메뉴 건너뛰기




Volumn 1, Issue 2, 2004, Pages 170-178

Equipoise: A case study of the views of clinicians involved in two neonatal trials

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FEMALE; HEALTH PERSONNEL ATTITUDE; HUMAN; MALE; MIDDLE AGED; NEONATOLOGY; PATIENT SELECTION; PHYSICIAN ATTITUDE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; TREATMENT OUTCOME; UNCERTAINTY;

EID: 33644901373     PISSN: 17407745     EISSN: None     Source Type: Journal    
DOI: 10.1191/1740774504cn020xx     Document Type: Article
Times cited : (22)

References (49)
  • 2
    • 0018739926 scopus 로고
    • Randomized clinical trials and the doctor-patient relationship: an ethical dilemma
    • Hellman S. Randomized clinical trials and the doctor-patient relationship: an ethical dilemma. Cancer Clin Trials 1979: 2: 189-193.
    • (1979) Cancer Clin Trials , vol.2 , pp. 189-193
    • Hellman, S.1
  • 3
    • 0020325090 scopus 로고
    • The ethics of the randomized clinical trial
    • Schafer A. The ethics of the randomized clinical trial. N Engl J Med 1982; 307, 719-724.
    • (1982) N Engl J Med , vol.307 , pp. 719-724
    • Schafer, A.1
  • 4
    • 85031515789 scopus 로고
    • Medical ethics - two codes of ethics in medicine
    • URL - Last accessed 6 February
    • Zajicek G. Medical ethics - two codes of ethics in medicine. Cancer J 1995; 8: 5. URL - http://www.tribunes.com/tribune/edito/8-5z.htm. Last accessed 6 February 2004.
    • (1995) Cancer J , vol.8 , pp. 5
    • Zajicek, G.1
  • 5
    • 0000559516 scopus 로고
    • Medical ethics and controlled trials
    • Bradford Hill A. Medical ethics and controlled trials. BMJ 1963; 2: 1043-1049.
    • (1963) BMJ , vol.2 , pp. 1043-1049
    • Bradford, H.A.1
  • 6
    • 0023185342 scopus 로고
    • Equipoise and the ethics of clinical research
    • Freedman B. Equipoise and the ethics of clinical research. New Engl J Med 1987; 317: 141-145.
    • (1987) New Engl J Med , vol.317 , pp. 141-145
    • Freedman, B.1
  • 7
    • 0025906439 scopus 로고
    • Of mice but not men: problems of the randomized clinical trial
    • Hellman S., Hellman D.S. Of mice but not men: problems of the randomized clinical trial. New Eng J Med 1991; 324: 1585-1589.
    • (1991) New Eng J Med , vol.324 , pp. 1585-1589
    • Hellman, S.1    Hellman, D.S.2
  • 10
    • 0038523941 scopus 로고    scopus 로고
    • Ethics of clinical trials from a Bayesian and decision analytic perspective: whose equipoise is it anyway?
    • Lilford R.J. Ethics of clinical trials from a Bayesian and decision analytic perspective: whose equipoise is it anyway? BMJ 2003; 326: 980-981.
    • (2003) BMJ , vol.326 , pp. 980-981
    • Lilford, R.J.1
  • 11
    • 0026494486 scopus 로고
    • Randomised controlled trial of laparoscopic versus mini cholecystectomy
    • (quoted by Lefering and Neugebager)
    • Barkun J.S., Barkun A.N., Sampalis J.S., et al. Randomised controlled trial of laparoscopic versus mini cholecystectomy. Lancet 1992; 340: 1116-1119 (quoted by Lefering and Neugebager).
    • (1992) Lancet , vol.340 , pp. 1116-1119
    • Barkun, J.S.1    Barkun, A.N.2    Sampalis, J.S.3
  • 12
    • 0026562213 scopus 로고
    • Laparoscopische Cholezystektomie versus Mini-Lap Cholezystektomy. Ergebnisse einer prospektiven, randomisierten Studie
    • (quoted by Lefering and Neugebager)
    • Kunz R., Orth K., Vogel J., et al. Laparoscopische Cholezystektomie versus Mini-Lap Cholezystektomy. Ergebnisse einer prospektiven, randomisierten Studie. Chirug 1992; 63: 291-295 (quoted by Lefering and Neugebager).
    • (1992) Chirug , vol.63 , pp. 291-295
    • Kunz, R.1    Orth, K.2    Vogel, J.3
  • 13
    • 84868889272 scopus 로고    scopus 로고
    • Problems of randomized controlled trials (RCT) in surgery
    • Heidelberg, 10-11 April Retrieved 5 February, 2004 from:
    • Lefering R and Neugebager E. Problems of randomized controlled trials (RCT) in surgery. Conference Proceedings - Nonrandomized Comparative Clinical Studies, Heidelberg, 10-11 April, 1997. Retrieved 5 February, 2004 from: http://www.symposion.com/nrccs/lefering.htm.
