-
1
-
-
1042277977
-
Osteoolastogenesis on tissue-engineered bone
-
Nakagawa K, Abukawa H, Shin MY, et al. Osteoolastogenesis on tissue-engineered bone. Tissue Eng 2004; 10:93-100.
-
(2004)
Tissue Eng
, vol.10
, pp. 93-100
-
-
Nakagawa, K.1
Abukawa, H.2
Shin, M.Y.3
-
2
-
-
11144244638
-
Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment
-
Wang K, Yamamoto H, Chin JR, et al. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem 2004; 279:53848-53856.
-
(2004)
J Biol Chem
, vol.279
, pp. 53848-53856
-
-
Wang, K.1
Yamamoto, H.2
Chin, J.R.3
-
3
-
-
0043208840
-
Articular cartilage functional histomorphology and mechanobiology: A research perspective
-
Wong M, Carter DR. Articular cartilage functional histomorphology and mechanobiology: a research perspective. Bone 2003; 33:1-13.
-
(2003)
Bone
, vol.33
, pp. 1-13
-
-
Wong, M.1
Carter, D.R.2
-
4
-
-
4844225379
-
Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression
-
MacLean JJ, Lee CR, Alini M, Iatridis JC. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. J Orthop Res 2004; 22:1193-1200. Characterization of anabolic and catabolic mRNA response demonstrates that the pattern efforce application is important in regulating gene expression. The type of force is important, but anatomical site matters as well.
-
(2004)
J Orthop Res
, vol.22
, pp. 1193-1200
-
-
MacLean, J.J.1
Lee, C.R.2
Alini, M.3
Iatridis, J.C.4
-
5
-
-
0346368086
-
In situ intercellular mechanics of the bovine outer annulus fibrosus subjected to biaxial strains
-
Bruehlmann SB, Hulme PA, Duncan NA. In situ intercellular mechanics of the bovine outer annulus fibrosus subjected to biaxial strains. J Biomech 2004; 37:223-231. Intercellular measured strains are smaller and do not correspond to applied strains. Intercellular strains are strongly dependent upon local structure and behavior of the ECM, resulting in nonuniformity, possibly because of relative sliding and recruitment of surrounding collagen fibers.
-
(2004)
J Biomech
, vol.37
, pp. 223-231
-
-
Bruehlmann, S.B.1
Hulme, P.A.2
Duncan, N.A.3
-
7
-
-
2342573679
-
A multi-station dynamic-culture force monitor system to study cell mechanobiology
-
Peperzak KA, Gilbert TW, Wang JH. A multi-station dynamic-culture force monitor system to study cell mechanobiology. Med Eng Phys 2004; 26:355-358.
-
(2004)
Med Eng Phys
, vol.26
, pp. 355-358
-
-
Peperzak, K.A.1
Gilbert, T.W.2
Wang, J.H.3
-
8
-
-
8644219769
-
'Culture shock' from the bone cell's perspective: Emulating physiological conditions for mechanobiological investigations
-
Sorkin AM, Dee KC, Knothe Tate ML 'Culture shock' from the bone cell's perspective: emulating physiological conditions for mechanobiological investigations. Am J Physiol Cell Physiol 2004; 287:C1527-C1536.
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Sorkin, A.M.1
Dee, K.C.2
Knothe Tate, M.L.3
-
9
-
-
0034086263
-
2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts
-
2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts. Am J Physiol Cell Physiol 2000; 278:C989-C997.
