New chromosome abnormalities and lack of BCL-6 gene rearrangements in Argentinean diffuse large B-cell lymphomas

European Journal of Haematology

Volumn 76, Issue 4, 2006, Pages 284-293

  Cerretini, Roxana ^a,b   Noriega, Maria F ^a   Narbaitz, Marina ^a   Slavutsky, Irma ^a  

^a INST DE INVEST HEMATOLOGICAS   (Argentina)

^b Centro Nacional de Genetica Medica de Buenos Aires   (Argentina)

Author keywords

BCL 2 gene; BCL 6 gene; Cytogenetic; Diffuse large B cell lymphoma; Fluorescence in situ hybridization; Molecular studies

Indexed keywords

PROTEIN BCL 6;

ADULT; AGED; ARGENTINA; ARTICLE; B CELL LYMPHOMA; CHROMOSOME 2; CHROMOSOME 6; CHROMOSOME 6Q; CHROMOSOME 8; CHROMOSOME 9; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME LOSS; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; LARGE CELL LYMPHOMA; MALE; MOLECULAR BIOLOGY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ARGENTINA; CHROMOSOMES, HUMAN; DNA-BINDING PROTEINS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; LYMPHOMA, LARGE-CELL, DIFFUSE; MALE; MIDDLE AGED; NEOPLASMS, SECOND PRIMARY; SEQUENCE DELETION; TRANSLOCATION, GENETIC;

EID: 33644842139     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2005.00616.x     Document Type: Article

References (59)