    • (1997) Conference Proceedings - Nonrandomized Comparative Clinical Studies
    • Lefering, R.1    Neugebager, E.2
  • 14
    • 0022317798 scopus 로고
    • Protecting the patient's interest
    • Starzl T.E. Protecting the patient's interest. Kidney Int 1985; 28(Suppl 17): S31-33.
    • (1985) Kidney Int , vol.28 , Issue.17 , pp. S31-S33
    • Starzl, T.E.1
  • 15
    • 84972539422 scopus 로고
    • Ethics and ECMO
    • Berry D.A. Ethics and ECMO, Stat Sci 1989; 4: 306-316.
    • (1989) Stat Sci , vol.4 , pp. 306-316
    • Berry, D.A.1
  • 16
    • 0036728882 scopus 로고    scopus 로고
    • Evidence, belief, and action: the failure of equipoise to resolve the ethical tension in the randomized clinical trial
    • Hellman D. Evidence, belief, and action: the failure of equipoise to resolve the ethical tension in the randomized clinical trial. J Law Med Ethics 2002; 30: 375-380.
    • (2002) J Law Med Ethics , vol.30 , pp. 375-380
    • Hellman, D.1
  • 17
    • 0028116617 scopus 로고
    • Ethics, randomization, and technology assessment
    • Lantos J. Ethics, randomization, and technology assessment. CANCER Supplement 1994; 74: 2653-2656.
    • (1994) CANCER Supplement , vol.74 , pp. 2653-2656
    • Lantos, J.1
  • 19
    • 0035828458 scopus 로고    scopus 로고
    • Equipoise is not synonymous with uncertainty
    • Lilford R.J. Equipoise is not synonymous with uncertainty BMJ 2001; 323: 574.
    • (2001) BMJ , vol.323 , pp. 574
    • Lilford, R.J.1
  • 20
    • 0031822776 scopus 로고    scopus 로고
    • The use of equipoise in clinical trials
    • Chard J.A., Lilford R.J. The use of equipoise in clinical trials. Soc Sci Med 1998; 47: 891-898.
    • (1998) Soc Sci Med , vol.47 , pp. 891-898
    • Chard, J.A.1    Lilford, R.J.2
  • 21
    • 0034706254 scopus 로고    scopus 로고
    • Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial
    • Weijer C., Shapiro S., Glass K., Enkin M. Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial. BMJ 2000; 321: 756-758.
    • (2000) BMJ , vol.321 , pp. 756-758
    • Weijer, C.1    Shapiro, S.2    Glass, K.3    Enkin, M.4
  • 22
    • 0034601804 scopus 로고    scopus 로고
    • Equipoise, a term whose time (if it ever came) has surely gone
    • Sackett D.L. Equipoise, a term whose time (if it ever came) has surely gone. CMAJ 2000; 163: 835-856.
    • (2000) CMAJ , vol.163 , pp. 835-856
    • Sackett, D.L.1
  • 23
    • 85007671041 scopus 로고    scopus 로고
    • Uncertainty about clinical equipoise. There is another exchange on equipoise and uncertainty
    • Sackett D.L. Uncertainty about clinical equipoise. There is another exchange on equipoise and uncertainty. BMJ. 2001; 322(7289): 795-796.
    • (2001) BMJ , vol.322 , Issue.7289 , pp. 795-796
    • Sackett, D.L.1
  • 24
    • 0141797654 scopus 로고    scopus 로고
    • A critique of clinical equipoise. Therapeutic misconception in the ethics of clinical trials
    • Miller F.G., Brody H. A critique of clinical equipoise. Therapeutic misconception in the ethics of clinical trials. Hastings Centre Report 2003; 33: 19-28.
    • (2003) Hastings Centre Report , vol.33 , pp. 19-28
    • Miller, F.G.1    Brody, H.2
  • 25
    • 0041758563 scopus 로고    scopus 로고
    • Failure of equipoise to resolve the ethical tension in a randomized clinical trial
    • Mann H., Djulbegovic B., Gold P. Failure of equipoise to resolve the ethical tension in a randomized clinical trial. J Law Med Ethics 2003; 31: 5-6.
    • (2003) J Law Med Ethics , vol.31 , pp. 5-6
    • Mann, H.1    Djulbegovic, B.2    Gold, P.3
  • 26
    • 0026094298 scopus 로고
    • Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study
    • Benson A.B., Pregler J.P., Bean J.A., Rademaker A.W., Eshler B., Anderson K. Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study. J Clin Oncol 1991; 9: 2067-2075.
