The role of T cells in immunity to Malaria and the pathogenesis of disease

Malaria: Molecular and Clinical Aspects

Volumn , Issue , 1999, Pages 403-438

  Troye Blomberg, Marita ^a   Weidanz, William P ^b   Van Der Heyde, Henri ^c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33645201117     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (245)

1. Abbas, A.K., Murphy, K.M. and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature, 383, 787–793.
2. Al-Yaman, E, Genton, B., Anders, R., Taraika, J., Ginny, M., Mellor, S., et al. (1995). Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and Spf66 in protecting Papua New Guinean children from clinical malaria. Parasite Immunol., 17, 493–501.
3. Al-Yaman, E, Genton, B., Taraika, J., Anders, R. and Alpers, M.P. (1997a). Association between cellular response (IL-4) to RESA/PFl55 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area. Parasite Immunol., 19, 249–254.
4. Al-Yaman, F., Genton, B., Taraika, J., Anders, R., and Alpers, M.P. (1997b). Cellular immunity to merozoite surface protein 2 (FC27 and 3D7) in Papua New Guinean children. Temporal variation and relation to clinical and parasitological status. Parasite Immunol., 19, 207–214.
5. Allen, R.J., Beattie, P., Bate, C., Van Hensbroek, M.B., Morris-Jones, S., Greenwood, B.M., et al. (1995). Strain variation in tumor necrosis factor induction by parasites from children with acute falciparum malaria. Infect. Immun., 63, 1173–1175.
6. Allison, A.C. (1984). Cellular immunity to malaria and babesia parasites: a personal viewpoint. Contemp. Top. Immunol., 12, 463–490.
7. Anders, R.F. (1986). Multiple cross-reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria. Parasite Immunol., 8, 529–539.
8. Anstey, N.M., Weinberg. J.B., Hassanali, M.Y., Mwaikambo, E.D., Manyenga, D., Misukonis, M.A. et al. (1996). Nitric oxide in Tanzanian children with malaria: Inverse relationship between malaria severity and nitric oxid production/nitric oxid synthase type 2 expression. J. Exp. Med., 184, 557–567.
9. Aribot, G., Rogier, C, Sarthou, J.-L., Trape, J.-F., Toure Balde, A., Druilhe, P, et al. (1996). Pattern of immunoglobulin isotype response to Plasmodium falciparum blood-stage antigens in individuals living in a holoendemic area of Senegal (Dielmo, West Africa). Amer. J. Trop. Med. Hyg., 54, 449–457.
10. Ballet, J.J., Jaurequiberry, G., P., D. and Agrapart, M. (1987). Stimulation of T lymphocyte-dependent differentiation of activated B lymphocytes in Plasmodium falciparum supernatants. J. Infect. Dis., 155, 1037–1040.
11. Batchelder, J.M., Cigel, F.K., Ternes, H.C., van der Heyde, H.C. and Weidanz, W.P. (1997). Type I but not type 2 cytokines are required for the activation of both cell-mediated and antibody-mediated immunity in experimental malaria. Amer. J. Trop. Med. Hyg., Suppl. 57, 266a.
12. Behr, C. and Dubois, P. (1992). Preferential expansion of VgVSd following stimulation of peripheral blood lymphocytes with extracts of Plasmodium falciparum. Int. Immunol., 4, 361–366.
13. Blackman, M.J., Heidrich, H.-G., Donachie, S., McBride, J.S. and Holder, A.A. (1990). A single fragment of a malaria merozoite surface protein remains on the parasite during red cellinvasionandisthetargetofinvasion-inhibiting antibodies. J. Exp. Med., 171, 379–382.
14. Blackman, M.J., Scott-Finnigan, TJ., Shai, S. and Holder, A.H. (1994). Antibodiesinhibit theprotease-mediatedprocessing of a malaria merozoite surface protein. J. Exp. Med., 180, 389–393.
15. Bouharoun-Tayoun, H., Attanath, P., Sabchareon, A., Chongsuphajaisiddhi, T. and Druilhe, P. (1990). Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monoeytes. J. Exp. Med., 172, 1633–1641.
16. Bouharoun-Tayoun, H. and Druilhe, P. (1992). Plasmodium falciparum malaria: Evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect. Immun., 60, 1473–1481.
17. Bouharoun-Tayoun, H., Oeuvray, C., Lunel, F. and Dmilhe, P. (1995). Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J. Exp. Med., 182, 409–418.
18. Bourdessoule, D., Gaulard, P. and Mason, D.Y. (1990). Preferential localisation ofhuman lymphocytes bearing gd+ T cell receptor to the red pulp of spleen. J. Clin. Path., 43, 461–464.
19. Boyle, D.B.F., Newbold, C.I., Smith, C.C. and Brown, K.N. (1982). Monoclonal antibodies that protect in vivo against Plasmodium chabaudi recognize a 250,000-dalton parasite polypeptide. Infect. Immun., 39, 94–102.
20. Brake, D.A., Weidanz, W.P. and Long, CA. (1986). Antigen-specific, interleukin-2-propagated T lymphocytes confer resistance to a murine parasite, Plasmodium chabaudi adami. J. Immunol., 137, 347–352.
21. Brown, K.N. and Brown, I.N. (1965). Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature, 208, 1286–1288.
22. Bruce-Chwatt, LJ. (1952). Malaria in African infants and children in southern Nigeria. Ann. Trop. Med. Parasitol., 46, 173–200.
23. Burgmann, H., Hollenstein, U., Wenisch, C., Thalhammer, F., Looareesuwan, S.and. Graninger, W. (1995). Serum concentrations of MIP-a and interleukin-8 in patients suffering from acute Plasmodiumfalciparum malaria. Clin. Immunol Immunopathol., 76, 32–36.
24. Bums, J.M., Jr., Majarian, W.R., Young, J.F., Daly, T.M. and Long, C.A. (1989). A protective monoclonal antibody recognizes an epitope in the carboxyl-terminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malaria parasite, Plasmodium yoelii. J. Immunol., 143, 2670–2676.
25. Butcher, G.A. (1992). HIV and malaria: a lesson in immunology. Parasitol. Today, 8, 307–311.
26. Capron, M. and Capron, A. (1994). ImmunoglobulinE and effector cells in schistosomiasis. Science, 264, 1876–1877.
27. Carter, R, Graves, P.M., Quakyi, L.A. and Good, M.F. (1989). Restricted or absent immune responses in human populations to Plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodies. J. Exp. Med., 169, 135–147.
28. Cavacini, L.A, Long, C.A. and Weidanz, W.P. (1986). T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells. Inject. Immun., 52, 637–643.
29. Chakkalath, H.R and Titus, R.G. (1994). Leishmania major-parasitized macrophages augment TH2-type T cell activation. J. Immunol., 153, 4378–4387.
30. Chang, W-L., van der Heyde, H., Maki, D.G., Malkovsky, M. and Weidanz, WP. (1992). Subset heterogeneity among yS+ T cells found in peripheral blood during Plasmodium falciparum malaria. Immunol. Lett., 32, 273–274.
31. Chen, J., Trounstine, M., Alt, F.W., Young, F., Kurahara, C., Loring, J.F., et al. (1993). Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol., 5, 647–656.