-
(2000)
Am J Physiol Cell Physiol
, vol.278
-
-
Chen, N.X.1
Ryder, K.D.2
Pavalko, F.M.3
-
10
-
-
9344258590
-
Mechanotransduction and strain amplification in osteocyte cell processes
-
U S A
-
Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A 2004; 101:16689-16694. A previous model predicting the effects of fluid flow through the pericellular matrix on induction of strains on actin filament bundles is refined here using recent ultrastructural data for the cell process cytoskeleton.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 16689-16694
-
-
Han, Y.1
Cowin, S.C.2
Schaffler, M.B.3
Weinbaum, S.4
-
11
-
-
2442585441
-
Osteocyte dendrogenesis in static and dynamic bone formation: An ultrastructural study
-
Palumbo C, Ferretti M, Marotti G. Osteocyte dendrogenesis in static and dynamic bone formation: an ultrastructural study. Anat Rec A Discov Mol Cell Evol Biol 2004; 278:474-480. An ultrastructural investigation into osteocyte dendro-genesis carried out on the perichondral center of ossification surrounding the mid-shaft level of various long bones. Formation of osteocyte dendrites is very different in the two types of osteogenesis and depends on osteocyte movement.
-
(2004)
Anat Rec A Discov Mol Cell Evol Biol
, vol.278
, pp. 474-480
-
-
Palumbo, C.1
Ferretti, M.2
Marotti, G.3
-
13
-
-
2642519625
-
Mechanical signals as regulators of stem cell fate
-
Estes BT, Gimble JM, Guilak F. Mechanical signals as regulators of stem cell fate. In: Current topics in developmental biology. 2004; 60:91-126. This chapter gives a comprehensive review of various genes up-regulated in response to different types of mechanical loading. The main focus is on the effects of mechanics on the differentiation of stem cells, potentially having an effect on embryonic development.
-
(2004)
In: Current Topics in Developmental Biology.
, vol.60
, pp. 91-126
-
-
Estes, B.T.1
Gimble, J.M.2
Guilak, F.3
-
14
-
-
4844221324
-
+/- mouse
-
+/- mouse. J Orthop Res 2004; 22:1276-1282. Cbfa1 is affected by the absence of one of the paired Cbfal genes, and results in inhibition of intramembranous ossification. In heterozygous Cbfa1 knockout mice, however, distraction osteogenesis was as successful as in control mice.
-
(2004)
J Orthop Res
, vol.22
, pp. 1276-1282
-
-
Isefuku, S.1
Joyner, C.J.2
Reed, A.A.C.3
Simpson, A.H.R.W.4
-
15
-
-
2342511492
-
Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo
-
Justesen J, Pedersen SB, Stenderup K, Kassem M. Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng 2004; 10:381-391. Subcutaneous adipocyte were able to trans-differentiate to bone-forming cells by culturing in osteoblast medium. These cells were able to express osteoblast-like mRNA, although at lower levels compared with cells differentiated from MSCs.
-
(2004)
Tissue Eng
, vol.10
, pp. 381-391
-
-
Justesen, J.1
Pedersen, S.B.2
Stenderup, K.3
Kassem, M.4
-
16
-
-
10744222403
-
CMF608 - A novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells
-
Segev O, Samach A, Faerman A, et al. CMF608 - a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Bone 2004; 34:246-260. A novel gene up-regulated in calvaria in response to mechanical force, CMF608, was found using microarray analysis. It is a unique marker of early osteochondro-progenitor cells, proposed to maintain cells in an immature state, and is downregulated preceding terminal differentiation.
-
(2004)
Bone
, vol.34
, pp. 246-260
-
-
Segev, O.1
Samach, A.2
Faerman, A.3
-
17
-
-
4344643927
-
WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair
-
French DM, Kaul RJ, D'Souza AL, et al. WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 2004; 165:855-867. Wnt-1 - induced secreted protein 1 expression promotes BMP-2 - induced osteoblastic differentiation, and represses chondrocytic differentiation.
-
(2004)
Am J Pathol
, vol.165
, pp. 855-867
-
-
French, D.M.1
Kaul, R.J.2
D'Souza, A.L.3
-
18
-
-
0036849497
-
Similarities between the Hedgehog and Wnt signaling pathways
-
Kalderon D. Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol 2002; 12:523-531.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 523-531
-
-
Kalderon, D.1
-
19
-
-
0344464720
-
Wnts and Hedgehogs: Lipid-modified proteins and similarities in signaling mechanisms at the cell surface
-
Nusse R. Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 2003; 130:5297-5305.
