Effects of mild leg exercise in a seated position on haemostatic parameters under normobaric hypoxic conditions

Canadian Journal of Applied Physiology

Volumn 30, Issue 6, 2005, Pages 708-722

  Schiffer, Thorsten ^a   Strüder, Heiko K ^a   Predel, Hans Georg ^a   Hollmann, Wildor ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Haemostasis; Hypoxia; Local aerobic exercise; Thrombosis

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADULT; ANOXIA; ARTICLE; ATMOSPHERIC PRESSURE; BLOOD; BLOOD GAS ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; HEART RATE; HEMATOCRIT; HUMAN; LEG; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AIR PRESSURE; ANOXIA; BLOOD GAS ANALYSIS; EXERCISE; HEART RATE; HEMATOCRIT; HUMANS; LEG; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1;

EID: 33644860300     PISSN: 10667814     EISSN: 15432718     Source Type: Journal    
DOI: 10.1139/h05-150     Document Type: Article

References (48)

1. Andrew, M., Carter, C., O'Brodovich, H., and Heigenhauser, G. (1986). Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity. J. Appl. Physiol. 60: 1917-1922.
2. Barthèlemy, P., Bregeon, F., Zattara-Hartmann, M.C., Humbert-Tena, C., and Jammes, Y. (2001). The change in leg blood flow during and after mild or severe acute hypoxaemia in healthy humans. Clin. Physiol. 21: 308-315.
3. Bärtsch, P. (2001). Hypobaric hypoxia. Lancet 357: 955.
4. Bärtsch, P., Haeberli, A., Franciolli, M., Kruithof, E.K., and Straub, W. (1989). Coagulation and fibrinolysis in acute mountain sickness and beginning pulmonary edema. J. Appl. Physiol. 66: 2136-2144.
5. Bärtsch, P., Haeberli, A., and Straub, P.W. (1990). Blood coagulation after long distance running: Antithrombin III prevents fibrin formation. Thromb. Haemost. 63: 430-334.
6. Bendz, B., Rostrup, M., Sevre, K., Anderson, T.O., and Sandset, P.M. (2000). Association between acute hypobaric hypoxia and activation of coagulation in human beings. Lancet 356: 1657-1658.
7. Bendz, B., and Sandset, P.M. (2003). Acute hypoxia and activation of coagulation. Lancet 361: 2207-2208.
8. Bonnaire, F., Brandt, T., Raedecke, J., and Bonk, A. (1994). Mechanical dynamic ankle passive motion for physical prevention of thrombosis? Changes in haemodynamics in the lower pressure system with new dynamic splints. Unfallchirurg 97: 366-371.
9. Crosby, A., Talbot, N.P., Harrison, P., Keeling, D., and Robbins, P.A. (2003). Relation between acute hypoxia and activation of coagulation in human beings. Lancet 28: 2207-2208.
10. Davis, G.L., Abildgaard, C.T., Bernauer, E.M., and Britton, M. (1976). Fibrinolytic and haemostatic changes during and after maximal exercise in males. J. Appl. Physiol. 40: 287-292.
11. Dufaux, B., Order, U., and Liesen, H. (1990). Effect of a short maximal physical exercise on coagulation, fibrinolysis, and complement system. Ink J. Sports Med. 12: 38-42.
12. Egeberg, O. (1965). Inherited antithrombin deficiency causing thrombophilia. Thromb. Diath. Haemorr. 13: 516-530.
13. Eklof, B., Kistner, R.L., Masuda, E.M., Sonntag, B.V., and Wong, H.P. (1996). Venous thrombembolism in association with prolonged air travel. Dermatol. Surg. 22: 637-641.
