Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection

International Journal of Immunogenetics

Volumn 33, Issue 2, 2006, Pages 73-79

  McIlroy, D ^a   Meyer, L ^c   Dudoit, Y ^b   Samri, A ^b   Delfraissy, J F ^c   Autran, B ^b   Debre P ^b   Theodorou, I ^b  

^a UNIVERSITÉ DE NANTES   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c BICÊTRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PERFORIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SCREENING; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENETICS; KAPLAN MEIER METHOD; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEROCONVERSION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33645114387     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2006.00571.x     Document Type: Article

References (34)

1. Ambach A. Bonnekoh B. Gollnick H. 2003 Routine flow cytometric immuno-staining of T-cell perforin is preserved using diethylene glycol for erythrocyte-lysis but lost by the use of ammonium chloride. Experimental Dermatology 12 825.
2. An P. Nelson G.W. Wang L. Donfield S. Goedert J.J. Phair J. et al. 2002 Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proceedings of the National Academy of Sciences of the USA 99 10002.
3. Appay V. Papagno L. Spina C.A. Hansasuta P. King A. Jones L. et al. 2002 Dynamics of T cell responses in HIV infection. Journal of Immunology 168 3660.
4. Barouch D.H. Kunstman J. Kuroda M.J. Schmitz J.E. Santra S. Peyerl F.W. et al. 2002 Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415 335.
5. Carrington M. Dean M. Martin M.P. O'Brien S.J. 1999 Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Human Molecular Genetics 8 1939.
6. Carrington M. O'Brien S.J. 2003 The influence of HLA genotype on AIDS. Annual Review of Medicine 54 535.
7. Chen G. Shankar P. Lange C. Valdez H. Skolnik P.R. Wu L. Manjunath N. Lieberman J. 2001 CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood 98 156.
8. Dix R.D. Podack E.R. Cousins S.W. 2003 Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. Journal of Virology 77 3402.
9. Garred P. Madsen H.O. Balslev U. Hofmann B. Pedersen C. Gerstoft J. Svejgaard A. 1997 Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannosebinding lectin. Lancet 349 236.
10. Ghiasi H. Cai S. Perng G. Nesburn A.B. Wechsler S.L. 1999 Perforin pathway is essential for protection of mice against lethal ocular HSV-1 challenge but not corneal scarring. Virus Research 65 97.
11. Goulder P.J. Phillips R.E. Colbert R.A. McAdam S. Ogg G. Nowak M.A. et al. 1997 Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nature Medicine 3 212.
12. Haridas V. McCloskey T.W. Pahwa R. Pahwa S. 2003 Discordant expression of perforin and granzyme A in total and HIV-specific CD8 T lymphocytes of HIV infected children and adolescents. Aids 17 2313.
13. Heintel T. Sester M. Rodriguez M.M. Krieg C. Sester U. Wagner R. Pees H.W. Gartner B. Maier R. Meyerhans A. 2002 The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection. Aids 16 1497.
14. Magierowska M. Theodorou I. Debre P. Sanson F. Autran B. Riviere Y. Charron D. Costagliola D. 1999 Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood 93 936.
15. McDermott D.H. Beecroft M.J. Kleeberger C.A. Al-Sharif F.M. Ollier W.E. Zimmerman P.A. et al. 2000 Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. Aids 14 2671.
16. McIlroy D. Cartron P.F. Tuffery P. Dudoit Y. Samri A. Autran B. Vallette F.M. Debre P. Theodorou I. 2003 A triple-mutated allele of granzyme B incapable of inducing apoptosis. Proceedings of the National Academy of Sciences of the USA 100 2562.
17. Meyer L. Magierowska M. Hubert J.B. Mayaux M.J. Misrahi M. Le Chenadec J. Debre P. Rouzioux C. Delfraissy J.-F. Theodorou I. 1999 CCR5 delta32 deletion and reduced risk of toxoplasmosis in persons infected with human immunodeficiency virus type 1. The SEROCO-HEMOCO-SEROGEST Study Groups. Journal of Infectious Disease 180 920.
18. Migueles S.A. Laborico A.C. Shupert W.L. Sabbaghian M.S. Rabin R. Hallahan C.W. et al. 2002 HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nature Immunology 3 1061.
19. Mullbacher A. Ebnet K. Blanden R.V. Hla R.T. Stehle T. Museteanu C. Simon M.M. 1996 Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proceedings of the National Academy of Sciences of the USA 93 5783.
20. Mullbacher A. Hla R.T. Museteanu C. Simon M.M. 1999a Perforin is essential for control of ectromelia virus but not related poxviruses in mice. Journal of Virology 73 1665.
21. Mullbacher A. Waring P. Tha Hla R. Tran T. Chin S. Stehle T. Museteanu C. Simon M.M. 1999b Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proceedings of the National Academy of Sciences of the USA 96 13950.
22. Nakayama E.E. Hoshino Y. Xin X. Liu H. Goto M. Watanabe N. et al. 2000 Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. Journal of Virology 74 5452.
23. Nakayama E.E. Meyer L. Iwamoto A. Persoz A. Nagai Y. Rouzioux C. et al. 2002 Protective effect of interleukin-4 T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load. Journal of Infectious Disease 185 1183.
24. Nixon D.F. Townsend A.R. Elvin J.G. Rizza C.R. Gallwey J. McMichael A.J. 1988 HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 336 484.
25. O'Brien S.J. Moore J.P. 2000 The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunological Reviews 177 99.
26. Quandt K. Frech K. Karas H. Wingender E. Werner T. 1995 MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Research 23 4878.
27. Schmitz J.E. Kuroda M.J. Santra S. Sasseville V.G. Simon M.A. Lifton M.A. et al. 1999 Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283 857.
28. Shin H.D. Winkler C. Stephens J.C. Bream J. Young H. Goedert J.J. et al. 2000 Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proceedings of the National Academy of Sciences of the USA 97 14467.
29. Stepp S.E. Dufourcq-Lagelouse R. Le Deist F. Bhawan S. Certain S. Mathew P.A. et al. 1999 Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286 1957.
30. Tang Y. Hugin A.W. Giese N.A. Gabriele L. Chattopadhyay S.K. Fredrickson T.N. Kagi D. Hartley J.W. Morse H.C. 3rd. ( 1997 Control of immunodeficiency and lymphoproliferation in mouse AIDS: studies of mice deficient in CD8+ T cells or perforin. Journal of Virology 71 1808.
31. Volker J.L. Rameh L.E. Zhu Q. DeCaprio J. Hansen U. 1997 Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes and Development 11 1435.
32. Walsh C.M. Matloubian M. Liu C.C. Ueda R. Kurahara C.G. Christensen J.L. Huang M.T. Young J.D. Ahmed R. Clark W.R. 1994 Immune function in mice lacking the perforin gene. Proceedings of the National Academy of Sciences of the USA 91 10854.
33. Wilson J.D. Ogg G.S. Allen R.L. Davis C. Shaunak S. Downie J. et al. 2000 Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. Aids 14 225.
34. Zhang D. Shankar P. Xu Z. Harnisch B. Chen G. Lange C. Lee S.J. Valdez H. Lederman M.M. Lieberman J. 2003 Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood 101 226.