Cumulative epinephrine dose during cardiopulmonary resuscitation and neurologic outcome

Annals of Internal Medicine

Volumn 129, Issue 6, 1998, Pages 450-456

  Behringer, Wilhelm ^a   Kittler, Harald ^a   Sterz, Fritz ^a   Domanovits, Hans ^a   Schoerkhuber, Waltraud ^a   Holzer, Michael ^a   Müllner, Marcus ^a   Laggner, Anton N ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

ADULT; AGED; ARTICLE; BRAIN FUNCTION; CIRCULATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HEART ARREST; HEART VENTRICLE FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROLOGICAL COMPLICATION; PRIORITY JOURNAL; RESUSCITATION; RETROSPECTIVE STUDY;

EID: 0032531109     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-129-6-199809150-00004     Document Type: Article

References (49)

1. Crile GW, Dolley DH. An experimental research into the resuscitation of dogs killed by anesthetics and asphyxia. J Exp Med. 1906;8:713-24.
2. Standards and guidelines for cardiopulmonary resuscitation and emergency cardiac care. American Heart Association. JAMA. 1992;268:2205-11.
3. Redding JS, Pearson JW. Resuscitation from asphyxia. JAMA. 1962;182: 283-6.
4. Redding JS, Pearson JW. Evaluation of drugs for cardiac resuscitation. Anesthesiology. 1963;24:203-7.
5. Redding JS, Pearson JW. Resuscitation from ventricular fibrillation. Drug therapy. JAMA. 1968;203:93-8.
6. Stiell IG, Hebert PC, Weitzman BN, Wells GA, Raman S, Stark RM, et al. High-dose epinephrine in adult cardiac arrest. N Engl J Med. 1992;327: 1045-50.
7. Brown CG, Martin DR, Pepe PE, Stueven H, Cummins RO, Gonzalez E, et al. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group. N Engl J Med. 1992;327:1051-5.
8. Callaham M, Madsen CD, Barton CW, Saunders CE, Pointer J. A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest. JAMA. 1992;268:2667-72.
9. Brown CG, Werman HA. Adrenergic agonists during cardiopulmonary resuscitation. Resuscitation. 1990;19:1-16.
10. Lindner KH, Ahnefeld FW. Comparison of epinephrine and norepinephrine in the treatment of asphyxial or fibrillatory cardiac arrest in a porcine model. Crit Care Med. 1989;17:437-41.
11. Olson DW, Thakur R, Stueven HA, Thompson B, Gruchow H, Hendley GE, et al. Randomized study of epinephrine versus methoxamine in prehospital ventricular fibrillation. Ann Emerg Med. 1989;18:250-3.
12. O'Neil BJ, Wilson RF. The controversies in cardiopulmonary resuscitation on high-dose epinephrine still continue [Editorial]. Crit Care Med. 1994;22: 194-5.
13. Paradis NA, Martin GB, Rosenberg J, Rivers EP, Goetting MG, Appleton TJ, et al. The effect of standard-and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation. JAMA. 1991;265:1139-44.
14. Wortsman J, Paradis NA, Martin GB, Rivers EP, Goetting MG, Nowak RM, et al. Functional responses to extremely high plasma epinephrine concentrations in cardiac arrest. Crit Care Med. 1993;21:692-7.
15. Barton C, Callaham M. High-dose epinephrine improves the return of spontaneous circulation rates in human victims of cardiac arrest. Ann Emerg Med. 1991;20:722-5.
16. Little RA, Frayn KN, Randall PE, Stoner HB, Yates DW, Laing GS, et al. Plasma catecholamines in patients with acute myocardial infarction and in cardiac arrest. Q J Med. 1985;54:133-40.
17. Goetting MG, Paradis NA. High-dose epinephrine improves outcome from pediatric cardiac arrest. Ann Emerg Med. 1991;20:22-6.
18. Marwick TH, Case C, Siskind V, Woodhouse SP. Adverse effect of early high-dose adrenaline on outcome of ventricular fibrillation. Lancet. 1988;2: 66-8.
19. Rivers EP, Wortsman J, Rady MY, Blake HC, McGeorge FT, Buderer NM. The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period. Chest. 1994;106:1499-507.
20. Livesay JJ, Follette DM, Fey KH, Nelson RL, DeLand EC, Barnard RJ, et al. Optimizing myocardial supply/demand balance with alpha-adrenergic drugs during cardiopulmonary resuscitation. J Thorac Cardiovasc Surg. 1978; 76:244-51.
21. Suga H, Hisano R, Goto Y, Yamada O, Igarashi Y. Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle. Circ Res. 1983;53:306-18.
22. Ditchey RV, Lindenfeld J. Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs. Circulation. 1988;78:382-9.
23. Tang W, Weil MH, Gazmuri RJ, Sun S, Duggal C, Bisera J. Pulmonary ventilation/perfusion defects induced by epinephrine during cardiopulmonary resuscitation. Circulation. 1991;84:2101-7.
24. Tang W, Weil MH, Sun S, Noc M, Yang L, Gazmuri RJ. Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation. 1995;92:3089-93.
