Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2518-2521

  Giner, José Luis ^a   Kehbein, Karen A ^a   Cook, James A ^b   Smith, Michele C ^b   Vlahos, Chris J ^b   Badwey, John A ^c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Enzyme inhibitors; Fluorescent probes; Phosphoinositol 3 kinase; Steroidal drugs

Indexed keywords

11 DEACETYLWORTMANNIN; 17 HYDROXYWORTMANNIN; 7 DIMETHYLAMINOCOUMARIN 4 ACETIC ACID; ACETIC ACID DERIVATIVE; DEMETHOXYVIRIDIN DERIVATIVE; FLUORESCENT DYE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SARCOSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; IC 50; MOLECULAR MODEL; MOLECULAR PROBE;

EID: 33645001286     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.091     Document Type: Article

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