Ionic conductances involved in generation and propagation of electrical slow waves in phasic gastrointestinal muscles

Neurogastroenterology and Motility

Volumn 16, Issue SUPPL. 1, 2004, Pages 100-105

  Sanders, K M ^a   Koh, S D ^a   Ordog T ^a   Ward, S M ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium channels; Interstitial cells of Cajal; Nonselective cation channels

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALMIDAZOLIUM; CALMODULIN; CALMODULIN INHIBITOR; CHLORIDE CHANNEL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MIBEFRADIL; NICARDIPINE; NIFEDIPINE; POTASSIUM CHANNEL;

AEROBIC METABOLISM; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONFERENCE PAPER; ELECTROPHYSIOLOGY; HUMAN; INTERSTITIAL CELL OF CAJAL; INTESTINE INNERVATION; INTESTINE MUSCLE; ION CONDUCTANCE; ION CURRENT; MOLECULAR MECHANICS; MOTONEURON; MUSCLE ACTION POTENTIAL; MYENTERIC PLEXUS; NEUROTRANSMISSION; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYNCYTIUM; VOLTAGE CLAMP;

ANIMALS; BIOLOGICAL CLOCKS; DIGESTIVE SYSTEM; GASTROINTESTINAL MOTILITY; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; MUSCLE, SMOOTH; NEURONS; SYNAPTIC TRANSMISSION;

EID: 2342505119     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1743-3150.2004.00483.x     Document Type: Conference Paper

References (27)

1. Cousins HM, Edwards FR, Hickey H, Hill CE, Hirst GD. Electrical coupling between the myenteric interstitial cells of Cajal and adjacent muscle layers in the guinea-pig gastric antrum. J Physiol (Lond) 2003; 550: 829-44.
2. Langton P, Ward SM, Carl A, Norell MA, Sanders KM. Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon. Proc Natl Acad Sci USA 1989; 86: 7280-4.
3. Ward SM, Burns AJ, Torihashi S, Sanders KM. Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol (Lond) 1994; 480: 91-7.
4. Huizinga JD, Thuneberg L, Klüppel M, Malysz J, Mikkelsen HB, Bernstein A. W/kit gene required for intestinal pacemaker activity. Nature 1995; 373: 347-9.
5. Torihashi S, Ward SM, Nishikawa S-I, Nishi K, Kobayashi S, Sanders KM. c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 1995; 280: 97-111.
6. Ördög T, Ward SM, Sanders KM. Interstitial cells of Cajal generate electrical slow waves in the murine stomach. J Physiol (Lond) 1999; 518: 257-69.
7. Burns AJ, Lomax AEJ, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci USA 1996; 93: 12008-12013.
8. Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20: 1393-403.
9. V mutant mice. Gastroenterology 2002; 123: 2028-40.
10. Publicover NG, Sanders KM. A technique to locate the pacemaker in smooth muscles. J Appl Physiol 1984; 57: 1586-90.
11. Bauer AJ, Publicover NG, Sanders KM. Origin and spread of slow waves in canine gastric antral circular muscle. Am J Physiol 1985; 249: G800-G806.
12. Horowitz B, Ward SM, Sanders KM. Cellular and molecular basis for electrical rhythmicity in gastrointestinal muscles. Annu Rev Physiol 1999; 61: 19-43.
13. Ward SM, Ördög T, Koh SD et al. Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria. J Physiol (Lond) 2000; 525: 355-61.
14. Suzuki H, Takano H, Yamamoto Y et al. Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. J Physiol (Lond) 2000; 525: 105-11.
15. Sanders KM, Ordog T, Koh SD, Ward SMA. Novel pacemaker mechanism drives gastrointestinal rhythmicity. News Physiol Sci 2000; 15: 291-8.
16. 2+-inhibited non-selective cation conductance contributes to pacemaker currents in cultured interstitial cells of Cajal. J Physiol (Lond) 2002; 540: 803-14.
17. Walker RL, Koh SD, Sergeant GP, Sanders KM, Horowitz B. TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal. Am J Physiol Cell Physiol 2002; 283: C1637-C1645.
18. Nose K, Suzuki H, Kannan H. Voltage dependency of the frequency of slow waves in antrum smooth muscle of the guinea-pig stomach. Japn J Physiol 2000; 50: 625-33.
19. Kito Y, Suzuki H. Properties of pacemaker potentials recorded from myenteric interstitial cells of Cajal distributed in the mouse small intestine. J Physiol (Lond) 2003; 553: 803-18.
20. Huizinga JD, Zhu Y, Ye J, Molleman A. High-conductance chloride channels generate pacemaker currents in interstitial cells of Cajal. Gastroenterology 2002; 123: 1627-36.
21. Sanders KM, Stevens R, Burke E, Ward SM, Slow waves actively propagate at submucosal surface of circular layer in canine colon. Am J Physiol 1990; 259: G258-G263.
22. Horiguchi K, Semple GSA, Sanders KM, Ward SM. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum. J Physiol (Lond) 2001; 537: 237-50.
23. 2+ uptake in canine colonie muscles. J Physiol (Lond) 2003; 549: 207-18.
24. Ward SM, Sanders KM. Dependence of electrical slow waves on canine colonie smooth muscle on calcium gradient. J Physiol (Lond) 1992; 455: 307-19.
25. Lee HK, Sanders KM. Comparison of ionic currents from interstitial cell and smooth muscle cells of canine colon. J Physiol (Lond) 1993; 460: 135-?152.
26. Kim YC, Koh SD, Sanders KM. Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine. J Physiol (Lond) 2002; 541: 797-810.
27. 3 receptors in permeabilized guinea-pig vascular smooth muscle cells. J Physiol (Lond) 1998; 506: 407-14.