25. Rubertsson S, Grenvik A, Zemgulis V, Wiklund L. Systemic perfusion pressure and blood flow before and after administration of epinephrine during experimental cardiopulmonary resuscitation. Crit Care Med. 1995;23: 1984-96.
26. Schindler MB, Bohn D, Cox PN, McCrindle BW, Jarvis A, Edmonds J, et al. Outcome of out-of-hospital cardiac or respiratory arrest in children. N Engl J Med. 1996;335:1473-9.
27. Cummins RO, Chamberlain DA, Abramson NS, Allen M, Baskett PJ, Becker L, et al. Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein Style. A statement for health professionals from a task force of the American Heart Association, the European Resuscitation Council, the Heart and Stroke Foundation of Canada, and the Australian Resuscitation Council. Circulation. 1991;84:960-75.
28. Eisenberg MS, Cummins RO, Damon S, Larsen MP, Hearne TR. Survival rates from out-of-hospital cardiac arrest: recommendations for uniform definitions and data to report. Ann Emerg Med. 1990;19:1249-59.
29. Becker LB, Ostrander MP, Barrett J, Kondos GT. Outcome of CPR in a large metropolitan area - where are the survivors? Ann Emerg Med. 1991;70: 355-61.
30. Pepe PE, Levine RL, Fromm RE Jr, Curka PA, Clark PS, Zachariah BS. Cardiac arrest presenting with rhythms other than ventricular fibrillation: contribution of resuscitative efforts toward total survivorship. Crit Care Med. 1993;21:1838-43.
31. Beer RJ, Teasdale TA, Ghusn HF, Taffet GE. Estimation of severity of illness with APACHE II: age-related implications in cardiac arrest outcomes. Resuscitation. 1994;27:189-95.
32. Hallstrom AP, Cobb LA, Yu BH. Influence of comorbidity on the outcome of patients treated for out-of-hospital ventricular fibrillation. Circulation. 1996;93:2019-22.
33. Mullie A, Lewi P, Van Hoeyweghen R. Pre-CPR conditions and the final outcome of CPR. The Cerebral Resuscitation Study Group. Resuscitation. 1989;17(Suppl):S11-21.
34. A randomized clinical study of cardiopulmonary-cerebral resuscitation: design, methods, and patient characteristics. Brain Resuscitation Clinical Trial I Study Group. Am J Emerg Med. 1986;4:72-86.
35. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1:480-4.
36. Altman DG. Practical Statistics for Medical Research. London: Chapman and Hall: 1991.
37. Lindner KH, Koster R. Vasopressor drugs during cardiopulmonary resuscitation. A statement for the Advanced Life Support Working Party of the European Resuscitation Council. Resuscitation. 1992;24:147-53.
38. Brown CG, Werman WA, Davis EA, Hamlin R, Hobson J, Ashton JA. Comparative effect of graded doses of epinephrine on regional brain blood flow during CPR in a swine model. Ann Emerg Med. 1986;15:1138-44.
39. Brunette DD, Jameson SJ. Comparison of standard versus high-dose epinephrine in the resuscitation of cardiac arrest in dogs. Ann Emerg Med. 1990;19:8-11.
40. Brown CG, Werman WA, Davis EA, Hobson J, Hamlin RL. The effects of graded doses of epinephrine on regional myocardial blood flow during cardiopulmonary resuscitation in swine. Circulation. 1987;75:491-7.
41. Lindner KH, Ahnefeld FW, Bowdler IM. Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model. Am J Emerg Med. 1991;9:27-31.
42. Choux C, Gueugniaud PY, Barbieux A, Pham E, Lae C, Dubien PY, et al. Standard doses versus repeated high doses of epinephrine in cardiac arrest outside the hospital. Resuscitation. 1995;29:3-9.
43. Callaham M, Barton CW, Kayser S. Potential complications of high-dose epinephrine therapy in patients resuscitated from cardiac arrest. JAMA. 1991; 265:1117-22.
44. Ritter G, Wolfe RA, Goldstein S, Landis JR, Vasu CM, Acheson A, et al. The effect of bystander CPR on survival of out-of-hospital cardiac arrest. Am Heart J. 1985;110:932-7.
45. Rogove HJ, Safar P, Sutton-Tyrrell K, Abramson NS. Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The Brain Resuscitation Clinical Trial I and II Study Groups. Crit Care Med. 1995;23:18-25.
46. Martens PR, Mullie A, Calle P, Van Hoeyweghen R. Influence on outcome after arrest of time elapsed between call for help and start of bystander basic CPR. The Belgian Cerebral Resuscitation Group. Resuscitation. 1993;25: 227-34.
47. Stueven HA. Prehospital CPR: a review, in perspective. Resuscitation. 1989; 17(Suppl):S71-7.
48. Ng AY, Clinton JE, Peterson G. Nontraumatic prehospital cardiac arrest ages 1 to 39 years. Am J Emerg Med. 1990;8:87-91.
49. Longstreth WT Jr, Diehr P, Inui TS. Prediction of awakening after out-of-hospital cardiac arrest. N Engl J Med. 1983;308:1378-82.