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Volumn 181, Issue 3, 2005, Pages 518-528

Clozapine increases cutaneous blood flow and reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats: Comparison with effects of haloperidol

Author keywords

5 HT 2A receptors; 5 HT1A receptors; 8 OH DPAT; Body temperature; Dopamine D1 receptors; Dopamine D2 receptors; L741,626; SCH23390; Schizophrenia; SR46349B

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CLOZAPINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; EPLIVANSERIN; HALOPERIDOL; L 471 626; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

EID: 26944447079     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-0012-9     Document Type: Article
Times cited : (21)

References (63)
  • 1
    • 20644436350 scopus 로고
    • Emotions and the peripheral vasomotor system
    • Ackner B (1956) Emotions and the peripheral vasomotor system. J Psychosom Res 1:3-20
    • (1956) J Psychosom Res , vol.1 , pp. 3-20
    • Ackner, B.1
  • 2
    • 0032007608 scopus 로고    scopus 로고
    • Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence
    • Arnt J, Skarsfeldt T (1998) Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18:63-101
    • (1998) Neuropsychopharmacology , vol.18 , pp. 63-101
    • Arnt, J.1    Skarsfeldt, T.2
  • 4
    • 0034745153 scopus 로고    scopus 로고
    • The 5-HT1A receptor in schizophrenia: A promising target for novel atypical neuroleptics?
    • Bantick RA, Deakin JF, Grasby PM (2001) The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics? J Psychopharmacol 15:37-46
    • (2001) J Psychopharmacol , vol.15 , pp. 37-46
    • Bantick, R.A.1    Deakin, J.F.2    Grasby, P.M.3
  • 5
    • 0345118148 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits
    • Blessing WW (2004a) 5-Hydroxytryptamine 1A receptor activation reduces cutaneous vasoconstriction and fever associated with the acute inflammatory response in rabbits. Neuroscience 123:1-4
    • (2004) Neuroscience , vol.123 , pp. 1-4
    • Blessing, W.W.1
  • 6
    • 5444264919 scopus 로고    scopus 로고
    • Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction
    • Berl
    • Blessing WW (2004b) Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction. Psychopharmacology (Berl) 175:487-493
    • (2004) Psychopharmacology , vol.175 , pp. 487-493
    • Blessing, W.W.1
  • 7
    • 0037430746 scopus 로고    scopus 로고
    • 2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats
    • 2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats. Neuroscience 117:939-948
    • (2003) Neuroscience , vol.117 , pp. 939-948
    • Blessing, W.W.1    Seaman, B.2
  • 8
    • 0031862745 scopus 로고    scopus 로고
    • Cutaneous vasoconstriction with alerting stimuli in rabbits reflects a patterned redistribution of cardiac output
    • Blessing WW, Arnolda LF, Yu YH (1998) Cutaneous vasoconstriction with alerting stimuli in rabbits reflects a patterned redistribution of cardiac output. Clin Exp Pharmacol Physiol 25:457-460
    • (1998) Clin Exp Pharmacol Physiol , vol.25 , pp. 457-460
    • Blessing, W.W.1    Arnolda, L.F.2    Yu, Y.H.3
  • 9
    • 0038043717 scopus 로고    scopus 로고
    • Clozapine reverses hyperthermia and sympathetically-mediated cutaneous vasoconstriction induced by MDMA (Ecstasy) in rabbits and rats
    • Blessing WW, Seaman B, Pedersen NP, Ootsuka Y (2003) Clozapine reverses hyperthermia and sympathetically-mediated cutaneous vasoconstriction induced by MDMA (Ecstasy) in rabbits and rats. J Neurosci 23:6385-6391
    • (2003) J Neurosci , vol.23 , pp. 6385-6391
    • Blessing, W.W.1    Seaman, B.2    Pedersen, N.P.3    Ootsuka, Y.4
  • 12
    • 4444229040 scopus 로고    scopus 로고
    • Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: Role of 5-HT1A receptor agonism
    • Chung YC, Li Z, Dai J, Meltzer HY, Ichikawa J (2004) Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. Brain Res 1023:54-63
    • (2004) Brain Res , vol.1023 , pp. 54-63
    • Chung, Y.C.1    Li, Z.2    Dai, J.3    Meltzer, H.Y.4    Ichikawa, J.5
  • 13
    • 0032834409 scopus 로고    scopus 로고
    • Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: Modification by the selective 5-HT(1A) receptor antagonist WAY 100635
    • Cryan JF, Kelliher P, Kelly JP, Leonard BE (1999) Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635. J Psychopharmacol 13:278-283
    • (1999) J Psychopharmacol , vol.13 , pp. 278-283
    • Cryan, J.F.1    Kelliher, P.2    Kelly, J.P.3    Leonard, B.E.4
  • 14
    • 1642372241 scopus 로고    scopus 로고
    • Dose response and dose equivalence of antipsychotics
    • Davis JM, Chen N (2004) Dose response and dose equivalence of antipsychotics. J Clin Psychopharmacol 24:192-208
    • (2004) J Clin Psychopharmacol , vol.24 , pp. 192-208
    • Davis, J.M.1    Chen, N.2
  • 16
    • 0023154544 scopus 로고
    • The effects of selective dopamine receptor agonists and antagonists on body temperature in rats
    • Faunt JE, Crocker AD (1987) The effects of selective dopamine receptor agonists and antagonists on body temperature in rats. Eur J Pharmacol 133:243-247
    • (1987) Eur J Pharmacol , vol.133 , pp. 243-247
    • Faunt, J.E.1    Crocker, A.D.2
  • 18
    • 0035863698 scopus 로고    scopus 로고
    • Tail artery blood flow measured by chronically implanted Doppler ultrasonic probes in unrestrained conscious rats
    • Garcia JN, Pedersen NP, Nalivaiko E, Blessing WW (2001) Tail artery blood flow measured by chronically implanted Doppler ultrasonic probes in unrestrained conscious rats. J Neurosci Methods 104:209-213
    • (2001) J Neurosci Methods , vol.104 , pp. 209-213
    • Garcia, J.N.1    Pedersen, N.P.2    Nalivaiko, E.3    Blessing, W.W.4
  • 19
    • 0034917841 scopus 로고    scopus 로고
    • Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review
    • Berl
    • Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl) 156:117-154
    • (2001) Psychopharmacology , vol.156 , pp. 117-154
    • Geyer, M.A.1    Krebs-Thomson, K.2    Braff, D.L.3    Swerdlow, N.R.4
  • 20
    • 0022906235 scopus 로고
    • Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors
    • Gudelsky GA, Koenig JI, Meltzer HY (1986) Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors. Neuropharmacology 25:1307-1313
    • (1986) Neuropharmacology , vol.25 , pp. 1307-1313
    • Gudelsky, G.A.1    Koenig, J.I.2    Meltzer, H.Y.3
  • 22
    • 0007710356 scopus 로고    scopus 로고
    • Interaction of antipsychotic drugs with dopamine receptor subtypes
    • Csernansky JG (ed) Springer, Berlin Heidelberg New York
    • Hartman D, Monsma F, Civelli O (1996) Interaction of antipsychotic drugs with dopamine receptor subtypes. In: Csernansky JG (ed) Handbook of experimental pharmacology. Springer, Berlin Heidelberg New York, pp 43-75
    • (1996) Handbook of Experimental Pharmacology , pp. 43-75
    • Hartman, D.1    Monsma, F.2    Civelli, O.3
  • 24
    • 0012426391 scopus 로고
    • Charactérisation et detection pharacologiques des substances hallucinogènes
    • Jacob J, Lafille C (1963) Charactérisation et detection pharacologiques des substances hallucinogènes. Arch Int Pharmacodyn 145:528-545
    • (1963) Arch Int Pharmacodyn , vol.145 , pp. 528-545
    • Jacob, J.1    Lafille, C.2
  • 25
    • 0035094264 scopus 로고    scopus 로고
    • Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics? A new hypothesis
    • Kapur S, Seeman P (2001) Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics? A new hypothesis. Am J Psychiatry 158:360-369
    • (2001) Am J Psychiatry , vol.158 , pp. 360-369
    • Kapur, S.1    Seeman, P.2
  • 26
  • 29
    • 0033118639 scopus 로고    scopus 로고
    • Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skin
    • Macefield VG, Wallin BG (1999) Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skin. J Physiol 516(Pt 1):303-314
    • (1999) J Physiol , vol.516 , Issue.1 PART , pp. 303-314
    • Macefield, V.G.1    Wallin, B.G.2
  • 30
    • 0026784676 scopus 로고
    • Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants
    • Martin KF, Phillips I, Hearson M, Prow MR, Heal DJ (1992) Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. Br J Pharmacol 107:15-21
