Cloninger's temperament dimensions and epidermal growth factor A61G polymorphism in Finnish adults

Genes, Brain and Behavior

Volumn 5, Issue 1, 2006, Pages 11-18

  Keltikangas Jarvinen L ^a   Puttonen, S ^a   Kivimaki M ^a   Rontu, R ^b,c   Lehtimaki T ^b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

Dopamine; Epidermal growth factor; Genotype; Harm avoidance; Novelty seeking; Persistence; Reward dependence; Temperament

Indexed keywords

EPIDERMAL GROWTH FACTOR;

ADULT; ARTICLE; AVOIDANCE BEHAVIOR; CLINICAL EXAMINATION; CONTROLLED STUDY; FEMALE; FINLAND; GENE FUNCTION; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; MALE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; TEMPERAMENT; HUMAN EXPERIMENT; MESENCEPHALON; NEUROTRANSMISSION; PERSONALITY;

ADULT; BRAIN; CROSS-SECTIONAL STUDIES; DOPAMINE; EPIDERMAL GROWTH FACTOR; EXPLORATORY BEHAVIOR; FEMALE; FINLAND; GENETICS, POPULATION; HUMANS; LINKAGE (GENETICS); LONGITUDINAL STUDIES; MALE; PERSONALITY; PERSONALITY TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SEX FACTORS; TEMPERAMENT;

EID: 33645065344     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00125.x     Document Type: Article

References (64)