    • (1991) J Clin Oncol , vol.9 , pp. 2067-2075
    • Benson, A.B.1    Pregler, J.P.2    Bean, J.A.3    Rademaker, A.W.4    Eshler, B.5    Anderson, K.6
  • 27
    • 0021339672 scopus 로고
    • Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer
    • Taylor K.M., Margolese R.G. and Soskolne C.L. Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. N Engl J Med 1984; 310: 1363-1367.
    • (1984) N Engl J Med , vol.310 , pp. 1363-1367
    • Taylor, K.M.1    Margolese, R.G.2    Soskolne, C.L.3
  • 28
    • 0018222864 scopus 로고
    • Physicians and patients as obstacles to a randomized trial
    • Lacher MJ. Physicians and patients as obstacles to a randomized trial. Clin Res 1978; 26: 375-379.
    • (1978) Clin Res , vol.26 , pp. 375-379
    • Lacher, M.J.1
  • 29
    • 0026636643 scopus 로고
    • Integrating conflicting professional roles: physician participation in randomized clinical trials
    • Taylor K.M. Integrating conflicting professional roles: physician participation in randomized clinical trials. Soc Sci Med 1992; 35: 217-224.
    • (1992) Soc Sci Med , vol.35 , pp. 217-224
    • Taylor, K.M.1
  • 30
    • 0025947304 scopus 로고
    • Randomised clinical trials in general practice: lessons from a failure
    • Tognoni G., Alli C., Avanzini F. et al. Randomised clinical trials in general practice: lessons from a failure. BMJ 1991; 303, 969-971.
    • (1991) BMJ , vol.303 , pp. 969-971
    • Tognoni, G.1    Alli, C.2    Avanzini, F.3
  • 31
    • 0027421475 scopus 로고
    • Randomized controlled trial of potentially life-saving therapies: are they ethical
    • Truog R.D. Randomized controlled trial of potentially life-saving therapies: are they ethical. Coronary Artery Disease 1993; 4: 835-836.
    • (1993) Coronary Artery Disease , vol.4 , pp. 835-836
    • Truog, R.D.1
  • 32
    • 0342293055 scopus 로고
    • A testing time: a doctor's thoughts on having his patients participate in double blind study of ticlopidine
    • Dobkin B.H. A testing time: a doctor's thoughts on having his patients participate in double blind study of ticlopidine. Discover 1990; 11: 86.
    • (1990) Discover , vol.11 , pp. 86
    • Dobkin, B.H.1
  • 33
    • 0030839611 scopus 로고    scopus 로고
    • Making sense of randomisation: responses of parents of critically ill babies to random allocation of treatment in a clinical trial
    • Snowdon C., Garcia J., Elbourne D. Making sense of randomisation: responses of parents of critically ill babies to random allocation of treatment in a clinical trial. Soc Sci Med 1997; 45: 1337-1355.
    • (1997) Soc Sci Med , vol.45 , pp. 1337-1355
    • Snowdon, C.1    Garcia, J.2    Elbourne, D.3
  • 34
    • 0033119953 scopus 로고    scopus 로고
    • Zelen randomization: attitudes of parents participating in a neonatal clinical trial
    • Snowdon C., Elbourne D., Garcia J. Zelen randomization: attitudes of parents participating in a neonatal clinical trial. Cont Clin Trials 1999; 20: 149-171.
    • (1999) Cont Clin Trials , vol.20 , pp. 149-171
    • Snowdon, C.1    Elbourne, D.2    Garcia, J.3
  • 35
    • 0032482697 scopus 로고    scopus 로고
    • Reactions of participants to the results of a randomised controlled trial: exploratory study
    • Snowdon C., Garcia J., Elbourne D. Reactions of participants to the results of a randomised controlled trial: exploratory study. BMJ 1998; 317:21-26.
    • (1998) BMJ , vol.317 , pp. 21-26
    • Snowdon, C.1    Garcia, J.2    Elbourne, D.3
  • 36
    • 84992836276 scopus 로고    scopus 로고
    • Decisions, Decisions: How Do Parents View the Decision They Made About a Randomized Clinical Trial? In Fullford KWM, Dickenson DL, Murray T
    • Oxford: Blackwell
    • Snowdon C., Garcia J., Elbourne D. Decisions, Decisions: How Do Parents View the Decision They Made About a Randomized Clinical Trial? In Fullford KWM, Dickenson DL, Murray T Healthcare Ethics and Human Values: An Introductory Text with Readings and Case Studies. Oxford: Blackwell, 2002: 261-269.
    • (2002) Healthcare Ethics and Human Values: An Introductory Text with Readings and Case Studies , pp. 261-269
    • Snowdon, C.1    Garcia, J.2    Elbourne, D.3
  • 37
    • 0030582184 scopus 로고    scopus 로고
    • UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation
    • UK Collaborative ECMO Trial Group. UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. Lancet 1996; 348: 75-82.