    • (1992) Br J Pharmacol , vol.107 , pp. 15-21
    • Martin, K.F.1    Phillips, I.2    Hearson, M.3    Prow, M.R.4    Heal, D.J.5
  • 31
    • 0036365725 scopus 로고    scopus 로고
    • Commentary on "clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia" (Psychopharmacology (1989) 99: S18-S27)
    • Berl
    • Meltzer HY (2002) Commentary on "clinical studies on the mechanism of action of clozapine; the dopamine-serotonin hypothesis of schizophrenia" (Psychopharmacology (1989) 99: S18-S27). Psychopharmacology (Berl) 163:1-3
    • (2002) Psychopharmacology , vol.163 , pp. 1-3
    • Meltzer, H.Y.1
  • 33
    • 2942538034 scopus 로고    scopus 로고
    • Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder
    • Meltzer HY, Arvanitis L, Bauer D, Rein W (2004) Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. Am J Psychiatry 161:975-984
    • (2004) Am J Psychiatry , vol.161 , pp. 975-984
    • Meltzer, H.Y.1    Arvanitis, L.2    Bauer, D.3    Rein, W.4
  • 34
    • 0042395224 scopus 로고    scopus 로고
    • Antiaggresive and anxiolytic effects of gepirone in mice, and their attenuation by WAY 100635
    • Mendoza DL, Bravo HA, Swanson HH (1999) Antiaggresive and anxiolytic effects of gepirone in mice, and their attenuation by WAY 100635. Pharmacol Biochem Behav 62:499-509
    • (1999) Pharmacol Biochem Behav , vol.62 , pp. 499-509
    • Mendoza, D.L.1    Bravo, H.A.2    Swanson, H.H.3
  • 35
    • 0033696731 scopus 로고    scopus 로고
    • Improving the treatment of schizophrenia: Focus on serotonin (5-HT1A) receptors
    • Millan MJ (2000) Improving the treatment of schizophrenia: focus on serotonin (5-HT1A) receptors. J Pharmacol Exp Ther 295:853-861
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 853-861
    • Millan, M.J.1
  • 36
    • 0027486344 scopus 로고
    • Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: A pharmacological characterization of the actions of novel agonists and antagonists
    • Millan MJ, Rivet JM, Canton H, Le Marouille-Girardon S, Gobert A (1993) Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. J Pharmacol Exp Ther 264:1364-1376
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 1364-1376
    • Millan, M.J.1    Rivet, J.M.2    Canton, H.3    Le Marouille-Girardon, S.4    Gobert, A.5
  • 37
    • 0028981393 scopus 로고
    • Evidence that dopamine D3 receptors participate in clozapine-induced hypothermia
    • Millan MJ, Audinot V, Melon C, Newman-Tancredi A (1995) Evidence that dopamine D3 receptors participate in clozapine-induced hypothermia. Eur J Pharmacol 280:225-229
    • (1995) Eur J Pharmacol , vol.280 , pp. 225-229
    • Millan, M.J.1    Audinot, V.2    Melon, C.3    Newman-Tancredi, A.4
  • 38
    • 0023696302 scopus 로고
    • Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat
    • Nash JF, Meltzer HY, Gudelsky GA (1988) Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. Eur J Pharmacol 151:463-469
    • (1988) Eur J Pharmacol , vol.151 , pp. 463-469
    • Nash, J.F.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 39
    • 0033956650 scopus 로고    scopus 로고
    • Atypical antipsychotics and dopamine D(1) receptor agonism: An in vivo experimental study using core temperature measurements in the rat
    • Oerther S, Ahlenius S (2000) Atypical antipsychotics and dopamine D(1) receptor agonism: an in vivo experimental study using core temperature measurements in the rat. J Pharmacol Exp Ther 292:731-736
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 731-736
    • Oerther, S.1    Ahlenius, S.2
  • 41
    • 0142062038 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically-mediated cutaneous vasoconstriction in rabbits
    • 552.1
    • Ootsuka Y, Blessing WW (2003) 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically-mediated cutaneous vasoconstriction in rabbits. J Physiol 552.1:303-314
    • (2003) J Physiol , pp. 303-314
    • Ootsuka, Y.1    Blessing, W.W.2
  • 42
    • 15544383342 scopus 로고    scopus 로고
    • Activation of slowly conducting medullary raphé-spinal neurons, including serotonergic neurons, increases cutaneous sympathetic vasomotor in rabbit
