Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats

Journal of Parenteral and Enteral Nutrition

Volumn 29, Issue 5, 2005, Pages 315-320

  Evans, Mary E ^a   Tian, Junqiang ^a   Gu, Li H ^a   Jones, Dean P ^a   Ziegler, Thomas R ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CASEIN; CELLULOSE; CHOLINE; DNA; MALTODEXTRIN; MINERAL; NUCLEOSIDE; NUCLEOTIDE; OROTIC ACID; PYRIMIDINE DERIVATIVE; SOYBEAN OIL; STARCH; SUCROSE; TERT BUTYLHYDROQUINONE; URACIL; VITAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; CRYPT CELL; DIET SUPPLEMENTATION; DNA CONTENT; INTESTINE ADAPTATION; INTESTINE VILLUS; JEJUNUM MUCOSA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SHORT BOWEL SYNDROME; SMALL INTESTINE ABSORPTION; SMALL INTESTINE RESECTION; TISSUE GROWTH; ADAPTATION; ANIMAL; CELL DIVISION; CYTOLOGY; DIET THERAPY; DISEASE MODEL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; INTESTINE ABSORPTION; INTESTINE MUCOSA; JEJUNUM; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALIA;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL DIVISION; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; MALE; OROTIC ACID; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SHORT BOWEL SYNDROME; URACIL;

EID: 33644877338     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607105029005315     Document Type: Article

References (50)