1. Åkerblom H.K. Uhari M. Pesonen E. Dahl M. Kaprio E.A. Nuutinen E.M. Pietikäinen M. Salo M.K. Aromaa A. Kannas L. Keltikangas-Järvinen L. Kuusela V. Räsänen L. Rönnemaa T. Knip M. Telama R. Välimäki I. Pyörälä K. Viikari J. 1991 Cardiovascular risk in young Finns Ann Med 23 35 39
2. Alexi T. Hefti F. 1993 Trophic actions of transforming growth factor alpha on mesencephalic dopaminergic neurons developing in culture Neuroscience 55 903 918
3. Anttila S. Illi A. Kampman O. Mattila K.M. Lehtimäki T. Leinonen E. 2004 Association of EGF polymorphism with schizophrenia in Finnish men Neuroreport 15 1215 1218
4. Barrett-Connor E. 1998 Rethinking estrogen and the brain J Am Geriatr Soc 46 918 920
5. Bau C.H. Roman T. Almeida S. Hutz M.H. 1999 Dopamine D4 receptor gene and personality dimensions in Brazilian male alcoholics Psychiatr Genet 9 139 143
6. Benjamin J. Ebstein R.P. Belmaker R.H. 2002 Molecular Genetics and the Human Personality American Psychiatric Publishing Inc Washington, DC
7. Benjamin J. Li L. Patterson C. Greenberg B.D. Murphy D.L. Hamer D.H. 1996 Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking Nat Genet 12 81 84
8. Benjamin J. Osher Y. Kotler M. Gritsenko I. Nemanov L. Belmaker R.H. Ebstein R.P. 2000 Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) Mol Psychiatry 5 96 100
9. Breier A. Kestler L. Adler C. Elman I. Wiesenfeld N. Malhotra A. Pickar D. 1998 Dopamine D2 receptor density and personal detachment in healthy subjects Am J Psychiatry 155 1440 1442
10. Carpenter G. Cohen S. 1979 Epidermal growth factor Annu Rev Biochem 48 193 216
11. Casper D. Roboz G.J. Blum M. 1994 Epidermal growth factor and basic fibroblast growth factor have independent actions on mesencephalic dopamine neurons in culture J Neurochem 62 2166 2177
12. Cloninger C.R. 1987 A systematic method for clinical description and classification of personality variants: a proposal Arch Gen Psychiatry 44 573 588
13. Cloninger C.R. 1999 A new conceptual paradigm from genetics and psychobiology for the science of mental health Aust N Z J Psychiatry 33 174 186
14. Cloninger C.R. Svrakic D.M. Przybeck T.R. 1993 A psychobiological model of temperament and character Arch Gen Psychiatry 50 975 990
15. Comings D.E. Gade-Andavolu R. Gonzalez N. Wu S. Muhleman D. Blake H. Mann M.B. Dietz G. Saucier G. MacMurray J.P. 2000 A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory Clin Genet 58 375 385
16. Dluzen D.E. 2000 Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system J Neurocytol 29 387 399
17. Dulawa S.C. Grandy D.K. Low M.J. Paulus M.P. Geyer M.A. 1999 Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli J Neurosci 19 9550 9556
18. Ebstein R.P. Belmaker R.H. 1997 Saga of an adventure gene: novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism Mol Psychiatry 2 381 384
19. Ebstein R.P. Nemanov L. Klotz I. Gritsenko I. Belmaker R.H. 1997a Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking Mol Psychiatry 2 472 477
20. Ebstein R.P. Novick O. Umansky R. Priel B. Osher Y. Blaine D. Bennett E.R. Nemanov L. Katz M. Belmaker R.H. 1996 Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking Nat Genet 12 78 80
21. Ebstein R.P. Segman R. Benjamin J. Osher Y. Nemanov L. Belmaker R.H. 1997b 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms Am J Med Genet 74 65 72
22. Ekelund J. Lichtermann D. Järvelin M.-R. Peltonen L. 1999 Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample Am J Psychiatry 156 1453 1455
23. Ferrari G. Toffano G. Skaper S.D. 1991 Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: comparison with basic fibroblast growth factor J Neurosci Res 30 493 497
24. Futamura T. Kakita A. Tohmi M. Sotoyama H. Takahashi H. Nawa H. 2003 Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development Mol Psychiatry 8 19 29
25. Futamura T. Toyooka K. Iritani S. Niizato K. Nakamura R. Tsuchiya K. Someya T. Kakita A. Takahashi H. Nawa H. 2002 Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients Mol Psychiatry 7 673 682
26. Gelernter J. Kranzler H. Coccaro E. Siever L. New A. Mulgrew C.L. 1997 D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects Am J Hum Genet 61 1144 1152
27. Herbst J. Zonderman A. McCrae R. Costa P. 2000 Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis Am J Psychiatry 157 1285 1290
28. James M.R. Hayward N.K. Dumenil T. Montgomery G.W. Martin N.G. Duffy D.L. 2004 Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia J Invest Dermatol 123 760 762
29. Johnson D.L. Wiebe J.S. Gold S.M. Andreasen N.C. Hichwa R.D. Watkins G.L. Boles Ponto L.L. 1999 Cerebral blood flow and personality: a positron emission tomography study Am J Psychiatry 156 252 257
30. Jonsson E.G. Nothen M.M. Gustavsson J.P. Neidt H. Forslund K. Mattila-Evenden M. Rylander G. Propping P. Asberg M. 1998 Lack of association between dopamine D4 receptor gene and personality traits Psychol Med 28 985 989
31. Keltikangas-Järvinen L. Elovainio M. Kivimäki M. Lichtermann D. Ekelund J. Peltonen L. 2003 Association between the type 4 dopamine receptor gene polymorphism and novelty seeking Psychosom Med 65 471 476
32. Keltikangas-Järvinen L. Ravaja N. Viikari J. 1999 Identifying Cloninger's temperament profiles as related to the early development of the metabolic cardiovascular syndrome in young men Arterioscler Thromb Vasc Biol 19 1998 2006