32. Chiwakata, C.B., Hort, G., Hemmer, C.J. and Dietrich, M. (1996). Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells. Inject. Immun., 64, 5106–5110.
33. Chougnet, C., Deloron, P., Lepers, J.P., Tallet, S., Rason, M.D., Astagneau, P., et al. (1990). Humoral and cell-mediated immune responses to the Plasmodiumfalciparum antigens Pfl55/RESA and CS protein: seasonal variations in a population recently reexposed to endemic malaria. Amer. J. Trop. Med. Hyg., 43, 234–242.
34. Cizauskas, C.A, Yanez, D.M., Batchfelder, J.B., van der Heyde, H.C. and W.P., Weidanz. (1997). Preferential localization of CD8+ T cells in sites of pathology during experimental malaria. Amer. J. Trop. Med. Hyg., Suppl 57, 25a.
35. Clark, LA. and Rockett, K.A. (1996). Nitric oxide and parasitic disease. Adv. Parasitol., 37, 1–56.
36. Clark, LA, Rockett, KA. and Cowden, W.B. (1992). Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Lancet, 340, 894–896.
37. Cohen, S., McGregor, LA and Carrington, S. (1961). Gamma-globulin and acquired immunity to human malaria.Nature, 192, 733–737.
38. Cronin, D.C., Stack, R and Fitch, F.W. (1995). IL-4 producing CD8+ T cell clones can provide B cell help. J. Immunol., 154, 3118–3127.
39. Cross, G.A.M. (1990). Cellular and genetic aspects of antigenic variation in trypanosomes. Ann. Rev. Immunol., 8, 83–110.
40. Cruz Cubas, AB., Gentilini, M. and Monjour, L. (1994). Cytokines and T-cell response in malaria. Biomed. Pharmacother., 48, 27–33.
41. Daly, T.M. and Long, C.A. (1993). A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Inject. Immun., 61, 2464–2467.
42. Day, KP. and Marsh, K. (1991). Naturally acquired immunity to Plasmodium falciparum. Immunol. Today, 12, A68-A71.
43. Del Prete, G.F., DeCarli, M., Almerigogna, F., Giudizi, M.-G., Biagiotti, R and Romagnani, S. (1993). Human IL-1O is produced by both type 1 helper (TH 1) and type 2 helper (TH2) T cell clones and inhibits their antigen-specific proliferation. J. Immunol., 150, 353–360.
44. Deloron, P., Le Bras, J., Savel, J. and Coulaud, J.P. (1987). Antibodies to the Pf155 antigen of P. falciparum. Measurement by cell-ELISA and correlation with expected immune protection. Amer. J. Trop. Med. Hyg., 37, 22–26.
45. Desowitz, R.S. (1989). Plasmodium-specific immunoglobulin E in sera from an area of holoendemic malaria. Trans. Roy. Soc. Trop. Med. Hyg., 83, 478–479.
46. Desowitz, RS., Elm, J. and Alpers, M.P. (1993). Plasmodium falciparum-specific immunoglobulin G (IgG), IgM, and IgE antibodies in paired maternal-cord sera from East Sepik Province, Papua New Guinea. Inject. Immun., 61, 988–993.
47. Dormer, P., Dietrich, M., Kern, P. and Horstmann, R.D. (1983). Ineffective erythropoeisis in acute human P. falciparum malaria. Blut, 46, 279–288.
48. Dugas, B., Mossalayi, D., Damais, C. and Kolb, J.P. (1995). Nitric oxide production by human monocytes: evidence for a role of CD23. Immunol. Today, 16, 574–580.
49. ElGhazali, G., Esposito, F. and Troye-Blomberg, M. (1995). Comparison of the number of IL-4 and IFN-_ secreting cells in response to the malaria vaccine candidate antigen Pf 155/RES A in two groups of naturally primed individuals living in a malaria endemic area of Burkina Faso. Scand. J. Immunol., 42, 39–45.
50. Eling, W.M. and Kremsner, P.G. (1994). Cytokines in malaria, pathology and protection. Biother., 7, 211–221.
51. Eling, W.M.C. and Sauwerwein, R.W. (1995). Severe and cerebral malaria: common or distinct pathophysiology? Rev. Med. Microbiol., 6, 17–25.
52. Elloso, M., van der Heyde, H., Troutt, A., Manning, D. and Weidanz, W.P.(1996). The human γδ T cell subset-proliferative response to malarial antigen in vitro depends on CD4+ T cells or cytokines that signal through components of IL-2R. J. Immunol., 153, 2096–3012.
53. Elloso, M.M., van der Heyde, H.C., Vande Waa, J.A., Manning, D.D. and Weidanz, W.P. (1994). Inhibition of Plasmodium falciparum in vitro by human γδ T cells. J. Immunol., 153, 1187–1194.
54. Fandeur, T., Dubois, P., Gysin, J., Dedet, J.P. and Pereira da Silva, L.(1984). In vitro and in vivo studies on protective and inhibitory antibodies against P falciparum in Saimiri monkeys. J. Immunol., 132, 432–437.
55. FelTeira, M.U., Kimura, E.A.S., Desouza, J.M. and Katzin, A.M. (1996). The isotype composition and avidity of naturally acquired anti-Plasmodium falciparum antibodies: Differential patterns in clinically immune Africans and Amazonian patients. Amer. J. Trop. Med. Hyg., 55, 315–323.
56. FelTick, D.A., Schrenzei, M.D., Mulvania, T., Hsieh, B., Ferlin, W.G. and Lepper, H. (1995). Differential production of interferon-γ and interleukin-4 in response to Th 1- and TH2 stimulating pathogens by γ/δ T cells in vivo. Nature, 373, 255–257.
57. Fievet, N., Maubert, B., Cot, M., Chougnet, C., Dubois, B., Bickii, J., et al. (1995). Humoral and cellular immune responses to synthetic peptides from the Plasmodium falciparum blood-stage antigen, Pf155/RESA, in Cameroonian women. Clin. Immunol. Immunopathol., 76, 164–169.
58. Fitch, F.W, McKisic, M.D., Lancki, D.W. and Gajewski, T.F. (1993). Differential regulation of murine T lymphocyte subsets. Ann. Rev. Immunol., 11, 29–48.
59. Freeman, G.J., Boussiotis, V.A., Anumanthan, A., Bernstein, G.M., Ke, X.-Y., Rennert, P.D., et al. (1995). B7-1 and B7-2 do not deliver identical costimulatory signals since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immun., 2, 523–532.
60. Freeman, G.J., Gray, G.S., Gimmi, C.D., Lombard, D.B., Zhou, L.J., White, M., et al. (1991). Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J. Exp. Med., 174, 625–631.
61. Freeman, G.J., Gribben, J.G., Boussiotis, VA., Ng, J.W., Restivo, VA., Jr., Lombard, L.A., et al. (1993). Cloning of B7-2: a CTLA-4 counter-receptor in B7-deficient mice. Science, 262, 907–909.
62. Friedland, J.S., Ho, M., Remick, G.D.G., Bunnag, D., White, N.J. and Griffin, G.E. (1993). Interleukin-8 and Plasmodium falciparum malaria in Thailand. Trans. Roy. Soc. Trop. Med. Hyg., 86, 54–55.
