Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis

Journal of Nutrition

Volumn 136, Issue 3, 2006, Pages

  Uda, Naoto ^a   Kashimoto, Naoki ^a   Sumioka, Isao ^a   Kyo, Eikai ^a   Sumi, Shin Ichiro ^a   Fukushima, Shoji ^b  

^a WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Aged garlic extract; Chemoprevention; Glutathione S transferase; Hepatocarcinogenesis; Medium term bioassay system

Indexed keywords

BROXURIDINE; GARLIC EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER REGENERATION; MALE; NONHUMAN; PARTIAL HEPATECTOMY; RAT;

ALLIUM SATIVUM; ANIMALIA;

EID: 33644845054     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.3.855s     Document Type: Conference Paper

References (49)

1. Wargovich MJ, Uda N, Woods C, Velasco M, McKee K. Allium vegetables: their role in the prevention of cancer. Biochem Soc Trans. 1996;24:811-4.
2. Wargovich MJ, Uda N. Allium vegetables and the potential for chemoprevention of cancer. Adv Exp Med Biol. 1996;401:171-7.
3. Dausch JG, Nixon DW. Garlic: A review of its relationship to malignant disease. Prev Med. 1990;19:346-61.
4. Stavric B. Role of chemopreventers in human diet. Clin Biochem. 1994;27:319-32.
5. Dorant E, van den Brandt PA, Goldbohm RA, Hermus RJJ, Sturmans F. Garlic and its significance for the prevention of cancer in humans: A critical view. Br J Cancer. 1993;67:424-9.
6. Takasugi N, Kotoo K, Fuwa T, Saito H. Effect of garlic on mice exposed to various stresses. Oyo Yakuri. 1984;28:991-1002.
7. Ide N, Lau BHS. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol. 1997;49:908-11.
8. Moriguchi T, Saito H, Nishiyama N. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull. 1996;19:305-7.
9. Nakagawa S, Kasuga S, Matsuura H. Prevention of liver damage by aged garlic extract and its components in mice. Phytother Res. 1989;3:50-3.
10. Sumioka I, Matsuura T, Kasuga S, Itakura Y, Yamada K. Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury on mice. Jpn J Pharmacol. 1998;78:199-207.
11. Lau BH, Yamasaki T, Gridley DS. Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother. 1991;3:103-7.
12. Morioka N, Sze LL, Morton DL, Irie RF. A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin-A. Cancer Immunol Immunother. 1993;37:316-22.
13. Kyo E, Uda N, Kakimoto M, Yokoyama K, Ushijima M, Sumioka I, Kasuga S, Itakura Y. Anti-allergic effects of aged garlic extract. Phytomedicine. 1997;4:335-40.
14. Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S, Itakura Y. Immunomodulation and anti-tumor activities of aged garlic extract. Phytomedicine. 1998;5:259-67.
15. Kyo E, Uda N, Kasuga S, Itakura Y, Sumiyoshi H. Immunomodulatory agents from plants. In: In: Wagner H, editor. Garlic as an immunostimulant. Switzerland: Birkhäuser Verlag Basel; 1999. p. 273-288.
16. Lau BH, Woolly JL, Marsh CL, Barker GR, Koobs DH, Torrey RR. Superiority of intralesional immunotherapy with Corynebacterium parvum and Allium sativum in control of murine transitional cell carcinoma. J Urol. 1986;136:701-5.
17. Amagase H, Milner JA. Impact of various sources of garlic and their constituents on 7,12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis. 1993;14:1627-31.
18. Sumiyoshi H, Wargovich MJ. Chemoprevention of 1,2-dimethylhydrazine- induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res. 1990;50:5084-7.
19. Wargovich MJ, Woods C, Eng VWS, Stephens LC, Gray K. Chemoprevention of n-nitrosomethyl-benzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide. Cancer Res. 1988;48:6872-5.
20. Sparnins VL, Mott AW, Barany G, Wattenberg LW. Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse. Nutr Cancer. 1986;8:211-5.
21. Nishino H, Iwashima A, Itakura Y, Matsuura H, Fuwa T. Antitumorpromoting activity of garlic extracts. Oncology. 1989;46:277-80.
22. Wattenberg LW, Sparnins VL, Barany G. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Cancer Res. 1989;49:2689-92.
23. Nakagawa S, Masamoto K, Sumiyoshi H, Kunihiro K, Fuwa T. Effect of raw garlic and extracted-aged garlic juice on growth of young rats and their organs after per oral administration. J Toxicol Sci. 1980;5:91-112.
24. Shashikanth KN, Basappa SC, Murthy VS. Effect of feeding raw and boiled garlic (A. sativum L.) extracts on the growth, caecal microflora and serum proteins of albino rats. Nutr Rep Int. 1986;33:313-9.
