Antispasmodic and bronchodilator activities of St John's wort are putatively mediated through dual inhibition of calcium influx and phosphodiesterase

Fundamental and Clinical Pharmacology

Volumn 19, Issue 6, 2005, Pages 695-705

  Gilani, Anwarul Hassan ^a   Khan, Arif Ullah ^a   Subhan, Fazal ^b   Khan, Munasib ^b  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

Ca2+ antagonist; Gastrointestinal and respiratory disorders; Hypericum perforatum; Phosphodiesterase inhibitor; St John's wort

Indexed keywords

CALCIUM ION; CARBACHOL; HYPERICUM PERFORATUM EXTRACT; ISOPRENALINE; PAPAVERINE; PHENYLEPHRINE; PHOSPHODIESTERASE; VERAPAMIL; BRONCHODILATING AGENT; CALCIUM; CHOLINERGIC RECEPTOR BLOCKING AGENT; PHOSPHODIESTERASE INHIBITOR;

ANIMAL TISSUE; AORTA; ARTICLE; BRONCHODILATING ACTIVITY; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; FEMALE; HEART ATRIUM; HYPERICUM PERFORATUM; IN VITRO STUDY; INTESTINE CONTRACTION; JEJUNUM; MALE; MUSCLE RELAXATION; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; RABBIT; SHIFT TO THE RIGHT; SMOOTH MUSCLE; TRACHEA; VASOCONSTRICTION; VASODILATATION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GUINEA PIG; ION TRANSPORT; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY;

ANIMALS; AORTA; BRONCHODILATOR AGENTS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HEART ATRIA; ION TRANSPORT; JEJUNUM; MALE; MUSCLE CONTRACTION; PARASYMPATHOLYTICS; PHOSPHODIESTERASE INHIBITORS; RABBITS;

EID: 33645232800     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2005.00378.x     Document Type: Article

References (45)