63. Gilbert, S.C., Plebanski, M., Gupta, S., MolTis, J., Cox, M., Aidoo, M, et al. (1998). Association of malaria parasite population structure, HLA and immunological antagonism. Science, 279, 1173–1177.
64. Goerlich, R., Hacker, G., Pfeffer, K., Heeg, K. and Wagner, H. (1991). Plasmodium falciparum merozoites primarily stimulate the Vy9 subset of human y8 T cells. Eur. J. Immunol., 21, 2613–2616.
65. Good, M.F., Miller, L.H., Kumar, S., Quakyi, I.A., Keister, D., Adams, J.H., et al. (1988). Limited immunological recognition of critical malaria vaccine candidate antigens. Science, 242, 574–577.
66. Goodier, M., Krausejauer, M., Sanni, A., Massougbodjii, A., Sadeler, B.C., Mitchell, G.H., et al. (1993). Gamma delta T cells in the peripheral blood of individuals from an area of holoendemic Plasmodium falciparum transmission. Trans. Roy. Soc. Trop. Med. Hyg., 87, 692–696.
67. Goodier, R.M., Lundqvist, C., Hammarstrom, M.L., Troye-Blomberg, M. and Langhorne, J. (1995). Cytokine profile for human Vy9+ T cells stimulated with Plasmodium falciparum. Parasite Immunol., 17, 413–423.
68. Grau, G.E. and Ning Lou, J. (1994). TNF-induced microvascular pathology in the TH1-mediated lesions of mouse cerebral malaria: possible new mechanisms. In Cytokines: Basic principles and practical applications, edited by S. Romagnani, G. Del Prete and A.K. Abbas, pp. 265–278. Rome: Ares-Sepono Symposia Publ.
69. Grau, G.E., Piguet, P.-F, Vassali, P. and Lambert, P.-H. (1989). Tumor-necrosis factor and disease severity in children with Plasmodium falciparum malaria. N. Eng. J. Med., 320, 1586–1591.
70. Grau, G.E., Piquet, P.F, Engers, H.D., Louis, J.A., Vassali, P and Lambert, P.-H. (1986). L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Irnrnunol., 137, 2348–2354.
71. Greenwood, B., Marsh, K and Snow, R. (1991). Why do some African children develop severe malaria? Parasitol. Today, 7, 277–281.
72. Greenwood, B.M. (1974), Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis. Lancet, I, 435–436.
73. Greenwood, B.M., Playfair, J.H. and Torrigiani, G. (1971). Immunosuppression in murine malaria. I. General characteristics. Clin. Exp. Immunol., 8, 467–478.
74. Groux, H. and Gysin, J. (1990). Opsonisation as an effector mechanism in human protection against asexual blood stages of Plasmodiumfalciparum. functional role of IgG subclasses. Res. Immunol., 141, 529–542.
75. Grun, J.L. and Weidanz, WP. (1981). Immunity to Plasmodium chabaudi adami in the B-cell deficient mice. Nature, 290, 143–145.
76. Grun, J.L. and Weidanz, WP. (1983). Antibody-independent immunity to reinfection malaria in B-cell-deficient mice. Infect. Immun., 41, 1197–1204.
77. Gupta, S., Hill, A.V.S., Kwiatkowski, D., Greenwood, A.M., Greenwood, B.M. and Day, K.P. (1994). Parasite virulence and disease pattern in Plasmodium falciparum malaria. PNAS, 91, 3715–3719.
78. Gyan, B., Troye-Blomberg, M., Perlmann, P. and Björkman, A. (1994). Human monocytes cultured with and without interferon-gamma inhibit Plasmodiumfalciparum parasite growth in vitro via secretion of reactive nitrogen intermediates. Parasite Immunol., 16, 371–375.
79. Harpaz, R., Edelman, R., Wasserman, S.S., Levine, M.M., Davies, J.R. and Sztein, M.B. (1992). Serum cytokine profiles in experimental human malaria. J. Clin. Invest., 90, 515–523.
80. Helmby, H., Perlmann, H, Troye-Blomberg, M. and Perlmann, P. (1996). Immunoglobulin E elevation in Plasmodium chabaudi malaria. Infect. Immun., 64, 1432–1433.
81. Hemmer, C.J., Kern, P., Holst, EG., Radtke, K.P, Egbring, R., Bierhaus, A. et al. (1991). Activation of the host response in human Plasmodium falciparum malaria: relation of parasitemia to tumor necrosis factor/cachectin, thrombin-anti thrombin III, and protein kinase C levels. Amer. J. Med., 91, 37–44.
82. Herrera, S., Herrera, M.A., Pelplaza, B.L., Burki, Y., Caspers, P., Dobeli, H., et al. (1990). Immunization of Aotus monkeys with Plasmodium falciparum blood-stage recombinant proteins. PNAS, 87, 4017–4021.
83. Hill, A.V.S., Allsopp, C.E.M., Kwiatkowski, D., Anstey, N.M., Twumasi, P., Rowe, P., et al. (1991). Common West African HLA antigens are associated with protection from severe malaria. Nature, 352, 595–600.
84. Ho, M., Tongtawe, P., Kriangkum, J., Wimonwattrawatee, T., Pattanapanyasat, K., Bryant, L., et al. (1994). Polyclonal expansion of peripheral y5+ T cells in human Plasmodium falciparum malaria. Infect. Immun., 62, 855–862.
85. Ho, M., Webster, H.K., Tongtawe, P., Pattanapanyasat, K. and Weidanz, W.P. (1990). Increased yO T cells in acute Plasmodium falciparum malaria. Immunoi. Lett., 25, 139–142.
86. Horner, A., Jabara, H., Ramesh, N. and Geha, R.S. (1995). gd T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J. Exp. Med., 181, 1239–1244.
87. Horstmann, R.D., Ehrich, J.H., Beck, J. and Dietrich, M. (1985). Fatal complications of tropical malaria in non-immune patients. A retrospective clinico-pathological analysis of 25 cases. Deutsche Mediz. Wochens.,110, 1651–1656.
88. Howard, R.J.(1989). Antigenic variation and antigenic diversity in malaria. Contributions to Microbiol. Immunol., 8, 183–203.
89. Hunter, K.W., Jr., Finkelman, F.D., Strickland, G.T., Sayles, P.C. and Scher, I. (1979). Defective resistance to Plasmodium yoelii in CBAIN mice. J. Immunol., 123, 133–137.
90. Hviid, L., Kurtzhals, J.A.L., Dodoo, D., Rodrigues, O., Ronn, A., Commey, J.O.O., et al. (1996). The ylO T cell response to Plasmodium falciparum malaria in a population in which malaria is endemic. Infect. Immun., 64, 4359–4362.
91. Hiigh, B., Marbiah, N.T., Petersen, E., Perlmann, H., Dolopaie, E., Hanson, A.P., et al. (1991). A longitudinal survey of antibodies to synthetic antigens of P. falciparum in infants and children living in a holoendemic area of Liberia. Amer. J. Trop. Med. Hyg., 44, 191–200.
92. Jacobs, P., Radzioch, D. and Stevenson, M.A. (1996). Thl associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood stage malaria in mice. Infect. Immun., 64, 535–541.
