Differential modulation of a polymorphism in the COOH terminus of the α-subunit of the human epithelial sodium channel by protein kinase Cδ

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 2, 2006, Pages

  Yan, Wusheng ^a   Suaud, Laurence ^a   Kleyman, Thomas R ^c   Rubenstein, Ronald C ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Oocyte; Phosphorylation; Trafficking

Indexed keywords

CALPHOSTIN C; CHIMERIC PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE C DELTA; SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM; FEMALE; GENETIC POLYMORPHISM; IN VITRO STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; ELECTRIC CONDUCTIVITY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ELECTRIC CONDUCTIVITY; EPITHELIAL SODIUM CHANNEL; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; OOCYTES; PHOSPHORYLATION; POLYMORPHISM, GENETIC; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; TRANSFECTION; XENOPUS LAEVIS;

EID: 33644856674     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00277.2005     Document Type: Article

References (35)

1. Ambrosius WT, Bloem LJ, Zhou L, Rebhun JF, Snyder PM, Wagner MA, Guo C, and Pratt JH. Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension 34: 631-637, 1999.
2. + channel. J Gen Physiol 115: 559-570, 2000.
3. Baker E, Jeunemaitre X, Portal AJ, Grimbert P, Markandu N, Persu A, Corvol P, and MacGregor G. Abnormalities of nasal potential difference measurement in Liddle's syndrome. J Clin Invest 102: 10-14, 1998.
4. Baker EH, Dong YB, Sagnella GA, Rothwell M, Onipinla AK, Markandu ND, Cappuccio FP, Cook DG, Persu A, Corvol P, Jeunemaitre X, Carter ND, and MacGregor GA. Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London. Lancet 351: 1388-1392, 1998.
5. Booth RE and Stockand JD. Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade. Am J Physiol Renal Physiol 284: F938-F947, 2003.
6. Canessa CM, Merillat AM, and Rossier BC. Membrane topology of the epithelial sodium channel in intact cells. Am J Physiol Cell Physiol 267: C1682-C1690, 1994.
7. Carattino MD, Hill WG, and Kleyman TR. Arachidonic acid regulates surface expression of epithelial sodium channels. J Biol Chem 278: 36202-36213, 2003.
8. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, and Lifton RP. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet 12: 248-253, 1996.
9. + channel cell surface expression. EMBO J 20: 7052-7059, 2001.
10. Firsov D, Gautschi I, Merillat AM, Rossier BC, and Schild L. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J 17: 344-352, 1998.
11. + channel involves proteolytic processing of the α- and γ-subunits. J Biol Chem 278: 37073-37082, 2003.
12. Hummler E. Epithelial sodium channel, salt intake, and hypertension. Curr Hypertens Rep 5: 11-18, 2003.
13. Hummler E and Horisberger JD. Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases. Am J Physiol Gastrointest Liver Physiol 276: G567-G571, 1999.
14. Johnson J and Capco DG. Progesterone acts through protein kinase C to remodel the cytoplasm as the amphibian oocyte becomes the fertilization- competent egg. Mech Dev 67: 215-226, 1997.
15. Kellenberger S and Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 82: 735-767, 2002.
16. Kerem E, Bistritzer T, Hanukoglu A, Hofmann T, Zhou Z, Bennett W, MacLaughlin E, Barker P, Nash M, Quittell L, Boucher R, and Knowles MR. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med 341: 156-162, 1999.
17. Kosari F, Sheng S, Li J, Mak DO, Foskett JK, and Kleyman TR. Subunit stoichiometry of the epithelial sodium channel. J Biol Chem 273: 13469-13474, 1998.
18. + channels in A6 cells, a regulatory role for protein kinase C. Am J Physiol Renal Fluid Electrolyte Physiol 256: F1094-F1103, 1989.
19. 2 is modulated by protein kinase C. J Clin Invest 90: 1328-1334, 1992.
20. + channel. J Biol Chem 269: 12981-12986, 1994.
21. Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, Sheng S, and Kleyman TR. Functional polymorphism in the carboxyl terminus of the α-subunit of the human epithelial sodium channel. J Biol Chem 279: 23900-23907, 2004.
22. Saxena A, Hanukoglu I, Saxena D, Thompson RJ, Gardiner RM, and Hanukoglu A. Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel α-, β-, and γ-subunit genes. J Clin Endocrinol Metab 87: 3344-3350, 2002.
23. Sheng S, Li J, McNulty KA, Avery D, and Kleyman TR. Characterization of the selectivity filter of the epithelial sodium channel. J Biol Chem 275: 8572-8581, 2000.
24. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW, Canessa CM, Rossier BC and Lifton RP. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
25. Snyder PM, Cheng C, Prince LS, Rogers JC, and Welsh MJ. Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J Biol Chem 273: 681-684, 1998.
26. Snyder PM, McDonald FJ, Stokes JB, and Welsh MJ. Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Chem 269: 24379-24383, 1994.
27. + channels. J Biol Chem 274: 28484-28490, 1999.
28. + channel. J Biol Chem 277: 5-8, 2002.
29. + channel subunit proteins. J Biol Chem 275: 25760-25765, 2000.
30. Sugiyama T, Kato N, Ishinaga Y, Yamori Y, and Yazaki Y. Evaluation of selected polymorphisms of the Mendelian hypertensive disease genes in the Japanese population. Hypertens Res 24: 515-521, 2001.
31. + channels. Am J Physiol Cell Physiol 281: C1477-C1486, 2001.
32. Yan W, Samaha FF, Ramkumar M, Kleyman TR, and Rubenstein RC. Cystic fibrosis transmembrane conductance regulator differentially regulates human and mouse epithelial sodium channels in Xenopus oocytes. J Biol Chem 279: 23183-23192, 2004.
33. Yanase M and Handler JS. Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am J Physiol Cell Physiol 250: C517-C522, 1986.
34. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, 1984.
35. Zentner MD, Lin HH, Wen X, Kim KJ, and Ann DK. The amiloride-sensitive epithelial sodium channel α-subunit is transcriptionally downregulated in rat parotid cells by the extracellular signal-regulated protein kinase pathway. J Biol Chem 273: 30770-30776, 1998.