Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace I: Carcass traits

Animal Genetics

Volumn 37, Issue 2, 2006, Pages 156-162

  Karlskov Mortensen, P ^a   Bruun, C S ^a   Braunschweig, M H ^b,c   Sawera, M ^a   Markljung, E ^d   Enfalt A C ^b   Hedebro Velander, I ^e   Josell, A ^f   Lindahl, G ^g   Lundstrom K ^b   Von Seth, G ^h   Jorgensen C B ^a   Andersson, L ^b,c   Fredholm, M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c UNIVERSITY OF BERN   (Switzerland)

^d UPPSALA UNIVERSITY   (Sweden)

^e Quality Genetics   (Sweden)

^f Ugglarps Slakteri AB ^*  (Sweden)

^g DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^h Tetra Pak AB   (Sweden)

Author keywords

Carcass traits; Genome scan; Hampshire; Landrace; Quantitative trait loci

Indexed keywords

ANIMAL; ANIMAL HUSBANDRY; ARTICLE; BODY COMPOSITION; CHROMOSOME MAP; CROSS BREEDING; FEMALE; GENETICS; GENOME; HISTOLOGY; INBREEDING; MALE; MEAT; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; STANDARD; SWINE;

ANIMAL HUSBANDRY; ANIMALS; BODY COMPOSITION; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; GENOME; INBREEDING; MALE; MEAT; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SWINE;

ANIMALIA; SUS SCROFA;

EID: 33645220795     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2005.01405.x     Document Type: Article

References (41)