93. Jakobsen, P.H., Bate, C.A.W., Taveme, J. and Playfair, J.H.L. (1995). Malaria: toxins, cytokines and disease. Parasite Immunol., 17, 223–231.
94. James, S.L. and Nacy, C. (1993). Effector functions of activated macrophages against parasites. Curr. Opin. Immunol., 5, 518–523.
95. Janeway, C.A. (1988). Frontiers of the immune system. Nature, 333, 804–806.
96. Jayawardena, A.N., Janeway, J.C.A. and Kemp, J.D. (1979). Experimental malaria in the CBA/N mouse. J. Immunol., 123, 2532–2539.
97. Jennings, VM., Lal, A.A. and Hunter, R.L. (1997). Role of mononuclear cell inflammation in protection from murine cerebral malaria. Amer. J. Trop. Med. Hyg., Suppl 57; 264a.
98. Jensen, J.B., Boland, M.T. and Akood, M.A.S. (1982). Induction of crisis forms in cultured Plasmodium falciparum with human immune semm from Sudan. Science, 216, 1230–1233.
99. Jepson, A., Banya, W., Sisay-Joof, F., Hassan-King, M., Nunes, C., Bennett, S., et al. (1997a). Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens. Infect. Immun., 65, 872–876.
100. Jepson, A, Sisay-Joof, E, Banya, W., Hassan-King, M., Frodsham, A, Bennett, S., et al. (l997b). Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs. Brit. Med. J., 315, 96–97.
101. Jerusalem, C., Polder, T., Weijers-Rouw, M., Eling, M., Osonkoya, B.O. and Trinh, P. (1983). Contributions to Microbiology and Immunology: Comparative clinical and experimental study on the pathogenesis of cerebral malaria, 7nd edn. Basel, Switzerland: Karger, AG.
102. Johansson, S.G.O., Bennich, H. and Berg, T. (1971). In vitro diagnosis of atopic allergy. HI Quantitative estimation of circulating IgE antibodies by the radioallergosorbent test. Int. Arch. AIL App. Immunol., 41, 443–451.
103. Kabilan, L., Sharma, V.P., Kaur, P., Ghosh, S.K., Yadav, R.S. and Chauhan, VS. (1994). Cellular and humoral immune responses to well-defined blood stage antigens (Major merozoite surface antigen). of Plasmodium falciparum in adults from an Indian zone where malaria is endemic. Infect. Immun., 62, 685–691.
104. Kabilan, L., Troye-Blomberg, M., Patarroyo, M.E., Björkman, A. and Perlmann, P. (1987). Regulation of the immune response in Plasmodium falciparum malaria: IV T cell dependent production of immunglobulin and anti-P falciparum antibodies in vitro. Clin. Exp. Immunol., 68, 288–297.
105. Kaufmann, S.H.E. (1993). Immunity to intracellular bacteria. Ann. Rev. Immunol., 11, 129–164.
106. Kemp-Mosey, J.R., Cigel, F.C., Batchelder, J.M., van der Heyde, H.C. and Weidanz, W.P. (1997). Plasticity of immune responses suppressing parasitemia during acute Plasmodium chabaudi malaria. Amer. J. Trop. Med. Hyg., Suppl. 57. 21a.
107. Kern, P., Hemmer, C.J., Van Damme, J., Grass, H.J. and Dietrich, (1989). Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for compl icated Plasmodium falcip arum malaria. Amer. J. Med., 87, 139–143.
108. Kern, P., Hemmer, J.C., Gallati, H., Neifer, S., Kremsner, P., Dietrich, M., et al. (1992). Soluble tumor necrosis factor receptors correlates with parasitemia and disease severity in human malaria. J. Infect. Dis., 166, 930–934.
109. Kharazmi, A. and Jepsen, S. (1984). Enhanced inhibition of in vivo multiplication of Pfalciparum by stimulated human polymorphonuclear leukocytes. Clin. Exp. Immunol., 57, 287–292.
110. Kowanko, I.C., Ferrante, A, Clemente, G. and Kumaratilake, L.M, (1996). Tumor necrosis factor primes neutrophils to kill Staphylococcus aureus by an oxygen-dependent mechanisms and Plasmodium falciparum by an oxygen-independent mechanism. Infect. Immun., 64, 3435–3437.
111. Kremsner, PG., Feldmeier, H., Zotter, G.M., Jansen-Rosseck, R., Graninger, W., Rocha, R.M., et al. (1989). Immunological alterations in uncomplicated Plasmodiumfalciparum malaria. Relationship between parasitaemia and indicators of macrophage activation. A eta Tropica, 46, 351–359.
112. Kremsner, PG., Zotter, G.M., Feldmeier, H., Graninger, M., Rocha, R.M., Rosseck, R.J., et al. (1990). Immune response in patients during and after Plasmodium falciparum infection. J. Infect. Dis., 161, 1025–1028.
113. Krishnan, L., Guilbert, L.J., Russell, A.S., Wegmann, T.G., Mosmann, T.R. and Belosevic, M. (1996a). Pregnancy impairs resistance of C57B1/6 mice to Leishmania major Infect. and causes decreased antigen-specific IFN-γ responses and increased production of T helper 2 cytokines. J. Immunol., 156, 644–652.
114. Krishnan, L., Guilbert, L.J., Wegmann, T.G., Belosevic, M. and Mosmann, T.R. (l996b). T helper I response against Leishmania major in pregnant C57B1/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-γ and TNF and reduced Il-lO production by placental cells. J. Immunol., 156, 653–662.
115. Kuchroo, V.K., Prabhu Das, M., Brown, J.A., Ranger, A.M., Zamvill, S.S., Sobel, R.A., et al. (1995). B7-1 and B7-2 costimulatory molecules activate differentially the Th 1/Th2 development pathways: Application to autoimmune disease therapy. Cell, 80, 707–718.
116. Kulane, A., Siddique, A.B., Perlmann, H., Ahlborg, N., Roussilhon, C., Tall, A, et al. (1997). T- and B-cell responses of malaria immune individuals to synthetic peptides corresponding to non-repeat sequences in the N-terminal region of the Plasmodium falciparum antigen PfI55/RESA. Acta Tropica, 68, 37–51.
117. Kullberg, M.C., Pearce, E.J., Hieny, S.E., Sher, A. and Berzofsky, J.A. (1992). Infection with Schistosoma mansoni alters Thl/Th2 cytokine responses to a non-parasite anti gen. J. Immunol., 148, 3264–3270.
118. Kumar, S., Good, M.F., Dontfraid, E, Vinetz, J.M. and Miller, L.H. (1989). Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. J. Immunol., 143, 2017–2023.
119. Kumaratilake, L.M. and FeiTante, A. (1992). IL-4 inhibits macrophage-mediated killing of Plasmodiumfalciparum in vitro. J. Immunol., 149, 194–199.
120. Kumaratilake, L.M, Ferrante, A., Jaeger, T. and Rzepczyk, C. (1996). GM-CSF-induced priming of human neutrophils for enhanced phagocytosis and killing of asexual blood stages of Plasmodium falciparum: synergistic effects of GM-CSF and TNE. Parasite Immunol., 18, 115–123.
