Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits

Brain Research

Volumn 1073-1074, Issue 1, 2006, Pages 252-261

  Ootsuka, Youichirou ^a   Blessing, William W ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Serotonin; Sympathetic nerve activity; Thermoregulation

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; COLD EXPOSURE; CONTROLLED STUDY; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAPHE NUCLEUS; SKIN TEMPERATURE; SYMPATHETIC NERVE; VASOCONSTRICTION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; BODY TEMPERATURE; COLD; MALE; PIPERAZINES; PYRIDINES; RABBITS; RAPHE NUCLEI; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SKIN; SYMPATHETIC NERVOUS SYSTEM; ULTRASONOGRAPHY, DOPPLER, COLOR; VASOCONSTRICTION; WAKEFULNESS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33644938792     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.12.031     Document Type: Article

References (39)

1. G.K. Aghajanian, and E. Sander-Bush Serotonin K.L. Davis D. Charney J.T. Coyle C. Nemeroff Neuropychopharmacology, The Fifth Generation of Progress 2002 Lippincott Williams and Wilkins New York 15 34
2. S.J. Bacon, A. Zagon, and A.D. Smith Electron microscopic evidence of a monosynaptic pathway between cells in the caudal raphe nuclei and sympathetic preganglionic neurons in the rat spinal cord Exp. Brain Res. 79 1990 589 602
3. S.G. Beck, Y.-Z. Pan, A.C. Akanwa, and L.G. Kirby Median and dorsal raphe neurons are not electrophysiologically identical J. Neurophysiol. 91 2004 994 1005
4. W.W. Blessing BAT control shows the way: medullary raphe/parapyramidal neurons and sympathetic regulation of brown adipose tissue [comment] Am. J. Physiol.: Regul., Integr. Comp. Physiol. 288 2005 R557 R560
5. W.W. Blessing Clozapine increases cutaneous blood flow and reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats: comparison with effects of haloperidol Psychopharmacology (Berlin) 181 2005 518 528
6. W.W. Blessing, and E. Nalivaiko Regional blood flow and nociceptive stimuli in rabbits: patterning by medullary raphe, not ventrolateral medulla J. Physiol. (London) 524 Pt. 1 2000 279 292
7. W.W. Blessing, and E. Nalivaiko Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats Neuroscience 105 2001 923 929
8. W.W. Blessing, B. Seaman, N.P. Pedersen, and Y. Ootsuka Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats J. Neurosci. 23 2003 6385 6391
9. V. Cornea-Hebert, M. Riad, C. Wu, S.K. Singh, and L. Descarries Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat J. Comp. Neurol. 409 1999 187 209
10. J.F. Cryan, P. Kelliher, J.P. Kelly, and B.E. Leonard Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635 J. Psychopharmacol. (Oxf) 13 1999 278 283
11. A. Fletcher, I.A. Cliffe, and C.T. Dourish Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents Trends Pharmacol. Sci. 14 1993 41 48
12. A. Fletcher, E.A. Forster, D.J. Bill, G. Brown, I.A. Cliffe, J.E. Hartley, D.E. Jones, A. McLenachan, K.J. Stanhope, D.J. Critchley, K.J. Childs, V.C. Middlefell, L. Lanfumey, R. Corradetti, A.M. Laporte, H. Gozlan, M. Hamon, and C.T. Dourish Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist Behav. Brain Res. 73 1996 337 353
13. G.A. Gudelsky, J.I. Koenig, and H.Y. Meltzer Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors Neuropharmacology 25 1986 1307 1313
14. N. Haddjeri, N. Lavoie, and P. Blier Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus Neuropsychopharmacology 29 2004 1800 1806
15. J.R. Haselton, R.W. Winters, D.R. Liskowsky, C.L. Haselton, P.M. McCabe, and N. Schneiderman Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit Brain Res. 453 1988 176 182
16. C.J. Helke, S. Capuano, N. Tran, and H. Zhuo Immunocytochemical studies of the 5-HT(1A) receptor in ventral medullary neurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity J. Comp. Neurol. 379 1997 261 270