1. H arris NL Mature B-cell neoplasms In J affe ES H arris NL S tein H V ardiman JW eds Pathology & Genetics Tumours of Haematopietic and Lymphoid Tissues. World Health Organization Classification of Tumours (WHO) Lyon IARC Press 2001 118 187
2. M itelman F J ohansson B M ertens F eds Mitelman Database of Catalogue of Chromosome Aberrations in Cancer Available from URL: 2005
3. C haganti RS N anjangud G S chmidt H T eruya -F eldstein J Recurring chromosomal abnormalities in non-Hodgkin's lymphoma: biologic and clinical significance Semin Hematol 2000 37 396 411
4. C igudosa JC P arsa NZ L ouie DC F ilippa DA J hanwar SC J ohansson B M itelman F C haganti RS Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas Genes Chrom Cancer 1999 25 123 133
5. J erkeman M J ohansson B A kerman M C avallin -S tahl E K ristoffersson U M itelman F Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas Eur J Haematol 1999 62 184 190
6. D ave BJ N elson M P ickering DL C han WC G reiner TC W eisenburger DD A rmitage JO S anger WG Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization Cancer Genet Cytogenet 2002 132 125 132
7. N anjangud G R ao PH H egde A T eruya -F eldstein J D onnelly G Q in J J hanwar SC Z elenetz AD C haganti RSK Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma Blood 2002 99 2554 2561
8. Y oshioka T M iura I K ume M et al Cytogenetic features of de novo CD5-positive diffuse large B-cell lymphoma: chromosome aberrations affecting 8p21 and 11q13 constitute major subgroups with different overall survival Genes Chrom Cancer 2005 42 149 157
9. Y e BH R ao PH C haganti RS D alla -F avera R Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma Cancer Res 1993 53 2732 2735
10. B astard C D eweindt C K erckaert JP L enormad B B ossi A P ezzella F F ruchart C D uval C M oncondult M T illy H LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype and clinical outcome in 217 patients Blood 1994 83 2423 2427
11. A isenberg AC W ilkes BM J acobson JO The Bcl-2 gene is rearranged in many diffuse B-cell lymphomas Blood 1988 71 969 972
12. J acobson JO W ilkes BM K waiatkowski DJ M edeiros LJ A isenberg AC H arris NL Bcl-2 rearrangements in de novo diffuse large cell lymphoma. Association with distinctive clinical features Cancer 1993 72 231 236
13. C arbone PP K aplan HS M usshoff K S mithers DW Z uliana M Report of the Committee on Hodgkin's Disease Staning Cancer Res 1971 31 1860 1861
14. M itelman F ed ISCN: An International System for Human Cytogenetic Nomenclature Basel Karger 1995
15. N oriega MF D e Brasi C N arbaitz M S lavutsky I Incidence of BCL-2 gene rearrangements in Argentinean non-Hodgkin lymphoma patients: increased frequency of breakpoints outside of MBR and MCR Blood Cells Mol Dis 2004 32 232 239
16. G ribben LG F reedman AS W oo SD B lake K S hu RS F reeman G L ongtine JA P inkus GS N adler LM All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment Blood 1991 78 3275 3280
17. A kasaka T A kasaka H Y onetani N O hno H Y amabe H F ukuhara S O kuma M Refinement of the BCL-2 immunoglobulin heavy chain fusion gene in t(14;18)(q32;q21) by polymerase chain reaction amplification for long targets Genes Chrom Cancer 1998 21 17 19
18. C erretini R A cevedo S C hena C B elli C L arripa I S lavutsky I Evaluation of constitutional chromosome aberrations in hematologic disorders Cancer Genet Cytogenet 2002 134 133 137
19. F an Y-S R izkalla K Comprehensive cytogenetic analysis including multicolor spectral karyotyping and interphase fluorescence in situ hybridization in lymphoma diagnosis: a summary of 154 cases Cancer Genet Cytogenet 2003 143 73 79
20. C hen P-M Y ang M-H Y u I-T L in J-T L in Y-C F an FS W ang W-S Y en C-C C hiou T-J L iu J-H Low incidence of BCL-6 gene alterations for diffuse large B-cell lymphomas in Taiwan Chinese Cancer 2001 94 2635 2644
21. M uramatsu M A kasaka T K adowaki N O hno H Y amabe H E damura S D oi S M ori T O kuma M F ukuhara S Rearrangement of the BCL-6 gene in B-cell lymphoid neoplasms: comparison with lymphomas associated with BCL-2 rearrangements Brit J Haematol 1996 93 911 920
22. O tt MM R osenwald A K atzenberger T D reyling M K rumdiek AK K alla J G reiner A O tt G M uller -H ermelink HK Marginal zone B-cell lymphomas (MZBL) arising at different sites represent different biological entities Genes Chrom Cancer 2000 28 380 386
23. S himazaki C I naba T S himura K et al. B-cell lymphoma associated with haemophagocytic syndrome: a clinical, immunological and cytogenetic study Br J Haematol 1999 104 672 679
24. F iedler W W eh HJ H ossfeld DK Comparison of chromosome analysis and BCL-1 rearrangement in a series of patients with multiple myeloma Br J Haematol 1992 81 58 61
25. S awyer JR L ukacs JL M unshi N D esikan KR S inghal S M ehta J S iegel D S haughnessy J B arlogie B Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping Blood 1998 92 4269 4278
26. H orsman DE C onnors JM P antzar T G ascoyne RD Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18) Genes Chrom Cancer 2001 30 375 382
27. M organ R C hen Z R ichkind K R oherty S V elasco J S andberg AA PHA/IL2: an efficient mitogen cocktail for cytogenetic studies of non-Hodgkin lymphoma and chronic lymphocytic leukemia Cancer Genet Cytogenet 1999 109 134 137
28. A sou N S anada I T anaka K H idaka M S uzushima H M atsuzaki H K awano F T akatsuki K Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia Cancer Genet Cytogenet 1992 61 197 200