-
(2003)
Development
, vol.130
, pp. 5297-5305
-
-
Nusse, R.1
-
20
-
-
1842426730
-
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
-
McBeath R, Pirone DM, Nelson CM, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 2004; 6:483-495. Cell shape can regulate differentiation by affecting endogenous RhoA activity, although constitutively active ROCK will result in osteogenesis regardless of shape. Effects of cell shape were studied by use of micro-patterning with islands of fibronectin.
-
(2004)
Dev Cell
, vol.6
, pp. 483-495
-
-
McBeath, R.1
Pirone, D.M.2
Nelson, C.M.3
-
21
-
-
12344262661
-
Skeletal overexpression of gremlin impairs bone formation and causes osteopenia
-
Gazzerro E, Pereira RC, Jorgetti V, et al. Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 2005; 146:655-665. The role of Gremlin in vivo, a BMP antagonist, was investigated. Transgenic mice showed reduced bone volume, with decreased osteoblast numbers and function.
-
(2005)
Endocrinology
, vol.146
, pp. 655-665
-
-
Gazzerro, E.1
Pereira, R.C.2
Jorgetti, V.3
-
22
-
-
21344464386
-
Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model
-
Zhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res 2004; 19:2021-2032. Combination gene transfer of BMP-2 and BMP-7 enhanced osteoblastic differentiation over single BMP gene transfer.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 2021-2032
-
-
Zhu, W.1
Rawlins, B.A.2
Boachie-Adjei, O.3
-
23
-
-
11144238386
-
Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization
-
Byers BA, Guldberg RE, Garcia AJ. Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng 2004; 10:1757-1766. Retroviral gene delivery was used to engineer bone marrow stromal cells with constitutive Runx2/Cbfa1 expression. Overexpression significantly up-regulated osteoblastic differentiation and mineralization of tissue-engineered polymer scaffolds.
-
(2004)
Tissue Eng
, vol.10
, pp. 1757-1766
-
-
Byers, B.A.1
Guldberg, R.E.2
Garcia, A.J.3
-
24
-
-
3342941827
-
Bono1: A gene associated with regions of deposition of bone and dentine
-
James MJ, Järvinen E, Thesleff I. Bono1: a gene associated with regions of deposition of bone and dentine. Gene Expr Patterns 2004; 4:595-599. Bono1 (bone and odontoblasts) was found to associate with areas of mineralization during bone and tooth development in mice. It is expressed later than bone sialoprotein, but in a complementary manner.
-
(2004)
Gene Expr Patterns
, vol.4
, pp. 595-599
-
-
James, M.J.1
Järvinen, E.2
Thesleff, I.3
-
25
-
-
5444266726
-
Effects of methotrexate on human bone cell responses to mechanical stimulation
-
Elliot KJ, Millward-Sadler SJ, Wright MO, et al. Effects of methotrexate on human bone cell responses to mechanical stimulation. Rheumatology 2004; 43:1226-1231. Methotrexate interferes with integrin-mediated signaling, a mechano-transduction pathway, but showed no effect on mechanically induced changes in collagen I or BMP-4 gene expression.
