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Volumn 16, Issue 7, 1997, Pages 345-349

Pharmacological protection of NSAID-induced intestinal permeability in the rat: Effect of tempo and metronidazole as potential free radical scavengers

Author keywords

51Cr EDTA; Intestinal permeability; Metronidazole; Nitric oxide; Non steroidal antiinflammatory drug small intestine

Indexed keywords

EDETATE CHROMIUM CR 51; FLURBIPROFEN; INDOMETACIN; METRONIDAZOLE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SCAVENGER;

EID: 0030841605     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701600701     Document Type: Article
Times cited : (43)

References (35)
  • 1
    • 0024306005 scopus 로고
    • Mechanisms of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs
    • Rainsford KD. Mechanisms of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. Scandinavian Journal of Gastroenterology 1989; 24: 9-16.
    • (1989) Scandinavian Journal of Gastroenterology , vol.24 , pp. 9-16
    • Rainsford, K.D.1
  • 2
    • 0026788165 scopus 로고
    • Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs
    • Allison MC et al. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. New England Journal of Medicine 1992; 327: 751-756.
    • (1992) New England Journal of Medicine , vol.327 , pp. 751-756
    • Allison, M.C.1
  • 3
    • 0027244454 scopus 로고
    • Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine
    • Bjarnason I, Hayllar J, Macpherson AJ, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine. Gastroenterology 1993; 104: 832-847.
    • (1993) Gastroenterology , vol.104 , pp. 832-847
    • Bjarnason, I.1    Hayllar, J.2    Macpherson, A.J.3    Russell, A.S.4
  • 4
    • 0028783342 scopus 로고
    • Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine
    • Davies NM. Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine. Diseases of the Colon and Rectum 1995; 38: 1311-1321.
    • (1995) Diseases of the Colon and Rectum , vol.38 , pp. 1311-1321
    • Davies, N.M.1
  • 5
    • 0026702494 scopus 로고
    • Structure of mitogen inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase
    • Fletcher BS, Kujubu DA, Perrin DM, Herschman HR. Structure of mitogen inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. Journal of Biological Chemistry 1992; 267: 4338-4344.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 4338-4344
    • Fletcher, B.S.1    Kujubu, D.A.2    Perrin, D.M.3    Herschman, H.R.4
  • 6
    • 0028035254 scopus 로고
    • The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs
    • Wallace JL, Cirino G. The development of gastrointestinal-sparing nonsteroidal anti-inflammatory drugs. Trends in Pharmacological Sciences 1994; 15: 405-406.
    • (1994) Trends in Pharmacological Sciences , vol.15 , pp. 405-406
    • Wallace, J.L.1    Cirino, G.2
  • 7
    • 0026632425 scopus 로고
    • Nitric oxide modulates epithelial permeability in the feline small intestine
    • Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. American Journal of Physiology 1992; 262: G1138-G1142.
    • (1992) American Journal of Physiology , vol.262
    • Kubes, P.1
  • 8
    • 0026016313 scopus 로고
    • The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit
    • May GR, Crook P, Moore PK, Page CP. The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. British Journal of Pharmacology 1991; 102: 759-766.
    • (1991) British Journal of Pharmacology , vol.102 , pp. 759-766
    • May, G.R.1    Crook, P.2    Moore, P.K.3    Page, C.P.4
  • 9
    • 0028111408 scopus 로고
    • A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats
    • Rachmilewitz D, Karmeli F, Okon E, Samuni A. A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats. Gut 1994; 35: 1181-1188.
    • (1994) Gut , vol.35 , pp. 1181-1188
    • Rachmilewitz, D.1    Karmeli, F.2    Okon, E.3    Samuni, A.4
  • 10
    • 0028307948 scopus 로고
    • A diclofenac derivative without ulcerogenic properties
    • Wallace JL et al. A diclofenac derivative without ulcerogenic properties. European Journal of Pharmacology 1994; 257: 249-255.
    • (1994) European Journal of Pharmacology , vol.257 , pp. 249-255
