Inhibitory effects of heavy metals on transcription factor Sp1

Industrial Health

Volumn 38, Issue 2, 2000, Pages 224-227

  Gong, Pengfei ^a,b   Ogra, Yasumitsu ^a,c   Koizumi, Shinji ^a  

^a NATL INSTITUTE OF INDUSTRIAL HEALTH   (Japan)

^b OCHSNER MEDICAL CENTER   (United States)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Cadmium; Heavy metal; Sp1; Transcription factor; Zinc

Indexed keywords

CADMIUM; COPPER; DNA BINDING PROTEIN; HEAVY METAL; MERCURY; TRANSCRIPTION FACTOR SP1; ZINC; ZINC FINGER PROTEIN;

ARTICLE; FOOD CONTAMINATION; HELA CELL; HUMAN; HUMAN CELL; METAL METABOLISM; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

EID: 0034020776     PISSN: 00198366     EISSN: None     Source Type: Journal    
DOI: 10.2486/indhealth.38.224     Document Type: Article

References (15)

1. Kang YJ (1997) Metals toxicology. In: Handbook of human toxicology, ed. by Massaro EJ, 3-302, CRC Press, Boca Raton.
2. Colemn JE (1992) Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Annu Rev Biochem 61, 897-946.
3. Hanas JS, Gunn CG (1996) Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions. Nucleic Acids Res 24, 924-30.
4. Thiesen H-J, Bach C (1991) Transition metals modulate DNA-protein interactions of Sp1 zinc finger domains with its cognate target site. Biochem Biophys Res Commun 176, 551-7.
5. Dynan WS, Tjian R (1983) The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35, 79-87.
6. Dynan WS, Saffer JD, Lee WS, Tjian R (1985) Transcription factor Sp1 recognizes promoter sequences from the monkey genome that are similar to the simian virus 40 promoter. Proc Natl Acad Sci USA 82, 4915-9.
7. Jones KA, Tjian R (1985) Sp1 binds to promoter sequences and activates herpes simplex virus 'immediate-early' gene transcription in vitro. Nature 317, 179-82.
8. Dynan WS, Sazer S, Tjian R, Schimke RT (1986) Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature 319, 246-8.
9. IIb gene. J Biol Chem 273, 5716-26.
10. Li R, Hodny Z, Luciakova K, Barath P, Nelson BD (1996) Sp1 activates and inhibits transcription from separate elements in the proximal promoter of the human adenine nucleotide translocase 2 (ANT2) gene. J Biol Chem 271, 18925-30.
11. Madsen CS, Hershey JC, Hautmann MB, White SL, Owens GK (1997) Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements. J Biol Chem 272, 6332-40.
12. A gene. In: Metallothionein IV. ed. by Klaassen CD, 237-41, Birkhäuser, Basel.
13. Koizumi S, Suzuki K, Ogra Y, Yamada H, Otsuka F (1999) Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene. Eur J Biochem 259, 635-42.
14. Karin M, Haslinger A, Heguy A, Dietlin T, Cooke T (1987) Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity. Mol Cell Biol 7, 606-13.
15. Lee W, Haslinger A, Karin M, Tjian R (1987) Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature 325, 368-72.