121. Kumaratilake, L.M., Ferrante, A., Jaeger, T. and Rzepczyk, C.M. (1992). Effect of cytokines, complement and antibody on the neutrophil respiratory burst and phagocytic response to Plasmodiumfalciparum merozoites. Infect. Immun., 60, 3731–3738.
122. Kumaratilake, L.M., Ferrante, A. and Rzepczyk, C.M. (1990). Tumor necrosis factor enhances neutrophil-mediated killing of Plasmodium falciparum. Infect. Immun., 58, 788–793.
123. Kwiatkowski, D. (1992). Malaria: becoming more specific about non-specific immunity. Curr. Opin. Immunol., 4, 425–431.
124. Kwiatkowski, D. (1995). Malarial toxins and the regulation of parasite density. Parasitol. Today, 11, 206–212.
125. Kwiatkowski, D., Hill, A.V.S., Sambou, J., Twusami, P., Castracane, J., Manogue, K.R., et al. (1990). TNF concentrations in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet, 336, 1201–1204.
126. Kwiatkowski, D., Molyneux, M.E., Stephens, S., Curtis, N., Klein, P., Poimotaire, M., et al. (1993). Anti-TNF therapy inhibits fever in cerebral malaria. Q. J. Med., 86, 91–98.
127. Langhome, J. (1996). gd T cells in malaria infections. Parasitol. Today, 12, 200–203.
128. Langhorne, J. and Simon-Haarhaus, B. (1991). Differential T cell responses to Plasmodium chabaudi chabaudi in peripheral blood and spleens of C57BL/6 mice during infection. J. Immunol., 146, 2771–2775.
129. Langhorne, J., Simon-Haarhaus, B. and Meding, SJ. (1990). The role of CD4+ T cells in the protective immune response to Plasm odium chabaudi in vivo. Immunol. Lett., 25, 101–107.
130. Lew, A.M., Langford, C.J., Anders, R.F., Kemp, D.J., Saul, A., Fardoulys, C., et al. (1989). A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami. PNAS, 86, 3768–3773.
131. Lucas, A.O., Hendrickse, R.G., Okubadejo, O.A., Richards, W.H.G., Neal, R.A.and Kofie, B.A.K. (1969). The suppression of malarial parasitaemia by pyrimethamine in combination with dapsoneorsulphomethoxine. Trans. Roy. Soc. Trop. Med. Hyg., 63, 216–229.
132. Luxemburger, C., Thwai, K.L., White, N.J., Webster, H.K., Kyle, D.E., MaelanKirri, K., et al. (1996). The epidemiology of malaria in a Karen population on the western border of Thailand. Trans. Roy. Soc. Trrp. Med. Hyg., 90, 105–111.
133. Majarian, W.R., Daly, T.M., Weidanz, W.P., and Long, C.A. (1984). Passive immunization against murine malaria with an IgG3 monoclonal antibody. J. Immunol., 132, 3131–3137.
134. Malo, D. and Skamene, E. (1994). Genetic control of host resistance to infection. Trends Gen., 10, 365–371.
135. Marsh, K., Forster, D., Waruira, C., Mwnagi, I., Winstanley, M., Marsh, V., et al. (1995).Indicatorsoflife-threatening malaria in African children. N Eng. J. Med., 332, 1399–1404.
136. Marsh, K. and Greenwood, B.M. (1992). Malaria — a neglected disease? Parasitology, 104, S53-S69.
137. Mason, D. (1996). The role of B cells in the programming of T cells and IL-4 synthesis. J. Exp. Med., 183, 717–719.
138. Matzinger, P. (1994). Tolerance, danger, and the extended family. Ann. Rev. Immunol., 12, 991–1045.
139. McGregor, LA., Carrington, S.C. and Cohen, S. (1963). Treatment of East African Plasmodium falciparum malaria with West African human gammaglobulin. Trans. Roy. Soc. Trop. Med. Hyg., 57, 170–175.
140. McGuire, w., Hill, A.V.S., Allsopp, C.E.M., Greenwood, B.M. and Kwiatkowski, D. (1994). Variation in the TNF-γ promotor region associated with susceptibility to cerebral malaria. Nature, 317, 508–511.
141. Melancon-Kaplan, J., Burns, J. Jr., Vaidya, A., Webster, H.K. and Weidanz, W.P.(1992). The immunology of malaria. In The Immunology and Molecular biology of parasitic diseases, edited by K. Warren, pp. 300–362. New York: Alan R. Liss.
142. Metzger, D.W., McNutt, R.M., Collins, J.T., Buchanan, J.M., Van Cleave, V.H. and Dunnick, W.A. (1997). Interleukin-12 act as an adjuvant for humoral immunity through interferon y-dependent and -independent mechanisms. Eur. J. Immunol., 27, 1958–1965.
143. Michalek, M.T., Benacerraf, B. and Rock, K.L. (1989). Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing. PNAS, 149, 1905–1911.
144. Migot, F., Chougnet, C., Raharimalala, L., Astagneau, P., Lepers, J.P. and Deloron, P.(1993). Human immune response to the Plasm odium falciparum ring-infected erythrocyte surface antigen (Pfl55/RESA) after a decrease in malaria transmission in Madagascar. Amer:J. Trop. Med. Hyg., 48, 432–439.
145. Miller, L.H., Good, M.F. and Milon, G. (1994). Malaria Pathogenesis. Science, 264, 1878–1783.
146. Milon, G., Del Giudice, G. and Louis, J.A. (1995). Immunobiology of experimental cutaneous leishmaniasis. Parasitol. Today, 11, 244–247.
147. Minoprio, P., Itohara, S., Heusser, C., Tonegawa, S. and Coutinho, A. (1989). Immunobiology of murine T cruzi infection: The predominance of parasite non-specific responses and the activation of TCR 1 T cells. Immunol. Rev., 112, 182–207.
148. Minty, A., Chalon, P., Derocq, J.-M., Dumont, X., Guillemont, J.-C., Kaghad, M., etal. (1993). Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature (Lond), 362, 248–250.
149. Modiano, D., Petrarea, v., Sirima, B.S., Nebie, I., Diallo, D., Esposito, F., et al.(1996). Different response to Plasmodium falciparum malaria in West African sympatric ethnic groups. PNAS, 93, 13206–13211.
150. Molyneux, M.E., Taylor, T.E., Wirima, J.J. and Grau, G.E. (1991). Tumour necrosis factor, interleukin-6 and malaria. Lancet, 337, 1098.
151. Mordmliller, B.G., Metzger, W.G., Juillard, P., Brinkman, B.M.N., Verweij, C.L., Grau, G.E., et al. (1997). Tumor necrosis factor in Plasmodium falciparum malaria: high plasma level is associated with fever, but high production capacity is associated with rapid fever clearance. Eur. Cyt. Net., 8, 29–35.
152. Morges, W. and Weidanz, W.P. (1980). Plasmodium yoelii: the thymus-dependent lymphocyte in mice immunodepressed by malaria. Exp. Parasitol., 50, 188–194.
153. Morris Jones, S., Goodier, M.R. and Langhorne, J. (1996). The response to γδ T cells to Plasmodiumfalciparum is dependent on activated CD4+ T cells and the recognition of MHC class I molecules. Immunol., 89, 405–412.