    • Wallace, J.L.1
  • 11
    • 0027396551 scopus 로고
    • The actions of nitric oxide donors in the prevention or induction of injury to rat gastric mucosa
    • Lopez-Belmonte J, Whittle BJR, Moncada S. The actions of nitric oxide donors in the prevention or induction of injury to rat gastric mucosa. British Journal of Pharmacology 1993; 108: 73-79.
    • (1993) British Journal of Pharmacology , vol.108 , pp. 73-79
    • Lopez-Belmonte, J.1    Whittle, B.J.R.2    Moncada, S.3
  • 12
    • 0029149469 scopus 로고
    • Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat
    • Ford J, Martin SW, Houston JB. Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat. Journal of Pharmacological and Toxicological Methods 1995; 34: 9-16.
    • (1995) Journal of Pharmacological and Toxicological Methods , vol.34 , pp. 9-16
    • Ford, J.1    Martin, S.W.2    Houston, J.B.3
  • 14
    • 0028151634 scopus 로고
    • Antiinflammatory drug-induced small intestinal permeability. The Rat Is a Suitable Model
    • Davies NM, Wright MR, Jamali F. Antiinflammatory drug-induced small intestinal permeability. The Rat Is a Suitable Model. Pharmaceutical Research 1994; 11: 1652-1656.
    • (1994) Pharmaceutical Research , vol.11 , pp. 1652-1656
    • Davies, N.M.1    Wright, M.R.2    Jamali, F.3
  • 15
    • 0014468568 scopus 로고
    • Small intestinal ulcers and intestinal flora in rats given indomethacin
    • Kent TH, Cardelli RM, Stamler FW. Small intestinal ulcers and intestinal flora in rats given indomethacin. American Journal of Pathology 1969; 54: 237-245.
    • (1969) American Journal of Pathology , vol.54 , pp. 237-245
    • Kent, T.H.1    Cardelli, R.M.2    Stamler, F.W.3
  • 16
    • 0017690751 scopus 로고
    • Resistance of germ free rats to indomethacin-induced intestinal lesions
    • Robert A, Asano T. Resistance of germ free rats to indomethacin-induced intestinal lesions. Prostaglandins 1977; 14: 333-341.
    • (1977) Prostaglandins , vol.14 , pp. 333-341
    • Robert, A.1    Asano, T.2
  • 17
    • 0026551770 scopus 로고
    • A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats
    • Melarange R et al. A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats. Alimentary Pharmacology and Therapeutics 1992; 6: 67-77.
    • (1992) Alimentary Pharmacology and Therapeutics , vol.6 , pp. 67-77
    • Melarange, R.1
  • 18
    • 0021026118 scopus 로고
    • Intestinal perforation associated with osmotic slow release indomethacin capsules
    • Day TK. Intestinal perforation associated with osmotic slow release indomethacin capsules. British Medical Journal 1983; 287: 1672.
    • (1983) British Medical Journal , vol.287 , pp. 1672
    • Day, T.K.1
  • 19
    • 0030022530 scopus 로고    scopus 로고
    • Non-steroidal antiinflammatory drug (NSAID)-induced enteropathy and severe chronic anemia in a patient with rheumatoid arthritis
    • Davies NM, Jamali F, Skeith KJ. Non-steroidal antiinflammatory drug (NSAID)-induced enteropathy and severe chronic anemia in a patient with rheumatoid arthritis. Arthritis and Rheumatism 1996; 39: 321-324.
    • (1996) Arthritis and Rheumatism , vol.39 , pp. 321-324
    • Davies, N.M.1    Jamali, F.2    Skeith, K.J.3
  • 21
    • 0028024181 scopus 로고
    • Nonsteroidal anti-inflammatory induced diaphragm disease of the small intestine: Complexities of diagnosis and management
    • Speed CA, Bramble MG, Corbett WA, Haslock I. Nonsteroidal anti-inflammatory induced diaphragm disease of the small intestine: complexities of diagnosis and management. British Journal of Rheumatology 1994; 33: 778-780.
    • (1994) British Journal of Rheumatology , vol.33 , pp. 778-780
    • Speed, C.A.1    Bramble, M.G.2    Corbett, W.A.3    Haslock, I.4
  • 22
    • 0015576440 scopus 로고
    • Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy
    • Sturges HF, Krone CL. Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy. American Journal of Gastroenterology 1973; 59: 162-169.
    • (1973) American Journal of Gastroenterology , vol.59 , pp. 162-169
    • Sturges, H.F.1    Krone, C.L.2
  • 23
    • 0026785849 scopus 로고