1. Miller L.G., Murray W.J. Herbal medicinals: a clinician's guide. Pharmaceutical Products Press, Binghamton, 1998, pp. 219-220.
2. Weiss R.F., Herbal medicine. Beaconsfield Publisher, Beaconsfield, 1988.
3. Nadkarni K.M. Indian materia medica, 3rd edn. Popular Prakashan, Bombay, 1976, p. 673.
4. Linde K., Riet G.T., Hondras M., Vickers A., Saller R., Melchart D. Systemic reviews of complementary therapies - an annotated bibliograplry. Part 2: Herbal medicine. BMC Complement. Altern. Med. (2001) 1 5.
5. Duke J.A. Handbook of phytochemical constituents of GRAS herbs and other economical plants. CRC Press, London, 1992, pp. 302-303.
6. Keles O., Bkirel T., Ak S., Alpmar A. The antibacterial activity of some plants used for medicinal purposes against pathogens of veterinary importance. Folia Vet. (2001) 45 22-25.
7. Vikas K., Singh P.N., Bhattacharya S.K. Antiinflammatory and analgesic activity of Indian Hypericum perforatum. Indian J. Exp. Biol. (2001) 39 339-343.
8. Serkendjieva J., Manolova N., Zgorniak-Nowosielska I., Zawilinsata B., Grzybek J. Anti-viral activity of the infusion (SHS 174) from flowers of Sambucus nigra, aerial parts of Hypericum perforatum and roots of Saponaria officinalis against influenza and herpes simplex viruses. Phytother. Res. (1990) 4 97-100.
9. Ozturk Y., Aydin S., Baser K.H.C., Kirmer N., Ozturk K.N. Hepatoprotective activity of Hypericum perforatum alcoholic extract in rodents. Phytother. Res. (1992) 6 44-46.
10. Girzu M., Carnat A., Privat A.M., Fialip J., Carnat A.P., Lamaison J.L. Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum. Phytother. Res. (1997) 11 395-397.
11. National Research Council. Guide for the care and use of laboratory animals. National Academy Press, Washington, 1996, pp. 1-7.
12. Tona L., Kambu K., Ngimbi N., Cimanga K., Vlietinck A.J. Antiamoebic and phytochemical screening of some congolese medicinal plants. J. Ethnopharmacol. (1998) 61 57-65.
13. ++ channel blocking activity of Artemesia scoparia extract. Phytother. Res. (1994) 8 161-165.
14. ++ antagonists. Gen. Pharmacol. (1991) 22 177-181.
15. Van-Rosum J.M. Cumulative concentration-response curves. 11. Techniques for the making of concentration-response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacodyn. Ther. (1963) 143 299-330.
16. Gilani S.A.H., Cobbin L.B. Cardioselectivity of himbacine: a muscarinic receptor antagonist. Naunyn Schmiedebergs Arch. Pharmacol. (1986) 332 16-20.
17. Ghayur M.N., Gilani A.H. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J. Cardiovasc. Pharmacol. (2005) 45 74-80.
18. Gilani A.H., Shaheen F., Christopoulos A., Mitchelson F. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Life Sci. (1997) 60 535-544.
19. Rang H.P., Dale M.M., Ritter J.M. Pharmacology, 4th edn. Churchill Livingstone, New York, 1999, pp. 289-290.
20. ++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev. Pharmacol. Toxicol. (1977) 17 149-166.
21. Godfraind T., Miller R., Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev. (1986) 38 312-416.
22. Gilani A.H., Shah A.J., Ghayur M.N., Majeed K. Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci. (2005) 76 3089-3105.
23. Hosseinzadeh H., Karimi G.R., Rakhshanizadeh M. Anticonvulsant effect of Hypericum perforatum: role of nitric oxide. J. Ethnopharmacol. (2005) 98 207-208.
24. Brain B., Hoffman M.D. Adrenoceptor activating and other sympathomimetic drugs, in: Katzung B.G. (Ed.), Basic and clinical pharmacology, 8th edn. McGraw-Hill, New York, 2001, pp. 120-137.
25. Orallo F., Camina M., Alvarez E., Basaran H., Lugnier C. Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus fruit flavonoid (±)-Naringenin. Planta Med. (2005) 71 99-107.
26. Tan Y.Y., Summers R.J. β-adrenoceptor regulation in rat heart, lungs and skin after chronic treatment with (-)-tertatolol or (-)-propranolol. J. Auton. Pharmacol. (1995) 15 1149-1154.
27. Teixeira M.M., Gristwood R.W., Cooper N., Hellewell P.G. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future. Trends Pharmacol. Sci. (1997) 18 164-171.
28. Mathewson H.S. Anti-asthmatic properties of calcium antagonists. Respir. Care (1985) 30 779-781.
29. Triggle D.J. Drug effecting calcium-regulation and actions, in: Smith G.M., Reynard A.M. (Eds), Textbook of pharmacology. W.B. Saunders, Philadelphia, 1992, pp. 453-479.
30. Vanhoutte P.M. Differential effects of calcium entry blockers on vascular smooth muscle, in: Weiss G.B. (Ed.), New perspective on calcium antagonists. American Physiological Society, Bethesda, 1981, pp. 109-121.
31. ++-blocking action of stereoisomers of CI-951, (NC)-1500 and (-)-CI-951 in the isolated muscle preparations. Gen. Pharmacol. (1992) 23 207-210.
32. Polster P., Christophe M., Damme V., Houlliche A., Chatelain P. SR33557, a novel calcium entry blocker. 1. In vitro isolated tissue studies. J. Pharmacol. Exp. Ther. (1990) 255 593-599.
33. Harrison P. Herbal medicine takes roots in Germany. Can. Med. Assoc. J. (1998) 158 637-639.
34. Gobbi M., Valle F.D., Diomede L. et al. Hypericum perforatum extract does not inhibit 5-HT transporters in rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. (1999) 360 262-269.
35. Thiede H.M., Walper A. Inhibition of MAO and COMT by Hypericum extracts and hypericin. J. Geriatr. Psychiatry Neurol. (1994) 7 54s-56s.
36. Kleber E., Obry T., Hippeli S., Schneider W., Elstner E.F. Biochemical activities of extracts from Hypericum perforatum. Arzneimittelforschung (1999) 49 106-109.
37. Ron B.H., Willis C.A., Bone K., Morgan M. Herbal products: active constituents, mode of action and quality control. Nutr. Res. Rev. (2000) 13 47-77.
38. Gaster B., Holryod J. St. John's Wort for depression. Arch. Intern. Med. (2000) 160 152-153.
39. Neary J.T., Bu Y. Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes. Brain Res. (1999) 816 358-363.
40. Muller W.E. Current St. John's Wort research from mode of action to clinical efficacy. Pharmacol. Res. (2003) 47 101-109.
41. Luo L., Sun Q., Mao Y.Y., Lu Y.H., Tan R.X. Inhibitory effect of flavonoids from Hypericum perforatum on nitric oxide synthase. J. Ethnopharmacol. (2004) 93 221-225.
42. Bidzinski A., Jankowska E., Pucilowski O. Antidepressant-like actions of nicardipine, verapamil, and hemicholinium-3 injected into anterior hypothalamus in the rat forced swim test. Pharmacol. Biochem. Behav. (1990) 36 795-798.
43. Pucilowski O. Psychopharmacological properties of calcium channel inhibitors. Psychopharmacology (1992) 109 12-29.
44. Pucilowski O. Calcium channel antagonists in mood disorders, in: Skolnick P. (Ed.), Antidepressants new pharmacological strategies. Humana Press, New Jersey, 1997, pp. 81-101.
45. Baldessarini R.J. Drugs and the treatment of psychiatric disorders: depression and anxiety, in: Hardman J.G., Limbird L.E., Gilman's A.G. (Eds), Goodman and Gilman's the pharmacological basis of therapeutics, 10th edn. McGraw-Hill, New York, 2001, pp. 447-483.