154. Mosmann, T.R. and Coffman, R.L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion leads to different functional properties. Ann. Rev. Immunol., 7, 145–173.
155. Mshana, R.N., Boulandi, J., Mshana, N.M., Mayombo, J. and Mendorne, G. (1991). Levels of IL-lp, IL-4, IL-6, TNF-β and IFN-γ in plasma of healthy individuals and malaria patients in a holoendemic area. J. Clin. Lab. Immunol., 34, 131–139.
156. Mshana, R.N., McLean, S. and Boulandi, J. (1990). In vitro cell-mediated immune responses to Plasmodium falciparum schizont antigens in adults from endemic area: CD8+ lymphocytes inhibit the responses of low responder individuals. Int. Immunol., 2, 1121–1133.
157. Nagendran, K. and Ramasamy, R. (1996). Isotypes of naturally acquired antibodies to a repetitive and non-repetitive epitope on Plasmodium falciparum surface proteins in an endemic area of Sri Lanka. Ind. J. Med. Res., 103, 142–145.
158. Nardin, E.H. and Nussenzweig, R.S. (1993). T-cell response to pre-erythrocytic stages of malaria: Role in protection and vaccine development against pre-erythrocytic stages. Ann. Rev. Immunol., 11, 687–685.
159. Nguyen-Dinh, P., Berzins, K., Collins, W.E., Wahlgren, M. and Udomsangpetch, R. (1987). Antibodies to Pf155 a major antigen of P. falciparum: Longitudinal studies in humans. Amer. J. Trop. Med, Hyg., 7, 501–505.
160. Noben-Trauth, N., Kropf, P. and Müller, I. (1996). Susceptibility to Leishmania major infection for interleukin-4-deficient mice. Science, 271, 987–990.
161. Nussler, A., Drapier, J.-C., Renia, L., Pied, S., Miltgen, F., Gentilini, M., et al. (1991). L-Arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation, Eur. J. Immunol., 21, 227–230.
162. Ockenhouse, C.F., Schulman, S. and Shear, H.L. (1984). Induction of crisis forms in the human malaria parasite Plasmodium falciparum by interferon activated monocyte-derived macrophages. J. Immunol., 133, 1601–1608.
163. Olerup, O., Troye-Blomberg, M., Schreuder, G.M.T, and Riley, E.M. (1991). HLA-DR and DQ gene polymorphism in West Africans is twice as extensive as in North European Caucasoids. PNAS, 89, 2101–2104.
164. Parish, C.R. (1971). Relationship between humoral and cell-mediated immunity. Transplant. Rev., 13, 35–66.
165. Patino, J.A.G., Holder, A.A., McBride, J.S. and Blackman, M.J. (1997). Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J. Exp. Med., 186, 1689–1699.
166. Perera, M.K., Carter, R., Goonewardena, R. and Mendis, K.M. (1994). Transient increase in circulating y/8 T cells during Plasmodium vivax malarial paroxysms. J. Exp. Med., 179, 311–315.
167. Perlmann, H., Helmby, H., Hagstedt, M., Carlson, J., Larsson, P.H., Troye-Blomberg, M., et al. (1994). IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin. Exp. Immunol., 97, 284–292.
168. Perlmann, P., Perlmann, H. and Troye-Blomberg, M. (1996). IgE and TNF in malaria infection. Protection and pathogenicity — two sides of the same coin. Immunologist, 4/5, 179–184.
169. Perlmann, P., Perlmann, H., Wahlin Flyg, B., Hagstedt, M., ElGhazali, G., Worku, S., et al. (1997). IgE-a pathogenic factor in P falciparum malaria. Infect. Immun., 65, 116–121.
170. Pen'aut, R., Mercereau-Puijalon, O., Mattei, D., Borreau, E., Garraud, O., Bonnemains, B., et al. (1995). Induction of opsonizing antibodies after injection of recombinant Plasmodium falciparum vaccine candidate antigen in preimmune Saimiri sciut'eus monkeys. Infect. Immun., 63, 554 -562.
171. Perrin, L.H., Simitsek, P. and Srivastava, I. (1988). Development of malaria vaccines. Trop. Geogr. Med., 40, 406–21.
172. Petersen, E., Hogh, B., Perlmann, H., Kabilan, L., Troye-Blomberg, M., Marbiah, N.T.et al. (1989). An epidemiological study of humoral and cell-mediated immune response to the Plasmodium falciparum antigen Pf155/RESA in adult Liberians. Am. J. Trop. Med. Hyg., 41, 386–394.
173. Peyron, F, Burdin, N., Ringwald, P., Vuillez, J.P, Rousset, F. and Banchererau, J. (1994). Highlevelsofcirculating IL-10 in human malaria. Clin. Exp. Immunol., 95, 300–303.
174. Pichyangkul, S., Saengkrai, P. and Webster, H.K. (1994). Plasmodium falciparum pigment induces monocytes to release high levels if tumor necrosis factor-a and interleukin ip. Am. J. Trop. Med. Hyg., 5, 430–435.
175. Picot, S., Peyron, E, Deloron, P., Boudin, C., Chumpitazi, B., Barbe, G.et al. (1993). Ring-infected erythrocyte surface antigen (Pf 155/RES A), induces tumor necrosis factor-alpha production. Clin. Exp. Immunol., 93, 184–188.
176. Quakyi, LA, Otoo, L.N., Pombo, D., Sugars, L.Y., Menon, A, Degroot, AS.et al. (1989). Differential nonresponsiveness in humans of candidate Plasmodium falciparum vac cine antigens. Am. J. Trop. Med. Hyg.,41, 125–134.
177. Rabbani, H., Pan, Q., Kondo, N., Smith, C.I.E. and Hammarstrom, L. (1996). Duplications and deletions of fbe human IGHC locus: evolutionary implications. Immunogene., 45, 136–141.
178. Rank, R.G. and Weidanz, W.P. (1976). Nonsterilizing immunity in avian malaria: an antibody-independent phenomenon. Proc. Soc. Exp. Biol. Med., 151, 257–259.
179. Reiner, S.L. and Locksley, R.M. (1995). The regulation of immunity to Leishmania major. Ann. Rev. Immunol., 13, 151–177.
180. Riley, E., Jobe, O. and Whittle, H.C. (1989). CD8+ T cells inhibit Plasmodum falciparum induced lymphoproliferation and gamma interferon production in cell preparations from some malaria-immune individuals. Infect. Imrnun., 57, 1281–1284.
181. Riley, E.M. (1996). The role of MHC- and non-MHC-associated genes in determining the human immune response to malaria antigens. Parasitol., 112, S39-S51.
182. Riley, E.M., Allen, S.J., Troye-Blomberg, M., Bennett, S., Perlmann, H., Andersson, G.et al. (1991). Association between immune recognition of the malaria vaccine candidate antigen Pfl55/RESA and resistance to clinical disease: a prospective study in a malaria-endemic region of West Africa. Trans. Roy. Soc. Trop. Med. Hyg., 85. 436–443.
