Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes

Free Radical Biology and Medicine

Volumn 40, Issue 7, 2006, Pages 1220-1226

  Hollins, Dawn L ^a   Suliman, Hagir B ^a   Piantadosi, Claude A ^a   Carraway, Martha Sue ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Free radical; Gluthathione; Lymphocytes; Mitochondrial DNA; Reactive oxygen species

Indexed keywords

BUTHIONINE SULFOXIMINE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; MITOCHONDRIAL DNA; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SYNTHESIS INHIBITION;

APOPTOSIS; DNA DAMAGE; DNA, MITOCHONDRIAL; GLOBINS; GLUTATHIONE; HUMANS; LYMPHOCYTES; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; TERT-BUTYLHYDROPEROXIDE;

EID: 33644922923     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.11.011     Document Type: Article

References (36)

1. D.P. Kelly, and R.C. Scarpulla Transcriptional regulatory circuits controlling mitochondrial biogenesis and function Genes Dev. 18 2004 357 368
2. D.C. Wallace Mitochondrial diseases in man and mouse Science 283 1999 1482 1488
3. T. Kanki, K. Ohgaki, M. Gaspari, C.M. Gustafsson, A. Fukuoh, N. Sasaki, N. Hamasaki, and D. Kang Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA Mol. Cell. Biol. 24 2004 9823 9834
4. D.Y. Lee, and D.A. Clayton Initiation of mitochondrial DNA replication by transcription and R-loop processing J. Biol. Chem. 273 1998 30614 30621
5. C. Richter, J.-W. Park, and B.N. Ames Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proc. Natl. Acad. Sci. USA 85 1988 6465 6467
6. S.W. Ballinger, C. Patterson, Y. Chang-Ning, R. Doan, D.L. Burow, C.G. Yount, F.M. Yakes, B. Van Houten, C.A. Ballinger, B.A. Freemen, and M.S. Runge Hydrogen peroxide-and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells Circ. Res. 86 2000 960 966
7. F.M. Yakes, and B. Van Houten Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress Proc. Natl. Acad. Sci. USA 94 1997 514 519
8. H.B. Suliman, M.S. Carraway, L.W. Velsor, B.J. Day, A.J. Ghio, and C.A. Piantadosi Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure Free Radic. Biol. Med. 32 2002 246 256
9. H.B. Suliman, M.S. Carraway, and C.A. Piantadosi Post-lipopolysaccharide oxidative damage of mitochondrial DNA Am. J. Respir. Crit. Care Med. 167 2003 570 579
10. S.W. Kang, H.Z. Chae, M.S. Seo, K. Kim, I.C. Baines, and S.G. Rhee Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha J. Biol Chem. 273 1998 6297 6302
11. K. Hirose, D.L. Longo, J.J. Oppenheim, and K. Matsushima Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation FASEB J. 7 1993 361 368
12. H. Van Remmen, W. Qi, M. Sabia, G. Freeman, L. Estlack, H. Yang, Z. Mao Guo, T.T. Huang, R. Strong, S. Lee, C.J. Epstein, and A. Richardson Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress Free Radic. Biol. Med. 36 2004 1625 1634
13. F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/ glutathione couple Free Radic. Biol. Med. 30 2001 1191 1212
14. K. Olafsdittir, and D.J. Reed Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment Biochim. Biophys. Acta 964 1988 377 382
15. C.S. Gardiner, and D.J. Reed Glutathione redox cycle-driven recovery of reduced glutathione after oxidation by tertiary-butyl hydroperoxide in preimplantation mouse embryos Arch. Biochem. Biophys. 321 1995 6 12
16. H.Y. Kim, O.H. Kim, and M.K. Sung Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers J. Am. Coll. Nutr. 22 3 2003 217 223
