Mucociliary clearance in patients with chronic asthma: Effects of β2 agonists

Respirology

Volumn 10, Issue 4, 2005, Pages 426-435

  Daviskas, Evangelia ^a   Anderson, Sandra D ^a   Shaw, Janet ^b   Eberl, Stefan ^a   Seale, J Paul ^c   Yang, Ian A ^b   Young, Iven H ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b THE PRINCE CHARLES HOSPITAL   (Australia)

^c University of Sydney   (Australia)

Author keywords

2 agonists; 2 adrenoceptor polymorphisms; Asthma; Mucociliary clearance

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; IPRATROPIUM BROMIDE; LONG ACTING DRUG; PLACEBO; SALMETEROL; TERBUTALINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ACUTE DRUG ADMINISTRATION; ADOLESCENT; ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; GENETIC POLYMORPHISM; HUMAN; MALE; MUCOCILIARY CLEARANCE; MUCUS SECRETION; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SPUTUM; CHRONIC DISEASE; DRUG ADMINISTRATION; GENETICS; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOPHYSIOLOGY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENERGIC BETA-AGONISTS; ADULT; AGED; ASTHMA; CHRONIC DISEASE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; MUCOCILIARY CLEARANCE; SPIROMETRY; TERBUTALINE;

EID: 33644837523     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2005.00738.x     Document Type: Article

References (49)

