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Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem. 2000;275:16795-16801.
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Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
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Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003;100:680-684.
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A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene
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Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 2005;46:295-300.
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Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
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WNK1 activates SGK1 to regulate the epithelial sodium channel
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Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003;100:14109-14114.
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Genetic variants of WNK4 in whites and African Americans with hypertension
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Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension. 2003;41:1191-1195.
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Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
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O'Reilly M, Marshall E, Speirs HJ, Brown RW. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol. 2003;14:2447-2456.
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Sodium excretion as modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension
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In press
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Kuznetsova T, Staessen JA, Brand E, Cwynar M, Stolarz K, Thijs L, Tikhonoff V, Wojciechowska W, Babeanu S, Brand-Herrmann SM, Casiglia E, Filipovsky J, Grodzicki T, Nikitin Y, Peleška J, Struijker-Boudier H, Bianchi G, Kawecka-Jaszcz K; European Project On Genes in Hypertension (EPOGH) Investigators. Sodium excretion as modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension. J Hypertens. In press.
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