Platelet-derived growth factor-BB-induced hypertrophy of peritubular smooth muscle cells is mediated by activation of p38 MAP-kinase and of Rho-kinase

Journal of Cellular Physiology

Volumn 207, Issue 1, 2006, Pages 123-131

  Romano, Francesca ^a   Chiarenza, Claudia ^a   Palombi, Fioretta ^a   Filippini, Antonio ^a   Padula, Fabrizio ^a   Ziparo, Elio ^a   De Cesaris, Paola ^b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING TRANSCRIPTION FACTOR 2; ALPHA SMOOTH MUSCLE ACTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE ROCK; RHO GUANOSINE TRIPHOSPHATASE; RHO KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ENLARGEMENT; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; CYTOFLUOROMETRY; ENZYME ACTIVATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MUSCLE FIBER CONTRACTION; MUSCLE HYPERTROPHY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; BLOTTING, WESTERN; CELL ENLARGEMENT; CELLS, CULTURED; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; TESTIS;

ANIMALIA;

EID: 33644882817     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20554     Document Type: Article

References (59)

1. Andrawis NS, Wang E, Abernethy DR. 1996. Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells. Life Sci 59:523-528.
2. Ashida N, Arai H, Yamasaki M, Kita T. 2001. Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis. J Biol Chem 276: 16555-16560.
3. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ. 2001. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294:1704-1708.
4. Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, Lydon NB. 1995. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci USA 92:2558-2562.
5. Chen KD, Chen LY, Huang HL, Lieu CH, Chang YN, Chang MD, Lai YK. 1998. Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. J Biol Chem 273:749-755.
6. Chiarenza C, Filippini A, Tripiciano A, Beccari E, Palombi F. 2000. Platelet-derived growth factor-BB stimulates hypertrophy of peritubular smooth muscle cells from rat testis in primary cultures. Endocrinology 141:2971-2981.
7. Chua BH, Krebs CJ, Chua CC, Diglio CA. 1992. Endothelin stimulates protein synthesis in smooth muscle cells. Am J Physiol 262:E412-E416.
8. Clerk A, Pham FH, Fuller SJ, Sahai E, Aktories K, Marais R, Marshall C, Sugden PH. 2001. Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol 21:1173-1184.
9. De Cesaris P, Starace D, Starace G, Filippini A, Stefanini M, Ziparo E. 1999. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor alpha leads to intercellular adhesion molecule-1 expression. J Biol Chem 274:28978-28982.
10. Etienne-Manneville S, Hall A. 2002. Rho GTPases in cell biology. Nature 420: 629-635.
11. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. 1998. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632.
12. Filippini A, Tripiciano A, Palombi F, Teti A, Paniccia R, Stefanini M, Ziparo E. 1993. Rat testicular myoid cells respond to endothelin: Characterization of binding and signal transduction pathway. Endocrinology 133:1789-1796.
13. Funakoshi Y, Ichiki T, Takeda K, Tokuno T, Iino N, Takeshita A. 2002. Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem 277:18710-18717.
14. Garat C, Van Putten V, Refaat ZA, Dessev C, Ran SY, Nemenoff RA. 2000. Induction of smooth muscle alpha-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen-activated protein kinase. J Biol Chem 275:22537-22543.
15. Geisterfer AA, Owens GK. 1989. Arginine vasopressin-induced hypertrophy of cultured rat aortic smooth muscle cells. Hypertension 14:413-420.
16. Geisterfer AA, Peach MJ, Owens GK 1988. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62:749-756.
17. Halayko AJ, Solway J. 2001. Molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 90:358-368.
18. Halayko AJ, Kartha S, Stelmack GL, McConville J, Tam J, Camoretti-Mercado B, Forsythe SM, Hershenson MB, Solway J. 2004. Phophatidylinositol-3 kinase/ mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation. Am J Respir Cell Mol Biol 31:266-275.
19. Hayashi K, Saga H, Chimori Y, Kimura K, Yamanaka Y, Sobue K 1998. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase. J Biol Chem 273:28860-28867.
20. Hayashi K, Takahashi M, Kimura K, Nishida W, Saga H, Sobue K. 1999. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells. J Cell Biol 145:727-740.
21. Hayashi K, Takahashi M, Nishida W, Yoshida K, Ohkawa Y, Kitabatake A, Aoki J, Arai H, Sobue K. 2001. Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ Res 89:251-258.
22. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. 1993. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 21:391-397.
23. Homcy CJ. 1998. Signaling hypertrophy: How many switches, How many wires. Circulation 97:1890-1892.
24. Ishizuka T, Okajima F, Ishiwara M, Iizuka K, Ichimonji I, Kawata T, Tsukagoshi H, Dobashi K, Nakazawa T, Mori M. 2001. Sensitized mast cells migrate toward the antigen: A response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase. J Immunol 167: 2298-2304.
25. Kaplan-Albuquerque N, Garat C, Desseva C, Jones PL, Nemenoff RA. 2003. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. J Biol Chem 278:39830-39838.
26. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
