Characterization of depolarization-evoked ERG K+ currents in interstitial cells of Cajal

Neurogastroenterology and Motility

Volumn 18, Issue 4, 2006, Pages 324-333

  Mckay, C M ^a   Ye, J ^a   Huizinga, J D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Depolarization evoked current; E4031; Ether a go go; Inward rectification; Plateau potential; Slow wave

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; BALANCED SALT SOLUTION; CESIUM; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CELL STIMULATION; DEPOLARIZATION; EVOKED RESPONSE; HYPERPOLARIZATION; INHIBITION KINETICS; INTERSTITIAL CELL OF CAJAL; INTRACELLULAR SPACE; JEJUNUM; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NEWBORN; NONHUMAN; PHYSIOLOGY; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECORDING; REGULATORY MECHANISM; REPOLARIZATION; STEADY STATE; WAVEFORM;

ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; INTESTINE, SMALL; MEMBRANE POTENTIALS; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS;

EID: 33645035314     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2006.00764.x     Document Type: Article

References (29)

1. Thomsen L Robinson TL Lee JCF Farraway L Hughes MJG Andrews DW Huizinga JD. Interstitial cells of Cajal generate a rhythmic pacemaker current Nat Med 1998 4 848 51
2. Koh SD Sanders KM Ward SM. Spontaneous electrical rhythmicity in cultured interstitial cells of cajal from the murine small intestine J Physiol (Lond) 1998 513 203 13
3. Der-Silaphet T Malysz J Arsenault AL Hagel S Huizinga JD. Interstitial cells of Cajal direct normal propulsive contractile activity in the small intestine Gastroenterology 1998 114 724 36
4. Huizinga JD Golden CM Zhu Y White EJ. Ion channels in interstitial cells of Cajal as targets for neurotransmitter action Neurogastroenterol Motil 2004 16 Suppl. 1 106 11
5. Takaki M. Gut pacemaker cells: the interstitial cells of Cajal (ICC) J Smooth Muscle Res 2003 39 137 61
6. Sanders KM Koh SD Ordog T Ward SM. Ionic conductances involved in generation and propagation of electrical slow waves in phasic gastrointestinal muscles Neurogastroenterol Motil 2004 16 Suppl. 1 100 5
7. Kito Y Suzuki H. Properties of pacemaker potentials recorded from myenteric interstitial cells of Cajal distributed in the mouse small intestine J Physiol 2003 553 803 18
8. + currents regulate pacemaker activity in ICC Am J Physiol Gastrointest Liver Physiol 2003 285 G1249 58
9. + channels in microglia J Gen Physiol 1998 111 781 94
10. + channels in microglia J Gen Physiol 1998 111 795 805
11. Akbarali HI Thatte H He XD Giles WR Goyal RK. Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle Am J Physiol 1999 277 C1284 90
12. Ohya S Asakura K Muraki K Watanabe M Imaizumi Y. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle Am J Physiol Gastrointest Liver Physiol 2002 282 G277 87
13. Smith PL Baukrowitz T Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel Nature 1996 379 833 6
14. Trudeau MC Warmke JW Ganetzky B Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family Science 1995 269 92 5
15. + channels in differentiation of NG108-15 neuroblastoma x glioma cells J Neurobiol 1999 38 466 74
16. Schonherr R Heinemann SH. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel J Physiol 1996 493 635 42
17. + J Physiol 2003 548 691 702
18. Sanguinetti MC Jiang C Curran ME Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel Cell 1995 81 299 307
19. + channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization J Physiol 1996 496 13 23
20. Golden C Wang XY Huizinga JD. Trp associated non-selective cation currents in interstitial cells of Cajal Can J Gastroenterol 2002 16 58A
21. Ohya S Sergeant GP Greenwood IA Horowitz B. Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current Circ Res 2003 92 1016 23
22. + currents in human prolactin-secreting adenoma cells Pflugers Arch 2003 445 589 600
23. + current regulates pacemaker activity in adult mouse sinoatrial node cells Am J Physiol Heart Circ Physiol 2004 286 H1757 66
24. Hille B. Ionic Channels of Excitable Membranes 2nd edn
25. + channels J Membr Biol 2001 182 1 15
26. + currents in rat embryonic serotonergic neurones J Physiol 2005 564 33 49
27. Abbott GW Sesti F Splawski I Buck ME Lehmann MH Timothy KW Keating MT Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia Cell 1999 97 175 87
28. + currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N in neonatal mouse hearts Pflugers Arch 2001 442 329 35
29. McKay CM Huizinga JD. ERG currents in ICC show a steep increase in amplitude at the slow wave plateau potential, signifying control of excitability Neurogastroenterol Motil 2004 16 6