17. M. Sorensen, H. Skov, H. Autrup, O. Hertel, and S. Loft Urban benzene exposure and oxidative DNA damage: influence of genetic polymorphisms in metabolism genes Sci. Tot. Environ. 309 2003 69 80
18. F. Tietze Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione Anal. Biochem. 27 1969 502 522
19. B.J. Buckley, and A.R. Whorton Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells Am. J. Physiol. Cell. Physiol. 279 2000 C1168 C1176
20. C.-S. Chen, and K.R. Gee Redox-dependent trafficking of 2,3,4,5,6-pentafluorodihydrotetramethylrosamine, a novel fluorogenic indicator of cellular oxidative activity Free Radic. Biol. Med. 28 2000 1266 1278
21. W.J. Driggers, G.P. Holmquist, S.P. LeDoux, and G.L. Wilson Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA Nucleic Acids Res. 25 1997 4362 4369
22. S. Melov, J.M. Shoffner, A. Kaufman, and D.C. Wallace Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle Nucleic Acids Res. 23 1995 4122
23. K. Polyak, Y. Li, H. Zhu, C. Lengauer, J.K.V. Willson, S.D. Markowitz, M. Trush, K.W. Kinzler, and B. Vogelstein Somatic mutations of the mitochondrial genome in human colorectal tumours Nat. Genet. 20 1998 291
24. J.-R. Alonso, F. Cardellach, J. Casademont, and Ò. Miró Reversible inhibition of mitochondrial complex IV activity in PBMC following acute smoking Eur. Respir. J. 23 2004 214 218
25. S. Schroeder, C. Lindemann, A. Hoeft, C. Putensen, D. Decker, A.A. von Ruecker, and F. Stuber Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis Crit. Care Med. 27 1999 1080 1084
26. U. Bommhardt, K.C. Chang, P.E. Swanson, T.H. Wagner, K.W. Tinsley, I.E. Karl, and R.S. Hotchkiss Akt decreases lymphocyte apoptosis and improves survival in sepsis J. Immunol. 172 2004 7583 7591
27. M.P. Fink Cytopathic hypoxia. Mitochondrial dysfunction as a mechanism contributing to organ dysfunction in sepsis Crit. Care Clin. 17 2001 219 237
28. S.G. Simonson, K. Welty-Wolf, Y.T. Huang, J.A. Griebel, M.S. Caplan, P.J. Fracica, and C.A. Piantadosi Altered mitochondrial redox responses in gram negative septic shock in primates Circ. Shock. 43 1994 34 43
29. C. Adrie, M. Bachelet, M. Vayssier-taussat, F. Russo-marie, I. Bouchaert, M. Adib-conquy, J.-M. Cavaillon, M.R. Pinsky, J.-F. Dhainaut, and B.S. Polla Mitochondrial membrane potential and apoptosis in peripheral blood monocytes in severe human sepsis Am. J. Respir. Crit. Care Med. 164 2001 389 395
30. S.P. Kantrow, D.E. Taylor, M.S. Carraway, and C.A. Piantadosi Oxidative metabolism in rat hepatocytes and mitochondria during sepsis Arch. Biochem. Biophys. 345 1997 278 288
31. D.C. Wallace, G. Singh, M.T. Lott, J.A. Hodge, T.G. Schurr, A.M. Lezza, L.J. Elsas, and E.K. Nikoskelainen Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy Science 242 1988 1427 1430
32. I.J. Holt, A.E. Harding, and J.A. Morgan-Hughes Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies Nature 331 1988 717 719
33. G.S. Shadel, and D.A. Clayton Mitochondrial DNA maintenance in vertebrates Annu. Rev. Biochem. 66 1997 409 435
34. J. Seyfried, F. Soldner, J.B. Schulz, T. Klockqether, K.A. Kovar, and U. Wullner Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells Neurosci. Lett. 264 1999 1 4
35. M. Mari, J. Bai, and A.I. Cederbaum Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria Free Radic. Biol. Med. 32 2002 73 83
36. A. Krippner, A. Matsuno-Yagi, R.A. Gottlieb, and B.M. Babior Loss of function of cytochrome c in Jurkat cells undergoing Fas-mediated apoptosis J. Biol. Chem. 271 1996 21629 21636