Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin

Journal of Clinical Investigation

Volumn 113, Issue 7, 2004, Pages 952-954

  Kolar, Grant R ^a   Capra, J Donald ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN;

B CELL LEUKEMIA; CANCER CLASSIFICATION; CANCER PATIENT; CANCER RISK; CHRONIC LYMPHATIC LEUKEMIA; HIGH RISK POPULATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 2142758730     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI21412     Document Type: Review

References (38)

1. Harris, N.L., et al. 1994. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 84:1361-1392.
2. Harris, N.L., et al. 1999. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J. Clin. Oncol. 17:3835-3849.
3. Binet, J.L., et al. 1981. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 48:198-206.
4. Rai, K.R., et al. 1975. Clinical staging of chronic lymphocytic leukemia. Blood. 46:219-234.
5. Matutes, E., et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 8:1640-1645.
6. McCarthy, H., et al. 2003. High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood. 101:4903-4908.
7. Hamblin, T.J., Davis, Z., Gardiner, A., Oscier, D.G., and Stevenson, F.K. 1999. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 94:1848-1854.
8. Damle, R.N., et al. 1999. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 94:1840-1847.
9. Naylor, M., and Capra, J.D. 1999. Mutational status of Ig V(H) genes provides clinically valuable information in B-cell chronic lymphocytic leukemia. Blood. 94:1837-1839.
10. Gurrieri, C., et al. 2002. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J. Exp. Med. 196:629-639.
11. Zupo, S., et al. 1996. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood. 88:1365-1374.
12. Chen, L., et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 100:4609-4614.
13. Krober, A., et al. 2002. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 100:1410-1416.
14. Rosenwald, A., et al. 2001. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J. Exp. Med. 194:1639-1647.
15. Klein, U., et al. 2001. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J. Exp. Med. 194:1625-1638.
16. Ghiotto, F., et al. 2004. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J. Clin. Invest. 113:1008-1016. doi:10.1172/JC1200419399.
17. Fais, F., et al. 1998. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Invest. 102:1515-1525.
18. Johnson, T.A., Rassenti, L.Z., and Kipps, T.J. 1997. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J. Immunol. 158:235-246.
19. Keating, M.J., et al. 2003. Biology and treatment of chronic iymphocytic lymphocytic leukemia. Hematology (Am. Soc. Hematol. Educ. Program). 153-175.
20. Chiorazzi, N., and Ferrarini, M. 2003. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu. Rev. Immunol. 21:841-894.
21. Potter, K.N., et al. 2003. Features of the overexpressed VI-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood. 101:3082-3084.
22. Dammacco, F., and Sansonno, D. 1992. Antibodies to hepatitis C virus in essential mixed cryoglobulinaemia. Clin. Exp. Immunol. 87:352-356.
23. Pascual, M., Perrin, L., Giostra, E., and Schifferli, J.A. 1990. Hepatitis C virus in patients with cryoglobulinemia type II. J. Infect. Dis. 162:569-570.
24. Chan, C.H., Hadlock, K.G., Foung, S.K., and Levy, S. 2001. V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen. Blood. 97:1023-1026.
25. Gharagozloo, S., Khoshnoodi, J., and Shokri, F. 2001. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia, multiple myeloma and chronic lymphocytic leukemia. Pathol. Oncol. Res. 7:135-139.
26. Capra, J.D., and Klapper, D.G. 1976. Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins (Lay/Pom) with shared idiotypic specificities. Scand. J. Immunol. 5:677-684.
27. Capra, J.D., and Kehoe, J.M. 1974. Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc. Natl. Acad. Sci. U. S. A. 71:4032-4036.
28. Sanz, I., and Capra, J.D. 1987. V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc. Natl. Acad. Sci. U. S. A. 84:1085-1089.
29. Hasemann, C.A., and Capra J.D. 1991. Mutational analysis of arsonate binding by a CRIA+ antibody. VH and VL junctional diversity are essential for binding activity. J. Biol. Chem. 266:7626-7632.
30. Hasemann, C.A., and Capra, J.D. 1991. Mutational analysis of the cross-reactive idiotype of the A strain mouse. J. Immunol. 147:3170-3179.
31. Rathbun, G., Sanz, I., Meek, K., Tucker, P., and Capra, J.D. 1988. The molecular genetics of the arsonate idiotypic system of A/J mice. Adv. Immunol. 42:95-164.
32. Meek, K., Sanz, I., Rathbun, G., Nisonoff, A., and Capra, J.D. 1987. Identity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains. Proc. Natl. Acad. Sci. U. S. A. 84:6244-6248.
33. Humphries, C.G., et al. 1988. A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. Nature. 331:446-449.
34. Lieberman, R., Potter, M., Mushinski, E.B., Humphrey, W., Jr., and Rudikoff, S. 1974. Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine. J. Exp. Med. 139:983-1001.
35. Martin, F., Oliver, A.M., and Kearney, J.F. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity. 14:617-629.
36. Vinuesa, C.G., et al. 2003. Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens. Eur. J. Immunol. 33:297-305.
37. Guinamard, R., Okigaki, M., Schlessinger, J., and Ravetch, J.V. 2000. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol. 1:31-36.
38. Fagarasan, S., and Honjo, T. 2000. T-independent immune response: new aspects of B cell biology. Science. 290:89-92.