Use of high-dose epinephrine and sodium bicarbonate during neonatal resuscitation: Is there proven benefit?

Clinics in Perinatology

Volumn 33, Issue 1, 2006, Pages 141-151

  Wyckoff, Myra H ^a   Perlman, Jeffrey M ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BICARBONATE;

ARTIFICIAL VENTILATION; BRAIN HEMORRHAGE; CARDIOPULMONARY ARREST; CLINICAL PRACTICE; CLINICAL TRIAL; DRUG EFFECT; DRUG MEGADOSE; HEART MUSCLE NECROSIS; HUMAN; HYPERTENSION; META ANALYSIS; NEWBORN INTENSIVE CARE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RESUSCITATION; REVIEW; SYSTEMATIC REVIEW; TACHYCARDIA;

ADRENERGIC AGONISTS; ANIMALS; CARDIOPULMONARY RESUSCITATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; HEART ARREST; HUMANS; INFANT, NEWBORN; INFUSIONS, INTRAVENOUS; SODIUM BICARBONATE;

EID: 33644903754     PISSN: 00955108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clp.2005.11.016     Document Type: Review

References (76)

1. J.S. Redding, and J.W. Pearson Evaluation of drugs for cardiac resuscitation Anesthesiology 24 1963 203 207
2. C.W. Otto, R.W. Yakaitis, and C.D. Blitt Mechanism of action of epinephrine in resuscitation from asphyxiated arrest Crit Care Med 9 1981 321 324
3. J.R. Michael, A.D. Guerci, and R.C. Koehler Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs Circulation 69 1984 822 835
4. N.A. Paradis, G.B. Martin, and E.P. Rivers Coronary perfusion pressure and the return of spontaneous ciruclation in human cardiopulmonary resuscitation JAMA 263 1990 1106 1113
5. J.S. Redding, and J.W. Pearson Resuscitation from ventricular fibrillation JAMA 203 1968 255 260
6. J. Kattwinkel, S. Niermeyer, and V. Nadkarni ILCOR advisory statement: resuscitation of the newly born infant: an advisory statement from the Pediatric Working Group of the International Liaison Committee on Resuscitation Pediatrics 103 1999 e56
7. M.H. Wyckoff, J.M. Perlman, and S. Niermeyer Medications during resuscitation-what is the evidence? Semin Neonatol 6 2001 251 259
8. J.M. Perlman, and R. Risser Cardiopulmonary resuscitation in the delivery room: associated clinical events Arch Pediatr Adolesc Med 149 1995 20 25
9. M.H. Wyckoff, J.M. Perlman, and A.R. Laptook Use of volume expansion during delivery room resuscitation in near-term and term infants Pediatrics 115 2005 950 955
10. 2 tension or extracellular bicarbonate concentration J Clin Invest 44 1965 8 20
11. M.N. Anderson, and C.V. Mouritzen Effect of acute respiratory and metabolic acidosis on cardiac output and peripheral resistance Ann Surg 163 1966 161 168
12. W. Tang, M.H. Weil, and R.J. Gazmuri Reversible impairment of myocardial contractility due to hypercarbic acidosis in the isolated perfused heart Crit Care Med 19 1991 218 224
13. H.H. Bendixen, M.B. Laver, and W.E. Flacke Influence of respiratory acidosis on circulatory effect of epinephrine in dogs Circ Res 8 1963 64 70
14. S.E. Downing, N.S. Talner, and T.H. Garner Cardiovascular responses to metabolic acidosis Am J Physiol 208 1965 237 242
15. G.D. Ford, W.H. Cline, and W.W. Fleming Influence of lactic acidosis on cardiovascular response to sympathomimetic amines Am J Physiol 215 1968 1123 1129
16. M.P. Preziosi, J.C. Roig, N. Hargrove, and D.J. Burchfield Metabolic acidemia with hypoxia attenuates the hemodynamic responses to epinephrine during resuscitation in lambs Crit Care Med 21 1993 1901 1907
17. C.G. Brown, H.A. Werman, and R.L. Hamlin Comparative effect of graded doses of epinephrine on regional brain blood flow during CPR in a swine model Ann Emerg Med 15 1986 1138 1144
18. C.G. Brown, H.A. Werman, and E.A. Davis The effects of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine Circulation 75 1987 491 497
19. K.H. Lindner, F.W. Ahnefeld, and I.M. Bowdler Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model Am J Emerg Med 9 1991 27 31
20. P.B. Chase, K.B. Kern, and A.B. Sanders Effects of graded doses of epinephrine on both noninvasive and invasive measures of myocardial perfusion and blood flow during cardiopulmonary resuscitation Crit Care Med 21 1993 413 419
21. J.W. Kosnik, R.E. Jackson, and S. Keats Dose-related response to centrally administered epinephrine on the change in aortic diastolic pressure during closed-chest massage in dogs Ann Emerg Med 14 1985 204 208
22. E.R. Gonzalez, J.P. Ornato, and A.R. Garnett Dose-dependent vasopressor response to epinephrine during CPR in human beings Ann Emerg Med 18 1989 920 926
