In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum

Drug Metabolism and Disposition

Volumn 34, Issue 4, 2006, Pages 667-682

  Daher, Wassim ^a   Pelinski, Lydie ^b   Klieber, Sylvie ^c   Sadoun, Freddy ^c   Meunier, Viviane ^c   Bourrié, Martine ^c   Biot, Christophe ^b   Guillou, François ^c   Fabre, Gérard ^c   Brocard, Jacques ^b   Fraisse, Laurent ^c   Maffrand, Jean Pierre ^c   Khalife, Jamal ^a   Dive, Daniel ^a,d  

^a INSERM   (France)

^b Ecole Nationale Superieure de Chimie de Lille   (France)

^c SANOFI   (France)

^d INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; CYTOCHROME P450; FERROQUINE; MONO N DEMETHYL FERROQUINE; N,N DEMETHYL FERROQUINE; SSR 97193; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; DOG; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MACACA; MALARIA; MALE; METABOLITE; MOUSE; NONHUMAN; OXIDATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RAT;

ANIMALIA; CANIS FAMILIARIS; MACACA; PLASMODIUM FALCIPARUM;

EID: 33645105858     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.104.003202     Document Type: Article

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