14. El-Sayed, M. (1993). Fibrinolytic and haemostatic parameter response after resistance exercise. Med. Sci. Sports Exerc. 25: 597-602.
15. Fink, T., Kazlauskas, A., Poellinger, L., Ebbesen, P., and Zachar, V. (2002). Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99: 2077-2083.
16. Gertler, J.P., Perry, L., L'Italien, G., Chung-Welch, N., Cambria, R.P., Orkin, R., and Abbot, W.M. (1993). Ambient oxygen tension modulates endothelial fibrinolysis. J. Vasc. Surg. 18: 939-946.
17. Gertler, J.P., Weibe, D.A., Ocasio, V.H., and Abbot, W.M. (1991). Hypoxia induces procoagulant activity in cultured human venous endothelium. J. Vasc. Surg. 13: 428-433.
18. Greenleaf, I.E., Rehrer, N.J., Mohler, S.R., Quach, D.T., and Evans, D.G. (2004). Airline chair-rest deconditioning: Induction of immobilisation thrombemboli. Sports Med. 34: 705-725.
19. 2 in venous valve pockets: Its possible bearing on thrombogenesis. Br. J. Surg. 68:166-170.
20. Hegde, S.S., Goldfarb, A.H., and Hedge, S. (2001). Clotting and fibrinolytic activity change during the 1 h after a submaximal run. Med. Sci. Sports Exerc. 33: 887-892.
21. Hodkinson, P.D., Hunt, B.J., Parmar, K., and Ernesting, J. (2003). Is mild normobaric hypoxia a risk factor for venous thrombembolism? J. Thromb. Haemost. 1: 2131-2133.
22. Hughes, R.J., Hopkins, R.J., Hill, S., Weatherall, M., Van de Water, N., Nowitz, M., Milne, D., Ayling, J., Wilsher, M., and Beasley, R. (2003). Frequency of venous thromboembolism in low to moderate risk long distance air travellers: The New Zealand Air Traveller's Thrombosis (NZATT) study. Lancet 20; 362: 2039-2044.
23. Kesteven, P.J., and Robinson, B.J. (2001). Clinical risk factors for venous thrombosis associated with air travel. Aviat. Space. Environ. Med. 72: 125-128.
24. Kesteven, P.L.J. (2000). Traveller's thrombosis. Thorax 55: 32-36.
25. Landgraf, H., Vanselow, B., Schulte-Huermann, D., Mulmann, M. V., and Bergau, L. (1994). Economy class syndrome: Rheology, fluid balance, and lower leg edema during a simulated 12-hour long distance flight. Aviat Space. Environ. Med. 65: 930-935.
26. Lapostolle, F., Surget, V., Borron, S.W., Desmaizieres, M., Sordelet, D., Lapandry, C., Cupa, M., and Adnet, F. (2001). Severe pulmonary embolism associated with air travel. N. Engl. J. Med. 345: 779-783.
27. Levin, E.G., Marzee, Y., Anderson, J., and Harker, L.A. (1984). Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells. J. Clin. Invest. 74: 1988-1995.
28. Makris, P.E., Louizou, C., Markakis, C., Trakiris, D.A., and Mandalaki, T. (1986). Long lasting sitting postition and haemostasis. Thromb. Haemost. 55: 119-121.
29. Mannucci, P.M., Gringeri, A., Peyvandi, F., Di Paolantonio, T., and Mariani, G. (2002). Short-term exposure to high altitude causes coagulation activation and inhibits fibrinolysis. Thromb. Haemost. 87: 342-343.
30. Molz, A.-B., Heyduck, B., Lill, H., Spanuth, E., and Röcker, L. (1993). The effect of different exercise intensities on the fibrinolytic system. Eur. J. Appl. Physiol. 67: 298-304.
31. Moyses, C., Mitchel, C.C., Ledingham, J.G.G., and Cederholm-Williams, S.A. (1985). Haemoconcentration and fibrinolytic activity in foot venous blood during sitting. Clin. Sci. 68: 13.
