, R. Mick, M. Maeurer, M.A. Cheever, P.A. Cohen, B.J. Czerniecki Rapid high efficiency sensitization of CD8+ T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism J Immunol 171 2003 2251
26. F. Ossendorp, E. Mengede, M. Camps, R. Filius, C.J.M. Melief Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors J Exp Med 187 1998 693
27. Z. Lu, L. Yuan, X. Zhou, E. Sotomayor, H.I. Levitsky, D.M. Pardoll CD40-independent pathways of T cell help for priming of CD8+ cytotoxic T lymphocytes J Exp Med 191 2000 541
28. D.H. Schuurhuis, S. Laban, R.E.M. Toes, P. Ricciardi-Castagnoli, M.J. Kleijmeer, E.I.H. van der Voort, D. Rea, R. Offringa, H.J. Geuze, C.J.M. Melief, F. Ossendorp Immature dendritic cells acquire CD8+ cytotoxic T lymphocyte priming capacity upon activation by T Helper cell-independent or -dependent stimuli J Exp Med 192 2000 145
29. S.W. Lee, Y. Park, J.K. Yoo, S.Y. Choi, Y.C. Sung Inhibition of TCR-induced CD8 T cell death by IL-12 regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12 J Immunol 170 2003 2456
30. J. Chang, J.H. Cho, S.W. Lee, S.Y. Choi, S.J. Ha, Y.C. Sung IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells J Immunol 172 2004 2818
31. V. Ozenci, M. Pashenkov, M. Kouwenhoven, L. Rinaldi, M. Soderstrom, H. Link IL-12/IL-12R system in multiple sclerosis J Neuroimmunol 114 2001 242
32. C.Y. Wu, M. Gadina, K. Wang, J. O'Shea, R.A. Seder Cytokine regulation of IL-12 receptor beta2 expression differential effects on human T and NK cells Eur J Immunol 30 2000 1364
33. N. Bhardwai, R.A. Seder, A. Reddy, M.V. Feldman IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro J Clin Invest 98 1996 715
34. I.N. Mbawuike, K. Fujihashi, S. DiFabio, S. Kawabata, J.R. McGhee, R.B. Couch, H. Kiyono Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes J Infect Dis 180 1999 1477
35. P.A. Welch, A.E. Namen, R.G. Goodwin, R. Armitage, M.D. Cooper Human IL-7 a novel T cell growth factor J Immunol 143 1989 3562
36. R.J. Armitage, A.E. Namen, H.M. Sassenfeld, K.H. Grabstein Regulation of human T cell proliferation by IL-7 J Immunol 144 1990 938
37. D.J. Morgan, H.T.C. Kreuwel, S. Fleck, H.I. Levitsky, D.M. Pardoll, L.A. Sherman Activation of low avidity CTL specific for a self epitope results in tumor rejection Bbut not autoimmunity J Immunol 160 1998 643