Perceptions of equipoise are crucial to trial participation: A qualitative study of men in the ProtecT study

Controlled Clinical Trials

Volumn 24, Issue 3, 2003, Pages 272-282

  Mills, Nicola ^a   Donovan, Jenny L ^a   Smith, Monica ^b   Jacoby, Ann ^c   Neal, David E ^d   Hamdy, Freddie C ^e  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Equipoise; Patients' perceptions; Prostate cancer; Randomized controlled trial; Recruitment; Trial participation

Indexed keywords

ARTICLE; CANCER RESEARCH; CLINICAL RESEARCH; CLINICAL TRIAL; DATA ANALYSIS; HUMAN; INFORMED CONSENT; INTERVIEW; METHODOLOGY; PERCEPTION; PROSTATE CANCER; QUALITATIVE ANALYSIS; RANDOMIZATION; RESEARCH;

EID: 0037693198     PISSN: 01972456     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-2456(03)00020-5     Document Type: Article

References (19)

1. Lovato L.C., Hill K., Hertert S., Hunninghake D.B., Probstfield J.L. Recruitment for controlled clinical trials: literature summary and annotated bibliography. Control Clin Trials. 18:1997;328-357.
2. Tognoni G., Alli C., Avanzini F., et al. Randomised clinical trials in general practice: lessons from a failure. BMJ. 303:1991;969-971.
3. Pringle M., Churchill R. Randomised controlled trials in general practice: gold standard or fool's gold? BMJ. 311:1995;1382-1383.
4. Ross S., Grant A., Counsell C., et al. Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol. 52:1999;1143-1156.
5. Llewellyn-Thomas H.A., McGreal M.J., Thiel E.C., Fine S., Erlichman C. Patients' willingness to enter clinical trials: measuring the association with perceived benefit and preference for decision participation. Soc Sci Med. 32:1991;35-41.
6. Fallowfield L.J., Jenkins V., Brennan C., et al. Attitudes of patients to clinical trials of cancer therapy. Eur J Cancer. 34:1998;1554-1559.
7. Snowdon C., Garcia J., Elbourne D. Making sense of randomization: responses of parents of critically ill babies to random allocation of treatment in a clinical trial. Soc Sci Med. 45:1997;1337-1355.
8. Featherstone K., Donovan J.L. Random allocation or allocation at random? Patient's perspectives of participation in a randomised controlled trial. BMJ. 317:1999;1177-1180.
9. Featherstone K., Donovan J.L. "Why don't they just tell me straight, why allocate it?" The struggle to make sense of participating in a randomised controlled trial. Soc Sci Med. 55:2002;709-719.
10. Freedman B. Equipoise and the ethics of clinical research. N Engl J Med. 317:1987;141-145.
11. Donovan J.L., Mills N., Smith M., et al. Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. BMJ. 325:2002;766-770.
12. Glaser B., Strauss A. The discovery of grounded theory. 1967;Aldine, Chicago.
13. Hammersley M., Atkinson P. Ethnography: principles in practice. 1983;Tavistock, London.
14. Edwards S.J.L., Lilford R.J., Braunholtz D.A., et al. Ethical issues in the design and conduct of randomised controlled trials. Health Technol Assess. 2:1998;1-132.
15. Chard J.A., Lilford R.J. The use of equipoise in clinical trials. Soc Sci Med. 47:1998;891-898.
16. Sackett D.L. Equipoise, a term whose time (if it ever came) has surely gone. CMAJ. 163:2000;835-836.
17. McPherson K. The best and the enemy of the good: randomised controlled trials, uncertainty, and assessing the role of patient choice in medical decision making. J Epidemiol Community Health. 48:1994;6-15.
18. Gorkin L., Schron E.B., Handshaw K., et al. Clinical trial enrollers vs nonenrollers: the cardic arrhythmia suppression trial (CAST) recruitment and enrollment assessment in clinical trials (REACT) project. Control Clin Trials. 17:1996;46-59.
19. Jenkins V., Fallowfield L.J., Souhami R.L., Sawtell M. How do doctors explain randomised clinical trials to their patients? Eur J Cancer. 35:1999;1187-1193.