32. Partsch, H. (2001). Air travel-related deep venous thrombosis. Vienna views. Cardiovasc. Surg. 9: 153-156.
33. Partsch, H., Niessner, H., Bergau, L., Blättler, W., Cerny, J., Gerlach, H., Haas, P., Hirschl, M., Korninger, H., Kyrle, P., Landgraf, H., Mahler, F., Minar, E., Pabinger, I., Prinz, A., Rabe, E., Radner, A., Ramelet, A.A., Schobersberger, W., Schuller-Petrovic, S., Stöberl, C., and Zinnagel, N. (2002). Traveller's thrombosis 2001. V.A.S.A. 31: 66-67.
34. Pinsky, D.J., Liao, H., Lawson, C.A., Yan, S.-F., Chen, J., Carmeliet, P., and Loskutoff, D.J. (1998). Coordination induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J. Clin. Invest 102: 919-928.
35. Prisco, D., Paniccia, R., Bandinelli, B., Fedi, S., Cellai, A.P., Liotta, A.A., Gatteschi, L., Giusti, B., Colella, A., Abbate, R., and Gensini, G.F. (1998). Evaluation of clotting and fibrinolytic activation after protracted physical exercise. Thromb. Res. 89: 73-78.
36. Rankinen, T., Vaisanen, S., Penttila, I., and Rauramaa, R. (1995). Acute and dynamic exercise increases fibrinolytic activity. Thromb. Haemost. 73: 281-286.
37. Risberg, B., and Stenberg, B. (1985). Modulation of tissue fibrinolysis from hypoxia and hyperoxia. Thromb. Res. 38: 129-136.
38. Schobersberger, W., Schobersberger, B., Mittermayr, M., and Fries, D. (2002). Travel-induced thrombosis: An update. Wien. Med. Wochenschr. 152: 445-449.
39. Stegnar, M., Peternel, P., and Chen, J.P. (1987). Acute hypoxemia does not increase blood fibrinolytic activity in man. Thromb. Res. 45: 333-343.
40. Szymanski, L.M., and Pate, R.R. (1994a). Effects of exercise intensity, duration, and time of day on fibrinolytic activity in physically active men. Med. Sci. Sports Exerc. 26: 1102-1108.
41. Szymanski, L.M., and Pate, R.R. (1994b). Fibrinolytic responses to moderate intenstiy exercise. Comparison of physically active and inactive men. Arterioscler. Thromb. 14: 1746-1750.
42. Tardy, B., Tardy-Poncet, B., Bara, L., Laporte-Simitsidis, S., Rascle, F., Samama, M.M., Guyotat, D., and Bertrand, J.C. (1996). Effects of long travels in sitting position in elderly volunteers on biological markers of coagulation activation and fibrinolysis. Thromb. Res. 83: 153-160.
43. Virchow, R. (1856). Gesammelte Abhandlungen zur wissenschaftlichen Medizin [Handbook of research in medicine]. Medinger, Frankfurt.
44. Weiss, C., and Bärtsch, P. (2003). Exercise-induced activation of blood coagulation and fibrinolysis. Dtsch. Z. Sportmed. 54: 130-135.
45. Weiss, C., Seitel, G., and Bärtsch, P. (1998a). Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med. Sci. Sports Exerc. 30: 246-251.
46. Weiss, C., Welsch, B., Albert, M., Friedmann, B., Strobel, G., Jost, J., Nawroth, P., and Bärtsch, P. (1998b). Coagulation and thrombomodulin in response to exercise of different type and duration. Med. Sci. Sports Exerc. 30: 1205-1210.
47. Wu, A., and Mansfield, A.O. (1980). The morphological changes of the endothelium to venous stasis as observed under the scanning electron microscope. J. Cardiovasc. Surg. 21: 193-202.
48. Yan, S.-F., Mackmann, N., Kisiel, W., Stern, D.M., and Pinsky, D.J. (1999). Hypoxia/hypoxemia-induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis. Arterioscler. Thromb. Vasc. Biol. 19: 2029-2035.