3,3′-Diindolylmethane is a novel topoisomerase IIα catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells

Molecular Pharmacology

Volumn 69, Issue 4, 2006, Pages 1320-1327

  Gong, Yixuan ^a   Firestone, Gary L ^a   Bjeldanes, Leonard F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3'3 DIINDOLYMETHANE; ETOPOSIDE; GYRASE INHIBITOR; UNCLASSIFIED DRUG; 3,3' DIINDOLYLMETHANE; 3,3'-DIINDOLYLMETHANE; DNA; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; INDOLE DERIVATIVE; TUMOR ANTIGEN;

ARTICLE; CELL CYCLE S PHASE; DNA CLEAVAGE; DNA SYNTHESIS INHIBITION; DRUG DNA INTERACTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; COMET ASSAY; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; ENZYMOLOGY; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MITOSIS; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, NEOPLASM; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; COMET ASSAY; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, NEOPLASM; DNA-BINDING PROTEINS; ETOPOSIDE; HUMANS; INDOLES; LIVER NEOPLASMS; MICROSCOPY, CONFOCAL; MITOSIS; S PHASE;

EID: 33645107038     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.018978     Document Type: Article

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