Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes

Brain Research

Volumn 816, Issue 2, 1999, Pages 358-363

  Neary, Joseph T ^a   Bu, Yurong ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Antidepressant; Astrocyte; Depression; Glia; Monoamine transporter; Norepinephrine uptake; Serotonin uptake

Indexed keywords

CARRIER PROTEIN; HYPERICUM PERFORATUM EXTRACT; MONOAMINE; NORADRENALIN; SEROTONIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; GLIA; NEUROTRANSMITTER UPTAKE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE; TRANSPORT KINETICS;

ANIMALS; ANTIDEPRESSIVE AGENTS; ASTROCYTES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HYPERICUM; NOREPINEPHRINE; PERYLENE; PLANT EXTRACTS; PLANTS, MEDICINAL; QUERCETIN; RATS; SEROTONIN UPTAKE INHIBITORS; XANTHENES;

EID: 0033596554     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01126-3     Document Type: Article

References (22)

1. Amara S.G., Kuhar M.J. Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 16:1993;73-93.
2. Bal N., Figueras G., Vilaro M.T., Sunol C., Artigas F. Antidepressant drugs inhibit a glial 5-hydroxytryptamine transporter in rat brain. Eur. J. Neurosci. 9:1997;1728-1738.
3. Bladt S., Wagner H. Inhibition of MAO by fractions and constituents of hypericum extract. J. Geriatr. Psychiatr. Neurol. 7:1994;S57-S59. (Suppl. 1).
4. Dave V., Mullaney K.J., Goderie S., Kimelberg H.K., Aschner M. Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake. Dev. Neurosci. 16:1994;222-231.
5. Fuller R.W., Wong D.T. Serotonin uptake and serotonin uptake inhibition. Ann. New York Acad. Sci. 600:1990;68-78.
6. Glowinski J., Axelrod J. Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds. Nature. 204:1964;1318-1319.
7. Harrer G., Schulz V. Clinical investigation of the antidepressant effectiveness of hypericum. J. Geriatr. Psychiatr. Neurol. 7:1994;S6-S8. (Suppl. 1).
8. Horn A.S., Coyle J.T., Snyder S.H. Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons. Mol. Pharmacol. 7:1971;66-80.
9. 3H ]norepinephrine by rat primary astrocyte cultures from neonatal rat cerebral cortex Brain Res. 602:1993;41-44.
10. Kimelberg H.K., Katz D.M. Regional differences in 5-hydroxytryptamine and catecholamine uptake in primary astrocyte cultures. J. Neurochem. 47:1986;1647-1652.
11. Kuhar M.J., Roth R.H., Aghajanian G.K. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. J. Pharmacol. Exp. Ther. 181:1972;36-45.
12. Linde K., Ramierez G., Mulrow C.D., Pauls A., Weidenhammer W., Melchart D. St. John's wort for depression - an overview and meta-analysis of randomised clinical trials. Br. Med. J. 313:1996;253-258.
13. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
14. Muller W.E., Rolli M., Schafer C., Hafner U. Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry. 30:1997;102-107. (Suppl.).
15. Murphy S., Pearce B. Functional receptors for neurotransmitters on astroglial cells. Neuroscience. 22:1987;381-394.
16. Neary J.T., Jorgensen S.L., Oracion A.M., Bruce J.H., Norenberg M.D. Inhibition of growth factor-induced DNA synthesis in astrocytes by ligands of peripheral-type benzodiazepine receptors. Brain Res. 675:1995;27-30.
17. Neary J.T., Whittemore S.R., Zhu Q., Norenberg M.D. Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factor and extracellular ATP. J. Neurochem. 63:1994;490-494.
18. 14C -5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain Acta Pharmacol. Toxicol. 36:1975;382-394.
19. Schildkraut J.J., Kety S.S. Biogenic amines and emotion. Science. 156:1967;21-30.
20. Shaskan E.G., Snyder S.H. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake. J. Pharmacol. Exp. Ther. 175:1970;404-418.
21. Snyder S.H. Putative neurotransmitters in the brain: selective neuronal uptake, subcellular localization, and interactions with centrally acting drugs. Biol. Psychiatry. 2:1970;367-389.
22. Thiede H.M., Walper A. Inhibition of MAO and COMT by hypericum extracts and hypericin. J. Geriatr. Psychiatr. Neurol. 7:1994;S54-S56. (Suppl. 1).