P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 4, 2006, Pages 882-890

  Erhardt, Joseph A ^a   Toomey, J R ^a   Douglas, S A ^a   Johns, D G ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

P2X1; Platelet; Purinergic

Indexed keywords

ADENOSINE TRIPHOSPHATE; FERRIC CHLORIDE; MRS 2159; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PURINE P2X1 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; THROMBIN; THROMBIN RECEPTOR; THROMBOPLASTIN; UNCLASSIFIED DRUG; FERRIC ION; PURINE P2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RISK REDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOGENESIS; ANIMAL; DRUG ANTAGONISM; HUMAN; LASER; METABOLISM; SPECIES DIFFERENCE; THROMBOCYTE; THROMBOSIS;

ANIMALS; BLOOD PLATELETS; FERRIC COMPOUNDS; HUMANS; LASERS; MICE; PLATELET AGGREGATION; RECEPTORS, PURINERGIC P2; RECEPTORS, THROMBIN; SPECIES SPECIFICITY; THROMBOSIS;

EID: 33644975670     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01849.x     Document Type: Article

References (25)

1. 2T purinoceptors in human platelets. J Biol Chem 1996; 271: 2879-81.
2. 2TAC receptors in ADP-evoked calcium signalling in human platelets. Cell Calcium 2000; 28: 119-26.
3. 1 purinoceptors with α,β-Methylene ATP. Thromb Haemost 2001; 85: 303-8.
4. 1 ion channel acts as a positive regulator of platelet responses to collagen. Thromb Haemost 2001; 86: 1264-71.
5. 1 -mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen. Blood 2002; 100: 2499-505.
6. 1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation. J Biol Chem 2003; 278: 46661-7.
7. Oury C, Kuijpers MJE, Toth-Zamboki E, Bonnefoy A, Danloy S, Vreys I, Feijge MAH, De Vos R, Vermylen J, Heemskerk JWM, Hoylaerts MF. Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype. Blood 2003; 101: 3969-76.
8. 1 cation channel in thrombosis of small arteries in vivo. J Exp Med 2003; 198: 661-7.
9. Vial C, Rolf MG, Mahaut-Smith MP, Evans RJ. A study of P2X 1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors. BJ Pharmacol 2002; 135: 363-72.
10. 1 receptors. J Thromb Haemost 2003; 1: 2626-35.
11. Fung CYE, Brearley CA, Farndale RW, Mahaut-Smith MP. A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets. Thromb Haemost 2005; 94: 37-40.
12. Oury C, Sticker E, Cornelissen H, De Vos R, Vermylen J, Hoylaerts M. ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation. J Biol Chem 2004; 279: 26266-26273.
13. 1 receptors in platelet activation. Platelets 2004; 15: 131-44.
14. US National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Washingtown, DC: National Academy Press, 1996: Publication No. 85 - 23.
15. Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. J Clin Invest 2004; 113: 441-50.
16. Johns DG, Ao Z, Willette RN, Macphee CH, Douglas SA. Role of p38 MAP kinase in postcapillary venule leukocyte adhesion induced by ischemia/ reperfusion injury. Pharmacol Res 2005; 51: 463-71.
17. 2+ influx on functional responses in human platelets. Thromb Haemost 2002; 88: 495-502.
18. Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 2004; 104: 3190-7.
19. Hechler B, Magnenat S, Zighetti ML, Kassack MU, Ullmann H, Cazenave JP, Evans R, Cattaneo M, Gachet C. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449
20. 1 receptor-null mice. J Clin Invest 1999; 104: 1731-7.
21. 1-deficient mice. Nat Med 1999; 5: 1199-202.
22. 1 receptor antagonist. J Thromb Haemost 2003; 1: 1144-9.
23. Foster CJ, Prosser DM, Agans JM, Zhai Y, Smith MD, Lachowicz JE, Zhang FL, Gustafson E, Monsma FJ, Wiekowski MT, Addondanzo SJ, Cook DN, Bayne ML, Lira SA, Chintala MS. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001; 107: 1591-8.
24. Andre P, Delaney SM, LaRocca T, Vincent D, DeGuzman F, Jurek M, Koller B, Phillips DR, Conley PB. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 2003; 112: 398-406.
25. Maurer-Spurej E, Devine DV. Platelet aggregation is not initiated by platelet shape change. Lab Invest 2001; 81: 1517-25.