1. Andersson L. Georges M. 2004 Domestic-animal genomics: deciphering the genetics of complex traits. Nature Review Genetics 5 202 12.
2. Andersson L. Haley C.S. Ellegren H. et al. 1994 Genetic-mapping of quantitative trait loci for growth and fatness in pigs. Science 263 1771 4.
3. Andersson-Eklund L. Marklund L. Lundstrom K. Haley C.S. Andersson K. Hansson I. Moller M. Andersson L. 1998 Mapping quantitative trait loci for carcass and meat quality traits in a wild boar × large white intercross. Journal of Animal Science 76 694 700.
4. Bidanel J.P. Milan D. Iannuccelli N. et al. 2001 Detection of quantitative trait loci for growth and fatness in pigs. Genetics Selection Evolution 33 289 309.
5. Bougneres P. 2003 Genetics of common obesity and type 2 diabetes: please forget diseases and study pathogenic traits. Diabetes and Metabolism 29 197 9.
6. Churchill G.A. Doerge R.W. 1994 Empirical threshold values for quantitative trait mapping. Genetics 138 963 71.
7. Enfält A.C. Lundstrom K. Hansson I. Johansen S. Nystrom P.E. 1997 Comparison of non-carriers and heterozygous carriers of the RN(-) allele for carcass composition, muscle distribution and technological meat quality in Hampshire-sired pigs. Livestock Production Science 47 221 9.
8. Enfält A.-C. Von Seth G. Josell Å. Lindahg G. Hedebro-Velander I. Braunschweig M. Andersson L. Lundström K. in press Effects of a second mutant allele (V199I) at the PRKAG3 (RN) locus on carcass composition in pigs. Livestock Production Science
9. Estrade M. Vignon X. Monin G. 1993 Effect of the Rn-gene on ultrastructure and protein-fractions in pig muscle. Meat Science 35 313 9.
10. Geldermann H. Muller E. Moser G. et al. 2003 Genome-wide linkage and QTL mapping in porcine F-2 families generated from Pietrain, Meishan and Wild Boar crosses. Journal of Animal Breeding and Genetics 120 363 93.
11. Green P. Falls K. Crooks S. 1990 Documentation for CRI-MAP Version 2.4. Washington University School of Medicine St Louis, MO.
12. Haley C.S. Knott S.A. 1992 A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69 315 24.
13. Haley C.S. Knott S.A. Elsen J.M. 1994 Mapping quantitative trait loci in crosses between outbred lines using least-squares. Genetics 136 1195 207.
14. Hamilton D.N. Ellis M. Miller K.D. McKeith F.K. Parrett D.F. 2000 The effect of the Halothane and Rendement Napole genes on carcass and meat quality characteristics of pigs. Journal of Animal Science 78 2862 7.
15. Hinney A. Schmidt A. Nottebom K. et al. 1999 Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. The Journal of Clinical Endocrinology and Metabolism 84 1483 6.
16. Houston R.D. Cameron N.D. Rance K.A. 2004 A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected Large White pig populations. Animal Genetics 35 386 90.
17. Huszar D. Lynch C.A. Fairchild-Huntress V. et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 131 41.
18. Jeon J.T. Carlborg O. Tornsten A. et al. 1999 A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics 21 157 8.
19. Kim K.S. Larsen N. Short T. Plastow G. Rothschild M.F. 2000a A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mammalian Genome 11 131 5.
20. Kim K.S. Larsen N.J. Rothschild M.F. 2000b Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene. Journal of Animal Science 78 791 2.
21. Knott S.A. Marklund L. Haley C.S. et al. 1998 Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs. Genetics 149 1069 80.
22. de Koning D.J. Rattink A.P. Harlizius B. Groenen M.A.M. Brascamp E.W. van Arendonk J.A.M. 2001 Detection and characterization of quantitative trait loci for growth and reproduction traits in pigs. Livestock Production Science 72 185 98.
23. Lindahl G. Enfält A.C. von Seth G. Josell A. Hedebro-Velander I. Andersen H.J. Braunschweig M. Andersson L. Lundstrom K. 2004 A second mutant allele (V199I) at the PRKAG3 (RN) locus - I. Effect on technological meat quality of pork loin. Meat Science 66 609 19.
24. Malek M. Dekkers J.C.M. Lee H.K. Baas T.J. Prusa K. Huff-Lonergan E. Rothschild M.F. 2001a A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. II. Meat and muscle composition. Mammalian Genome 12 637 45.
25. Malek M. Dekkers J.C.M. Lee H.K. Baas T.J. Rothschild M.F. 2001b A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition. Mammalian Genome 12 630 6.
26. Milan D. Jeon J.T. Looft C. et al. 2000 A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science 288 1248 51.
27. Milan D. Bidanel J.P. Iannuccelli N. Riquet J. Amigues Y. Gruand J. Le Roy P. Renard C. Chevalet C. 2002 Detection of quantitative trait loci for carcass composition traits in pigs. Genetics Selection Evolution 34 705 28.
28. Nezer C. Moreau L. Brouwers B. Coppieters W. Detilleux J. Hanset R. Karim L. Kvasz A. Leroy P. Georges M. 1999 An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nature Genetics 21 155 6.
29. Nezer C. Moreau L. Wagenaar D. Georges M. 2002 Results of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain × Large White intercross. Genetics Selection Evolution 34 371 87.
30. Paszek A.A. Wilkie P.J. Flickinger G.H. Miller L.M. Louis C.F. Rohrer G.A. Alexander L.J. Beattie C.W. Schook L.B. 2001 Interval mapping of carcass and meat quality traits in a divergent swine cross. Animal Biotechnology 12 155 65.
31. Rohrer G.A. 2000 Identification of quantitative trait loci affecting birth characters and accumulation of backfat and weight in a Meishan-White Composite resource population. Journal of Animal Science 78 2547 53.
32. Rohrer G.A. Keele J.W. 1998a Identification of quantitative trait loci affecting carcass composition in swine: II. Muscling and wholesale product yield traits. Journal of Animal Science 76 2255 62.
33. Rohrer G.A. Keele J.W. 1998b Identification of quantitative trait loci affecting carcass composition in swine: I. Fat deposition traits. Journal of Animal Science 76 2247 54.
34. Rohrer G.A. Alexander L.J. Hu Z.L. Smith T.P.L. Keele J.W. Beattie C.W. 1996 A comprehensive map of the porcine genome. Genome Research 6 371 91.
35. Seaton G. Haley C.S. Knott S.A. Kearsey M. Visscher P.M. 2002 QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18 339 40.
36. Vaisse C. Clement K. Guy-Grand B. Froguel P. 1998 A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics 20 113 4.
37. Van Laere A.S. Nguyen M. Braunschweig M. et al. 2003 A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425 832 6.
38. Varona L. Ovilo C. Clop A. et al. 2002 QTL mapping for growth and carcass traits in an Iberian by Landrace pig intercross: additive, dominant and epistatic effects. Genetical Research 80 145 54.
39. Visscher P.M. Thompson R. Haley C.S. 1996 Confidence intervals in QTL mapping by bootstrapping. Genetics 143 1013 20.
40. Whittemore C. 1993 The Science and Practice of Pig Production. Longman Group UK Limited Essex, UK.
41. Yeo G.S. Farooqi I.S. Aminian S. Halsall D.J. Stanhope R.G. O'Rahilly S. 1998 A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genetics 20 111 2.