Exercise-induced activation of blood coagulation and fibrinolysis;Aktivierung der blutgerinnung und fibrinolyse durch körperliche belastung

Deutsche Zeitschrift fur Sportmedizin

Volumn 54, Issue 5, 2003, Pages 130-135

  Weiss, C ^a,b   Bartsch P ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Medizinische Klinik und Poliklinik V   (Germany)

Author keywords

Coronary artery disease; Exercise; Fibrinolysis; Fibrinopeptide A; Hemostasis

Indexed keywords

EID: 24944490376     PISSN: 03445925     EISSN: 03445925     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Andrew M, Carter C, O'Brodovich H, Heigenhauser G: Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity. J Appl Physiol 60 (1986) 1917-1922.
2. Bärtsch P: Platelet activation with exercise and risk of cardiac events. Lancet 354 (1999) 1747-1748.
3. Bärtsch P, Haeberli A, Straub PW: Blood coagulation after long distance running: antithrombin III prevents fibrin formation. Thromb Haemost 63 (1990) 430-434.
4. Bärtsch P, Schmidt EK, Straub PW: Fibrinopeptide A after strenuous physical exercise at high altitude. J Appl Physiol 53 (1982) 40-43.
5. Bärtsch P, Welsch B, Albert M, Friedmann B, Levi M, Kruithof EKO: Balanced activation of coagulation and fibrinolysis after a 2-h triathlon. Med Sci Sports Exerc 27 (1995) 1465-1470.
6. Bauer KA, Weiss LM, Sparrow D, Vokonas PS, Rosenberg RD: Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study. J Clin Invest 80 (1987) 1527-1534.
7. Biggs R, Macfarlane RG, Pilling J: Observations on fibrinolysis: Experimental activity produced by exercise or adrenaline. Lancet 1 (1947) 402-405.
8. Bounameaux H, Righetti A, de Moerloose P, Bongard O, Reber G: Effects of exercise test on plasma markers of an activation of coagulation and/or fibrinolysis in patients with symptomatic or silent myocardial ischemia. Thromb Res 65 (1992) 27-32.
9. Bourey RE, Santoro SA: Interactions of exercise, coagulation, platelets, and fibrinolysis - a brief review. Med Sci Sports Exerc 20 (1988) 439-446.
10. Britton BJ, Wood WG, Smith M, Hawkey C, Irving MH: The effect of beta adrenergic blockade upon exercise-induced changes in blood coagulation and fibrinolysis. Thromb Haemost 35 (1976) 396-402.
11. Cannon WB: Bodily changes in pain, hunger, fear, and rage. 2nd Ed. New York: Appleton; 1929.
12. Chandler WL, Veith RC, Fellingham GW, Levy WC, Schwartz RS, Cerqueira MD, Kahn SE, Larson VG, Cain KC, Beard JC, Abrass IB, Stratton JR: Fibrinolytic response during exercise and epinephrine infusion in the same subjects. J Am Coll Cardiol 19 (1992) 1412-1420.
13. Cohen RJ, Epstein SE, Cohen LS, Dennis LH: Alterations of fibrinolysis and blood coagulation induced by exercise and the role of beta- adrenergicreceptor stimulation. Lancet 2 (1968) 1264-1266.
14. Cortellaro M, Cofrancesco E, Boschetti C, Mussoni L, Donati MB, Cardillo M, Catalano M, Gabrielli L, Lombardi B, Specchia G, Tavazzi L, Tremoli E, Pozzoli E, Turri M, for the PLAT Group: Increased fibrin turnover and high PAI-1 activity as predictors of ischemic events in atherosclerotic patients: A case-control study. Arterioscler Thromb 13 (1993) 1412-1417.
15. Davis GL, Abildgaard CF, Bernauer EM, Britton M: Fibrinolytic and hemostatic changes during and after maximal exercise in males. J Appl Physiol 40 (1976) 287-292.
16. Dufaux B, Order U, Hollmann W: Can physical exercise induce an effective fibrinolysis? Thromb Res 36 (1984) 37-43.
17. Dill DB, Costill DL: Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37 (1974) 247-248.
18. Edgington TS, Mackman N, Fan ST, Ruf W: Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock. Nouv Rev Fr Hematol 34 (1992) S15-S27.
19. El-Sayed MS: Fibrinolytic and hemostatic parameter response after resistance exercise. Med Sci Sports Exerc 25 (1993) 597-602.
20. El-Sayed MS, Sale C, Jones PG, Chester M: Blood hemostasis in exercise and training. Med Sci Sports Exerc 32 (2000) 918-925.
21. Eriksson-Berg M, Egberg N, Eksborg S, Schenck-Gustafsson K: Retained fibrinolytic response and no coagulation activation after acute physical exercise in middle-aged women with previous myocardial infarction. Thromb Res 105 (2002) 481-486.
22. Ferguson EW, Bernier LL, Banta GR, Yu-Yahiro J, Schoomaker EB: Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J Appl Physiol 62 (1987) 1416-1421.
