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33747548563
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note
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+: 464.1239; found: 464.1294.
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-
-
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19
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33747543755
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note
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+: 532.1865; found: 532.1930.
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-
-
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20
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33747565412
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note
-
13C spectra was observed in the NMR spectra of the diphosphate compounds. This result was found to be concentration and substrate dependent, and is thought to reflect slow rotation about the vinylogous carbamate bonds. The doubling of signals was especially prevalent in the farnesyl derivative 2, and was observed, although to a less degree (ca. 10-15%), in the intermediates that lead up to the farnesyl diphosphate derivative (5b and 6b). The doubling of the NMR signals however, was not observed for the geranyl intermediates (5a and 6a).
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21
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33747531860
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unpublished results
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K. Alexandrov, E. Rostkova, A. J. Scheidig, R. S. Goody, D. Owen, H. Waldmann, unpublished results.
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Alexandrov, K.1
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Waldmann, H.6
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22
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33747546845
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note
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2O and precipitating the protein with 10% trichloroacetic acid. The protein pellet was washed with cold acetone and re-suspended in SDS-PAGE loading buffer. Proteins were resolved on the 15% SDS-PAGE gel and the prenylated proteins were visualized with a Fluor 100 (BioRad) fluorescence scanner.
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23
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0029831063
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0032478581
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For the expression and purification of REP-1, see K. Alexandrov, I. Simon, A. Iakovenko, B. Holz, R. S. Goody, A. Scheidig FEBS Lett. 1998, 425, 460.
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26
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0028040141
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RabGGTase baculoviral expression vectors pVL-RabGGTalpha and pVL-RabGGTbeta were obtained from the American Type Culture Collection (order numbers 87154 and 87155, respectively). Baculoviruses were generated and RabGGTase was expressed and purified as described previously: F. P. Cremers, S. A. Armstrong, M. C. Seabra, M. C. Brown, J. L. Goldstein J. Biol. Chem. 1994, 209, 2111.
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