27. Leeson CR, Leeson TS. 1963. The postnatal development and differentiation of the boundary tissue of the seminiferous tubule of the rat. Anat Rec 147:243-259.
28. Marino MW, Dunbar JD, Wu LW, Ngaiza JR, Han HM, Guo D, Matsushita M, Nairn AC, Zhang Y, Kolesnick R, Jaffe EA, Donner DB. 1996. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine. J Biol Chem 271:28624-28629.
29. Mauro A, Ciccarelli C, De Cesaris P, Scoglio A, Bouche M, Molinaro M, Aquino A, Zani BM. 2002. PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells. J Cell Sci 115:3587-3599.
30. Nemenoff RA. 1998. Vasopressin signaling pathways in vascular smooth muscle. Front Biosci 3:d194-d207.
31. Owens GK. 1995. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75:487-517.
32. Palombi F, Di Carlo C. 1988. Alkaline phosphatase is a marker for myoid cells in cultures of rat peritubular and tubular tissue. Biol Reprod 39:1101-1109.
33. Palombi F, Farini D, Salanova M, de Grossi S, Stefanini M. 1992. Development and cytodifferentiation of peritubular myoid cells in the rat testis. Anat Rec 233:32-40.
34. Paranko J, Pelliniemi LJ, DYm M, Fujiwara K, Pollard T. 1981. Postnatal development of myosin containing cells in the mail rat reproductive tract. In: Byskov AG, Peters H, editors. Development and function of reproductive organs. Excerpta Medica, Amsterdam: Oxford, Princeton, pp 191-198.
35. Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. 2000. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev 14:574-584.
36. Ren XD, Kiosses WB, Schwartz MA. 1999. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18:578-585.
37. Reusch HP, Zimmermann S, Schaefer M, Paul M, Moelling K. 2001. Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276:33630-33637.
38. Rice AB, Ingram JL, Bonner JC. 2002. p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts. Am J Respir Cell Mol Biol 27:759-765.
39. Ross R. 1993. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362:801-809.
40. Rossi F, Ferraresi A, Romagni P, Silvestroni L, Santiemma V. 2002. Angiotensin II stimulates contraction and growth of testicular peritubular myoid cells in vitro. Endocrinology 143:3096-3104.
41. Roy J, Kazi M, Hedin U, Thyberg J. 2001. Phenotypic modulation of arterial smooth muscle cells is associated with prolonged activation of ERK1/2. Differentiation 67:50-58.
42. Santiemma V, Rossi F, Guerrini L, Markouizou A, Pasimeni G, Palleschi S, Fabbrini A. 2001. Adrenomedullin inhibits the contraction of cultured rat testicular peritubular myoid cells induced by endothelin-1. Biol Reprod 64: 619-624.
43. Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS. 2003. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J 22:2788-2797.
44. Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber DS, Alexander RW, Griendling KK. 2004. Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells. Am J Physiol Cell Physiol 287:C494-C499.
45. Thyberg J. 1998. Phenotypic modulation of smooth muscle cells during formation of neointimal thickenings following vascular injury. Histol Histopathol 13: 871-891.
46. Thyberg J, Palmberg L, Nilsson J, Ksiazek T, Sjolund M. 1983. Phenotype modulation in primary cultures of arterial smooth muscle cells. On the role of platelet-derived growth factor. Differentiation 25:156-167.
47. Tripiciano A, Filippini A, Giustiniani Q, Palombi F. 1996. Direct visualization of rat peritubular myoid cell contraction in response to endothelin. Biol Reprod 55:25-31.
48. Tripiciano A, Palombi F, Ziparo E, Filippini A. 1997. Dual control of seminiferous tubule contractility mediated by ETA and ETB endothelin receptor subtypes. FASEB J 11:276-286.
49. Tung PS, Fritz IB. 1990. Characterization of rat testicular peritubular myoid cells in culture: Alpha-smooth muscle isoactin is a specific differentiation marker. Biol Reprod 42:351-365.
50. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. 1997. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389:990-994.
51. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. 1998. p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem 273:15022-15029.
52. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK. 1999. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 274:22699-22704.
53. Virtanen I, Kallajoki M, Narvanen O, Paranko J, Thornell LE, Miettinen M, Lehto VP. 1986. Peritubular myoid cells of human and rat testis are smooth muscle cells that contain desmin-type intermediate filaments. Anat Rec 215:10-20.
54. Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
55. Wang CC, Gurevich I, Draznin B. 2003. Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 52: 2562-2569.
56. Yamakawa T, Tanaka S, Numaguchi K, Yamakawa Y, Motley ED, Ichihara S, Inagami T. 2000. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension 35:313-318.
57. Zetser A, Gredinger E, Bengal E. 1999. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor. J Biol Chem 274:5193-5200.
58. Zhan Y, Kim S, Izumi Y, Izumiya Y, Nakao T, Miyazaki H, Iwao H. 2003. Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression. Arterioscler Thromb Vasc Biol 23:795-801.
59. Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, Eves EM, Rosner MR, Solway J, Hershenson MB. 2004. Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma. Am J Respir Crit Care Med 169:703-711.