The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-α-stimulated host cells

Journal of Viral Hepatitis

Volumn 13, Issue 3, 2006, Pages 150-157

  Hartwig, D ^a   Schutte C ^a   Warnecke, J ^a   Dorn, I ^a   Hennig, H ^a   Kirchner, H ^a   Schlenke, P ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Adenosine deaminase acting on RNA 1; Editing; Hepatitis delta virus; Interferon

Indexed keywords

ADENOSINE DEAMINASE; ADENOSINE DEAMINASE ACTING ON RNA 1; ALPHA INTERFERON; ANTISENSE OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED RNA; HEPATITIS DELTA ANTIGEN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; HEPATITIS DELTA VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INCUBATION TIME; INNATE IMMUNITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; VIRUS REPLICATION;

ADENOSINE DEAMINASE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE SILENCING; HEPATITIS DELTA VIRUS; HUMANS; IMMUNOBLOTTING; INTERFERON-ALPHA; OLIGORIBONUCLEOTIDES, ANTISENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA EDITING; RNA, MESSENGER; RNA, VIRAL;

EID: 33645097965     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2005.00663.x     Document Type: Article

References (30)

1. Rizzetto M Hoyer B Canese MG Shih JW Purcell RH Gerin JL Delta agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees Proc Natl Acad Sci 1980 77 6124 6128
2. Wang KS Choo QL Weiner AJ et al. Structure, sequence and expression of the hepatitis delta viral genome Nature 1986 323 508 514
3. Lai MM The molecular biology of hepatitis delta virus Annu Rev Biochem 1985 64 259 286
4. Bergmann KF Gerin JL Antigens of hepatitis delta virus in the liver and serum of humans and animals J Infect Dis 1986 154 702 706
5. Weiner AJ Choo QL Wang KS et al. A single antigenomic open reading frame of the hepatitis delta virus encodes epitopes of both hepatitis delta antigen polypeptides p24 delta and p27 delta J Virol 1988 62 594 599
6. Casey JL Gerin JL Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA J Virol 1995 69 7593 7600
7. Luo GX Chao M Hsieh SY Sureau C Nishikura K Taylor J A specific base transition occurs on replicating hepatitis delta virus RNA J Virol 1990 64 1021 1027
8. Polson AG Bass BL Casey JL RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase Nature 1996 380 454 456
9. Kuo MY Chao M Taylor J Initiation of replication of the human hepatitis delta virus genome from cloned DNA: role of delta antigen J Virol 1989 63 1945 1950
10. Ryu WS Bayer M Taylor J Assembly of hepatitis delta virus particles J Virol 1992 66 2310 2315
11. Sato S Cornillez-Ty C Lazinsky DW By inhibiting replication, the large hepatitis delta antigen can indirectly regulate amber/W editing and its own expression J Virol 2004 78 8120 8134
12. Jayan GC Casey JL Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression J Virol 2002 76 12399 12404
13. Patterson JB Samuel CE Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human: evidence for two forms of the deaminase Mol Cell Biol 1995 15 5376 5388
14. George CX Samuel CE Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible, Proc Natl Acad Sci 1999 96 4621 4626
15. Kawakubo K Samuel CE Human RNA-specific adenosine deaminase (ADAR1) gene specifies transcripts that initiate from a constitutively active alternative promoter Gene 2000 258 165 172
16. Wong SK Sato S Lazinsky DW Elevated activity of the large form of ADAR1 in vivo: very efficient RNA editing occurs in the cytoplasm RNA 2003 9 586 598
17. Samuel CE Antiviral actions of interferons Clin Microb Rev 2001 14 778 809
18. Liu Y Wolff KC Jacobs BL Samuel CE Vaccinia virus E2L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity Virology 2001 289 378 387
19. Cattaneo R Biased (A-to-I) hypermutation of animal RNA virus genomes Curr Opin Genet Dev 1994 4 895 900
20. Wong SK Lazinski DW Replicating hepatitis delta virus RNA is edited in the nucleus by the small form of ADAR 1 PNAS 2002 99 15118 15123
21. Zheng H Fu TB Lazinski D Taylor J Editing on the genomic RNA of Human hepatitis delta virus J Virol 1992 66 4693 4697
22. Hartwig D Schoeneich L Greeve J et al. Interferon alpha stimulation of liver cells enhances hepatitis delta virus RNA editing in early infection J Hepatol 2004 41 667 672
23. -ΔΔCt method Methods 2001 25 402 408
24. Greeve J Hartwig D Windler E Greten H Requirement for editing in the genomic RNA of hepatitis delta virus Biochimie 1994 76 1209 1216
25. Macnaughton TB Lai MC Genomic but not antigenomic hepatitis delta virus RNA is preferentially exported from the nucleus immediately after synthesis and processing J Virol 2002 76 3928 3935
26. Jilbert AR Burrell J Gowans EJ Hertzog PJ Linnane AW Marmion BP Cellular localization of α-interferon in hepatitis B virus infected liver tissue Hepatology 1986 6 957 961
27. Fang J Wu PC Lai CL Lo CK Meager A Lau J Hepatic expression of interferon-α in chronic hepatitis B virus infection Dig Dis Sci 1994 39 2014 2021
28. Dienes HP Hess G Wöorsdörfer M et al. Ultrastructural localization of interferon-producing cells in the livers of patients with chronic hepatitis B Hepatology 1991 13 321 326
29. Nouri-Aria KT Arnold J Davison F et al. Interferon-α gene transcripts and products in liver specimens from acute and chronic hepatitis B virus infection Hepatology 1991 13 1029 1034
30. Niro GA Rosina F Rizzetto M Treatment of hepatitis D J Viral Hep 2005 12 2 9