-
(2004)
Rheumatology
, vol.43
, pp. 1226-1231
-
-
Elliot, K.J.1
Millward-Sadler, S.J.2
Wright, M.O.3
-
26
-
-
2942711895
-
Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways
-
Sakata T, Wang Y, Halloran BP, et al. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res 2004; 19:436-446. Unloading decreases α-5-β-3 integrin expression, which may result in resistance to IGF-I, by undermining its ability to activate signaling pathways.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 436-446
-
-
Sakata, T.1
Wang, Y.2
Halloran, B.P.3
-
27
-
-
16644366879
-
Skeletal unloading alleviates the anabolic action of intermittent PTH(1-34) in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells
-
Tanaka S, Sakai A, Tanaka M, et al. Skeletal unloading alleviates the anabolic action of intermittent PTH(1-34) in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells. J Bone Miner Res 2004; 19:1813-1820. Unloading reduces PTH-induced increase of bone formation and accelerates bone resorption, causing reduced bone mass. The action of PTH is related to the suppression of c-fos mRNA expression.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1813-1820
-
-
Tanaka, S.1
Sakai, A.2
Tanaka, M.3
-
28
-
-
2942722529
-
Bone biomechanical properties in LRP5 mutant mice
-
Akhter MP, Wells DJ, Short SJ, et al. Bone biomechanical properties in LRP5 mutant mice. Bone 2004; 35:162-169. The G171V mutation in LRP5 results in high bone mass phenotype, with greater structural and apparent material strength, stiffness, and percent bone ash weight. This over-adaption may be the result of greater bone formation sensitivity to normal mechanical stimuli.
-
(2004)
Bone
, vol.35
, pp. 162-169
-
-
Akhter, M.P.1
Wells, D.J.2
Short, S.J.3
-
29
-
-
13444295117
-
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
-
Holmen SL, Giambernardi TA, Zylstra CR, et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 2004; 19:2033-2040. Mutations in LRP5 and LRP6 result in decreased bone mass density, with severity dose-dependent. LRP5 and LRP6 both affect bone accumulation but may act at redundant sites.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 2033-2040
-
-
Holmen, S.L.1
Giambernardi, T.A.2
Zylstra, C.R.3
-
30
-
-
0842287568
-
Mechanobiology of mandibular distraction osteogenesis: Experimental analyses with a rat model
-
Loboa EG, Fang TD, Warren SM, et al. Mechanobiology of mandibular distraction osteogenesis: experimental analyses with a rat model. Bone 2004; 34:336-343. Strains in the range of 10-12.5% facilitate a high rate of intramembranous ossification during distraction osteogenesis.
-
(2004)
Bone
, vol.34
, pp. 336-343
-
-
Loboa, E.G.1
Fang, T.D.2
Warren, S.M.3
-
31
-
-
2342438153
-
Magneto-mechanical stimulation of bone growth in a bonded array of ferromagnetic fibres
-
Markaki AE, Clyne W. Magneto-mechanical stimulation of bone growth in a bonded array of ferromagnetic fibres. Biomaterials 2004; 25:4805-4815. Strains sufficient to enhance bone growth can be generated by an externally imposed magnetic field acting on a bonded array of ferromagnetic fibers. This result shows potential for use in clinical treatments.
-
(2004)
Biomaterials
, vol.25
, pp. 4805-4815
-
-
Markaki, A.E.1
Clyne, W.2
-
32
-
-
0023198738
-
Influences of mechanical stress on prenatal and postnatal skeletal development
-
Carter DR, Orr TE, Fyhrie DP, Schurman DJ. Influences of mechanical stress on prenatal and postnatal skeletal development. Clin Orthop Rel Res 1987; 219:237-250.
-
(1987)
Clin Orthop Rel Res
, vol.219
, pp. 237-250
-
-
Carter, D.R.1
Orr, T.E.2
Fyhrie, D.P.3
Schurman, D.J.4
-
33
-
-
0034193415
-
Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: Ion-channel dependent transduction of matrix deformation signals
-
Wu QQ, Chen Q. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp Cell Res 2000; 256:383-391.
-
(2000)
Exp Cell Res
, vol.256
, pp. 383-391
-
-
Wu, Q.Q.1
Chen, Q.2
-
34
-
-
16844375144
-
Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression
-
Tavella S, Biticchi R, Schito A, et al. Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. J Bone Miner Res 2004; 19:1678-1688. Overexpression of SHH causes defects in chondrocytes differentiation, affecting endochondral ossification.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1678-1688
-
-
Tavella, S.1
Biticchi, R.2
Schito, A.3
-
35
-
-
0035929599
-
Indian Hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation
-
Wu QQ, Zhang Y, Chen Q. Indian Hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J Biol Chem 2001; 276:35290-35296.