1. Wanner A Salathe M O'Riordan TG. State of the art. Mucociliary clearance in the airways. Am. J. Respir. Crit. Care Med. 1996 154 : 1868 902.
2. Djukanovic R Roche WR Wilson JW et al. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 1990 142 : 434 57.
3. Dunnill MS Massarella GR Anderson JA. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969 24 : 176 9.
4. Ordonez CL Khashayar R Wong HH et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. J. Respir. Crit. Care Med. 2001 163 : 517 23.
5. Rogers DF. Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory? Clin. Exp. Allergy 2002 32 : 1124 7.
6. Rogers DF. Airway mucus hypersecretion in asthma: an undervalued pathology? Curr. Opin. Pharmacol. 2004 4 : 241 50.
7. O'Riordan TG Zwang J Smaldone GC. Mucociliary clearance in adult asthma. Am. Rev. Respir. Dis. 1992 146 : 598 603.
8. Hogg JC. Pathology of asthma. J. Allergy Clin. Immunol. 1993 92 : 1 5.
9. Kuyper LM Pare PD Hogg JC et al. Characterization of airway plugging in fatal asthma. Am. J. Med. 2003 115 : 6 11.
10. Salathe M O'Riordan TG Wanner A. Treatment of mucociliary dysfunction. Chest 1996 110 : 1048 57.
11. Barnes PJ Pedersen S Busse WW. Efficacy and safety of inhaled corticosteroids: new developments. Am. J. Respir. Crit. Care Med. 1998 157 : S1 53.
12. Woolcock AJ. Strategies for the management of asthma. Respirology 1996 1 : 79 83.
13. Sanderson MJ Dirksen ER. Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am. Rev. Respir. Dis. 1989 139 : 432 40.
14. Mossberg B Strandberg K Philipson K Camner P. Tracheobronchial clearance in bronchial asthma: response to beta-adrenoceptor stimulation. Scand. J. Respir. Dis. 1976 57 : 119 28.
15. Isawa T Teshima T Hirano T Ebina A Anazawa Y Konno K. Effect of bronchodilation on the deposition and clearance of radioaerosol in bronchial asthma in remission. J. Nucl. Med. 1987 28 : 1901 6.
16. Isawa T Teshima T Hirano T et al. Does a beta 2-stimulator really facilitate mucociliary transport in the human lungs in vivo? A study with procaterol. Am. Rev. Respir. Dis. 1990 141 : 715 20.
17. Bateman JR Pavia D Sheahan NF Newman SP Clarke SW. Effects of terbutaline sulphate aerosol on bronchodilator response and lung mucociliary clearance in patients with mild stable asthma. Br. J. Clin. Pharmacol. 1983 15 : 695 700.
18. Mortensen J Groth S Lange P Hermansen F. Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after inhalation from a pressurised inhaler and a dry powder inhaler. Thorax 1991 46 : 817 23.
19. Mortensen J Lange P Nyboe J Groth S. Lung mucociliary clearance. Eur. J. Nucl. Med. 1994 21 : 953 61.
20. Phipps RJ Williams IP Richardson PS Pell J Pack RJ Wright N. Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro. Clin. Sci. (Lond.) 1982 63 : 23 8.
21. Leikauf GD Ueki IF Nadel JA. Autonomic regulation of viscoelasticity of cat tracheal gland secretions. J. Appl. Physiol. 1984 56 : 426 30.
22. Tay HL Armoogum N Tan LK. Nasal mucociliary clearance and salmeterol. Clin. Otolaryngol. 1997 22 : 68 70.
23. Melloni B Germouty J. The influence of a new beta agonist: formoterol on mucociliary function. Rev. Mal. Respir. 1992 9 : 503 7 (in French).
24. Hasani A Toms N O'Connor J Dilworth JP Agnew JE. Effect of salmeterol xinafoate on lung mucociliary clearance in patients with asthma. Respir. Med. 2003 97 : 667 71.
25. Bennett WD. Effect of beta-adrenergic agonists on mucociliary clearance. J. Allergy Clin. Immunol. 2002 110 : S291 7.
26. Reihsaus E Innis M MacIntyre N Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am. J. Respir. Cell Mol. Biol. 1993 8 : 334 9.
27. Green SA Rathz DA Schuster AJ Liggett SB. The Ile164 beta (2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G (s). Eur. J. Pharmacol. 2001 421 : 141 7.
28. McGraw DW Forbes SL Kramer LA Liggett SB. Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J. Clin. Invest. 1998 102 : 1927 32.
29. Robinson M Eberl S Tomlinson C et al. Regional mucociliary clearance in patients with cystic fibrosis. J. Aerosol Med. 2000 13 : 73 86.
30. Daviskas E Anderson SD Gonda I Chan HK Cook P Fulton R. Changes in mucociliary clearance during and after isocapnic hyperventilation in asthmatic and healthy subjects. Eur. Respir. J. 1995 8 : 742 51.
31. Daviskas E Anderson SD Gonda I et al. Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur. Respir. J. 1996 9 : 725 32.
32. Haney S Hancox RJ. Rapid onset of tolerance to beta-agonist bronchodilation. Respir. Med. 2005 99 : 566 71.
33. Pavia D Bateman JR Sheahan NF Clarke SW. Effect of ipratropium bromide on mucociliary clearance and pulmonary function in reversible airways obstruction. Thorax 1979 34 : 501 7.
34. Pavia D Bateman JR Sheahan NF Clarke SW. Clearance of lung secretions in patients with chronic bronchitis: effect of terbutaline and ipratropium bromide aerosols. Eur. J. Respir. Dis. 1980 61 : 245 53.
35. Daviskas E Anderson SD Eberl S Chan HK Bautovich G. Inhalation of dry powder mannitol improves clearance of mucus in patients with bronchiectasis. Am. J. Respir. Crit. Care Med. 1999 159 : 1843 8.
36. Phipps PR Gonda I Bailey DL Borham P Bautovich G Anderson SD. Comparisons of planar and tomographic gamma scintigraphy to measure the penetration index of inhaled aerosols. Am. Rev. Respir. Dis. 1989 139 : 1516 23.
37. Martinez FD Graves PE Baldini M Solomon S Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J. Clin. Invest. 1997 100 : 3184 8.
38. Liggett SB Wagoner LE Craft LL et al. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. J. Clin. Invest. 1998 102 : 1534 9.
39. Daviskas E Anderson SD Brannan JD Chan H-K Eberl S Bautovich G. Inhalation of dry powder mannitol increases mucociliary clearance. Eur. Respir. J. 1997 10 : 2449 54.
40. Daviskas E Anderson SD Eberl S Chan HK Young IH. The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest 2001 119 : 414 21.
41. Regnis JA Robinson M Bailey DL et al. Mucociliary clearance in patients with cystic fibrosis and in normal subjects. Am. J. Respir. Crit. Care Med. 1994 150 : 66 71.
42. Devalia JL Sapsford RJ Rusznak C Toumbis MJ Davies RJ. The effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells, in vitro. Pulm. Pharmacol. 1992 5 : 257 63.
43. Smaldone GC Foster WM O'Riordan TG Messina MS Perry RJ Langenback EG. Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease. Chest 1993 103 : 1390 6.
44. Agnew JE Bateman JR Pavia D Clarke SW. Peripheral airways mucus clearance in stable asthma is improved by oral corticosteroid therapy. Bull. Eur. Physiopathol. Respir. 1984 20 : 295 301.
45. Green SA Turki J Innis M Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994 33 : 9414 19.
46. Green SA Turki J Bejarano P Hall IP Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 1995 13 : 25 33.
47. Taylor DR Drazen JM Herbison GP Yandava CN Hancox RJ Town GI. Asthma exacerbations during long term beta agonist use: influence of beta (2) adrenoceptor polymorphism. Thorax 2000 55 : 762 7.
48. Israel E Drazen JM Liggett SB et al. The effect of polymorphisms of the beta (2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 2000 162 : 75 80.
49. Holloway JW Dunbar PR Riley GA et al. Association of beta2-adrenergic receptor polymorphisms with severe asthma. Clin. Exp. Allergy 2000 30 : 1097 103.