17-β-estradiol inhibits transforming-growth-factor-β-induced MCF-7 cell migration by Smad3-repression

European Journal of Pharmacology

Volumn 534, Issue 1-3, 2006, Pages 39-47

  Malek, Daniela ^a   Gust, Ronald ^a   Kleuser, Burkhard ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

17 estradiol; Breast cancer cell; Chemotaxis; Estrogen receptor; Smad proteins; Transforming growth factor

Indexed keywords

ESTRADIOL; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CELL CULTURE; CELL MIGRATION; CELL STRAIN MCF 7; CELL VIABILITY; CHEMOKINESIS; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; METASTASIS; PHOSPHORYLATION; PRIORITY JOURNAL; REPORTER GENE;

CELL LINE, TUMOR; CELL MOVEMENT; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ESTRADIOL; GENE EXPRESSION REGULATION; HUMANS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33644931870     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.01.025     Document Type: Article

References (45)

1. C.L. Arteaga, A.K. Tandon, D.D. von Hoff, and C.K. Osborne Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells Cancer Res. 48 1988 3898 3904
2. G.S. Ashcroft, and A.B. Roberts Loss of Smad3 modulates wound healing Cytokine Growth Factor Rev. 11 2000 125 131
3. G.S. Ashcroft, X. Yang, A.B. Glick, M. Weinstein, J.L. Letterio, D.E. Mizel, M. Anzano, T. Greenwell-Wild, S.M. Wahl, C. Deng, and A.B. Roberts Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response Nat. Cell Biol. 1 1999 260 266
4. M.G. Brattain, Y. Ko, S.S. Banerji, G. Wu, and J.K. Willson Defects of TGF-beta receptor signaling in mammary cell tumorigenesis J. Mammary Gland Biol. Neoplasia 1 1996 365 372
5. M.B. Buck, P. Fritz, J. Dippon, G. Zugmaier, and C. Knabbe Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients Clin. Cancer Res. 10 2004 491 498
6. J.F. Couse, D.O. Bunch, J. Lindzey, D.W. Schomberg, and K.S. Korach Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouse Endocrinology 140 1999 5855 5865
7. S.F. Doisneau-Sixou, C.M. Sergio, J.S. Carroll, R. Hui, E.A. Musgrove, and R.L. Sutherland Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells Endocr. Relat. Cancer 10 2003 179 186
8. J. Donovan, and J. Slingerland Transforming growth factor-beta and breast cancer: cell cycle arrest by transforming growth factor-beta and its disruption in cancer Breast Cancer Res. 2 2000 116 124
9. K.C. Flanders Smad3 as a mediator of the fibrotic response Int. J. Exp. Pathol. 85 2004 47 64
10. J.S. Foster, D.C. Henley, S. Ahamed, and J. Wimalasena Estrogens and cell-cycle regulation in breast cancer Trends Endocrinol. Metab. 12 2001 320 327
11. L.A. Gilad, T. Bresler, J. Gnainsky, P. Smirnoff, and B. Schwartz Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells J. Endocrinol. 185 2005 577 592
12. S.A. Hahn, M. Schutte, A.T. Hoque, C.A. Moskaluk, L.T. da Costa, E. Rozenblum, C.L. Weinstein, A. Fischer, C.J. Yeo, R.H. Hruban, and S.E. Kern DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 Science 271 1996 350 353
13. S.A. Hayes, M. Zarnegar, M. Sharma, F. Yang, D.M. Peehl, P. ten Dijke, and Z. Sun SMAD3 represses androgen receptor-mediated transcription Cancer Res. 61 2001 2112 2118
14. M.D. Hjelmeland, A.B. Hjelmeland, S. Sathornsumetee, E.D. Reese, M.H. Herbstreith, N.J. Laping, H.S. Friedman, D.D. Bigner, X.F. Wang, and J.N. Rich SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility Mol. Cancer Ther. 3 2004 737 745
15. H. Iwase Molecular action of the estrogen receptor and hormone dependency in breast cancer Breast Cancer 10 2003 89 96
16. D. Javelaud, and A. Mauviel Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis Oncogene 24 2005 5742 5750
17. E. Kalkhoven, E. Beraldi, M.L. Panno, J.P. De Winter, J.H. Thijssen, and B. Van Der Burg Growth inhibition by anti-estrogens and progestins in TGF-beta-resistant and -sensitive breast-tumor cells Int. J. Cancer 65 1996 682 687
18. H.Y. Kang, K.E. Huang, S.Y. Chang, W.L. Ma, W.J. Lin, and C. Chang Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4 J. Biol. Chem. 277 2002 43749 43756
19. S.J. Kim, Y.H. Im, S.D. Markowitz, and Y.J. Bang Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis Cytokine Growth Factor Rev. 11 2000 159 168