    • Metronidazole reduces intestinal inflammation and blood loss in non-steroidal antiinflammatory drug induced enteropathy
    • Bjarnason I et al. Metronidazole reduces intestinal inflammation and blood loss in non-steroidal antiinflammatory drug induced enteropathy. Gut 1992; 33: 1204-1208.
    • (1992) Gut , vol.33 , pp. 1204-1208
    • Bjarnason, I.1
  • 24
    • 0029164325 scopus 로고
    • Characteristics of ulcers of the small bowel induced by non-steroidal anti-inflammatory drugs in the rat: Implications for clinical practice
    • Collins AJ, Reid J, Soper CJ, Notarianni LJ. Characteristics of ulcers of the small bowel induced by non-steroidal anti-inflammatory drugs in the rat: Implications for clinical practice. British Journal of Rheumatology 1995; 34: 727-731.
    • (1995) British Journal of Rheumatology , vol.34 , pp. 727-731
    • Collins, A.J.1    Reid, J.2    Soper, C.J.3    Notarianni, L.J.4
  • 25
    • 0019351569 scopus 로고
    • Temporal relationship between cycloxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat
    • Whittle BJR. Temporal relationship between cycloxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 1981; 80: 94-98.
    • (1981) Gastroenterology , vol.80 , pp. 94-98
    • Whittle, B.J.R.1
  • 26
    • 0027410796 scopus 로고
    • Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability
    • Davies GR, Wilkie ME, Rampton DS. Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability. Digestive Diseases and Sciences 1993; 38: 417-425.
    • (1993) Digestive Diseases and Sciences , vol.38 , pp. 417-425
    • Davies, G.R.1    Wilkie, M.E.2    Rampton, D.S.3
  • 27
    • 0024528916 scopus 로고
    • The mechanisms of action of nonsteroidal antiinflammatory drugs
    • Abramson SB, Weissmann G. The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis and Rheumatism 1991; 32: 1-8.
    • (1991) Arthritis and Rheumatism , vol.32 , pp. 1-8
    • Abramson, S.B.1    Weissmann, G.2
  • 28
    • 0022591426 scopus 로고
    • Oxygen free radicals interact with indomethacin to cause gastrointestinal injury
    • Del Soldato P, Foschi D, Benoni G, Scarpignato C. Oxygen free radicals interact with indomethacin to cause gastrointestinal injury. Agents and Actions 1985; 17: 484-488.
    • (1985) Agents and Actions , vol.17 , pp. 484-488
    • Del Soldato, P.1    Foschi, D.2    Benoni, G.3    Scarpignato, C.4
  • 30
  • 31
    • 0025043632 scopus 로고
    • The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: A possible mechanism of action of metronidazole in rosacea and acen
    • Akamatsu H et al. The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: A possible mechanism of action of metronidazole in rosacea and acen. Archives of Dermatology Research 1991; 282: 449-454.
    • (1991) Archives of Dermatology Research , vol.282 , pp. 449-454
    • Akamatsu, H.1
  • 32
    • 0023555094 scopus 로고
    • The effects of 5-lipoxygenase inhibitors and leucotriene antagonists on the development of gastric lesions induced by non-steroidal anti-inflammatory drugs in mice
    • Rainsford KD. The effects of 5-lipoxygenase inhibitors and leucotriene antagonists on the development of gastric lesions induced by non-steroidal anti-inflammatory drugs in mice. Agents and Actions 1987; 21: 316-319.
    • (1987) Agents and Actions , vol.21 , pp. 316-319
    • Rainsford, K.D.1
  • 34
    • 0026782056 scopus 로고
    • A critical evaluation of the present status of toxicity of aminoxyl radicals
    • Sosnovsky G. A critical evaluation of the present status of toxicity of aminoxyl radicals. Journal of Pharmaceutical Sciences 1992; 81: 496-499.
    • (1992) Journal of Pharmaceutical Sciences , vol.81 , pp. 496-499
    • Sosnovsky, G.1
  • 35
    • 0029007136 scopus 로고
    • Simultaneous resistance to metronidazole, co-amoxiclav, and imipenem clinical isolate of Bacteroides fragilis
    • Turner P et al. Simultaneous resistance to metronidazole, co-amoxiclav, and imipenem clinical isolate of Bacteroides fragilis. Lancet 1995; 345: 1275-1277.
    • (1995) Lancet , vol.345 , pp. 1275-1277
    • Turner, P.1


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