23. C.W. Barton, and M. Callaham High-dose epinephrine improves the return of spontaneous circulation rates in human victims of cardiac arrest Ann Emerg Med 20 1991 722 725
24. M. Callaham, C.D. Madsen, and C.W. Barton A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest JAMA 268 1992 2667 2672
25. P.-Y. Gueugniaud, P. Mols, and P. Goldstein A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. European Epinephrine Study Group N Engl J Med 339 1998 1595 1601
26. I.G. Stiell, P.C. Hebert, and B.N. Weitzman High-dose epinephrine in adult cardiac arrest N Engl J Med 327 1992 1045 1050
27. C.G. Brown, D.R. Martin, and P.E. Pepe A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group N Engl J Med 327 1992 1051 1055
28. C. Choux, P.Y. Gueugniaud, and A. Barbieux Standard doses versus repeated high doses of epinephrine in cardiac arrest outside the hospital Resuscitation 29 1995 3 9
29. C. Vandycke, and P. Martens High dose versus standard dose epinephrine in cardiac arrest-a meta-analysis Resuscitation 45 2000 161 166
30. U. Hornchen, C. Lussi, and J. Schuttler Potential risks of high-dose epinephrine for resuscitation from ventricular fibrillation in a porcine mode J Cardiothorac Vasc Anesth 7 1993 184 187
31. W. Tang, M.H. Weil, and S. Sun Epinephrine increases the severity of postresuscitation myocardial dysfunction Circulation 92 1995 3089 3093
32. G.L. Todd, G. Baroldi, and G.M. Pieper Experimental catecholamine-induced myocardial necrosis: morphology, quantification and regional distribution of the acute contraction band lesion J Mol Cell Cardiol 17 1985 317 338
33. R.A. Berg, C.W. Otto, and K.B. Kern High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study Crit Care Med 22 1994 282 290
34. R.W. Hilwig, K.B. Kern, and R.A. Berg Catecholamines in cardiac arrest: role of alpha agonists, beta-adrenergic blockers and high-dose epinephrine Resuscitation 47 2000 203 208
35. W. Behringer, H. Kittler, and F. Sterz Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome Ann Intern Med 129 1998 450 456
36. R. Gedeborg, H.C. Silander, and E. Ronne-Engström Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation Crit Care Med 28 2000 1423 1430
37. M.G. Goetting, and N.A. Paradis High dose epinephrine in refractory pediatric cardiac arrest Crit Care Med 17 1989 1258 1262
38. M.G. Goetting, and N.A. Paradis High-dose epinephrine improves outcome from pediatric cardiac arrest Ann Emerg Med 20 1991 22 26
39. T.C. Carpenter, and K.R. Stenmark High-dose epinephrine is not superior to standard-dose epinephrine in pediatric in-hospital cardiopulmonary arrest Pediatrics 99 1997 403 408
40. R.A. Dieckmann, and R. Vardis High-dose epinephrine in pediatric out-of-hospital cardiopulmonary arrest Pediatrics 95 1995 901 913
41. M.B.M. Perondi, A.G. Reis, and E.F. Paiva A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest N Engl J Med 350 2004 1722 1730
42. K.O. Schwab, and H.B. von Stockhausen Plasma catecholamines after endotracheal administration of adrenaline during postnatal resuscitation Arch Dis Child Fetal Neonatal Ed 70 1994 F213 F217
43. R. Lindemann Resuscitation of the newborn: endotracheal administration of epinephrine Acta Paediatr Scand 73 1984 210 212
44. A.I. O'Donnell, P.H. Gray, and Y.M. Rogers Mortality and neurodevelopmental outcome for infants receiving adrenaline in neonatal resuscitation J Paediatr Child Health 34 1998 551 556
45. R.A. Berg, C.W. Otto, and K.B. Kern A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest Crit Care Med 24 1996 1695 1700
46. J.F. Pasternak, D.R. Groothius, and D.P. Fischer Regional cerebral blood flow in the beagle puppy model of neonatal intraventricular hemorrhage: studies in systemic hypertension Neurology 33 1983 559 566
47. K. Adamson, R. Behrman, and G.S. Dawes The treatment of acidosis with alkali and glucose during asphyxia in foetal rhesus monkeys J Physiol 169 1963 679 689
48. K. Adamson, R. Behrman, and G.S. Dawes Resuscitation by positive pressure ventilation and TRIS-hydroxymethylaminomethane of rhesus monkeys asphyxiated at birth J Pediatr 65 1964 807 818
49. G.S. Dawes, H.N. Jacobson, and J.C. Mott The treatment of asphyxiated, mature foetal lambs and rhesus monkeys with intravenous glucose and sodium carbonate J Physiol 169 1963 167 184
50. G.S. Dawes, E. Hibbard, and W.F. Windle The effect of alkali and glucose infusion on permanent brain damage in rhesus monkeys asphyxiated at birth J Pediatr 65 1964 801 806
