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Volumn 85, Issue 3, 2000, Pages 183-190

Synergistic interactions among antifolates

Author keywords

Antifolates; Dihydrofolate reductase; Glycinamide ribonucleotide formyltransferase; Synergy; Thymidylate synthase

Indexed keywords

FOLIC ACID; FOLIC ACID ANTAGONIST; METHOTREXATE; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; PEMETREXED; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE INHIBITOR; TETRAHYDROFOLIC ACID DERIVATIVE; THYMIDINE PHOSPHATE; TRIMETREXATE;

EID: 0034026479     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(99)00056-X     Document Type: Conference Paper
Times cited : (19)

References (20)
  • 1
    • 0031725620 scopus 로고    scopus 로고
    • Thymine metabolism and thymineless death in prokaryotes and eukaryotes
    • Ahmad S.I., Kirk S.H., Eisenstark A. Thymine metabolism and thymineless death in prokaryotes and eukaryotes. Annu Rev Microbiol. 52:1998;591-625.
    • (1998) Annu Rev Microbiol , vol.52 , pp. 591-625
    • Ahmad, S.I.1    Kirk, S.H.2    Eisenstark, A.3
  • 2
    • 0343133536 scopus 로고    scopus 로고
    • Using computer modeling to explain the "kisliuk effect."
    • Bloom L.A. Using computer modeling to explain the "Kisliuk effect." Proc Am Assoc Cancer Res. 39:1998;431.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 431
    • Bloom, L.A.1
  • 3
    • 0012504651 scopus 로고    scopus 로고
    • AG2034: A Garft inhibitor with selective cytotoxicity to cells that lack a gi checkpoint
    • A. Jackman. Totowa: Humana Press
    • Boritzki T.J., Zhang C., Bartlett C.A., Jackson R.C. AG2034. a Garft inhibitor with selective cytotoxicity to cells that lack a gi checkpoint Jackman A. Antifolate Drugs in Cancer Therapy. 1999;281-292 Humana Press, Totowa.
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 281-292
    • Boritzki, T.J.1    Zhang, C.2    Bartlett, C.A.3    Jackson, R.C.4
  • 4
    • 0023924915 scopus 로고
    • Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells
    • Bunni M., Doig M., Donato H., Kesavan V., Priest D.G. Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells. Cancer Res. 48:1988;3398-3404.
    • (1988) Cancer Res , vol.48 , pp. 3398-3404
    • Bunni, M.1    Doig, M.2    Donato, H.3    Kesavan, V.4    Priest, D.G.5
  • 5
    • 0032527904 scopus 로고    scopus 로고
    • Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation
    • Faessel H.M., Slocum H.K., Jackson R.C., Boritzki T.J., Rustum Y.M., Nair M.G., Greco W.R. Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes. the critical role of polyglutamylation Cancer Res. 58:1998;3036-3050.
    • (1998) Cancer Res , vol.58 , pp. 3036-3050
    • Faessel, H.M.1    Slocum, H.K.2    Jackson, R.C.3    Boritzki, T.J.4    Rustum, Y.M.5    Nair, M.G.6    Greco, W.R.7
  • 6
    • 0033104229 scopus 로고    scopus 로고
    • Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin-6-yl-(S) -ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034)
    • Faessel H.M., Slocum H.K., Rustum Y.M., Greco W.R. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin-6-yl-(S) -ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034). Biochem Pharmacol. 57:1999;567-577.
    • (1999) Biochem Pharmacol , vol.57 , pp. 567-577
    • Faessel, H.M.1    Slocum, H.K.2    Rustum, Y.M.3    Greco, W.R.4
  • 8
    • 0023201233 scopus 로고
    • Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N-10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine
    • a
    • Galivan J., Nimec Z., Rhee M. Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N-10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine. Cancer Res. 47:1988;5256-5260. a.