1. DiBaise JK, Young RJ, Vanderhoof JA. Intestinal rehabilitation and the short bowel syndrome: part 1. Am J Gastroenterol. 2004;99:1386-1395.
2. DiBaise JK, Young RJ, Vanderhoof JA. Intestinal rehabilitation and the short bowel syndrome: part 2. Am J Gastroenterol. 2004;99:1823-1832.
3. Ziegler TR, Fernandez-Estivariz C, Gu LH, et al. Distribution of the H+/peptide transporter pept1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr. 2002;75:922-930.
4. Fukushima T, Ziegler TR. Liver disease and parenteral nutrition. In: Zakim DM, Boyer TD, eds. Hepatology: A Textbook of Liver Disease. 4th ed. Philadelphia, PA: W.B. Saunders Co; 2003:1677-1698.
5. Howard L, Ashley C. Management of complications in patients receiving home parenteral nutrition. Gastroenterology. 2003;124:1651-1661.
6. O'Keefe SJ, Burnes JU, Thompson RL. Recurrent sepsis in home parenteral nutrition patients: an analysis of risk factors. JPEN J Parenter Enteral Nutr. 1994;18:256-263.
7. Byrne TA, Cox S, Karimbakas M, et al. Bowel rehabilitation: an alternative to long-term parenteral nutrition and intestinal transplantation for some patients with short bowel syndrome. Transplant Proc. 2002;34:887-890.
8. Jeppesen PB, Mortensen PB. Enhancing bowel adaptation in short bowel syndrome. Curr Gastroenterol Rep. 2002;4:338-347.
9. Wilmore DW. Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome. Best Pract Res Clin Gastroenterol. 2003;17:895-906.
10. Buchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology. 2003;124:1111-1134.
11. Hanson WR, Osborne JW, Sharp JG. Compensation by the residual intestine after intestinal resection in the rat, II: influence of postoperative time interval. Gastroenterology. 1977;72:701-705.
12. Hanson WR, Osborne JW, Sharp JG. Compensation by the residual intestine after intestinal resection in the rat, I. influence of amount of tissue removed. Gastroenterology. 1977;72:692-700.
13. Williamson RC. Intestinal adaptation (first of two parts): structural, functional and cytokinetic changes. N Engl J Med. 1978;298:1393-1402.
14. Dowling RH, Booth CC. Structural and functional changes following small intestinal resection in the rat. Clin Sci. 1967;32:139-149.
15. Tappenden KA, Thomson AB, Wild GE, McBurney MI. Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats. Gastroenterology. 1997;112:792-802.
16. Ziegler TR, Mantell MP, Chow JC, Rombeau JL, Smith RJ. Intestinal adaptation after extensive small bowel resection: differential changes in growth and insulin-like growth factor system messenger ribonucleic acids in jejunum and ileum. Endocrinology. 1998;139:3119-3126.
17. Swartz-Basile DA, Wang L, Tang Y, Pitt HA, Rubin DC, Levin MS. Vitamin A deficiency inhibits intestinal adaptation by modulating apoptosis, proliferation, and enterocyte migration. Am J Physiol Gastrointest Liver Physiol. 2003;285:G424-G432.
18. Jarboe MD, Juno RJ, Bernal NP, et al. Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function. Surgery. 2004;136:121-126.
19. Helmrath MA, VanderKolk WE, Can G, Erwin CR, Warner BW. Intestinal adaptation following massive small bowel resection in the mouse. J Am Coll Surg. 1996;183:441-449.
20. Ziegler TR, Evans ME, Fernandez-Estivariz C, Jones DP. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr. 2003;23:229-261.
21. Yang H, Wildhaber BE, Teitelbaum DH. 2003 Harry M. Vars Research Award: keratinocyte growth factor improves epithelial function after massive small bowel resection. JPEN J Parenter Enteral Nutr. 2003;27:198-206.
22. Ziegler TR, Mantell MP, Chow JC, Rombeau JL, Smith RJ. Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration. Am J Physiol. 1996;271:G866-G875.
23. Zhou X, Li YX, Li N, Li JS. Glutamine enhances the gut-trophic effect of growth hormone in rat after massive small bowel resection. J Surg Res. 2001;99:47-52.
24. Washizawa N, Gu LH, Gu L, Openo KP, Jones DP, Ziegler TR. Comparative effects of glucagon-like peptide-2 (GLP-2), growth hormone (GH), and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats. JPEN J Parenter Enteral Nutr. 2004;28:399-409.
25. Sanchez-Pozo A, Gil A. Nucleotides as semiessential nutritional components. Br J Nutr. 2002;87(Suppl 1):S135-S137.
26. Van Buren CT, Rudolph F. Dietary nucleotides: a conditional requirement. Nutrition. 1997;13:470-472.
27. Sanderson IR, He Y. Nucleotide uptake and metabolism by intestinal epithelial cells. J Nutr. 1994;124(Suppl 1):131S-137S.
28. Tsujinaka T, Kishibuchi M, Iijima S, Yano M, Monden M. Nucleotides and intestine. JPEN J Parenter Enteral Nutr. 1999;23(5 Suppl):S74-S77.
29. Ortega MA, Gil A, Sanchez-Pozo A. Maturation status of small intestine epithelium in rats deprived of dietary nucleotides. Life Sci. 1995;56:1623-1630.
30. Lopez-Navarro AT, Ortega MA, Peragon J, Bueno JD, Gil A, Sanchez-Pozo A. Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats. Gastroenterology. 1996;110:1760-1769.
31. Tsujinaka T, Kishibuchi M, Iijima S, Yano M, Monden M. Role of supplementation of a nucleic acid solution on the intestinal mucosa under total parenteral nutrition. Nutrition. 1997;13:369-371.
32. Kishibuchi M, Tsujinaka T, Yano M, et al. Effects of nucleosides and a nucleotide mixture on gut mucosal barrier function on parenteral nutrition in rats. JPEN J Parenter Enteral Nutr. 1997;21:104-111.
33. Adjei AA, Yamauchi K, Chan YC, Konishi M, Yamamoto S. Comparative effects of dietary nucleoside-nucleotide mixture and its components on endotoxin induced bacterial translocation and small intestinal injury in protein deficient mice. Gut. 1996;38:531-537.
34. Carver JD, Saste M, Sosa R, Zaritt J, Kuchan M, Barness LA. The effects of dietary nucleotides on intestinal blood flow in preterm infants. Pediatr Res. 2002;52:425-429.
35. He Y, Chu SH, Walker WA. Nucleotide supplements alter proliferation and differentiation of cultured human (Caco-2) and rat (IEC-6) intestinal epithelial cells. J Nutr. 1993;123:1017-1027.
36. Sato N, Nakano T, Kawakami H, Idota T. In vitro and in vivo effects of exogenous nucleotides on the proliferation and maturation of intestinal epithelial cells. J Nutr Sci Vitaminol (Tokyo). 1999;45:107-118.
37. Iijima S, Tsujinaka T, Kishibuchi M, et al. A total parenteral nutrition solution supplemented with a nucleoside and nucleotide mixture sustains intestinal integrity, but does not stimulate intestinal function after massive bowel resection in rats. J Nutr. 1996;126:589-595.
38. Reeves PG, Rossow KL, Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr. 1993;123:1923-1931.
39. Tang Y, Swartz-Basile DA, Swietlicki EA, Yi L, Rubin DC, Levin MS. Bax is required for resection-induced changes in apoptosis, proliferation, and members of the extrinsic cell death pathways. Gastroenterology. 2004;126:220-230.
40. Iijima S, Tsujinaka T, Kido Y, et al. Intravenous administration of nucleosides and a nucleotide mixture diminishes intestinal mucosal atrophy induced by total parenteral nutrition. JPEN J Parenter Enteral Nutr. 1993;17:265-270.
41. Domeneghini C, Di Giancamillo A, Savoini G, Paratte R, Bontempo V, Dell'Orto V. Structural patterns of swine ileal mucosa following L-glutamine and nucleotide administration during the weaning period: an histochemical and histometrical study. Histol Histopathol. 2004;19:49-58.
42. Arnaud A, Lopez-Pedrosa JM, Torres MI, Gil A. Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea. J Pediatr Gastroenterol Nutr. 2003;37:124-131.
43. Leleiko NS, Martin BA, Walsh M, Kazlow P, Rabinowitz S, Sterling K. Tissue-specific gene expression results from a purine- and pyrimidine-free diet and 6-mercaptopurine in the rat small intestine and colon. Gastroenterology. 1987;93:1014-1020.
44. Evans ME, Jones DP, Ziegler TR. Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. Am J Physiol Gastrointest Liver Physiol. 2005;May 5;[Epub ahead of print] 15878985.
45. McCauley R, Kong SE, Hall J. Glutamine and nucleotide metabolism within enterocytes. JPEN J Parenter Enteral Nutr. 1998;22:105-111.
46. Valdes R, Ortega MA, Casado FJ, et al. Nutritional regulation of nucleoside transporter expression in rat small intestine. Gastroenterology. 2000;119:1623-1630.
47. Scharrer E, Rech KS, Grenacher B. Characteristics of Na(+)-dependent intestinal nucleoside transport in the pig. J Comp Physiol [B]. 2002;172:309-314.
48. Ngo LY, Patil SD, Unadkat JD. Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine. Am J Physiol Gastrointest Liver Physiol. 2001;280:G475-G481.
49. Moyer JD, Henderson JF. Salvage of uridine in the mouse: effect of uridine phosphorylase pretreatment. Biochem Pharmacol. 1985;34:101-105.
50. Uauy R, Quan R, Gil A. Role of nucleotides in intestinal development and repair: implications for infant nutrition. J Nutr. 1994;124(8 Suppl):1436S-1441S.