Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung?

Respirology

Volumn 11, Issue SUPPL. 1, 2006, Pages

  Nakata, Koh ^a   Kanazawa, Hiroko ^a   Watanabe, Masato ^a  

^a NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

Author keywords

Alveolar macrophages; Antibody; Granulocyte macrophage colony stimulating factor; Pulmonary alveolar proteinosis; Transcription factor

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

BRAIN; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONFERENCE PAPER; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC PULMONARY ALVEOLAR PROTEINOSIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE; KIDNEY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN;

ANIMALS; ANIMALS, NEWBORN; AUTOANTIBODIES; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES, ALVEOLAR; MICROSCOPY, CONFOCAL; PROTO-ONCOGENE PROTEINS; PULMONARY ALVEOLAR PROTEINOSIS; RATS; TRANS-ACTIVATORS;

EID: 33645103271     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2006.00812.x     Document Type: Conference Paper

References (9)

1. Dranoff G Crawford AD Sadelain M et al. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis Science 1994 264 713 16
2. Nishinakamura R Nakayama N Hirabayashi Y et al. Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal Immunity 1995 2 211 22
3. Nishinakamura R Wiler R Dirksen U et al. The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation JExpMed 1996 183 2657 62
4. Huffman JA Hull WM Dranoff G Mulligan RC Whitsett JA Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice JClinInvest 1996 97 649 55
5. Kitamura T Tanaka N Watanabe J et al. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor JExpMed 1999 190 875 80
6. Shibata Y Berclaz PY Chroneos ZC Yoshida H Whitsett JA Trapnell BC GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1 Immunity 2001 15 557 67
7. Berclaz PY Shibata Y Whitsett JA Trapnell BC GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma- mediated molecular connection between innate and adaptive immunity in the lung Blood 2002 100 4193 200
8. Bonfield TL Raychaudhuri B Malur A et al. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor AmJPhysiolLung CellMolPhysiol 2003 285 L1132 6
9. Tazawa R Hamano E Arai T et al. Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis AmJRespirCritCare Med 2005 171 1142 9