23. Gunga HC, Kirsch K, Beneke R, Böning D, Hopfenmüller W, Leithauser R, Hutler M, Röcker L: Markers of coagulation, fibrinolysis and angiogenesis after strenuous short-term exercise (wingate-test) in male subjects of varying fitness levels. Int J Sports Med 23 (2002) 495-499.
24. Herren T, Bärtsch P, Haeberli A, Straub PW: Increased thrombin-antithrombin III complexes after 1 hour of physical exercise. J Appl Physiol 73 (1992) 2499-2504.
25. Herren T, Stricker H, Haeberli A, Do D-D, Straub PW: Fibrin formation and degradation in patients with arteriosclerotic disease. Circulation 90 (1994) 2679-2686.
26. Hilberg T, Prasa D, Sturzebecher J, Glaser D, Gabriel HH: Thrombin potential and thrombin generation after exhaustive exercise. Int J Sports Med 23 (2002) 500-504.
27. Hunter J: A treatise on the blood, inflammation, and gun-shot wounds. John Richardson, London;1794, p 88.
28. Iatridis SG, Ferguson JH: Effect of physical exercise on blood clotting and fibrinolysis. J Appl Physiol 18 (1963) 337-344.
29. Ikkala E, Myllylä G, Sarajas HSS: Haemostatic changes associated with exercise. Nature 199 (1963) 459-461.
30. Jilma B, Dirnberger E, Eichler HG, Matulla B, Schmetterer L, Kapiotis S, Speiser W, Wagner OF: Partial blockade of nitric oxide synthase blunts the exercise-induced increase of von Willebrand factor antigen and of factor VIII in man. Thromb Haemost 78 (1997) 1268-1271.
31. Kopitzky RG, Switzer MP, Williams RS, McKee PA: The basis for the increase in factor VIII procoagulant activity during exercise. Thromb Haemost 49 (1983) 53-57.
32. Lassila R, Peltonen S, Lepäntalo M, Saarinen O, Kauhanen P, Manninen V: Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin. Arterioscler Thromb 13 (1993) 1738-1742.
33. Mandalaki T, Dessypris A, Louizou C, Bossinakou I, Panahotopoulou C, Antonopoulou A: Marathon run I: effects on blood coagulation and fibrinolysis. Thromb Haemost 37 (1977) 444-455.
34. Maron BJ, Epstein SE, Roberts WC: Causes of sudden death in competitive athletes. J Am Coll Cardiol 7 (1986) 204-214.
35. Marsh NA, Gaffney PJ: Exercise-induced fibrinolysis - fact or fiction? Thromb Haemost 48 (1982) 201-203.
36. Rankinen T, Väisänen S, Penttilä I, Rauramaa R: Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost 73 (1995) 281-286.
37. Riedler GF, Straub PW, Frick PG: The effect of acute intravascular hemolysis on coagulation and fibrinolysis. II. March hemoglobinemia and hemoglobulinuria. Helv Med Acta 34 (1968) 217-222.
38. Röcker L, Drygas WK, Heyduck B: Blood platelet activation and increase in thrombin activity following a marathon race. Eur J Appl Physiol 55 (1986) 374-380.
39. Röcker L, Taenzer M, Drygas WK, Lill H, Heyduck B, Altenkirch HU: Effect of prolonged physical exercise on the fibrinolytic system. Eur J Appl Physiol 60 (1990) 478-481.
40. Shimokawa H, Vanhoutte PM: Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 64 (1989) 900-914.
41. Siscovick DS, Weiss NS, Fletcher RH, Lasky T: The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med 311 (1984) 874-877.
42. Stegmann H, Kindermann W, Schnabel A: Lactate kinetics and individual anaerobic threshold. Int J Sports Med 2 (1981) 160-165.
43. Streiff M, Bell WR: Exercise and hemostasis in humans. Semin Hematol 31 (1994) 155-165.
44. Van den Burg PJM, Hospers JEH, van Vliet M, Mosterd WL, Huisveld IA: Unbalanced haemostatic changes following strenuous physical exercise: A study in young sedentary males. Eur Heart J 16 (1995) 1995-2001.
45. Vogt A, Hofmann V, Straub PW: Lack of fibrin formation in exercise-induced activation of coagulation. Am J Physiol 236 (1979) H577-579.
46. Weiss C, Bierhaus A, Kinscherf R, Hack V, Luther T, Nawroth PP, Bärtsch P: Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin. J Appl Physiol 92 (2002) 211-218.
47. Weiss C, Seitel G, Bärtsch P: Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med Sci Sports Exerc 30 (1998) 246-251.
48. Weiss C, Velich T, Niebauer J, Hauer K, Kälberer B, Kübler W, Bärtsch P: Activation of coagulation and fibrinolysis after rehabilitative exercise in patients with coronary artery disease. Am J Cardiol 81 (1998) 672-677.
49. Weiss C, Welsch B, Albert M, Friedmann B, Strobel G, Jost J, Nawroth P, Bärtsch P: Coagulation and thrombomodulin in response to exercise of different type and duration. Med Sci Sports Exerc 30 (1998) 1205-1210.
50. Wheeler ME, Davis GL, Gillespie WJ, Bern MM: Physiological changes in hemostasis associated with acute exercise. J Appl Physiol 60 (1986) 986-990.