-
(2001)
J Biol Chem
, vol.276
, pp. 35290-35296
-
-
Wu, Q.Q.1
Zhang, Y.2
Chen, Q.3
-
36
-
-
4544278143
-
Tissue engineering of articular cartilage under the influence of collagen I/III membranes and low oxygen tension
-
Kurz B, Domm C, Jin M, et al. Tissue engineering of articular cartilage under the influence of collagen I/III membranes and low oxygen tension. Tissue Eng 2004; 10:1277-1286.
-
(2004)
Tissue Eng
, vol.10
, pp. 1277-1286
-
-
Kurz, B.1
Domm, C.2
Jin, M.3
-
37
-
-
0037135713
-
DNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure
-
Sironen RK, Karjalainen HM, Eo MA, et al. cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Biochim Biophys Acta 2002; 1591:45-54.
-
(2002)
Biochim Biophys Acta
, vol.1591
, pp. 45-54
-
-
Sironen, R.K.1
Karjalainen, H.M.2
Eo, M.A.3
-
38
-
-
2442681981
-
Indian Hedgehog: A mechanotransduction mediator in condylar cartilage
-
Tang GH, Rabie ABM, Hägg U. Indian Hedgehog: a mechanotransduction mediator in condylar cartilage. J Dent Res 2004; 83:434-438. Mandibular advancement triggers Ihh expression in condylar cartilage, resulting in an increase in mesenchymal cell population. This points to IHH converting mechanical signals to stimulate proliferation.
-
(2004)
J Dent Res
, vol.83
, pp. 434-438
-
-
Tang, G.H.1
Abm, R.2
Hägg, U.3
-
39
-
-
1842581698
-
RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation
-
Wang G, Woods A, Sabari S, et al. RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J Biol Chem 2004; 279:13205-13214. RhoA overexpression increases proliferation of chondrocytes, while inhibition of Rho/ROCK signaling inhibits chondrocytes proliferation and accelerates hypertrophic differentiation.
-
(2004)
J Biol Chem
, vol.279
, pp. 13205-13214
-
-
Wang, G.1
Woods, A.2
Sabari, S.3
-
40
-
-
2942705959
-
The mechanical consequences of mineralization in embryonic bone
-
Tanck E, Van Donkelaar CC, Jepsen KJ, et al. The mechanical consequences of mineralization in embryonic bone. Bone 2004; 35:186-190. Embryonic bones can increase stiffness by up to two orders of magnitude within a day. Stress shielding of hypertrophic chondrocytes may explain cartilage resorption as well as apoptosis caused by lack of nutrients.
-
(2004)
Bone
, vol.35
, pp. 186-190
-
-
Tanck, E.1
Van Donkelaar, C.C.2
Jepsen, K.J.3
-
41
-
-
8544255751
-
Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering
-
Wenger A, Stahl A, Weber H, et al. Modulation of in vitro angiogenesis in a three-dimensional spheroidal coculture model for bone tissue engineering. Tissue Eng 2004; 10:1536-1547.
-
(2004)
Tissue Eng
, vol.10
, pp. 1536-1547
-
-
Wenger, A.1
Stahl, A.2
Weber, H.3
-
42
-
-
16644380299
-
Increase of both angiogenesis and bone mass in response to exercise depends on VEGF
-
Yao Z, Lafage-Proust M-H, Plouët J, et al. Increase of both angiogenesis and bone mass in response to exercise depends on VEGF. J Bone Miner Res 2004; 19:1471-1480. Loading up-regulates VEGF, and blocking VEGF over time can fully prevent exercise-induced bone mass gain.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1471-1480
-
-
Yao, Z.1
Lafage-Proust, M.-H.2
Plouët, J.3
-
43
-
-
3242706026
-
VEGF expression in adult permanent thyroid cartilage: Implications for lack of cartilage ossification
-
Pufe T, Mentlein R, Tsokos M, et al. VEGF expression in adult permanent thyroid cartilage: implications for lack of cartilage ossification. Bone 2004; 35:543-552. Concentrations of VEGF splice forms were found to increase with age for male participants and decrease for female participants.
