Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies

Protein Engineering, Design and Selection

Volumn 19, Issue 4, 2006, Pages 155-161

  Ingram, Richard N ^a   Orth, Peter ^a   Strickland, Corey L ^a   Le, Hung V ^a   Madison, Vincent ^a   Beyer, Brian M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Autoproteolysis; Protein engineering; Soakable crystal form; Structure based drug design; TACE

Indexed keywords

CRYSTALS; DEMONSTRATIONS; KINETIC ENERGY; SUBSTRATES;

AUTOPROTEOLYSIS; PROTEIN ENGINEERING; SOAKABLE CRYSTAL FORM; STRUCTURE-BASED DRUG DESIGN; TACE; TNF-ALPHA CONVERTING ENZYME;

ENZYMES;

PEPTIDE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CONCENTRATION RESPONSE; CRYSTALLIZATION; DRUG DESIGN; IC 50; MOLECULAR BIOLOGY; MUTANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SCREENING TEST;

ADAM PROTEINS; CLONING, MOLECULAR; CRYSTALLIZATION; DRUG DESIGN; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 33644916123     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzj014     Document Type: Article

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