183. Riley, E.M., Allen, S.J., Wheeler, J.G., Blackman, M.J., Bennett, S., Takacs, B.et al. (1992a). Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSPL). of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol., 14, 321–337.
184. Riley, E.M., Olerup, O., Bennett, S., Owe, P., Allen, S.J., Blackman, M.J. et al. (1992b). MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum. Int. Immunol., 4, 1055–1063.
185. Roberts, D.W. and Weidanz, W.P. (1979). T-cell immunity to malaria in the B-cell deficient mouse. Am. J. Trop. Med. Hyg., 28, 1–3.
186. Romagnani, S. (1994). Lymphokine production by human T cells in disease states. Ann. Rev. Immunol, 5, 227–257.
187. Romero, P. (1992). Malaria vaccines. Curro Opin. Immunol, 4, 432–441.
188. Rosenberg, YJ. (1978). Autoimmune and polyclonal B cell response during murine malaria. Nature, 274, 170–172.
189. Roussilhon, C, Agrapart, M., Ballet, J.J., and Bensussan, A. (1990). T lymphocytes bearing the y8+ T cell receptor in patients with acute Plasmodium falciparum malaria. J. Infect. Dis., 162, 283–285.
190. Roussilhon, C., Agrapart, M., Guglielmi, P., Bensussan, A, Brasseur, P. and Ballet, J.J. (1994). Human TCR y8 lymphocyte response on primary exposure to Plasmodium falciparum. Clin. Exp. Immunol., 95, 9197.
191. Rzepczyk, C., Hake, K., Wodroffe, N., Bobogare, A, Csurhes, P., Ishii, Aet al. (1997). Humoral immune responses of Solomon Islander to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass. Infect. Immun., 65, 1098–1100.
192. Rzepczyk, C.M., Stamatiou, S., Anderson, K., Stowers, A., Cheng, Q., Saul, A.et al. (1996). Experimental human Plasmodium falciparum infections: Longitudinal analysis of lymphocyte responses with particular reference to y8 T cells. Scand. J. Immunol. 43, 219–277.
193. Sabchareon, S., Burnouf, T, Ouattara, D., Attanath, T, Bouharoun-Tayon, H., Chantavanich, P.et al. (1991). Parasitological and clinical response to immunoglobulin administration in P. falcip arum malaria. Am. J. Trop. Med. Hyg., 45, 297–308.
194. Salgame, P., Abrams, J.S., Clayberger, C, Goldstein, H., Convit, J., Modlin, R.L.et al. (1991). Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science, 254, 279–282.
195. Sarthou, J.-L., Angel, G., Aribot, G., Rogier, C., Dieye, A, Toure Balde, Aet al. (1997). Prognostic value of anti-Plasmodiumfalciparum-specific immunoglobulin G3, cytokines, and their soluble receptors in West African patients with severe malaria. Infect. Immun., 65, 3721–3276.
196. Schofield, L. and Hackett, F. (1993). Signal transduction in host cells by a glycosylphospatidylinositol toxin of malaria parasites. J. Exp. Med., 177, 145–153.
197. Schofield, L. and Tachado, S.D. (1996). Regulation of host cell function by glycosylphospatidylinositols of parasitic protozoa. Immunol, and Cell Biol., 74, 555–563.
198. Schwartz, E., Shapiro, R., Shina, S. and Bank, L. (1996). Delayed expansion of V delta 2 and V delta 1 gamma delta T cells after acute Plasmodium falciparum
199. Seder, R.A and Le Gros, G.G. (1995). The functional role of CD8+ T helper type 2 cells. J. Exp. Med., 181, 5–7.
200. Sengers, R.C., Jerusalem, C.R. and Doesburg, W.H. (1971). Murine malaria. IV. Disturbed immunological responsiveness during Plasmodium berg/lei Infect. Exp. Parasitol., 30, 41–53.
201. Siler, A and Coffman, R.L. (1992). Regulation of immunity to parasites by T cellsand Tcellderived cytokines.Ann. Rev. Immunol., 10, 385–410.
202. Simon, AK., Seipelt, E., Wu, P., Wenzel, B., Braun, J. and Sieper, J. (1993). Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis: predominance of Thl subsets. Clin. Exp. Immunol., 94, 122–126.
203. Sjöberg, K., Lepers, J.P., Rahalimalala, L., Larsson, Å., Olerup, O., Marbiah, N.T. et al. (1992). Genetic regulation of human anti-malarial antibodies in twins. PNAS, 89, 2101–2104.
204. Song, Z., Casalaro, V., Chen, R., Georas, S.N., Monos, D. and Ono, S.J. (1996). Polymorphic nucleotide within the human IL-4 promotor that mediate overexpression of the gene. J. Immunol., 156, 424–429.
205. Taylor, R.R., Smith, D.B., Robinson, VJ., McBride, J.S. and Riley, EM.(1995). Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass. Infect. Immun., 63, 4382–4388.
206. Taylor-Robinson, A.W., Phillips, R.S., Severn, A., Moncada, S. and Liew, F.Y. (1993). The role of TH1 and TH2 cells in a rodent malaria Infect. Science, 260, 1931–1934.
207. Theander, T.G., Hviid, L., Dodoo, D., Afari, E.A, Jensen, J.B. and Rzepczyk, C.M. (1997).HumanT-cellrecognition of synthetic peptides representing conserved and variant sequences from the merozoite surface protein 2 of Plasmodium falciparum. Immunol. Lett., 58, 1–8.
208. Thomson, G. (1995). HLA disease associations: models for the study of complex human genetic disorders. Crit. Rev. Clin. Lab. Sci., 32, 183–219.
209. Treutiger, C.-J., Hedlund, I., Helmby, H., Carlsson, J., Jepson, A., Twumasi, P.et al. (1992). Rosette formation in Plasmodium falciparum isolates and anti-rosette activity in sera from Gambians with cerebral or uncomplicated malaria. Am. J. Trrp. Med. Hyg., 46, 503–510.
210. Trinchieri, G. and Scott, P. (1995). Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res. Immunol., 146, 423–651.
211. Troye-Blomberg, M., Berzins, K. and Perlmann, P. (1994). T-cell control of immunity to the asexual blood stages of the malaria parasite. Crit. Rev. Immunol., 14, 131–151.
212. Troye-B1omberg, M., Fogdell, A., ElGhazali, G., Larsson, Å., Hassan King, M., Sisay-Joof, F.et al. (1997). Analysis of the T-cell receptor Vβ usage in monozygotic twins living in a Plasmodiumfalciparum endemic area in West Africa. Scand. J. Immunol., 45, 541–545.
213. Troye-Blomberg, M., Lepers, J.-P., Sjöberg, K., Rahalimalala, L., Larsson, A., Olerup, O.et al.(1994). Presentation of the Plasmodium falciparum antigen Pf155fRESA to human T cells. Variations in responsiveness induced by antigen presenting cells from different but MHC class II identical donors. Immunol. Lett., 43, 59–66.
214. Troye-Blomberg, M., Olerup, O., Larsson, A., Sjöberg, K., Perlmann, Riley, E. et al. (1991). Failure to detect MHC class II association of the human immune responses induced by repeated malaria infections to Plasmodium falciparum. Int. Immunol., 4, 1055–1063.