20. D.J. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R.M. Evans The nuclear receptor superfamily: the second decade Cell 83 1995 835 839
21. J. Massague TGF-beta signal transduction Annu. Rev. Biochem. 67 1998 753 791
22. J. Massague, S.W. Blain, and R.S. Lo TGFbeta signaling in growth control, cancer, and heritable disorders Cell 103 2000 295 309
23. A.C. Mathew, T.T. Rajah, G.M. Hurt, S.M. Abbas Abidi, J.J. Dmytryk, and J.T. Pento Influence of antiestrogens on the migration of breast cancer cells using an in vitro wound model Clin. Exp. Metastasis 15 1997 393 399
24. T. Matsuda, T. Yamamoto, A. Muraguchi, and F. Saatcioglu Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3 J. Biol. Chem. 276 2001 42908 42914
25. M. Miyaki, T. Iijima, M. Konishi, K. Sakai, A. Ishii, M. Yasuno, T. Hishima, M. Koike, N. Shitara, T. Iwama, J. Utsunomiya, T. Kuroki, and T. Mori Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis Oncogene 18 1999 3098 3103
26. K. Miyazono, H. Suzuki, and T. Imamura Regulation of TGF-beta signaling and its roles in progression of tumors Cancer Sci. 94 2003 230 234
27. R.S. Muraoka, N. Dumont, C.A. Ritter, T.C. Dugger, D.M. Brantley, J. Chen, E. Easterly, L.R. Roebuck, S. Ryan, P.J. Gotwals, V. Koteliansky, and C.L. Arteaga Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases J. Clin. Invest. 109 2002 1551 1559
28. R.S. Muraoka-Cook, N. Dumont, and C.L. Arteaga Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression Clin. Cancer Res. 11 2005 937s 943s
29. C.K. Osborne, and R. Schiff Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer Breast 12 2003 362 367
30. C.K. Osborne, H. Zhao, and S.A. Fuqua Selective estrogen receptor modulators: structure, function, and clinical use J. Clin. Oncol. 18 2000 3172 3186
31. C.K. Osborne, J. Shou, S. Massarweh, and R. Schiff Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer Clin. Cancer Res. 11 2005 865s 870s
32. R. Parsons, L.L. Myeroff, B. Liu, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer Cancer Res. 55 1995 5548 5550
33. N. Platet, A.M. Cathiard, M. Gleizes, and M. Garcia Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasion Crit. Rev. Oncol./Hematol. 51 2004 55 67
34. F. Pouliot, and C. Labrie Expression profile of agonistic Smads in human breast cancer cells: absence of regulation by estrogens Int. J. Cancer 81 1999 98 103
35. C.O. Rambo, and C.M. Szego Estrogen action at endometrial membranes: alterations in luminal surface detectable within seconds J. Cell. Biol. 97 1983 679 685
36. B. Sauer, R. Vogler, H. von Wenckstern, M. Fujii, M.B. Anzano, A.B. Glick, M. Schafer-Korting, A.B. Roberts, and B. Kleuser Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes J. Biol. Chem. 279 2004 38471 38479
37. Y. Shang, and M. Brown Molecular determinants for the tissue specificity of SERMs Science 295 2002 2465 2468
38. C.Z. Song, X. Tian, and T.D. Gelehrter Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3 Proc. Natl. Acad. Sci. U. S. A. 96 1999 11776 11781
39. L. Sun, G. Wu, J.K. Willson, E. Zborowska, J. Yang, I. Rajkarunanayake, J. Wang, L.E. Gentry, X.F. Wang, and M.G. Brattain Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells J. Biol. Chem. 269 1994 26449 26455
40. G.M. Tong, T.T. Rajah, X.P. Zang, and J.T. Pento The effect of antiestrogens on TGF-beta-mediated chemotaxis of human breast cancer cells Anticancer Res. 22 2002 103 106
41. R. Vogler, B. Sauer, D.S. Kim, M. Schafer-Korting, and B. Kleuser Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing J. Invest. Dermatol. 120 2003 693 700
42. L.M. Wakefield, and A.B. Roberts TGF-beta signaling: positive and negative effects on tumorigenesis Curr. Opin. Genet. Dev. 12 2002 22 29
43. L. Wu, Y. Wu, B. Gathings, M. Wan, X. Li, W. Grizzle, Z. Liu, C. Lu, Z. Mao, and X. Cao Smad4 as a transcription corepressor for estrogen receptor alpha J. Biol. Chem. 278 2003 15192 15200
44. T. Yamamoto, F. Saatcioglu, and T. Matsuda Cross-talk between bone morphogenic proteins and estrogen receptor signaling Endocrinology 143 2002 2635 2642
45. J. Yanagisawa, Y. Yanagi, Y. Masuhiro, M. Suzawa, M. Watanabe, K. Kashiwagi, T. Toriyabe, M. Kawabata, K. Miyazono, and S. Kato Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators Science 283 1999 1317 1321