29. B rito -B abapulle V P ittman S M elo JV P arreira L C atovsky D The 14q+ marker in hairy cell leukaemia. A cytogenetic study of 15 cases Leuk Res 1986 10 131 138
30. B erger R F landrin G B ernhein A V alensi F S igaux F D aniel M-T O choa -N oguera MH Cytogenetic studies in 32 malignant lymphomas In S otto JJ V rousos C V incent F eds Non-Hodgkin's Lymphomas: New Techniques and Treatments Basel Karger 1985 79 86
31. L loveras E G ranada I Z amora L et al Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia Cancer Genet Cytogenet 2004 148 71 76
32. B uhmann R K urzeder C R ehklau J W esthaus D B ursch S H iddemann W H aferlach T H allek M S choch C CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B-cell chronic lymphocytic leukaemia cells Br J Haematol 2002 18 968 975
33. M ohamed AN P alutke M E isenberg L A l -K atib A Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant Cancer Genet Cytogenet 2001 126 45 51
34. W hang -P eng J K nutsen T J affe ES S teinberg SM R affeld M Z hao WP D uffey P C ondron K Y ano T L ongo DL Sequential analysis of 43 patients with non-Hodgkin's lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping, and molecular studies Blood 1995 85 203 216
35. B ello MJ R ey JA M oreno S M artinez Castro P B enitez J Cytogenetic study of exudates secondary to hematologic processes Sangre (Barc) 1988 33 165 170
36. H ashimoto K M iura I C hyubachi A S aito M M iura AB Correlations of chromosome abnormalities with histologic and immunologic characteristics in 49 patients from Akita, Japan with non-Hodgkin lymphoma Cancer Genet Cytogenet 1995 81 56 65
37. T sukadaira A O kubo Y O gasawara H U rushibata K H onda T M iura I K ubo K Chromosomal aberrations in intravascular lymphomatosis Am J Clin Oncol 2002 25 178 181
38. N arayan G P ulido HA K oul S et al Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progression Oncogene 2003 22 3489 3499
39. Y amamoto N M izoe JE N umasawa H Y okoe H U zawa K S hibahara T T sujii H N oma H T anzawa H Allelic loss of chromosome 2 in human oral squamous cell carcinoma: correlation with lymph node metastases Oral Oncol 2003 39 64 68
40. L iang H S amanta S N agarajan L SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells Oncogene 2005 24 2625 2634
41. D e Luca A B ernardini L C eccarini C S inibalde L N ovelli A G iustini S D aniele I C alvieri S M ingarelli R Fluorescence in situ hybridization analysis of allelic losses involving the long arm of chromosome 17 in NF1-associated neurofibromas Cancer Genet Cytogenet 2004 150 168 172
42. L ossos IS A lizadeth AA D iehn M W arnke R T horstenson Y O efner PJ B rown PO B otstein D L evy R Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes Proc Natl Acad Sci 2002 99 8886 8891
43. L opez -G uillermo A C abanillas F M cdonell TI et al Correlation of Bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma Blood 1999 93 3081 3087
44. K nuutila S K lefstrom J S zymanska J L akkala T P eltomaki P E ray M T eerenhovi L E lonen E F ranssila KO K aartinen M Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterization Eur J Haematol 1994 52 65 72
45. L adanyi M O ffit K J hanwar SC F ilippa DA C haganti RSK MYC rearrangements and translocations involving band 8q24 in diffuse large-cell lymphomas Blood 1991 77 1057 1063
46. Y ano T J affe ES L ongo DL R affeld M Myc rearrangements in histologically progressed follicular lymphomas Blood 1992 80 758 767
47. K nezevich S L udkovski O S alski C C hhanabhai M L am W K lasa R C onnors JM D yers MJS G ascoyne RD H orsman DE Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas Leukemia 2005 19 659 663
48. J anz S P otter M R abkin C Lymphoma and leukemia associated chromosomal translocation in healthy individuals Gene Chrom Cancer 2003 36 211 223
49. N ordenson I L enner P R oos G Patient with B-cell neoplasia (immunoblastic sarcoma) and the Philadelphia chromosome Cancer Genet Cytogenet 1983 9 37 43
50. F ujii H Y ashige H M isawa S T anaka S U rata Y M atuyama F Ph chromosome in a patient with non-leukemic non-Hodgkin B-cell lymphoma Am J Hematol 1990 35 213 215
51. B ea S C olomo L L ópez -G uillermo A S alaverria I P uig X P inyol M R ives S M ontserrat E C ampo E Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas J Clin Oncol 2004 22 3498 3506
52. M onni O J oensuu H F ranssila K K nuutila S DNA copy number changes in diffuse large B-cell lymphoma. Comparative Genomic Hibridization study Blood 1996 87 5269 5278
53. B erglund M E nblad G F lordal E et al Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization Mod Pathol 2002 15 807 816
54. S andberg AA. In The Chromosomes in Human Cancer and Leukemia 2nd edn New York Elsevier Science Publishing 1990 151 172
55. T sung SH H eckman MG Klinefelter syndrome, immunological disorders, and malignant neoplasm: report of a case Arch Pathol 1974 98 351 354
56. B echer R Klinefelter's syndrome and malignant lymphoma Cancer Genet Cytogenet 1986 21 271 274
57. A ttard -M ontalto SP S chuller I L astowska MA G ibbons B K ingston JE E den OB Non-Hodgkin's lymphoma and Klinefelter syndrome Pediatr Hematol Oncol 1994 11 197 200
58. H umphreys M L avery P M orris C N evin N Klinefelter syndrome and non-Hodgkin lymphoma Cancer Genet Cytogenet 1997 97 111 113
59. O hyashiki K Y oshida MA O hyashiki J B lock AW D abski K S andberg AA Chromosome changes in mycosis fungoides in an XYY male Cancer Genet Cytogenet 1985 18 295 302