25. Sumiyoshi H, Kanezawa A, Masamoto K, Harada H, Nakagami S, Yokota A, Nishikawa M, Nakagawa S. Chronic toxicity test of garlic extract in rats. J Toxicol Sci. 1984;9:61-75.
26. The Research Group for Population-based Cancer Registration in JapanCancer incidence and incidence rates in Japan in 1997: estimates based on data from 12 population-based cancer registries. Jpn J Clin Oncol. 2002;32:318-22.
27. Ito N, Imaida K, Asamoto M, Shirai T. Early detection of carcinogenic substances and modifiers in rats. Mutat Res. 2000;462:209-17.
28. Moore MA, Tsuda H, Tamano S, Hagiwara A, Imaida K, Shirai T, Ito N. Marriage of a medium-term liver model to surrogate markers-a practical approach for risk and benefit assessment. Toxicol Pathol. 1999;27:237-42.
29. Higgins GM, Anderson RM. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol. 1931;12:186-202.
30. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577-80.
31. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, Aoki T, Uwagawa S, Kagawa M, Ogiso T, et al. Enhancing effects of various hepatocarcinogenesis on induction of preneoplastic glutathione S-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system. Carcinogenesis. 1988;9:387-94.
32. Sato K, Kitahara A, Satoh K, Ishikawa T, Tatematsu M, Ito N. The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis. Gann. 1984;75:199-202.
33. Satoh K, Kitahara A, Soma Y, Inaba Y, Hatayama I, Sato K. Purification, induction and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in rat chemical carcinogenesis. Proc Natl Acad Sci USA. 1985;82:3964-8.
34. Hagiwara A, Matsuda T, Tamano S, Kitano M, Imaoka S, Funae Y, Takesada Y, Shirai T, Fukushima S. Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay. Cancer Lett. 1996;110:155-62.
35. Takada N, Yano Y, Wanibuchi H, Otani S, Fukushima S. S-Methylcysteine and cysteine are inhibitors of induction of glutathione S-transferase placental formpositive foci during initiation and promotion phases of rat hepatocarcinogenesis. Jpn J Cancer Res. 1997;88:435-42.
36. Ito N, Hasegawa R, Imaida K, Takahashi S, Shirai T. Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis. Drug Metab Rev. 1994;26:431-42.
37. Ogiso T, Tatematsu M, Tamano S, Tsuda H, Ito N. Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol Pathol. 1985;13:257-65.
38. Ogiso T, Tatematsu M, Tamano S, Hasegawa R, Ito N. Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis. 1990;11:561-6.
39. Weinberg DS, Manier ML, Richardson MD, Haibach FG. Identification and quantification of organosulfur compliance markers in a garlic extract. J Agric Food Chem. 1993;41:37-41.
40. Ide N, Lau BHS, Ryu K, Matsuura H, Itakura Y. Antioxidant effects of fructosyl arginine, a maillard reaction product in aged garlic extract. J Nutr Biochem. 1999;10:372-6.
41. Kodera Y, Matuura H, Yoshida S, Sumida T, Itakura Y, Fuwa T, Nishino H. Allixin, a stress compound from garlic. Chem Pharm Bull (Tokyo). 1989;37:1656-8.
42. Nishino H, Nishino A, Takayasu J, Iwashima A, Itakura Y, Kodera Y, Matsuura H, Fuwa T. Antitumor-promoting activity of allixin, a stress compound produced by garlic. Cancer J. 1990;3:20-1.
43. Yamasaki T, Teel RW, Lau BH. Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1. Cancer Lett. 1991;59:89-94.
44. Takada N, Matsuda T, Otoshi T, Yano Y, Otani S, Hasegawa T, Nakae D, Konishi Y, Fukushima S. Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver. Cancer Res. 1994;54:2895-9.
45. Takada N, Kitano M, Chen T, Yano Y, Otani S, Fukushima S. Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: Association with increased cell proliferation and elevated ornithine decarboxylase activity. Jpn J Cancer Res. 1994;85:1067-72.
46. Fukushima S, Takada N, Hori T, Wanibuchi H. Cancer prevention by organosulfur compounds from garlic and onion. J Cell Biochem. 1997; Suppl 27:100-5.
47. Iberl E, Winkler G, Knobloch K. Products of allicin transformation: Ajoenes and dithiins, characterization and their determination by HPLC. Planta Med. 1990;56:202-11.
48. Frohlich RH, Kunze M, Kiefer I. Cancer preventive value of natural, nonnutritive food constituents. Acta Med Austriaca. 1997;24:108-13.
49. Yoshida S, Hirao Y, Nakagawa S. Mutagenicity and cytotoxicity tests of garlic. J Toxicol Sci. 1984;9:77-86.