17. S. Hjorth Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT J. Neural Transm. 61 1985 131 135
18. R.F. Kirby, G. Sokoloff, E. Perdomo, and M.S. Blumberg Thermoregulatory and cardiac responses of infant spontaneously hypertensive and Wistar-Kyoto rats to cold exposure Hypertension 33 1999 1465 1469
19. A. Korsak, and M.P. Gilbey Rostral ventromedial medulla and the control of cutaneous vasoconstrictor activity following i.c.v. prostaglandin E1 Neuroscience 124 2004 709 717
20. F. Lejeune, J.-M. Rivet, A. Gobert, H. Canton, and M.J. Millan WAY 100,135 and (-)-tertatolol act as antagonists at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in vivo Eur. J. Pharmacol. 240 1993 307
21. A.D. Loewy Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat Brain Res. 222 1981 129 133
22. S.F. Morrison Activation of 5-HT1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis Am. J. Physiol.: Regul., Integr. Comp. Physiol. 286 2004 R832 R837
23. S.F. Morrison, A.F. Sved, and A.M. Passerin GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue Am. J. Physiol. 276 1999 R290 R297
24. M.K. Mundey, A. Fletcher, and C.A. Marsden Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing Br. J. Pharmacol. 117 1996 750 756
25. K. Nakamura, K. Matsumura, T. Hubschle, Y. Nakamura, H. Hioki, F. Fujiyama, Z. Boldogkoi, M. Konig, H.-J. Thiel, R. Gerstberger, S. Kobayashi, and T. Kaneko Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions J. Neurosci. 24 2004 5370 5380
26. E. Nalivaiko, Y. Ootsuka, and W.W. Blessing Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits Am. J. Physiol.: Regul., Integr. Comp. Physiol. 289 2005 R596 R604
27. A.P. Nicholas, V.A. Pieribone, U. Arvidsson, and T. Hökfelt Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate Neurosci. 48 1992 545 559
28. Y. Ootsuka, and W.W. Blessing 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically mediated cutaneous vasoconstriction in rabbits J. Physiol. (London) 552 2003 303 314
29. Y. Ootsuka, and W.W. Blessing Activation of slowly conducting medullary raphe-spinal neurons, including serotonergic neurons, increases cutaneous sympathetic vasomotor discharge in rabbit Am. J. Physiol.: Regul., Integr. Comp. Physiol. 288 2005 R909 R918
30. Y. Ootsuka, and W.W. Blessing Inhibition of medullary raphe/parapyramidal neurons prevents cutaneous vasoconstriction elicited by alerting stimuli and by cold exposure in conscious rabbits Brain Res. 1051 2005 189 193
31. Y. Ootsuka, and R.M. McAllen Interactive drives from two brainstem premotor nuclei are essential to support rat tail sympathetic activity Am. J. Physiol.: Regul., Integr. Comp. Physiol. 289 2005 R1107 R1115
32. Y. Ootsuka, W. Rong, E. Kishi, T. Koganezawa, and N. Terui Rhythmic activities of the sympatho-excitatory neurons in the medulla of rabbits: neurons controlling cutaneous vasomotion Auton. Neurosci. 101 2002 48 59
33. Y. Ootsuka, W.W. Blessing, and R.M. McAllen Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries Neurosci. Lett. 357 2004 58 62
34. Y. Ootsuka, E. Nalivaiko, and W.W. Blessing Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4- methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine Brain Res. 1014 2004 34 44
35. N.P. Pedersen, and W.W. Blessing Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits J. Neurosci. 21 2001 8648 8654
36. J.A. Rathner, N.C. Owens, and R.M. McAllen Cold-activated raphe-spinal neurons in rats J. Physiol. (London) 535 2001 841 854
37. J.E. Smith, A.S. Jansen, M.P. Gilbey, and A.D. Loewy CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat Brain Res. 786 1998 153 164
38. M. Tanaka, K. Nagashima, R.M. McAllen, and K. Kanosue Role of the medullary raphé in thermoregulatory vasomotor control in rats J. Physiol. (London) 540 2002 657 664
39. Y.H. Yu, and W.W. Blessing Amygdala co-ordinates sudden falls in ear pinna blood flow in response to unconditioned salient stimuli in conscious rabbits Neuroscience 93 1999 135 141