Short-term simvastatin treatment has no effect on plasma cytokine response in a human in vivo model of low-grade inflammation

Clinical and Experimental Immunology

Volumn 144, Issue 1, 2006, Pages 94-100

  Erikstrup, C ^a,b   Ullum, H ^a,b   Pedersen, B K ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

Author keywords

Cytokines; Endotoxin; In vivo; Inflammation; Statins

Indexed keywords

CYTOKINE; ENDOTOXIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BLOOD ANALYSIS; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; HUMAN; INFLAMMATION; LEUKOCYTE; LEUKOCYTE COUNT; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

ADULT; AREA UNDER CURVE; C-REACTIVE PROTEIN; CHOLESTEROL, LDL; CYTOKINES; ENDOTOXINS; ESCHERICHIA COLI; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNE TOLERANCE; INFLAMMATION; INTERLEUKIN-6; LEUKOCYTE COUNT; MALE; MODELS, BIOLOGICAL; RECEPTORS, INTERLEUKIN-1; SIMVASTATIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645104046     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03042.x     Document Type: Article

References (29)

1. Holm T Andreassen AK Ueland T et al. Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients*1 Am J Cardiol 2001 87 815 8
2. Plenge JK Hernandez TL Weil KM et al. Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction Circulation 2002 106 1447 52
3. Ridker PM Rifai N Pfeffer MA Sacks F Braunwald E Long-term effects of pravastatin on plasma concentration of C-reactive protein Circulation 1999 100 230 5
4. Weitz-Schmidt G Welzenbach K Brinkmann V et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site Nat Med 2001 7 687 92
5. Weitz-Schmidt G Statins as anti-inflammatory agents Trends Pharmacol Sci 2002 23 482 6
6. Ikeda U Shimada K Statins and monocytes Lancet 1999 353 2070
7. Rosenson RS Tangney CC Casey LC Inhibition of proinflammatory cytokine production by pravastatin Lancet 1999 353 983 4
8. Jialal I Stein D Balis D Grundy SM Adams-Huet B Devaraj S Effect of hydroxymethyl glutaryl coenzyme a reductase inhibitor therapy on high sensitive C-reactive protein levels Circulation 2001 103 1933 5
9. Koh KK Son JW Ahn JY et al. Vascular effects of diet and statin in hypercholesterolemic patients*1 Int J Cardiol 2004 95 185 91
10. Almog Y Shefer A Novack V et al. Prior statin therapy is associated with a decreased rate of severe sepsis Circulation 2004 110 880 5
11. Guijarro C Blanco-Colio LM Ortego M et al. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture Circ Res 1998 83 490 500
12. Laufs U Endres M Custodis F et al. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription Circulation 2000 102 3104 10
13. Endres M Laufs U Effects of statins on endothelium and signaling mechanisms Stroke 2004 35 2708 11
14. Cordle A Koenigsknecht-Talboo J Wilkinson B Limpert A Landreth G Mechanisms of statin-mediated inhibition of small G-protein function J Biol Chem 2005 280 34202 9
15. Baumgarten G Knuefermann P Nozaki N Sivasubramanian N Mann DL Vallejo JG In vivo expression of proinflammatory mediators in the adult heart after endotoxin administratio: the role of Toll-like receptor-4 J Infect Dis 2001 183 1617 24
16. Beutler B Inferences, questions and possibilities in Toll-like receptor signalling Nature 2004 430 257 63
17. Michie HR Manogue KR Spriggs DR et al. Detection of circulating tumor necrosis factor after endotoxin administration N Engl J Med 1988 318 1481 6
18. Martich GD Boujoukos AJ Suffredini AF Response of man to endotoxin Immunobiology 1993 187 403 16
19. Krabbe KS Bruunsgaard H Qvist J et al. Activated T lymphocytes disappear from circulation during endotoxemia in humans Clin Diagn Lab Immunol 2002 9 731 5
20. Krogh-Madsen R Moller K Dela F Kronborg G Jauffred S Pedersen BK Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans Am J Physiol-Endoc M 2004 286 E766 72
21. Starkie R Ostrowski SR Jauffred S Febbraio M Pedersen BK Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans FASEB J 2003 17 884 6
22. Albert MA Danielson E Rifai N Ridker PM Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study JAMA 2001 286 64 70
23. Strandberg TE Vanhanen H Tikkanen MJ Effect of statins on C-reactive protein in patients with coronary artery disease Lancet 1999 353 118 9
24. Li JJ Chen MZ Chen X Fang CH Rapid effects of simvastatin on lipid profile and C-reactive protein in patients with hypercholesterolemia Clin Cardiol 2003 26 472 6
25. Steiner S Speidl WS Pleiner J et al. Simvastatin blunts endotoxin-induced tissue factor in vivo Circulation 2005 111 1841 6
26. Ferroni P Martini F Cardarello CM Gazzaniga PP Davi G Basili S Enhanced interleukin-1(beta) in hypercholesterolemia: effects simvastatin low-dose aspirin Circulation 2003 108 1673 5
27. Lang CH Bagby GJ Endotoxin tolerance diminishes endotoxin-induced alterations in carbohydrate kinetics Circ Shock 1986 20 141 50
28. Lang CH Spitzer JA Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion Metabolism 1987 36 469 74
29. Sanchez-Cantu L Rode HN Christou NV Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor Arch Surg 1989 124 1432 5