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Volumn 7, Issue 3, 2006, Pages 433-435

Monitoring chemical reactions by using ion-channel-forming peptides

Author keywords

Biotechnology; Gramicidin A; Membranes; Self assembly; Sensors

Indexed keywords

GRAMICIDIN A;

EID: 33644931601     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200500532     Document Type: Article
Times cited : (32)

References (49)
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  • 36
    • 33644889669 scopus 로고    scopus 로고
    • note
    • The increase in conductance in the presence of HCI is due to the higher permeability of protons through gramicidin channels compared to potassium ions.
  • 37
    • 33644908505 scopus 로고    scopus 로고
    • note
    • Over the course of the reaction, we observed an intermediate current state of 17.9pA, which presumably arose from the conversion of 1 to an intermediate of the reaction (e.g., the carbamic acid) that converts more slowly to product 2. The observed current at 17.9 pA might arise from a combination of indistinguishable conductance states generated from this intermediate of the reaction and/or asymmetric gramicidin channels formed from this intermediate and 2. Indistinguishable conductance states between symmetric and asymmetric gramicidin A channels have been previously reported in ref. [1d].
  • 40
    • 33644887473 scopus 로고    scopus 로고
    • note
    • For both of the reactions we describe in this work, the final products are the same regardless of whether the synthetic transformations occur while the peptides are in the membrane or in the aqueous phase. Although the order in which the reagents are added to the reaction vessels will not change the final products of the reactions, it is possible that the reaction rates are influenced by the local environment of the peptide. Therefore the observed kinetics of the reactions might depend on the order in which the reagents are added to the bilayer setup.
  • 47
    • 0035801512 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2001, 40, 3118-3130;
    • (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 3118-3130


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.