-
(2004)
Bone
, vol.35
, pp. 543-552
-
-
Pufe, T.1
Mentlein, R.2
Tsokos, M.3
-
45
-
-
12344249771
-
Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stresses
-
Collins JM, Ramamoorthy K, Da Silveira A, et al. Expression of matrix metalloproteinase genes in the rat intramembranous bone during postnatal growth and upon mechanical stresses. J Biomech 2005; 38:485-492. Expression of MMP-2 in sutures at different time points was investigated. MMP-2 expression can be induced by mechanical stresses at times when it is normally not present.
-
(2005)
J Biomech
, vol.38
, pp. 485-492
-
-
Collins, J.M.1
Ramamoorthy, K.2
Da Silveira, A.3
-
46
-
-
4344575677
-
Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones
-
Takahara M, Naruse T, Takagi M, et al. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. J Orthop Res 2004; 22:1050-1057. Matrix metallo-proteinase 9-positive cells cooperate with vascular endothelial cells in cartilage angiogenesis.
-
(2004)
J Orthop Res
, vol.22
, pp. 1050-1057
-
-
Takahara, M.1
Naruse, T.2
Takagi, M.3
-
47
-
-
10344245561
-
Critical roles for collagenase-13 (Mmp13) in development of growth plate cartilage and in endochondral ossification
-
U S A
-
Inada M, Wang Y, Byrne MH, et al. Critical roles for collagenase-13 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 2004; 101:17192-17197. Lack of MMP-13 results in profound defects in growth plate cartilage with increased hypertrophic domains and a delay in endochondral ossification.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 17192-17197
-
-
Inada, M.1
Wang, Y.2
Byrne, M.H.3
-
48
-
-
2942596129
-
Physical signals and solute transport in cartilage under dynamic unconfined compression: Finite element analysis
-
Yao H, Gu WY. Physical signals and solute transport in cartilage under dynamic unconfined compression: finite element analysis. Ann Biomed Eng 2004; 32:380-390.
-
(2004)
Ann Biomed Eng
, vol.32
, pp. 380-390
-
-
Yao, H.1
Gu, W.Y.2
-
49
-
-
4344575380
-
Mechanical environment alters tissue formation patterns during fracture repair
-
Smith-Adaline EA, Volkman SK, Ignelzi MA Jr, et al. Mechanical environment alters tissue formation patterns during fracture repair. J Orthop Res 2004; 22:1079-1085. Strain distributions are correlated with patterns of tissue formation using finite element models.
-
(2004)
J Orthop Res
, vol.22
, pp. 1079-1085
-
-
Smith-Adaline, E.A.1
Volkman, S.K.2
Ignelzi Jr., M.A.3
-
50
-
-
6344284572
-
Genetically linked site-specificity of disuse osteoporosis
-
Judex S, Garman R, Squire M, et al. Genetically linked site-specificity of disuse osteoporosis. J Bone Miner Res 2004; 19:607-613. Genetically distinct strains of mice show different responses to mechanical unloading. A relationship between baseline morphology and sensitivity to mechanics may exist, with genetic effects very site-specific.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 607-613
-
-
Judex, S.1
Garman, R.2
Squire, M.3
-
51
-
-
13844309259
-
Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading
-
Squire M, Donahue L-R, Rubin C, Judex S. Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading. Bone 2004; 35:1353-1360. Trabecular bone shows more change in morphology with unloading, with sex, genotype, and anatomical location defining the response.
-
(2004)
Bone
, vol.35
, pp. 1353-1360
-
-
Squire, M.1
Donahue, L.-R.2
Rubin, C.3
Judex, S.4
|