    • Ootsuka Y, Blessing W (2005) Activation of slowly conducting medullary raphé-spinal neurons, including serotonergic neurons, increases cutaneous sympathetic vasomotor in rabbit. Am J Physiol 288:R909-R918
    • (2005) Am J Physiol , vol.288
    • Ootsuka, Y.1    Blessing, W.2
  • 43
    • 2942716696 scopus 로고    scopus 로고
    • 2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine
    • 2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4- methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine. Brain Res 1014:34-44
    • (2004) Brain Res , vol.1014 , pp. 34-44
    • Ootsuka, Y.1    Nalivaiko, E.2    Blessing, W.W.3
  • 45
    • 0035503298 scopus 로고    scopus 로고
    • Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits
    • Pedersen NP, Blessing WW (2001) Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits. J Neurosci 21:8648-8654
    • (2001) J Neurosci , vol.21 , pp. 8648-8654
    • Pedersen, N.P.1    Blessing, W.W.2
  • 46
    • 0026483144 scopus 로고
    • 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex
    • Rigdon GC, Weatherspoon JK (1992) 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. J Pharmacol Exp Ther 263:486-493
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 486-493
    • Rigdon, G.C.1    Weatherspoon, J.K.2
  • 49
    • 0027256736 scopus 로고
    • 2 receptors in the regulation of body temperature in the rat
    • 2 receptors in the regulation of body temperature in the rat. Eur J Pharmacol 236:395-400
    • (1993) Eur J Pharmacol , vol.236 , pp. 395-400
    • Salmi, P.1    Jimenez, P.2    Ahlenius, S.3
  • 50
    • 0028123540 scopus 로고
    • Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat
    • Salmi P, Karlsson T, Ahlenius S (1994) Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat. Eur J Pharmacol 253:67-73
    • (1994) Eur J Pharmacol , vol.253 , pp. 67-73
    • Salmi, P.1    Karlsson, T.2    Ahlenius, S.3
  • 51
    • 0025092714 scopus 로고
    • Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors
    • Schmidt CJ, Black CK, Abbate GM, Taylor VL (1990) Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors. Brain Res 529:85-90
    • (1990) Brain Res , vol.529 , pp. 85-90
    • Schmidt, C.J.1    Black, C.K.2    Abbate, G.M.3    Taylor, V.L.4
  • 54
    • 7444243779 scopus 로고    scopus 로고
    • 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction
    • 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. Brain Res 1028:191-202
    • (2004) Brain Res , vol.1028 , pp. 191-202
    • Sipe, K.1    Leventhal, L.2    Burroughs, K.3    Cosmi, S.4    Johnston, G.H.5    Deecher, D.C.6
  • 56
    • 0037424293 scopus 로고    scopus 로고
    • Acute effects of antipsychotic drugs on cardiovascular responses to stress
    • van den Buuse M (2003) Acute effects of antipsychotic drugs on cardiovascular responses to stress. Eur J Pharmacol 464:55-62
    • (2003) Eur J Pharmacol , vol.464 , pp. 55-62
    • Van Den Buuse, M.1
  • 58
    • 0023870490 scopus 로고
    • Peripheral sympathetic neural activity in conscious humans
    • Wallin BG, Fagius J (1988) Peripheral sympathetic neural activity in conscious humans. Annu Rev Physiol 50:565-576
    • (1988) Annu Rev Physiol , vol.50 , pp. 565-576
    • Wallin, B.G.1    Fagius, J.2
  • 61
    • 0031031635 scopus 로고    scopus 로고
    • Cutaneous vasoconstriction in conscious rabbits during alerting responses detected by hippocampal theta-rhythm
    • Yu YH, Blessing WW (1997) Cutaneous vasoconstriction in conscious rabbits during alerting responses detected by hippocampal theta-rhythm. Am J Physiol 272:R208-R216
    • (1997) Am J Physiol , vol.272
    • Yu, Y.H.1    Blessing, W.W.2
  • 62
    • 0027171065 scopus 로고
    • Autonomic effects of clozapine in schizophrenia: Comparison with placebo and fluphenazine
    • Zahn TP, Pickar D (1993) Autonomic effects of clozapine in schizophrenia: comparison with placebo and fluphenazine. Biol Psychiatry 34:3-12
    • (1993) Biol Psychiatry , vol.34 , pp. 3-12
    • Zahn, T.P.1    Pickar, D.2


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