    • (1988) Cancer Res , vol.47 , pp. 5256-5260
    • Galivan, J.1    Nimec, Z.2    Rhee, M.3
  • 9
    • 0023942227 scopus 로고
    • Antifolate drug interactions: Enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate
    • b
    • Galivan J., Nimec Z., Rhee M., Boschelli D., Oronsky A.L., Kerwar S.S. Antifolate drug interactions. enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate Cancer Res. 48:1988;2421-2425. b.
    • (1988) Cancer Res , vol.48 , pp. 2421-2425
    • Galivan, J.1    Nimec, Z.2    Rhee, M.3    Boschelli, D.4    Oronsky, A.L.5    Kerwar, S.S.6
  • 10
    • 0024353841 scopus 로고
    • The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihdyrofolate reductase
    • Galivan J., Rhee M.S., Johnson T.B., Dilwith R., Nair M.G., Bunni M., Priest D.G. The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihdyrofolate reductase. J Biol Chem. 264:1989;10685-10692.
    • (1989) J Biol Chem , vol.264 , pp. 10685-10692
    • Galivan, J.1    Rhee, M.S.2    Johnson, T.B.3    Dilwith, R.4    Nair, M.G.5    Bunni, M.6    Priest, D.G.7
  • 11
    • 76449119241 scopus 로고
    • Folate enhancement of antifolate synergism
    • H.C. Curtius, S. Ghisla, & N. Blau. Berlin: Walter de Gruyter
    • Gaumont Y., Kisliuk R.L., Emkey R., Piper J.R., Nair M.G. Folate enhancement of antifolate synergism. Curtius H.C., Ghisla S., Blau N. Chemistry and Biology of Pteridines. 1989;1131-1136 Walter de Gruyter, Berlin.
    • (1989) Chemistry and Biology of Pteridines , pp. 1131-1136
    • Gaumont, Y.1    Kisliuk, R.L.2    Emkey, R.3    Piper, J.R.4    Nair, M.G.5
  • 12
    • 0026721234 scopus 로고
    • Quantitation of folic acid enhancement of antifolate synergism
    • Gaumont Y., Kisliuk R.L., Parsons J.C., Greco W.R. Quantitation of folic acid enhancement of antifolate synergism. Cancer Res. 52:1992;2228-2235.
    • (1992) Cancer Res , vol.52 , pp. 2228-2235
    • Gaumont, Y.1    Kisliuk, R.L.2    Parsons, J.C.3    Greco, W.R.4
  • 13
    • 0029036955 scopus 로고
    • The search for synergy: A critical review from a response surface perspective
    • Greco W.R., Bravo G., Parsons J.C. The search for synergy. a critical review from a response surface perspective Pharm Rev. 47:1995;331-385.
    • (1995) Pharm Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 14
    • 0020105949 scopus 로고
    • Synergism in the folate pathway
    • Harvey R.J. Synergism in the folate pathway. Rev Infect Dis. 4:1982;255-260.
    • (1982) Rev Infect Dis , vol.4 , pp. 255-260
    • Harvey, R.J.1
  • 15
    • 0009655896 scopus 로고    scopus 로고
    • Antifolate drugs. Past and future perspectives
    • A. Jackman. Totowa: Humana Press
    • Jackson R.C. Antifolate drugs. Past and future perspectives. Jackman A. Antifolate Drugs in Cancer Therapy. 1999;1-12 Humana Press, Totowa.
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 1-12
    • Jackson, R.C.1
  • 17
    • 0002162964 scopus 로고    scopus 로고
    • Folate biochemistry in relation to antifolate selectivity
    • A. Jackman. Totowa: Humana Press
    • Kisliuk R.L. Folate biochemistry in relation to antifolate selectivity. Jackman A. Antifolate Drugs in Cancer Therapy. 1999;13-36 Humana Press, Totowa.
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 13-36
    • Kisliuk, R.L.1
  • 20
    • 0032475855 scopus 로고    scopus 로고
    • Cellular folates prevent polyglutamation of 5,10-dideazatetrahydrofolate
    • Tse A., Moran R.G. Cellular folates prevent polyglutamation of 5,10-dideazatetrahydrofolate. J Biol Chem. 273:1998;25944-25952.
    • (1998) J Biol Chem , vol.273 , pp. 25944-25952
    • Tse, A.1    Moran, R.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.