Differentiation of the HaCaT keratinocyte cell line: Modulation by adrenomedullin

British Journal of Dermatology

Volumn 154, Issue 4, 2006, Pages 602-608

  Pleguezuelos, O ^a   Kapas, S ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adrenomedullin; Interleukin 6; Keratinocyte differentiation; NF B

Indexed keywords

ADRENOMEDULLIN; CALCIUM; CALCIUM CHLORIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PEPTIDE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRANSCRIPTION FACTOR E2F1;

ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL STRAIN HACAT; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; INCUBATION TIME; INTEGUMENT; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKIN;

ADRENOMEDULLIN; ADULT; CALCIUM CHLORIDE; CELL DIFFERENTIATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-6; KERATINOCYTES; NF-KAPPA B; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33644856165     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2005.07117.x     Document Type: Article

References (44)

1. Kitamura K Kangawa K Kawamoto M et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma Biochem Biophys Res Commun 1993 192 553 60
2. Hinson JP Kapas S Smith DM Adrenomedullin, a multifunctional regulatory peptide Endoc Rev 2000 21 138 67
3. Zudaire E Martinez A Cuttitta F Adrenomedullin and cancer Reg Pept 2003 112 175 83
4. Allaker RP Zhini C Kapas S An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora FEMS Immunol Med Microbiol 1999 23 289 93
5. Elsaesser TH Kahl S Adrenomedullin has multiple roles in disease stress: development and remission of the inflammatory response Microsc Res Tech 2002 57 120 9
6. Kapas S Bansal A Bhargava V et al. Adrenomedullin expression in pathogen-challenged oral epithelial cells Peptides 2001 22 1485 9
7. Martinez A Miller MJ Unsworth EJ Expression of adrenomedullin in normal human lung and in pulmonary tumors Endocrinology 1995 136 4099 105
8. Martinez A Elsasser TH Muro-Cacho C Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument Endocrinology 1997 138 5597 604
9. Tajima A Osamura RY Takekoshi S Distribution of adrenomedullin (AM), proadrenomedullin N-terminal 20 peptide, and AM mRNA in the rat gastric mucosa by immunocytochemistry and in situ hybridization Histochem Cell Biol 1999 112 139 46
10. Cameron VA Fleming AM Novel sites of adrenomedullin gene expression in mouse and rat tissues Endocrinology 1998 139 2253 64
11. Welsch U Unterberger P Hofter E Adrenomedullin in mammalian and human skin glands including the mammary gland Acta Histochem 2002 104 65 72
12. Allaker RP Kapas S Adrenomedullin and mucosal defence: interaction between host and microorganism Reg Pept 2003 112 147 52
13. Pleguezuelos O Hagi-Pavli E Crowther G Kapas S Adrenomedullin signals through NF-κB in epithelial cells FEBS Lett 2004 577 249 54
14. Withers DJ Coppock HA Seufferlein T Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells FEBS Lett 1996 378 83 7
15. Hagi-Pavli E Farthing PM Kapas S Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin Am J Physiol Cell Physiol 2004 286 C239 46
16. Hagi-Pavli E Farthing PM Henshaw FN Kapas S Presentation of ICAM-1 protein at the cell surface of oral keratinocytes in the presence of adrenomedullin and corticotrophin Cell Physiol Biochem 2005 15 167 74
17. Rothwarf DM Zandi E Natoli G Karin M IKK-γ is an essential regulatory subunit of the IκB kinase complex Nature 1998 395 297 300
18. Takao J Yudate T Das A et al. Expression of NF-κB in epidermis and the relationship between NF-κB activation and inhibition of keratinocyte growth Br J Dermatol 2003 148 680 8
19. Seitz CS Lin Q Deng H Khavari PA Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB Proc Natl Acad Sci USA 1998 95 2307 12
20. Boukamp P Petrussevska RT Breiykreutz D et al. Normal keratinization in a spontaneous immortalized aneuploid human keratinocyte cell line J Cell Biol 1988 106 761 71