    • (1996) Lancet , vol.348 , pp. 75-82
  • 38
    • 0034701551 scopus 로고    scopus 로고
    • Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25-29 weeks' gestation: a randomised trial
    • Ainsworth S.B., Beresford M.W., Milligan D.W.A. et al. Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25-29 weeks' gestation: a randomised trial. Lancet 2000; 355; 1387-1392.
    • (2000) Lancet , vol.355 , pp. 1387-1392
    • Ainsworth, S.B.1    Beresford, M.W.2    Milligan, D.W.A.3
  • 39
    • 2342582101 scopus 로고    scopus 로고
    • Perinatal pathology in the context of a clinical trial: a review of the literature
    • in press
    • Snowdon C., Elbourne D., Garcia J. Perinatal pathology in the context of a clinical trial: a review of the literature. Arch Dis Child 2004, in press.
    • (2004) Arch Dis Child
    • Snowdon, C.1    Elbourne, D.2    Garcia, J.3
  • 40
    • 2342614169 scopus 로고    scopus 로고
    • Perinatal pathology in the context of a clinical trial: attitudes of neonatologists and pathologists
    • in press
    • Snowdon C., Elbourne D., Garcia J. Perinatal pathology in the context of a clinical trial: attitudes of neonatologists and pathologists. Arch Dis Child 2004, in press.
    • (2004) Arch Dis Child
    • Snowdon, C.1    Elbourne, D.2    Garcia, J.3
  • 41
    • 2342618160 scopus 로고    scopus 로고
    • Perinatal pathology in the context of a clinical trial: attitudes of bereaved parents
    • in press
    • Snowdon C., Elbourne D., Garcia J. Perinatal pathology in the context of a clinical trial: attitudes of bereaved parents. Arch Dis Child 2004, in press.
    • (2004) Arch Dis Child
    • Snowdon, C.1    Elbourne, D.2    Garcia, J.3
  • 42
    • 0020821124 scopus 로고
    • Scientific enquiry and authoritarianism in perinatal care and education
    • Chalmers I. Scientific enquiry and authoritarianism in perinatal care and education. Birth 1983; 10: 3: 151-166.
    • (1983) Birth , vol.10 , Issue.3 , pp. 151-166
    • Chalmers, I.1
  • 44
    • 0022782957 scopus 로고
    • Minimizing harm and maximising benefit during innovation in health care: controlled or uncontrolled experimentation
    • Chalmers I. Minimizing harm and maximising benefit during innovation in health care: controlled or uncontrolled experimentation. Birth 1986; 13: 155-164.
    • (1986) Birth , vol.13 , pp. 155-164
    • Chalmers, I.1
  • 45
    • 0027453807 scopus 로고
    • Fully informed consent can be needlessly cruel
    • Tobias J.S. and Souhami R.L. Fully informed consent can be needlessly cruel. BMJ 1993; 307: 1199-1120.
    • (1993) BMJ , vol.307 , pp. 1120-1199
    • Tobias, J.S.1    Souhami, R.L.2
  • 46
    • 0028281114 scopus 로고
    • Clinical trials - a brave new partnership: a response to Mrs Thornton
    • Baum M. Clinical trials - a brave new partnership: a response to Mrs Thornton. J Med Ethics 1994; 20: 23-25.
    • (1994) J Med Ethics , vol.20 , pp. 23-25
    • Baum, M.1
  • 47
    • 0026500461 scopus 로고
    • Redressing the balance: the ethics of not entering an eligible patient on a randomized clinical trial
    • Segelov E., Tattersall M.H., Coates A.S. Redressing the balance: the ethics of not entering an eligible patient on a randomized clinical trial. Ann Oncol 1992; 3: 103-105.
    • (1992) Ann Oncol , vol.3 , pp. 103-105
    • Segelov, E.1    Tattersall, M.H.2    Coates, A.S.3
  • 48
    • 0037693198 scopus 로고    scopus 로고
    • Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study
    • Mills N., Donovan J.L., Smith M., Jacoby A., Neal D.E., Hamdy F.C. Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study. Control Clin Trials 2003; 24: 272-282.
    • (2003) Control Clin Trials , vol.24 , pp. 272-282
    • Mills, N.1    Donovan, J.L.2    Smith, M.3    Jacoby, A.4    Neal, D.E.5    Hamdy, F.C.6
  • 49
    • 0037037334 scopus 로고    scopus 로고
    • Describing randomisation: patients' and the public's preferences compared with clinicians' preference
    • Jenkins V., Leach L., Fallowfield L., Nicholls K., Newsham A. Describing randomisation: patients' and the public's preferences compared with clinicians' preference. Br J Cancer Res 2002; 87: 854-858.
    • (2002) Br J Cancer Res , vol.87 , pp. 854-858
    • Jenkins, V.1    Leach, L.2    Fallowfield, L.3    Nicholls, K.4    Newsham, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.