Differential effect of imipenem treatment on injury caused by cecal ligation and puncture in wild-type and NK cell-deficient β2-microgloblin knockout mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 2, 2006, Pages

  Enoh, Victor T ^a   Lin, Cheng Y ^a   Varma, Tushar K ^a,b   Sherwood, Edward R ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

2 microglobulin knockout mice treated with anti asialoGM1; CD8+ T cells; Cecal ischemia; Inflammation; Natural killer cells; Peritonitis

Indexed keywords

BETA 2 MICROGLOBULIN; CHEMOKINE; GANGLIOTETRAOSYLCERAMIDE; IMIPENEM; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; SODIUM CHLORIDE; ANTIINFECTIVE AGENT; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; CECUM DISEASE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HYPOTHERMIA; INFECTION; INTESTINE INJURY; KERATINOCYTE; KNOCKOUT MOUSE; METABOLIC ACIDOSIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SURVIVAL; WILD TYPE; ACID BASE BALANCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CECUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; INJURY; LIGATION; MICROBIOLOGY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TEMPERATURE;

ACID-BASE EQUILIBRIUM; ANIMALS; ANTI-BACTERIAL AGENTS; BETA 2-MICROGLOBULIN; CECUM; COLONY COUNT, MICROBIAL; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMIPENEM; KILLER CELLS, NATURAL; LIGATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SURVIVAL; TEMPERATURE;

EID: 33644860163     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00338.2005     Document Type: Article

References (34)

1. Burne-Taney MJ, Kofler J, Yokota N, Weisfeldt M, Traystman RJ, and Rabb H. Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury. Am J Physiol Renal Physiol 285: F87-F94, 2003.
2. Doerschug KC, Powers LS, Monick MM, Thorne PS, and Hunninghake GW. Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis. Crit Care Med 32: 489-494, 2004.
3. El Sawy T, Miura M, and Fairchild R. Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am J Pathol 165: 147-157, 2004.
4. Emoto M, Miyamoto M, Yoshizawa I, Emoto Y, Schaible UE, Kita E, and Kaufmann SH. Critical role of NK cells rather than V alpha 14(+)NKT cells in lipopolysaccharide-induced lethal shock in mice. J Immunol 169: 1426-1432, 2002.
5. Heuer JG, Sharma GR, Gerlitz B, Zhang T, Bailey DL, Ding C, Berg DT, Perkins D, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Grinnell B, and Jakubowski JA. Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. Crit Care Med 32: 1570-1578, 2004.
6. Horie Y, Wolf R, Chervenak RP, Jennings SR, and Granger DN. T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion. Microcirculation 6: 267-280, 1999.
7. Kieran NE and Rabb H. Immune responses in kidney preservation and reperfusion injury. J Investig Med 52: 310-314, 2004.
8. Leung FW, Su KC, Pique JM, Thiefin G, Passaro E Jr, and Guth PH. Superior mesenteric artery is more important than inferior mesenteric artery in maintaining colonic mucosal perfusion and integrity in rats. Dig Dis Sci 37: 1329-1335, 1992.
9. Magnotti LJ, Xu DZ, Lu Q, and Deitch EA. Gut-derived mesenteric lymph: a link between burn and lung injury. Arch Surg 134: 1333-1340, 1999.
10. McKay DM. Intestinal inflammation and the gut microflora. Can J Gastroenterol 13: 509-516, 1999.
11. McKay DM. Bacterial superantigens: provocateurs of gut dysfunction and inflammation? Trends Immunol 22: 497-501, 2001.
12. Musch MW, Petrof EO, Kojima K, Ren H, McKay DM, and Chang EB. Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun 72: 3187-3194, 2004.
13. Ogasawara K, Takeda K, Hashimoto W, Satoh M, Okuyama R, Yanai N, Obinata M, Kumagai K, Takada H, Hiraide H, and Seki S. Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. J Immunol 160: 3522-3527, 1998.
14. Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, and Abo T. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol 30: 1919-1928, 2000.
15. Quinn DG, Zajac AJ, Hioe CE, and Frelinger JA. Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice. J Virol 71: 8392-8396, 1997.
16. Remick DG, Bolgos GR, Siddiqui J, Shin J, and Nemzek JA. Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 17: 463-467, 2002.
17. Rolph MS, Raupach B, Kobernick HH, Collins HL, Perarnau B, Lemonnier FA, and Kaufmann SH. MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis. Eur J Immunol 31: 1944-1949, 2001.
18. Sherwood ER, Enoh VT, Murphey ED, and Lin CY. Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture. Lab Invest 84: 1655-1665, 2004.
19. Sherwood ER, Lin CY, Tao W, Hartmann CA, Dujon JE, French AJ, and Varma TK. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 167: 1641-1649, 2003.
20. Shigematsu T, Wolf RE, and Granger DN. T-lymphocytes modulate the microvascular and inflammatory responses to intestinal ischemia-reperfusion. Microcirculation 9: 99-109, 2002.
21. Singleton KD and Wischmeyer PE. Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat. Eur Surg Res 35: 486-491, 2003.
22. Sun XQ, Fu XB, Zhang R, Lu Y, Deng Q, Jiang XG, and Sheng ZY. Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats. World J Gastroenterol 7: 555-558, 2001.
23. Suzuki Y, Deitch EA, Mishima S, Lu Q, and Xu D. Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury. Crit Care Med 28: 3692-3696, 2000.
24. Tao W, Deyo DJ, Traber DL, Johnston WE, and Sherwood ER. Hemodynamic and cardiac contractile function during sepsis caused by cecal ligation and puncture in mice. Shock 21: 31-37, 2004.
25. Tao W, Enoh VT, Lin CY, Johnston WE, Li P, and Sherwood ER. Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1. Am J Physiol Regul Integr Comp Physiol 289: R478-R485, 2005.
26. Tao W and Sherwood ER. β2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis. Am J Physiol Regul Integr Comp Physiol 286: R569-R575, 2004.
27. Turnbull IR, Javadi P, Buchman TG, Hotchkiss RS, Karl IE, and Coopersmith CM. Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock 21: 121-125, 2004.
28. Turnbull IR, Wlzorek JJ, Osborne D, Hotchkiss RS, Coopersmith CM, and Buchman TG. Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock 19: 310-313, 2003.
29. Varma TK, Lin CY, Toliver-Kinsky TE, and Sherwood ER. Endotoxin-induced gamma interferon production: contributing cell types and key regulatory factors. Clin Diagn Lab Immunol 9: 530-543, 2002.
30. Vianna RC, Gomes RN, Bozza FA, Amancio RT, Bozza PT, David CM, and Castro-Faria-Neto HC. Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release. Shock 21: 115-120, 2004.
31. Vyas D, Javadi P, Dipasco PJ, Buchman TG, Hotchkiss RS, and Coopersmith CM. Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die based upon high IL-6 levels. Am J Physiol Regul Integr Comp Physiol 289: R1048-R1053, 2005.
32. Williams DL, Ha T, Li C, Kalbfleisch JH, and Ferguson DA Jr. Early activation of hepatic NFkappaB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality. Ann Surg 230: 95-104, 1999.
33. Yokota N, Daniels F, Crosson J, and Rabb H. Protective effect of T cell depletion in murine renal ischemia-reperfusion injury. Transplantation 74: 759-763, 2002.
34. Ysebaert DK, De Greef KE, De Beuf A, Van Rompay AR, Vercauteren S, Persy VP, and De Broe ME. T cells as mediators in renal ischemia/reperfusion injury. Kidney Int 66: 491-496, 2004.