Omeprazole attenuates oxygen-derived free radical production from human neutrophils

Free Radical Biology and Medicine

Volumn 21, Issue 5, 1996, Pages 727-731

  Suzuki, Masayuki ^a   Mori, Mikiji ^a   Miura, Soichiro ^a   Suematsu, Makoto ^a   Fukumura, Dai ^a   Kimura, Hiroyuki ^a   Ishii, Hiromasa ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Free radicals; Lysosomal pH; Neutrophil; Omeprazole; Respiratory burst

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; OXYGEN RADICAL;

ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INFLAMMATION; LEUKOCYTE ACTIVATION; LYSOSOME; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPERFUSION INJURY; RESPIRATORY BURST; STOMACH MUCOSA LESION;

EID: 0029739594     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(96)00180-3     Document Type: Article

References (20)

1. 1. Mattsson, H. Protective effects of omeprazole in the gastric mucosa. Scand. J. Gastroenterol. 86:21; 1986.
2. 2. Wandall, J. H. Effects of omeprazole on neutrophil chemotaxis, superoxide poduction, degranulation, and translocation of cytochrome b-245. Gut 33:617-621; 1992.
3. 3. Wallace, J. L.; Arfors, K-E.; McKnight, G. W. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 100:878-883; 1991.
4. 4. Asako, H.; Kubes, P.; Wallace, J.; Wolf, R. E.; Granger, D. N. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 103:146-152; 1992.
5. 5. Asako, H.; Kubes, P.; Wallace, J.; Gaginella, T.; Wolf, R. E.; Granger, D. N. Indomethacin-induced leukocyte adhesion in mesenteric venules: Role of lipoxygenase products. Am. J. Physiol. (Gastrointest. Liver Physiol.) 262:G903-G908; 1992.
6. 6. Sugiyama, T.; Yabana, T.; Yachi, A. Mucosal immune response and cytotoxic mechanism in Helicobacter pylori gastritis. In: Tsuchiya, M.; Yodoi, J.; Hibi, T.; Miura, S. eds. Current topics in mucosal immunology 1993. Amsterdam: Elsevier Science; 1994:143-146.
7. 7. Nielsen, H.; Andersen, L. P. Activation of human phagocyte oxidative metabolism by Helicobacter pylori. Gastroenterology 103:1747-1753; 1992.
8. 8. Suzuki, M.; Miura, S.; Suematsu, M.; Fukumura, D.; Kurose, I.; Suzuki, H.; Kai, A.; Kudoh, Y.; Ohashi, M.; Tsuchiya, M. Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am. J. Physiol. (Gastrointest. Liver Physiol) 263:G719-G725; 1992.
9. 9. Crabtree, J. E.; Wyatt, J. I.; Trejdosiewicz, L. K.; Peichl, P.; Nichols, P. H.; Ramsay, N.; Primrose, J. N.; Lindley, J. D. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. J. Clin. Pathol 47:61-66; 1994.
10. 10. Suematsu, M.; Suzuki, M.; Miura, S.; Nagata, H.; Oshio, C.; Asakura, H.; Watanabe, M.; Tsuchiya, M. Sulfasalazine and its metabolites attenuate respiratory burst of leukocyte - A possible mechanism of anti-inflammatory effects. J. Clin. Lab. Immunol. 23:31-33; 1987.
11. 11. Ohkuma, S.; Poole, B. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. USA 75:3327-3331; 1978.
12. +-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 266:17707-17712; 1991.
13. 13. Segal, A. W.; Geisow, M.; Garcia, R.; Harper, A.; Miller, R. The respiratory burst of phagocytic cells is associated with a ríse in vacuolar pH. Nature 290:406-409; 1981.
14. 14. Suzuki, M.; Nakamura, M.; Mori, M.; Miura, S.; Tsuchiya, M.; Ishii, H. Lansoprazole inhibits oxygen-derived free radical production from neutrophils activated by Helicobacter pylori. J. Clin. Gastroenterol. 20(suppl 2):S93-S96; 1995.
15. +ATPase isolated from human gastric mucosa. Scand. J. Gastroenterol. 21:268-272; 1986.
16. 16. Styrt, B.; Klempner, M. S. Inhibition of neutrophil oxidative metabolism by lysosomotropic weak bases. Blood 67:334-342; 1986.
17. 17. Cederberg, C.; Anderson, T.; Skanberg, I. Omeprazole: Pharmacokinetics and metabolism in man. Scand. J. Gastroenterol. 24(Suppl. 166):33-40; 1989.
18. 18. Miura, S.; Suematsu, M.; Tanaka, S.; Nagata, H.; Houzawa, S.; Suzuki, M.; Kurose, I.; Serizawa, H.; Tsuchiya, M. Microcirculatory disturbance in indomethacin-induced intestinal ulcer. Am. J. Physiol. (Gastrointest. Liver Physiol.) 261:G213-G219; 1991.
19. 19. Suematsu, M.; Suzuki, M.; Kitahora, T.; Miura, S.; Suzuki, K.; Hibi, T.; Watanabe, M.; Nagata, H.; Asakura, H.; Tsuchiya, M. Increased respiratory burst of leukocytes in inflammatory bowel disease - The analysis of free radical generation by using chemiluminescence probe. J. Clin. Lab. Immunol. 24:125-128; 1987.
20. 20. Heinzow, U.; Schlegelberger, T. Omeprazole in ulcerative colitis. Lancet 343:477; 1994.