51. E.M. Ostrea Jr, and G.B. Odell The influence of bicarbonate administration on blood pH in a "closed system": clinical implications J Pediatr 80 1972 671 680
52. W. Grundler, M.H. Weil, and E.C. Rackow Arteriovenous carbon dioxide and pH gradients during cardiac arrest Circulation 74 1986 1071 1074
53. M.H. Weil, E.C. Rackow, and R. Trevino Difference in acid-base state between venous and arterial blood during cardiopulmonary resuscitation N Engl J Med 315 1986 153 156
54. F. Kette, M.H. Weil, and M. von Planta Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation Circulation 81 1990 1660 1666
55. A.H. Idris, E.D. Staples, and D.J. O'Brien Effect of ventilation on acid-base balance and oxygenation in low blood-flow states Crit Care Med 22 1994 1827 1834
56. H.J. Adrogué, N. Rashad, and A.B. Gorin Assessing acid-base status in circulatory failure N Engl J Med 320 1989 1312 1316
57. F. Kette, M.H. Weil, and R.J. Gazmuri Buffer solutions may compromise cardiac resuscitation by reducing coronary perfusion pressure JAMA 266 1991 2121 2126
58. L. Finberg, C. Luttrell, and H. Reed Pathogenesis of lesions in the nervous system in hypernatremic states: II. experimental studies of gross anatomic changes and alterations of chemical composition of the tissues Pediatrics 23 1959 46 53
59. C.N. Luttrell, L. Finberg, and L.P. Drawdy Hemorrhagic encephalopathy induced by hypernatremia: II. experimental observations on hyperosmolarity in cats Arch Neurol 1 1959 153 160
60. A.S. Wheeler, S. Sadri, and B.B. Gutsche Intracranial hemorrhage following intravenous administration of sodium bicarbonate or saline solution in the newborn lamb asphyxiated in utero Anesthesiology 51 1979 517 521
61. M.A. Simmons, E.W. Adcock 3rd, H. Bard, and F.C. Barraglia Hypernatremia and intracranial hemorrhage in neonates N Engl J Med 291 1974 6 10
62. D. Sessler, P. Mills, and G. Gregory Effects of bicarbonate on arterial and brain intracellular pH in neonatal rabbits recovering from hypoxic lactic acidosis J Pediatr 111 1987 817 823
63. 2 delivery during hypoxemia and acidemia in the piglet Pediatr Res 19 1985 815 819
64. H.C. Lou, N.A. Lassen, and B. Friis-Hansen Decreased cerebral blood flow after administration of sodium bicarbonate in the distressed newborn infant Acta Neurol Scand 57 1978 239 247
65. L. Lokesh, P. Kumar, S. Murki, and A. Narang A randomized controlled trial of sodium bicarbonate in neonatal resuscitation-effect on immediate outcome Resuscitation 60 2004 219 223
66. A.D. Guerci, N. Chandra, and E. Johnson Failure of sodium bicarbonate to improve resuscitation from ventricular fibrillation in dogs Circulation 74 Suppl IV 1986 75 79
67. L. Wiklund, G. Ronquist, H. Stjernstrom, and A. Waldenstrom Effects of alkaline buffer administration on survival and myocardial energy metabolism in pigs subjected to ventricular fibrillation and closed chest CPR Acta Anaesthesiol Scand 34 1990 430 439
68. C.S. Federiuk, A.B. Sanders, and K.B. Kern The effect of bicarbonate on resuscitation from cardiac arrest Ann Emerg Med 20 1991 1173 1177
69. S. Rubertsson, and L. Wiklund Hemodynamic effects of epinephrine in combination with different alkaline buffers during experimental, open-chest, cardiopulmonary resuscitation Crit Care Med 21 1993 1051 1057
70. R.W. Neumar, N.G. Bircher, and K.M. Sim Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats Resuscitation 29 1995 249 263
71. B.E. Bleske, R.L. Rice, and E.W. Warren The effect of sodium bicarbonate administration on the vasopressor effect of high-dose epinephrine during cardiopulmonary resuscitation in swine Am J Emerg Med 11 1993 439 443
72. R.B. Vukmir, N.G. Bircher, and P. Safar Sodium bicarbonate may improve outcome in dogs with brief or prolonged cardiac arrest Crit Care Med 23 1995 515 522
73. G. Bar-Joseph, T. Weinberger, and T. Castel Comparison of sodium bicarbonate, Carbicarb, and THAM during cardiopulmonary resuscitation in dogs Crit Care Med 26 1998 1397 1408
74. E.C.M. Leong, J.C. Bendall, and A.C. Boyd Sodium bicarbonate improves the chance of resuscitation after 10 minutes of cardiac arrest in dogs Resuscitation 51 2001 309 315
75. M.M. Levy An evidence-based evaluation of the use of sodium bicarbonate during cardiopulmonary resuscitation Crit Care Clin 14 1998 457 483
76. T. Dybvik, T. Strand, and P.A. Steen Buffer therapy during out-of-hospital cardiopulmonary resuscitation Resuscitation 29 1995 89 95