33. Kuhn K.U. Meyer K. Nothen M.M. Gansicke M. Papassotiropoulos A. Maier W. 1999 Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests Am J Med Genet 88 168 172
34. Laakso A. Wallius E. Kajander J. Bergman J. Eskola O. Solin O. Ilonen T. Salokangas R.K. Syvälahti E. Hietala J. 2003 Personality traits and striatal dopamine synthesis capacity in healthy subjects Am J Psychiatry 160 904 910
35. Lazar L.M. Blum M. 1992 Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay J Neurosci 12 1688 1697
36. Lee H.J. Lee H.S. Kim Y.K. Kim S.H. Kim L. Lee M.S. Joe S.H. Jung I.K. Suh K.Y. Kim S. 2003a Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population Am J Med Genet 118B 76 80
37. Lee H.J. Lee H.S. Kim Y.K. Kim L. Lee M.S. Jung I.K. Suh K.Y. Kim S. 2003b D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population Am J Med Genet 121B 44 49
38. Livak K.J. 1999 Allelic discrimination using fluorogenic probes and the 5′ nuclease assay Genet Anal 14 143 149
39. Lusher J.M. Chandler C. Ball D. 2001 Dopamine D4 receptor gene (DRD4) is associated with Novelty Seeking (NS) and substance abuse: the saga continues Mol Psychiatry 6 497 499
40. Lusher J. Ebersole L. Ball D. 2000 Dopamine D4 receptor gene and severity of dependence Addict Biol 5 469 472
41. Malhotra A.K. Virkkunen M. Rooney W. Eggert M. Linnoila M. Goldman D. 1996 The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking Mol Psychiatry 1 388 391
42. McCarron S.L. Bateman A.C. Theaker J.M. Howell W.M. 2003 EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma Int J Cancer 107 673 675
43. McDermott J.L. 1993 Effects of estrogen upon dopamine release from the corpus striatum of young and aged female rats Brain Res 606 118 125
44. Menza M.A. Forman N.E. Goldstein H.S. Golbe L.I. 1990 Parkinson's disease, personality, and dopamine J Neuropsychiatry Clin Neurosci 2 282 287
45. Menza M.A. Golbe L.I. Cody R.A. Forman N.E. 1993 Dopamine-related personality traits in Parkinson's disease Neurology 43 505 508
46. Menza M.A. Mark M.H. Burn D.J. Brooks D.J. 1995 Personality correlates of [18F] dopa striatal uptake: results of positron-emission tomography in Parkinson's disease J Neuropsychiatry Clin Neurosci 7 176 179
47. Missale C. Castelletti L. Boroni F. Memorandum M. Spano P. 1991 Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line Endocrinology 128 13 20
48. Nieoullon A. Coquerel A. 2003 Dopamine: a key regulator to adapt action, emotion, motivation and cognition Curr Opin Neurol 16 S3 S9
49. Noble E.P. Ozkaragoz T.Z. Ritchie T.L. Zhang X. Belin T.R. Sparkes R.S. 1998 D2 and D4 dopamine receptor polymorphisms and personality Am J Med Genet 81 257 267
50. Okuyama Y. Ishiguro H. Nankai M. Shibuya H. Watanabe A. Arinami T. 2000 Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait Mol Psychiatry 5 64 69
51. Ono Y. Manki H. Yoshimura K. Muramatsu T. Mizushima H. Higuchi S. Yagi G. Kanba S. Asai M. 1997 Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects Am J Med Genet 74 501 503
52. Powell S.B. Paulus M.P. Hartman D.S. Godel T. Geyer M.A. 2003 RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice Neuropharmacology 44 473 481
53. Raitakari O.T. Juonala M. Kähönen M. Taittonen L. Laitinen T. Mäki-Torkko N. Järvisalo M.J. Uhari M. Jokinen E. Rönnemaa T. Åkerblom H.K. Viikari J.S. 2003 Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study JAMA 290 2277 2283
54. Rogers G. Joyce P. Mulder R. Sellman D. Miller A. Allington M. Olds R. Wells E. Kennedy M. 2004 Association of a duplicated repeat polymorphism in the 5′-untranslated region of the DRD4 gene with novelty seeking Am J Med Genet 126B 95 98
55. Ronai Z. Szekely A. Nemoda Z. Lakatos K. Gervai J. Staub M. Sasvari-Szekely M. 2001 Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene Mol Psychiatry 6 35 38
56. Shahbazi M. Pravica V. Nasreen N. Fakhoury H. Fryer A.A. Strange R.C. Hutchinson P.E. Osborne J.E. Lear J.T. Smith A.G. Hutchinson I.V. 2002 Association between functional polymorphism in EGF gene and malignant melanoma Lancet 359 397 401
57. Strobel A. Wehr A. Michel A. Brocke B. 1999 Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of Novelty Seeking in a German population Mol Psychiatry 4 378 384
58. Sugiura M. Kawashima R. Nakagawa M. Okada K. Sato T. Goto R. Sato K. Ono S. Schormann T. Zilles K. Fukuda H. 2000 Correlation between human personality and neural activity in cerebral cortex Neuroimage 11 541 546
59. Suhara T. Yasuno F. Sudo Y. Yamamoto M. Inoue M. Okubo Y. Suzuki K. 2001 Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking Neuroimage 13 891 895
60. Sullivan P.F. Fifield W.J. Kennedy M.A. Mulder R.T. Sellman J.D. Joyce P.R. 1998 No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples Am J Psychiatry 155 98 101
61. Szekely A. Ronai Z. Nemoda Z. Kolmann G. Gervai J. Sasvari-Szekely M. 2004 Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms Am J Med Genet 126B 106 110
62. Tomitaka M. Tomitaka S. Otuka Y. Kim K. Matuki H. Sakamoto K. Tanaka A. 1999 Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects Am J Med Genet 88 469 471
63. Vandenbergh D.J. Zonderman A.B. Wang J. Uhl G.R. Costa P.T. Jr. 1997 No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants Mol Psychiatry 2 417 419
64. Youn T. Lyoo I.K. Kim J.K. Park H.J. Ha K.S. Lee D.S. Abrams K.Y. Lee M.C. Kwon J.S. 2002 Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography Biol Psychol 60 109 120