215. Troye-Blomberg, M., Riley, E.M., Kabilan, L., Holmberg, M., Perlmann, H., Andersson, U.et al. (1990). Production by activated human T cells of interleukin 4 but not interferon-γ is associated with elevated levels of serum antibodies to activating malaria antigens. PNAS, 87, 5484–5488.
216. Udeinya, I.J., Miller, L.H., McGegor, I.A. and Jensen, J.B. (1983). P.falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic cells. Nature, 303, 429–431.
217. Udomsangpetch, R., Troye-Blomberg, M., Brown, A.E., Thaithong, S., Perlmann, P. and Webster, H.K. (1994). Lymphocyte responses to Plasmodiumfalciparum ring-infected erythrocyte surface antigen (Pf 155/RES A), peptides in individuals with naturally acquired Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg., 50, 465–471.
218. van der Heyde, H.C., Elloso, M.M., Chang, W.-L., Pepper, B.J., Batchfelder, J. and Weidanz, W.P. (1996). Expansion of the γδ T cell subset in vivo during bloodstage malaria in B cell-deficient mice. J. Leuko. Biol., 60, 221–229.
219. van der Heyde, H.C., Elloso, M.M., Chang, W.L., Kaplan, M., Manning, D.D. and Weidanz, W.P. (1995a). Gammadelta T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria. J. Immunol., 154, 3985–3990.
220. van der Heyde, H.C., Elloso, M.M., vande Waa, J., Schell, K. and Weidanz, W.P. (1995b). Use of hydroethidine and flow cytometry to assess the effects of leukocytes on the malaria parasite Plasmodium falciparum. Clin. Diag. Lab. Immunol., 2, 417–425.
221. van der Heyde, H.C., Huszar, D., Woodhouse, C., Manning, D.D. and Weidanz, W.P. (1994). The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. J. Immunol., 152, 4557–4561.
222. van der Heyde, H.C., Manning, D.D., Roopenian, D.C. and Weidanz, W.P. (1993). Resolution of blood-stage malarial infections in CD8+ cell-deficient B 2m0i0 mice, J. Immunol., 151, 3187–3191.
223. van der Heyde, H.C., Manning, D.D. and Weidanz, W.P. (1993). Role of CD4+ T cells in the expansion of the CD4-, CD8- γδ T cell subset in the spleens of mice during blood-stage malaria. J. Immunol, 151, 6311—6317.
224. van derHeyde, H.C., Pepper, B., Batchelder, J., Cigel, F., and Weidanz, W.P. (1997). The time course of selected malarial infections in cytokine-deficient mice. Exp. Parasitol., 85, 206–213.
225. Varney, N.R., Roberts, R.J., Springer, J.A., Connell, S.K and Wood, P.S. (1997). Neuropsychiatric sequelae of cerebral malaria in Vietnam veterans. J. Nerv. Ment. Dis., 185, 695–703.
226. Vinetz, J.M., Kumar, S., Good, M.F., Fowlkes, J.A., Berzofsky, J.A. and Miller, L.H. (1990). Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to bloodstage Plasmodium yoelii malaria. J. Immunol., 144, 1069–1074.
227. Vinetz, J.M., Li, J., McCutchan, TF. and Kaslow, D.C. (1998). Plasm odium malariae Infect, in an aymptomatic 74-year-old-greek woman with splenomegaly. New Engl. J. Med., 338, 367–371.
228. Von der Weid, T, Honarvar, N. and Langhorne, J. (1996). Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. J. Immunol., 156, 2510–2516.
229. von der Weid, T., Kopf, M., Kohler, G. and Langhorne, J. (1994). The immune response to Plasmodium chabaudi in interleukin-4 deficient mice. Eur. J. Immunol., 24, 2285–2293.
230. Wahlgren, M., Björkman, A., Perlmann, H., Berzins, K. and Perlmann, P. (1986). Anti-P. falciparum antibodies acquired by residents in a holoendemic area of Liberia during development of clinical immunity. Am. J. Trop. Med. Hyg., 35, 22–29.
231. Warsame, M., Wemsdorfer, W.H., Perlmann, H., Lebbad, M., Ericsson, ö., Matola, YG.et al. (1997). A malariometric survey in a rural community in the Muheza district, Tanzania: age profiles in the development of humoral immune responses. Acta Tropica, 68, 239–253.
232. Wegmann, T.G., Lin, H., Guilbert, L. and Mosmann, T.R.(1993). Birectional cytokine interactions in the matemal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today, 14, 353–356.
233. Weidanz, WP. and Grun, J.L. (1981). Antibody-independent mechanisms in development of acquired immunity to malaria. Adv. Exp. Med. Biol., 162, 409–423.
234. Weidanz, WP. and Long, C.A. (1988). The role of T cells in immunity to malaria. Prog. Aller., 41, 215–252.
235. Weidanz, W.P., Melancon-Kaplan, J. and Cavacini, L.A. (1990). Cell-mediated immunity to the asexual blood stages of malarial parasites: animal models. Immunol. Lett., 25, 87–95.
236. Weinbaum, F.I., Evans, C.B. and Tigelaar, R.E. (1976). Immunity to Plasmodium yoelii in mice. I. The course of Infect. in T cell and B cell deficient mice. J. Immunol., 117, 1999–2005.
237. Wenisch, C., Parschalk, B., Nartz, E., Looareesuwan, S. and Graninger, W. (1995). Elevated serum levels of IL-IO and IFN-γ in patients with acute Plasmodium falciparum malaria. Clin. Immunol. Immunopathol., 74, 115–117.
238. White, N.J. and Ho, M. (1992). The pathophysiology of malaria. Adv. Parasitol., 31, 83–173.
239. White, W.I., Evans, C.B. and Taylor, D.W. (1991). Antimalarial antibody of the IgG2a isotype modulate parasitemia in mice infected with Plasmodium yoelii. Inject. Immun., 59, 3547–3554.
240. WHO (1993). World malaria situation in1991: Part 1. Weekly Epidemiol. Rep., 68, 253–260.
241. Worku, S., Björkman, A., Troye-Blomberg, M., Jemaneh, L., Farnert, A. and Christensson, B. (1997). Lymphocyte activation and subset redistribution in the peripheral blood in acute malaria illness:distinctyS+Tcellpattern in Plasmodium falciparum and P. vivax Infect.s. Clin. Exp. Immunol., 108, 34—41.
242. Wahlin, B., K., B., Perlmann, H., Anders, R.F., and Perlmann, P. (1994). Human antibodies to a Mr 155,000 P. falciparum antigen efficiently inhibiting merozoite invasion. PNAS, 81, 7912–7916.
243. Yanez, D.M., Manning, D.D., Cooley, A.J., Weidanz, W.P. and van der Heyde, H.C. (1996). Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria. J. Immunol., 157, 1620–1624.
244. Yap, G.S. and Stevenson, M.M. (1994). Differential requirements for an intact spleen in induction and expression of B-cell-dependent immunity to Plasmodium chabaudi AS. Inject. Immun., 62, 4219–4225.
245. Zurawski, G. and de Vries, J.E. (1994). Interleukin 13, an interleukin 4-like cytokine thatacts onmonocytesand B cells, but not on T cells. Immunol. Today, 15, 19–26.