21. Schreiber E Matthias P Muller MM Schaffner W Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells Nucl Acids Res 1989 17 6419
22. Gough NM Rapid and quantitative preparation of cytoplasmic RNA from small number of cells Anal Biochem 1988 173 93 5
23. Amrani Y Tliba O Choubey D et al. IFN-γ inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway Am J Physiol Lung Cell Mol Physiol 2003 284 L1063 71
24. Popa C Dicker AJ Dahler AL et al. Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible Br J Dermatol 1999 141 460 8
25. Albertin G Carraro G Parnigotto PP et al. Human skin keratinocytes and fibroblasts express adrenomedullin and its receptors, and adrenomedullin enhances their growth in vitro by stimulating proliferation and inhibiting apoptosis Int J Mol Med 2003 11 635 9
26. Schoop VM Mirancea N Fusenig NE Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts J Invest Dermatol 1999 112 343 53
27. Lavia P Jansen-Durr P E2F target genes and cell-cycle checkpoint control Bioessays 1999 21 221 30
28. Yuspa SH Kilkenny AE Steinert PM et al. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro J Cell Biol 1989 109 1207 17
29. Menon GK Elias PM Lee SH et al. Localization of calcium in murine epidermis following disruption and repair of the permeability barrier Cell Tissue Res 1992 270 503 12
30. Braga VM Hodivala KJ Watt FM Calcium-induced changes in distribution and solubility of cadherins. Integrins and their associated cytoplasmic proteins in human keratinocytes Cell Adhes Commun 1995 3 201 15
31. Green H Easley K Iuchi S Marker succession during the development of keratinocytes from cultured human embryonic stem cells Proc Natl Acad Sci USA 2003 100 15625 30
32. Hohl D De Viragh PA Amiguet-Barras F et al. The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins J Invest Dermatol 1995 104 902 9
33. Gibson DF Ratnam AV Bikle DD Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes J Invest Dermatol 1996 106 154 61
34. Thacher SM Purification of keratinocyte transglutaminase and its expression during squamous differentiation J Invest Dermatol 1989 92 578 84
35. Breitkreutz D Stark HJ Plein P et al. Differential modulation of epidermal keratinization in immortalized (HaCaT) and tumorigenic human skin keratinocytes (HaCaT-ras) by retinoic acid and extracellular Ca2+ Differentiation 1993 54 201 17
36. Bocker U Schottelius A Watson JM et al. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1β-mediated NF-κB activation and IL-8 gene expression in intestinal epithelial cells J Biol Chem 2000 275 12207 13
37. Udono T Takahashi K Nakayama M et al. Adrenomedullin in cultured human retinal pigment epithelial cells Invest Ophthalmol Visual Sci 2000 41 1962 70
38. Allaker RP Kapas S Adrenomedullin expression by gastric epithelial cells in response to infection Clin Diag Lab Immunol 2003 10 546 51
39. Kubo A Minamino N Isumi Y et al. Adrenomedullin production is correlated with differentiation in human leukemia cell lines and peripheral blood monocytes FEBS Lett 1998 426 233 7
40. Kubo A Minamino N Isumi Y et al. Production of adrenomedullin in macrophage cell line and peritoneal macrophage J Biol Chem 1998 273 16730 8
41. Abiko Y Nishimura M Kusano K et al. Upregulated expression of human β defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b J Dermatol Sci 2003 31 225 8
42. Liu AY Destoumieux D Wong AV et al. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation J Invest Dermatol 2002 118 275 81
43. Nilsson MF Sandstedt B Sorensen O et al. The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6 Infect Immun 1999 67 2561 6
44. Brandtzaeg P Gabrielsen TO Dale I et al. The leukocyte protein L1 (calprotectin): a putative nonspecific defence factor at epithelial surfaces Adv Exp Med Biol 1995 371A 201 6